LOCUS       NP_001153563             433 aa            linear   MAM 22-DEC-2022
DEFINITION  N-lysine methyltransferase SMYD2 [Sus scrofa].
ACCESSION   NP_001153563
VERSION     NP_001153563.1
DBSOURCE    REFSEQ: accession NM_001160091.1
KEYWORDS    RefSeq.
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Peng YB, Yerle M and Liu B.
  TITLE     Mapping and expression analyses during porcine foetal muscle
            development of 12 genes involved in histone modifications
  JOURNAL   Anim Genet 40 (2), 242-246 (2009)
   PUBMED   19133938
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H,
            Okumura N, Hamasima N and Awata T.
  TITLE     PEDE (Pig EST Data Explorer): construction of a database for ESTs
            derived from porcine full-length cDNA libraries
  JOURNAL   Nucleic Acids Res 32 (Database issue), D484-D488 (2004)
   PUBMED   14681463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EU661943.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU661943.1, AK237867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02584789 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Sus scrofa"
                     /db_xref="taxon:9823"
                     /chromosome="9"
                     /map="9"
     Protein         1..433
                     /product="N-lysine methyltransferase SMYD2"
                     /EC_number="2.1.1.354"
                     /note="Histone methyltransferase SMYD2; SET and MYND
                     domain-containing protein 2"
                     /calculated_mol_wt=49628
     Region          7..269
                     /region_name="SET_SMYD2"
                     /note="SET domain (including post-SET domain) found in SET
                     and MYND domain-containing protein 2 (SMYD2) and similar
                     proteins; cd19202"
                     /db_xref="CDD:380979"
     Site            order(16..19,105,135,137,141,145,149,177,179..185,196,
                     203..207,238..240,257..260)
                     /site_type="active"
                     /db_xref="CDD:380979"
     Site            order(16..19,135,137,181..182,203..207,240,258,260)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380979"
     Region          52..90
                     /region_name="zf-MYND"
                     /note="MYND finger; pfam01753"
                     /db_xref="CDD:426410"
     Site            order(105,141,145,149,177,179..185,196,203,238..240,
                     257..259)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380979"
     Site            order(105,179,181..185,193,203,239..240,242,258)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:380979"
     Site            order(209,262,264,267)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:380979"
     Region          388..422
                     /region_name="TPR_10"
                     /note="Tetratricopeptide repeat; pfam13374"
                     /db_xref="CDD:433156"
     CDS             1..433
                     /gene="SMYD2"
                     /coded_by="NM_001160091.1:169..1470"
                     /db_xref="GeneID:100294706"
                     /db_xref="VGNC:VGNC:93273"
ORIGIN      
        1 mraegdggle rfcspgkgrg lralqpfqvg dllfscpaya yvltvnergn hcefcfarke
       61 glskcgrckq afycnvecqk edwpmhklec spmvvfgenw npsetvrlta rilakqkihp
      121 ertpseklla vkefeshldk ldnekrdliq sdiaalhhfy skhlefpdsd slvvlfaqvn
      181 cngftiedee lshlgsxifp dvalmnhscc pnvivtykgt laevravqei hpgeevftsy
      241 idllyptedr ndrlrdsyff tcecqecttk dkdkakveir klndppkaea irdmvryarn
      301 vieefrrakh ykspsellei celsqekmsc vfedsnvyml hmmyqamgvc lymqdwegal
      361 rygqkiiqpy skhyplysln vasmwlklgr lymglenkaa geralrkaia imevahgkdh
      421 pyiseikqei esh
//