GenomeNet

Database: RefSeq
Entry: NP_001171528
LinkDB: NP_001171528
Original site: NP_001171528 
LOCUS       NP_001171528             691 aa            linear   PRI 23-DEC-2018
DEFINITION  angiotensin-converting enzyme isoform 3 precursor [Homo sapiens].
ACCESSION   NP_001171528
VERSION     NP_001171528.1
DBSOURCE    REFSEQ: accession NM_001178057.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 691)
  AUTHORS   Lopez-Sublet M, Caratti di Lanzacco L, Danser AHJ, Lambert M,
            Elourimi G and Persu A.
  TITLE     Focus on increased serum angiotensin-converting enzyme level: From
            granulomatous diseases to genetic mutations
  JOURNAL   Clin. Biochem. 59, 1-8 (2018)
   PUBMED   29928904
  REMARK    GeneRIF: summary of current knowledge about circulating ACE
            elevation in patients with granulomatous and non-granulomatous
            diseases.
            Review article
REFERENCE   2  (residues 1 to 691)
  AUTHORS   Wang ZY, Li HY, Jiang ZP and Zhou TB.
  TITLE     Relationship between angiotensin-converting enzyme
            insertion/deletion gene polymorphism and prostate cancer
            susceptibility
  JOURNAL   J Cancer Res Ther 14 (Supplement), S375-S380 (2018)
   PUBMED   29970692
  REMARK    GeneRIF: Angiotensin-converting enzyme insertion/deletion gene
            polymorphism is associated with prostate cancer susceptibility.
REFERENCE   3  (residues 1 to 691)
  AUTHORS   Silva RFD, Lacchini R, Pinheiro LC, Dionisio TJ, Jacomini A,
            Tanus-Santos JE, Amaral SL, Santos CF and Zago AS.
  TITLE     Preliminary study about the relationship between estimated training
            status and RAS polymorphisms on blood pressure and ACE activity in
            the elderly
  JOURNAL   J Renin Angiotensin Aldosterone Syst 19 (2), 1470320318782622
            (2018)
   PUBMED   29923443
  REMARK    GeneRIF: This study aimed to investigate the relationship between
            estimated training status (TS), blood pressure and
            angiotensin-converting enzyme (ACE) activity in elderly people
            classified as low or high risk to develop hypertension according to
            genetic profile.
REFERENCE   4  (residues 1 to 691)
  AUTHORS   Pan Y and Lu H.
  TITLE     Angiotensin-converting enzyme insertion/deletion polymorphism and
            susceptibility to Kawasaki disease: a meta-analysis
  JOURNAL   Afr Health Sci 17 (4), 991-999 (2017)
   PUBMED   29937869
  REMARK    GeneRIF: study found a significant association between the ACE
            insertion/deletion polymorphism and Kawasaki disease risk -
            meta-analysis
REFERENCE   5  (residues 1 to 691)
  AUTHORS   Pavlyushchik,O.O., Afonin,V.Y., Sarokina,V.N., Chak,T.A.,
            Khapaliuk,A.V. and Anisovich,M.V.
  TITLE     Association of the ace I/D gene polymorphism with DNA damage in
            hypertensive men
  JOURNAL   Tsitol. Genet. 50 (5), 48-58 (2016)
   PUBMED   30480916
  REMARK    GeneRIF: The study suggests that the ACE I/D polymorphism may
            contribute to mechanisms and intensity of DNA damage in
            hypertensive and normotensive individuals.
REFERENCE   6  (residues 1 to 691)
  AUTHORS   Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc
            G, Bard JM, Bara L, Ricard S et al.
  TITLE     Deletion polymorphism in the gene for angiotensin-converting enzyme
            is a potent risk factor for myocardial infarction
  JOURNAL   Nature 359 (6396), 641-644 (1992)
   PUBMED   1328889
REFERENCE   7  (residues 1 to 691)
  AUTHORS   Wei L, Clauser E, Alhenc-Gelas F and Corvol P.
