LOCUS NP_001166520 341 aa linear ROD 20-JUN-2025
DEFINITION low affinity immunoglobulin gamma Fc region receptor II precursor
[Cavia porcellus].
ACCESSION NP_001166520
VERSION NP_001166520.1
DBSOURCE REFSEQ: accession NM_001173049.1
KEYWORDS RefSeq.
SOURCE Cavia porcellus (domestic guinea pig)
ORGANISM Cavia porcellus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
REFERENCE 1 (residues 1 to 341)
AUTHORS Yamashita,T., Shinohara,K. and Yamashita,Y.
TITLE Expression cloning of complementary DNA encoding three distinct
isoforms of guinea pig Fc receptor for IgG1 and IgG2
JOURNAL J Immunol 151 (4), 2014-2023 (1993)
PUBMED 8345193
REFERENCE 2 (residues 1 to 341)
AUTHORS Tominaga,M., Sakata,A., Ohmura,T., Yamashita,T., Koyama,J. and
Onoue,K.
TITLE The structure and expression of the guinea pig Fc receptor for IgG1
and IgG2 (Fc gamma 1/gamma 2R)
JOURNAL Biochem Biophys Res Commun 168 (2), 683-689 (1990)
PUBMED 1692213
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from D13693.1.
##Evidence-Data-START##
Transcript exon combination :: D13693.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN02693769, SAMN02693772
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..341
/organism="Cavia porcellus"
/db_xref="taxon:10141"
Protein 1..341
/product="low affinity immunoglobulin gamma Fc region
receptor II precursor"
/note="Fc-gamma RII; IgG Fc receptor II; Low affinity
immunoglobulin gamma Fc region receptor II;
Fc-gamma-1/gamma-2 receptor"
/calculated_mol_wt=32374
sig_peptide 1..43
/calculated_mol_wt=4736
mat_peptide 44..341
/product="low affinity immunoglobulin gamma Fc region
receptor II"
/calculated_mol_wt=32374
Region 50..128
/region_name="Ig1_FcgammaR_like"
/note="First immunoglobulin (Ig)-like domain of
Fcgamma-receptors (FcgammaRs), and similar domains;
cd05752"
/db_xref="CDD:409410"
Region 51..54
/region_name="Ig strand A"
/note="Ig strand A [structural motif]"
/db_xref="CDD:409410"
Site order(53..54,72,80..83)
/site_type="other"
/note="pentraxin binding site [polypeptide binding]"
/db_xref="CDD:409410"
Region 59..62
/region_name="Ig strand A'"
/note="Ig strand A' [structural motif]"
/db_xref="CDD:409410"
Region 66..72
/region_name="Ig strand B"
/note="Ig strand B [structural motif]"
/db_xref="CDD:409410"
Site 79
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Region 82..87
/region_name="Ig strand C"
/note="Ig strand C [structural motif]"
/db_xref="CDD:409410"
Region 89..91
/region_name="Ig strand C'"
/note="Ig strand C' [structural motif]"
/db_xref="CDD:409410"
Region 97..102
/region_name="Ig strand E"
/note="Ig strand E [structural motif]"
/db_xref="CDD:409410"
Site 106
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Region 109..114
/region_name="Ig strand F"
/note="Ig strand F [structural motif]"
/db_xref="CDD:409410"
Region 122..128
/region_name="Ig strand G"
/note="Ig strand G [structural motif]"
/db_xref="CDD:409410"
Region 132..214
/region_name="Ig2_FcgammaR_like"
/note="Second immunoglobulin (Ig)-like domain of
Fcgamma-receptors (FcgammaRs), and similar domains;
cd05753"
/db_xref="CDD:409411"
Site order(132,155,161..162)
/site_type="other"
/note="Fc binding site [polypeptide binding]"
/db_xref="CDD:409411"
Region 132..136
/region_name="Ig strand A"
/note="Ig strand A [structural motif]"
/db_xref="CDD:409411"
Region 141..143
/region_name="Ig strand A'"
/note="Ig strand A' [structural motif]"
/db_xref="CDD:409411"
Site order(145..147,156,161,200)
/site_type="other"
/note="pentraxin binding site [polypeptide binding]"
/db_xref="CDD:409411"
Region 147..154
/region_name="Ig strand B"
/note="Ig strand B [structural motif]"
/db_xref="CDD:409411"
Region 161..167
/region_name="Ig strand C"
/note="Ig strand C [structural motif]"
/db_xref="CDD:409411"
Region 170..175
/region_name="Ig strand C'"
/note="Ig strand C' [structural motif]"
/db_xref="CDD:409411"
Region 179..183
/region_name="Ig strand E"
/note="Ig strand E [structural motif]"
/db_xref="CDD:409411"
Site 180
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Site 187
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Region 193..198
/region_name="Ig strand F"
/note="Ig strand F [structural motif]"
/db_xref="CDD:409411"
Site 195
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Region 204..214
/region_name="Ig strand G"
/note="Ig strand G [structural motif]"
/db_xref="CDD:409411"
Site 225..245
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q60513.1)"
Region 255..274
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q60513.1)"
Region 289..310
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q60513.1)"
Region 318..323
/region_name="ITIM motif"
/note="propagated from UniProtKB/Swiss-Prot (Q60513.1)"
Site 320
/site_type="phosphorylation"
/note="Phosphotyrosine, by SRC-type Tyr-kinases.
/evidence=ECO:0000250; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
Region 322..341
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q60513.1)"
Site 337
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:P08101; propagated from
UniProtKB/Swiss-Prot (Q60513.1)"
CDS 1..341
/gene="Fcgr2b"
/gene_synonym="FCGR2; FcRII; Gpifcgr"
/coded_by="NM_001173049.1:75..1100"
/db_xref="GeneID:100192391"
ORIGIN
1 maipsflpvl gtkshradyk plqtlshmll witvlflapv agtsadppka vvrleppwiq
61 vlrgdrvtlt cegapspgnh stqwlhngrl iptqvlpsyr ftakgndsge yrcqaggtsl
121 sdpvrldvis dwlvlqtsql ifqegdvivl rchswnnwpl akvtfyhngv akkyfsiskn
181 fsipqanhsh sgaynctgli grtshtsppv titvqgpkss dssmvviiva avigiataai
241 vvavvaiicl kkkqppgnpe hremgetlpe dpgeysvvfg gsmmscpglp dglepartdl
301 snlsdpeeva kseventity sllkhpeaqd ddtehdyqnh i
//
