LOCUS NP_001155894 225 aa linear PRI 30-APR-2025
DEFINITION protein C-ets-1 isoform 3 [Homo sapiens].
ACCESSION NP_001155894
VERSION NP_001155894.1
DBSOURCE REFSEQ: accession NM_001162422.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 225)
AUTHORS Chatterjee,P., Ghosh,D., Chowdhury,S.R. and Roy,S.S.
TITLE ETS1 drives EGF-induced glycolytic shift and metastasis of
epithelial ovarian cancer cells
JOURNAL Biochim Biophys Acta Mol Cell Res 1871 (8), 119805 (2024)
PUBMED 39159682
REMARK GeneRIF: ETS1 drives EGF-induced glycolytic shift and metastasis of
epithelial ovarian cancer cells.
REFERENCE 2 (residues 1 to 225)
AUTHORS Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
Cao,Q., Zhou,G.P. and Jin,R.
TITLE ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
TGF-beta1-induced epithelial-mesenchymal transition in human
bronchial epithelial cells
JOURNAL Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
PUBMED 39002703
REMARK GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
suppress TGF-beta1-induced epithelial-mesenchymal transition in
human bronchial epithelial cells.
REFERENCE 3 (residues 1 to 225)
AUTHORS Guo,Y., Pan,J., Gao,X. and Zheng,Y.
TITLE Circ-PITX1 promotes non-small-cell lung cancer progression through
regulating ETS1 expression via miR-615-5p
JOURNAL Thorac Cancer 15 (27), 1946-1957 (2024)
PUBMED 39138880
REMARK GeneRIF: Circ-PITX1 promotes non-small-cell lung cancer progression
through regulating ETS1 expression via miR-615-5p.
REFERENCE 4 (residues 1 to 225)
AUTHORS Sreelakshmi,B.J., Karthika,C.L., Ahalya,S., Kalpana,S.R.,
Kartha,C.C. and Sumi,S.
TITLE Mechanoresponsive ETS1 causes endothelial dysfunction and
arterialization in varicose veins via NOTCH4/DLL4 signaling
JOURNAL Eur J Cell Biol 103 (2), 151420 (2024)
PUBMED 38759515
REMARK GeneRIF: Mechanoresponsive ETS1 causes endothelial dysfunction and
arterialization in varicose veins via NOTCH4/DLL4 signaling.
REFERENCE 5 (residues 1 to 225)
AUTHORS Guo,J.R., He,K.Y., Yuan,J.L., An,W., Yin,W.T., Li,Q.T., Lu,L.Y.,
Yang,J.Y., Liu,M.J., Li,Y.J., Zhao,Y., Yang,Q., Lei,X.Y., Gao,F.,
Zhang,L., Wu,D.H., Li,J.Q., Zhao,Z.L., Liu,H., Zhu,L.J.,
Xiang,X.Y., Sun,Q.H., Jian,Y.P. and Xu,Z.X.
TITLE HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR
inhibitors through the ETS1-FKBP12 axis
JOURNAL Int J Biol Sci 20 (7), 2640-2657 (2024)
PUBMED 38725843
REMARK GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to
mTOR inhibitors through the ETS1-FKBP12 axis.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 225)
AUTHORS Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
TITLE Gene fusion with an ETS DNA-binding domain caused by chromosome
translocation in human tumours
JOURNAL Nature 359 (6391), 162-165 (1992)
PUBMED 1522903
REFERENCE 7 (residues 1 to 225)
AUTHORS Majerus,M.A., Bibollet-Ruche,F., Telliez,J.B., Wasylyk,B. and
Bailleul,B.
TITLE Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
JOURNAL Nucleic Acids Res 20 (11), 2699-2703 (1992)
PUBMED 1614856
REFERENCE 8 (residues 1 to 225)
AUTHORS Nye,J.A., Petersen,J.M., Gunther,C.V., Jonsen,M.D. and Graves,B.J.
TITLE Interaction of murine ets-1 with GGA-binding sites establishes the
ETS domain as a new DNA-binding motif
JOURNAL Genes Dev 6 (6), 975-990 (1992)
PUBMED 1592264
REFERENCE 9 (residues 1 to 225)
AUTHORS Cocquerelle,C., Daubersies,P., Majerus,M.A., Kerckaert,J.P. and
Bailleul,B.
TITLE Splicing with inverted order of exons occurs proximal to large
introns
JOURNAL EMBO J 11 (3), 1095-1098 (1992)
PUBMED 1339341
REFERENCE 10 (residues 1 to 225)
AUTHORS Bhat,N.K., Thompson,C.B., Lindsten,T., June,C.H., Fujiwara,S.,
Koizumi,S., Fisher,R.J. and Papas,T.S.
TITLE Reciprocal expression of human ETS1 and ETS2 genes during T-cell
activation: regulatory role for the protooncogene ETS1
JOURNAL Proc Natl Acad Sci U S A 87 (10), 3723-3727 (1990)
PUBMED 2187191
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK301405.1, AK291840.1,
BX640634.1, BM468663.1, CA407336.1, AP003397.2 and AK001630.1.
Summary: This gene encodes a member of the ETS family of
transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus
DNA sequence GGAA/T in target genes. These proteins function either
as transcriptional activators or repressors of numerous genes, and
are involved in stem cell development, cell senescence and death,
and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this
gene.[provided by RefSeq, Jul 2011].
Transcript Variant: This variant (3) uses an alternate promoter,
and differs in the 5' UTR and 5' coding region compared to variant
1. It is also missing four consecutive in-frame coding exons,
resulting in a shorter isoform (3, also known as Ets-1 p27) with a
distinct N-terminus and lacking an internal protein segment
compared to isoform 1. This isoform has been shown to exert a
dominant negative effect on the transcriptional properties and the
subcellular localization of Ets-1 p51 isoform (PMID:19377509).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY943926.1 [ECO:0000332]
RNAseq introns :: partial sample support SAMEA1965299,
SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..225
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.3"
Protein 1..225
/product="protein C-ets-1 isoform 3"
/note="Avian erythroblastosis virus E26 (v-ets) oncogene
homolog-1; protein C-ets-1; v-ets avian erythroblastosis
virus E26 oncogene homolog 1; v-ets avian erythroblastosis
virus E2 oncogene homolog 1"
/calculated_mol_wt=25566
Site 8
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 15
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region <26..118
/region_name="Ets1_N_flank"
/note="Ets1 N-terminal flanking region of Ets domain;
pfam19525"
/db_xref="CDD:466113"
Region 118..202
/region_name="ETS"
/note="erythroblast transformation specific domain;
smart00413"
/db_xref="CDD:197710"
CDS 1..225
/gene="ETS1"
/gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
/coded_by="NM_001162422.2:317..994"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS53724.1"
/db_xref="GeneID:2113"
/db_xref="HGNC:HGNC:3488"
/db_xref="MIM:164720"
ORIGIN
1 mkaavdlkpt ltiiktekvd lelfpspgkl ggqdsfesie sydscdrltq swssqssfns
61 lqrvpsydsf dsedypaalp nhkpkgtfkd yvrdradlnk dkpvipaaal agytgsgpiq
121 lwqfllellt dkscqsfisw tgdgwefkls dpdevarrwg krknkpkmny eklsrglryy
181 ydkniihkta gkryvyrfvc dlqsllgytp eelhamldvk pdade
//