  TITLE     The two homologous domains of human angiotensin I-converting enzyme
            interact differently with competitive inhibitors
  JOURNAL   J. Biol. Chem. 267 (19), 13398-13405 (1992)
   PUBMED   1320019
REFERENCE   8  (residues 1 to 691)
  AUTHORS   Jeunemaitre X, Lifton RP, Hunt SC, Williams RR and Lalouel JM.
  TITLE     Absence of linkage between the angiotensin converting enzyme locus
            and human essential hypertension
  JOURNAL   Nat. Genet. 1 (1), 72-75 (1992)
   PUBMED   1338766
REFERENCE   9  (residues 1 to 691)
  AUTHORS   Ehlers MR and Riordan JF.
  TITLE     Angiotensin-converting enzyme: zinc- and inhibitor-binding
            stoichiometries of the somatic and testis isozymes
  JOURNAL   Biochemistry 30 (29), 7118-7126 (1991)
   PUBMED   1649623
REFERENCE   10 (residues 1 to 691)
  AUTHORS   Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
  TITLE     The role of the renin-angiotensin-aldosterone system in
            cardiovascular homeostasis in normal human subjects
  JOURNAL   Circulation 53 (3), 400-405 (1976)
   PUBMED   174834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM908222.1, M26657.1,
            AB208971.1, AK301988.1 and AC113554.9.
            
            Summary: This gene encodes an enzyme involved in catalyzing the
            conversion of angiotensin I into a physiologically active peptide
            angiotensin II. Angiotensin II is a potent vasopressor and
            aldosterone-stimulating peptide that controls blood pressure and
            fluid-electrolyte balance. This enzyme plays a key role in the
            renin-angiotensin system. Many studies have associated the presence
            or absence of a 287 bp Alu repeat element in this gene with the
            levels of circulating enzyme or cardiovascular pathophysiologies.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified, and two most abundant
            spliced variants encode the somatic form and the testicular form,
            respectively, that are equally active. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (3) lacks multiple 5' exons and an
            in-frame exon in the 3' region, but has an alternate 5' exon,
            compared to variant 1. The resulting isoform (3) is shorter, and
            has a distinct N-terminus and lacks an internal segment, compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     Protein         1..691
                     /product="angiotensin-converting enzyme isoform 3
                     precursor"
                     /EC_number="3.4.15.1"
                     /note="kininase II; CD143 antigen; angiotensin converting
                     enzyme, somatic isoform; peptidase P; carboxycathepsin;
                     dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase
                     I; angiotensin I converting enzyme (peptidyl-dipeptidase
                     A) 1"
                     /calculated_mol_wt=76501
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2212
     variation       1
                     /replace="t"
                     /db_xref="dbSNP:1185338409"
     variation       1
                     /replace="v"
                     /db_xref="dbSNP:571813294"
     variation       2
                     /replace="g"
                     /db_xref="dbSNP:757155317"
     variation       3
                     /replace="h"
                     /db_xref="dbSNP:1178827928"
     variation       3
                     /replace="r"
                     /db_xref="dbSNP:778807415"
     variation       4
                     /replace="d"
                     /db_xref="dbSNP:745822083"
     variation       4
                     /replace="g"
                     /db_xref="dbSNP:771846117"
     variation       4
                     /replace="s"
                     /db_xref="dbSNP:1400568891"
     variation       5
                     /replace="*"
                     /db_xref="dbSNP:1347404320"
     variation       5
                     /replace="s"
                     /db_xref="dbSNP:1337219696"
     variation       6
                     /replace="v"
                     /db_xref="dbSNP:547129536"
     variation       7
                     /replace="a"
                     /db_xref="dbSNP:1276973332"
     variation       8
                     /replace="a"
                     /db_xref="dbSNP:560419983"
     variation       8
                     /replace="t"
                     /db_xref="dbSNP:746566272"
     variation       9
                     /replace="e"
                     /db_xref="dbSNP:1272682009"
     variation       10
                     /replace="f"
                     /db_xref="dbSNP:1344119283"
     variation       11
                     /replace="s"
                     /db_xref="dbSNP:776196929"
     variation       12
