GenomeNet

Database: RefSeq
Entry: NP_001155894
LinkDB: NP_001155894
Original site: NP_001155894 
LOCUS       NP_001155894             225 aa            linear   PRI 03-SEP-2019
DEFINITION  protein C-ets-1 isoform 3 [Homo sapiens].
ACCESSION   NP_001155894
VERSION     NP_001155894.1
DBSOURCE    REFSEQ: accession NM_001162422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 225)
  AUTHORS   Nazir SU, Kumar R, Singh A, Khan A, Tanwar P, Tripathi R, Mehrotra
            R and Hussain S.
  TITLE     Breast cancer invasion and progression by MMP-9 through Ets-1
            transcription factor
  JOURNAL   Gene 711, 143952 (2019)
   PUBMED   31265880
  REMARK    GeneRIF: Study demonstrates the effect of Ets-1 in the invasion and
            epithelial to mesenchymal transition in the pathway of breast
            cancer progression, and suggests a plausible role of Ets-1
            dependent regulation of MMP-9 gene which may have a significant
            impact on breast carcinogenesis.
            Erratum:[Gene. 2019 Oct 20;716:144013. PMID: 31377019]
REFERENCE   2  (residues 1 to 225)
  AUTHORS   Jin L, Fang X, Dai C, Xiang N, Tao J, Sun X, Azmi F, Cao Q, Li X,
            Wang Y and Li X.
  TITLE     The potential role of Ets-1 and miR-326 in CD19(+)B cells in the
            pathogenesis of patients with systemic lupus erythematosus
  JOURNAL   Clin. Rheumatol. 38 (4), 1031-1038 (2019)
   PUBMED   30456527
  REMARK    GeneRIF: Our results suggest that miR-326 might promote B cells
            differentiation by targeting Ets-1, a negative regulator of B cells
            differentiation and therefore participate in the pathogenesis of
            systemic lupus erythematosus.
REFERENCE   3  (residues 1 to 225)
  AUTHORS   Li S, Yan G, Yue M, Kang Z and Wang L.
  TITLE     MicroRNA766 inhibits the malignant biological behaviours of
            pancreatic ductal adenocarcinoma by directly targeting ETS1
  JOURNAL   Mol Med Rep 19 (2), 1380-1387 (2019)
   PUBMED   30569091
  REMARK    GeneRIF: ETS1 knockdown simulated the inhibitory effects of the
            overexpression of miR766 on PDAC cells.
REFERENCE   4  (residues 1 to 225)
  AUTHORS   Furlan A, Vercamer C, Heliot L, Wernert N, Desbiens X and Pourtier
            A.
  TITLE     Ets-1 drives breast cancer cell angiogenic potential and
            interactions between breast cancer and endothelial cells
  JOURNAL   Int. J. Oncol. 54 (1), 29-40 (2019)
   PUBMED   30365153
  REMARK    GeneRIF: Study demonstrates that Ets-1 overexpression in breast
            cancer cells promotes their adhesion to endothelial cells and
            invasion.
REFERENCE   5  (residues 1 to 225)
  AUTHORS   Shao Z, Li Y, Dai W, Jia H, Zhang Y, Jiang Q, Chai Y, Li X, Sun H,
            Yang R, Cao Y, Feng F and Guo Y.
  TITLE     ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma
            cells via regulating transcription factor activity of PXR
  JOURNAL   Pharmacol. Res. 135, 188-200 (2018)
   PUBMED   30114438
  REMARK    GeneRIF: Overexpression of ETS-1 accelerates the metabolic
            clearance of Sorafenib in hepatocellular carcinoma and leads to the
            better survival and faster migration of those cells. ETS-1 could
            enhance the activation of PXR and be a potential therapeutic target
            for overcoming Sorafenib resistance in hepatocellular carcinoma
            treatment.
REFERENCE   6  (residues 1 to 225)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   7  (residues 1 to 225)
  AUTHORS   Majerus MA, Bibollet-Ruche F, Telliez JB, Wasylyk B and Bailleul B.
  TITLE     Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
  JOURNAL   Nucleic Acids Res. 20 (11), 2699-2703 (1992)
   PUBMED   1614856
REFERENCE   8  (residues 1 to 225)
  AUTHORS   Nye JA, Petersen JM, Gunther CV, Jonsen MD and Graves BJ.
  TITLE     Interaction of murine ets-1 with GGA-binding sites establishes the
            ETS domain as a new DNA-binding motif
  JOURNAL   Genes Dev. 6 (6), 975-990 (1992)
   PUBMED   1592264
REFERENCE   9  (residues 1 to 225)
  AUTHORS   Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP and Bailleul
            B.
  TITLE     Splicing with inverted order of exons occurs proximal to large
            introns
  JOURNAL   EMBO J. 11 (3), 1095-1098 (1992)
   PUBMED   1339341
REFERENCE   10 (residues 1 to 225)
  AUTHORS   Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S,
            Fisher RJ and Papas TS.
  TITLE     Reciprocal expression of human ETS1 and ETS2 genes during T-cell
            activation: regulatory role for the protooncogene ETS1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (10), 3723-3727 (1990)
   PUBMED   2187191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301405.1, AK291840.1,
            BX640634.1, BM468663.1, CA407336.1, AP003397.2 and AK001630.1.
            
            Summary: This gene encodes a member of the ETS family of
            transcription factors, which are defined by the presence of a
            conserved ETS DNA-binding domain that recognizes the core consensus
            DNA sequence GGAA/T in target genes. These proteins function either
            as transcriptional activators or repressors of numerous genes, and
            are involved in stem cell development, cell senescence and death,
            and tumorigenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (3) uses an alternate promoter,
            and differs in the 5' UTR and 5' coding region compared to variant
            1. It is also missing four consecutive in-frame coding exons,
            resulting in a shorter isoform (3, also known as Ets-1 p27) with a
            distinct N-terminus and lacking an internal protein segment
            compared to isoform 1. This isoform has been shown to exert a
            dominant negative effect on the transcriptional properties and the
            subcellular localization of Ets-1 p51 isoform (PMID:19377509).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY943926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01820687, SAMN01820695
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     Protein         1..225
                     /product="protein C-ets-1 isoform 3"
                     /note="Avian erythroblastosis virus E26 (v-ets) oncogene
                     homolog-1; protein C-ets-1; v-ets avian erythroblastosis
                     virus E26 oncogene homolog 1; v-ets avian erythroblastosis
                     virus E2 oncogene homolog 1"
                     /calculated_mol_wt=25566
     Site            8
                     /site_type="acetylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            15
                     /site_type="acetylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          118..202
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..225
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /coded_by="NM_001162422.1:317..994"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS53724.1"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
ORIGIN      
        1 mkaavdlkpt ltiiktekvd lelfpspgkl ggqdsfesie sydscdrltq swssqssfns
       61 lqrvpsydsf dsedypaalp nhkpkgtfkd yvrdradlnk dkpvipaaal agytgsgpiq
      121 lwqfllellt dkscqsfisw tgdgwefkls dpdevarrwg krknkpkmny eklsrglryy
      181 ydkniihkta gkryvyrfvc dlqsllgytp eelhamldvk pdade
//
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