LOCUS NP_001135738 646 aa linear VRT 11-NOV-2023
DEFINITION neuroendocrine convertase 2 precursor [Danio rerio].
ACCESSION NP_001135738 XP_001343761
VERSION NP_001135738.1
DBSOURCE REFSEQ: accession NM_001142266.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 646)
AUTHORS Singh SP, Chawla P, Hnatiuk A, Kamel M, Silva LD, Spanjaard B, Eski
SE, Janjuha S, Olivares-Chauvet P, Kayisoglu O, Rost F, Blasche J,
Krankel A, Petzold A, Kurth T, Reinhardt S, Junker JP and Ninov N.
TITLE A single-cell atlas of de novo beta-cell regeneration reveals the
contribution of hybrid beta/delta-cells to diabetes recovery in
zebrafish
JOURNAL Development 149 (2) (2022)
PUBMED 35088828
REFERENCE 2 (residues 1 to 646)
AUTHORS Klingbeil K, Nguyen TQ, Fahrner A, Guthmann C, Wang H, Schoels M,
Lilienkamp M, Franz H, Eckert P, Walz G and Yakulov TA.
TITLE Corpuscles of Stannius development requires FGF signaling
JOURNAL Dev Biol 481, 160-171 (2022)
PUBMED 34666023
REFERENCE 3 (residues 1 to 646)
AUTHORS Hsieh YW, Tsai YW, Lai HH, Lai CY, Lin CY and Her GM.
TITLE Depletion of Alpha-Melanocyte-Stimulating Hormone Induces
Insatiable Appetite and Gains in Energy Reserves and Body Weight in
Zebrafish
JOURNAL Biomedicines 9 (8), 941 (2021)
PUBMED 34440144
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 646)
AUTHORS Delgadillo-Silva LF, Tsakmaki A, Akhtar N, Franklin ZJ, Konantz J,
Bewick GA and Ninov N.
TITLE Modelling pancreatic beta-cell inflammation in zebrafish identifies
the natural product wedelolactone for human islet protection
JOURNAL Dis Model Mech 12 (1) (2019)
PUBMED 30679186
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 646)
AUTHORS Chen L, Wang Y, Giesy JP, Chen F, Shi T, Chen J and Xie P.
TITLE Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI)
axis in early life stages (embryos and larvae) of zebrafish
JOURNAL Environ Pollut 241, 540-548 (2018)
PUBMED 29883955
REFERENCE 6 (residues 1 to 646)
AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
Hertzano R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
REFERENCE 7 (residues 1 to 646)
AUTHORS Ojanen MJ, Turpeinen H, Cordova ZM, Hammaren MM, Harjula SK,
Parikka M, Ramet M and Pesu M.
TITLE The proprotein convertase subtilisin/kexin furinA regulates
zebrafish host response against Mycobacterium marinum
JOURNAL Infect Immun 83 (4), 1431-1442 (2015)
PUBMED 25624351
REFERENCE 8 (residues 1 to 646)
AUTHORS Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusimaki A, Ramet
M, Parikka M, Hytonen VP, Nykter M and Pesu M.
TITLE Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential
for the zebrafish development and bioavailability of transforming
growth factor beta1a (TGFbeta1a)
JOURNAL J Biol Chem 288 (51), 36610-36623 (2013)
PUBMED 24178295
REFERENCE 9 (residues 1 to 646)
AUTHORS Fuzzen ML, Van Der Kraak G and Bernier NJ.
TITLE Stirring up new ideas about the regulation of the
hypothalamic-pituitary-interrenal axis in zebrafish (Danio rerio)
JOURNAL Zebrafish 7 (4), 349-358 (2010)
PUBMED 21091199
REFERENCE 10 (residues 1 to 646)
AUTHORS Morash MG, MacDonald AB, Croll RP and Anini Y.
TITLE Molecular cloning, ontogeny and tissue distribution of zebrafish
(Danio rerio) prohormone convertases: pcsk1 and pcsk2
JOURNAL Gen Comp Endocrinol 162 (2), 179-187 (2009)
PUBMED 19332069
REMARK GeneRIF: Pcsk2 has been sequenced and characterized.
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from FJ373315.1.
On Nov 26, 2008 this sequence version replaced XP_001343761.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FJ373315.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2168446, SAMEA2168447
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..646
/organism="Danio rerio"
/db_xref="taxon:7955"
/chromosome="13"
/map="13"
Protein 1..646
/product="neuroendocrine convertase 2 precursor"
/EC_number="3.4.21.94"
/note="proprotein convertase type 2"
/calculated_mol_wt=68700
sig_peptide 1..28
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=3098
Region 37..115
/region_name="S8_pro-domain"
/note="Peptidase S8 pro-domain; pfam16470"
/db_xref="CDD:435357"
Region 128..424
/region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
in-lik"
/note="Peptidase S8 family domain in Protein convertases;
cd04059"
/db_xref="CDD:173789"
Site order(129,182,228)
/site_type="other"
/note="calcium binding site 1 [ion binding]"
/db_xref="CDD:173789"
Site order(173..174,211,214,257,275,285,316,326,390)
/site_type="active"
/db_xref="CDD:173789"
Site order(173,214,390)
/site_type="active"
/note="catalytic triad [active]"
/db_xref="CDD:173789"
Site order(321,351)
/site_type="other"
/note="calcium binding site 2 [ion binding]"
/db_xref="CDD:173789"
Site order(329,331,334,336)
/site_type="other"
/note="calcium binding site 3 [ion binding]"
/db_xref="CDD:173789"
Region 510..598
/region_name="P_proprotein"
/note="Proprotein convertase P-domain; pfam01483"
/db_xref="CDD:426283"
CDS 1..646
/gene="pcsk2"
/coded_by="NM_001142266.1:1..1941"
/db_xref="GeneID:100004460"
/db_xref="ZFIN:ZDB-GENE-090608-1"
ORIGIN
1 mrrfrghhrt apalfltlig almmsaaaed elfitghflv qmreaapeda qklalehgfe
61 sarklpfged lfhfyplemp ktrrkrslhq qhhrlasdhr vknvfpqegf grqkrgyrdl
121 pntdvnmsdp lftkqwylin tgqadgtpgl dlnvaeawsl gftgkgvtia imddgidylh
181 pdlasnynae asfdfssndp ypyprytddw fnshgtrcag evsavsnnni cgvgvaynsk
241 vagirmldqp fmtdiieass ishmpqvidi ysaswgptdd gktvdgprel tlqamadgvn
301 kgrggkgsiy vwasgdggsy ddcncdgyas smwtisinsa indgrtalyd escsstlast
361 fsngrkrnpe agvattdlyg nctlrhsgts aaapeaagvf alaleanpnl twrdlqhltv
421 ltskrnklhd evhqwrrngv glefnhlfgy gvldaggmvk lardwktvpe rfhcvagsmq
481 dihkiqsgnk lllsistdac qgkdnfvryl ehvqavitvn asrrgdlnin mtspmgtksi
541 llsrrprddd akvgfdkwpf mtthtwgedp rgpwllevgf qsqsdmqsgl lkewtlmlhg
601 tqsapyidqv vrdyqsklam skkeeleeel deaverslks llsknn
//