                     /replace="a"
                     /db_xref="dbSNP:1469385277"
     variation       12
                     /replace="q"
                     /db_xref="dbSNP:1156450082"
     variation       12
                     /replace="r"
                     /db_xref="dbSNP:771711347"
     variation       13
                     /replace="f"
                     /db_xref="dbSNP:761425615"
     variation       13
                     /replace="l"
                     /db_xref="dbSNP:1214578918"
     variation       14
                     /replace="l"
                     /db_xref="dbSNP:377588481"
     variation       15
                     /replace="f"
                     /db_xref="dbSNP:773520398"
     variation       16
                     /replace="l"
                     /db_xref="dbSNP:1201950456"
     variation       17
                     /replace="l"
                     /db_xref="dbSNP:1244104618"
     variation       17
                     /replace="l"
                     /db_xref="dbSNP:763468579"
     variation       18
                     /replace="f"
                     /db_xref="dbSNP:1477913711"
     variation       18
                     /replace="p"
                     /db_xref="dbSNP:766732535"
     variation       20
                     /replace="y"
                     /db_xref="dbSNP:532464035"
     variation       21
                     /replace="r"
                     /db_xref="dbSNP:552179722"
     mat_peptide     22..691
                     /product="angiotensin-converting enzyme isoform 3"
                     /calculated_mol_wt=76501
     variation       22
                     /replace="h"
                     /db_xref="dbSNP:1330572442"
     variation       22
                     /replace="y"
                     /db_xref="dbSNP:1418353784"
     variation       25
                     /replace="l"
                     /db_xref="dbSNP:759581971"
     variation       27
                     /replace="l"
                     /db_xref="dbSNP:1400803106"
     variation       27
                     /replace="p"
                     /db_xref="dbSNP:4316"
     variation       28
                     /replace="r"
                     /db_xref="dbSNP:1406238387"
     variation       29
                     /replace="q"
                     /db_xref="dbSNP:1321239382"
     variation       30
                     /replace="e"
                     /db_xref="dbSNP:752995823"
     variation       31
                     /replace="-"
                     /db_xref="dbSNP:775470950"
     variation       32
                     /replace="p"
                     /db_xref="dbSNP:4317"
     variation       33
                     /replace="*"
                     /db_xref="dbSNP:1351210343"
     variation       34
                     /replace="e"
                     /db_xref="dbSNP:1239390292"
     variation       35
                     /replace="m"
                     /db_xref="dbSNP:1221995320"
     variation       36
                     /replace="i"
                     /db_xref="dbSNP:1292405452"
     variation       37
                     /replace="a"
                     /db_xref="dbSNP:750174798"
     variation       37
                     /replace="i"
                     /db_xref="dbSNP:778864574"
     variation       38
                     /replace="t"
                     /db_xref="dbSNP:758206968"
     variation       39
                     /replace="q"
                     /db_xref="dbSNP:1337949202"
     variation       39
                     /replace="r"
                     /db_xref="dbSNP:779911816"
     variation       40
                     /replace="e"
                     /db_xref="dbSNP:746945418"
     variation       40
                     /replace="g"
                     /db_xref="dbSNP:1183009650"
     variation       41
                     /replace="a"
                     /db_xref="dbSNP:1240468013"
     variation       42
                     /replace="n"
                     /db_xref="dbSNP:1237255738"
     variation       43
                     /replace="n"
                     /db_xref="dbSNP:768093130"
     variation       45
                     /replace="-"
                     /db_xref="dbSNP:760370486"
     variation       45
                     /replace="s"
                     /db_xref="dbSNP:780642247"
     variation       47
                     /replace="t"
                     /db_xref="dbSNP:1380322560"
     variation       48
                     /replace="g"
                     /db_xref="dbSNP:1351615223"
     variation       48
                     /replace="n"
                     /db_xref="dbSNP:747820655"
     variation       49
                     /replace="g"
                     /db_xref="dbSNP:4318"
     variation       49
                     /replace="s"
                     /db_xref="dbSNP:1281526284"
     variation       50
                     /replace="*"
                     /db_xref="dbSNP:980857256"
     variation       50
                     /replace="attssq"
                     /db_xref="dbSNP:1335563391"
     variation       50
                     /replace="r"
                     /db_xref="dbSNP:773575155"
     variation       53
                     /replace="a"
                     /db_xref="dbSNP:1330442011"
     variation       54
                     /replace="q"
                     /db_xref="dbSNP:1445758551"
     variation       54
                     /replace="y"
                     /db_xref="dbSNP:370963034"
     variation       55
                     /replace="r"
                     /db_xref="dbSNP:934773366"
     variation       56
                     /replace="a"
                     /db_xref="dbSNP:374093911"
     variation       56
                     /replace="v"
                     /db_xref="dbSNP:749684750"
     variation       57
                     /replace="m"
                     /db_xref="dbSNP:760045141"
     variation       57
                     /replace="t"
                     /db_xref="dbSNP:767512451"
     variation       58
                     /replace="a"
                     /db_xref="dbSNP:972512569"
     variation       59
                     /replace="h"
                     /db_xref="dbSNP:1240253641"
     variation       59
                     /replace="p"
                     /db_xref="dbSNP:763902829"
     variation       60
                     /replace="*"
                     /db_xref="dbSNP:1456758664"
     variation       61
                     /replace="a"
                     /db_xref="dbSNP:17855598"
     variation       62
                     /replace="-"
                     /db_xref="dbSNP:1178347760"
     variation       63
                     /replace="a"
                     /db_xref="dbSNP:1426027153"
     variation       63
                     /replace="t"
                     /db_xref="dbSNP:775653132"
     variation       64
                     /replace="r"
                     /db_xref="dbSNP:760982123"
     variation       65
                     /replace="s"
                     /db_xref="dbSNP:764476839"
     variation       67
                     /replace="i"
                     /db_xref="dbSNP:759386648"
     variation       67
                     /replace="k"
                     /db_xref="dbSNP:1300962232"
     Region          69..606
                     /region_name="Peptidase_M2"
                     /note="Angiotensin-converting enzyme; pfam01401"
                     /db_xref="CDD:279709"
     variation       69
                     /replace="a"
                     /db_xref="dbSNP:1317871269"
     variation       69
                     /replace="m"
                     /db_xref="dbSNP:767279985"
     variation       70
                     /replace="s"
                     /db_xref="dbSNP:752660066"
     variation       70
                     /replace="t"
                     /db_xref="dbSNP:760553706"
     variation       71
                     /replace="a"
                     /db_xref="dbSNP:1281544974"
     variation       71
                     /replace="d"
                     /db_xref="dbSNP:753318005"
     variation       71
                     /replace="n"
                     /db_xref="dbSNP:763603427"
     variation       73
                     /replace="t"
                     /db_xref="dbSNP:1325764936"
     variation       78
                     /replace="y"
                     /db_xref="dbSNP:1393713094"
     variation       79
                     /replace="l"
                     /db_xref="dbSNP:1248095456"
     variation       81
                     /replace="*"
                     /db_xref="dbSNP:1371611657"
     variation       81
                     /replace="d"
                     /db_xref="dbSNP:1487276305"
     variation       82
                     /replace="y"
                     /db_xref="dbSNP:756717025"
     variation       84
                     /replace="q"
                     /db_xref="dbSNP:892146398"
     variation       84
                     /replace="r"
                     /db_xref="dbSNP:1338720214"
     variation       84
                     /replace="w"
                     /db_xref="dbSNP:778684365"
     variation       85
                     /replace="t"
                     /db_xref="dbSNP:1441313370"
     variation       86
                     /replace="c"
                     /db_xref="dbSNP:147429960"
     variation       87
                     /replace="l"
                     /db_xref="dbSNP:1406304639"
     variation       88
                     /replace="g"
                     /db_xref="dbSNP:1379553980"
     variation       88
                     /replace="v"
                     /db_xref="dbSNP:373521244"
     variation       89
                     /replace="l"
                     /db_xref="dbSNP:1178170347"
     variation       90
                     /replace="*"
                     /db_xref="dbSNP:1419177611"
     variation       91
                     /replace="n"
                     /db_xref="dbSNP:758871975"
     variation       92
                     /replace="k"
                     /db_xref="dbSNP:201804955"
     variation       93
                     /replace="c"
                     /db_xref="dbSNP:1434646780"
     variation       94
                     /replace="a"
                     /db_xref="dbSNP:747542111"
     variation       95
                     /replace="g"
                     /db_xref="dbSNP:1266247312"
     variation       95
                     /replace="k"
                     /db_xref="dbSNP:769228405"
     variation       96
                     /replace="d"
                     /db_xref="dbSNP:1177823963"
     variation       97
                     /replace="s"
                     /db_xref="dbSNP:538715770"
     variation       99
                     /replace="k"
                     /db_xref="dbSNP:564928656"
     variation       101
                     /replace="h"
                     /db_xref="dbSNP:1245129210"
     variation       101
                     /replace="n"
                     /db_xref="dbSNP:773535888"
     variation       104
                     /replace="v"
                     /db_xref="dbSNP:371131106"
     variation       105
                     /replace="a"
                     /db_xref="dbSNP:771872424"
     variation       105
                     /replace="i"
                     /db_xref="dbSNP:532375661"
     variation       105
                     /replace="t"
                     /db_xref="dbSNP:775205401"
     variation       106
                     /replace="t"
                     /db_xref="dbSNP:760606594"
     variation       107
                     /replace="d"
                     /db_xref="dbSNP:764154741"
     variation       108
                     /replace="n"
                     /db_xref="dbSNP:753705010"
     variation       109
                     /replace="s"
                     /db_xref="dbSNP:148491967"
     variation       110
                     /replace="n"
                     /db_xref="dbSNP:1453772021"
     variation       110
                     /replace="r"
                     /db_xref="dbSNP:1208760916"
     variation       112
                     /replace="l"
                     /db_xref="dbSNP:1237524761"
     variation       113
                     /replace="l"
                     /db_xref="dbSNP:759228081"
     variation       115
                     /replace="k"
                     /db_xref="dbSNP:141790596"
     variation       116
                     /replace="n"
                     /db_xref="dbSNP:1334386288"
     variation       117
                     /replace="v"
                     /db_xref="dbSNP:775191459"
     variation       118
                     /replace="*"
                     /db_xref="dbSNP:1260448350"
     variation       118
                     /replace="q"
                     /db_xref="dbSNP:760990165"
     variation       120
                     /replace="a"
                     /db_xref="dbSNP:150811476"
     variation       120
                     /replace="t"
                     /db_xref="dbSNP:764410917"
     variation       121
                     /replace="s"
                     /db_xref="dbSNP:762256846"
     variation       122
                     /replace="n"
                     /db_xref="dbSNP:1187097777"
     variation       123
                     /replace="s"
                     /db_xref="dbSNP:765315607"
     variation       124
                     /replace="l"
                     /db_xref="dbSNP:780083903"
     variation       125
                     /replace="k"
                     /db_xref="dbSNP:758500055"
     variation       126
                     /replace="y"
                     /db_xref="dbSNP:780199864"
     variation       127
                     /replace="s"
                     /db_xref="dbSNP:1172339137"
     variation       129
                     /replace="h"
                     /db_xref="dbSNP:751787326"
     variation       130
                     /replace="v"
                     /db_xref="dbSNP:756018163"
     variation       132
                     /replace="r"
                     /db_xref="dbSNP:777673950"
     variation       134
                     /replace="n"
                     /db_xref="dbSNP:1303374381"
     variation       135
                     /replace="v"
                     /db_xref="dbSNP:749263426"
     variation       136
                     /replace="i"
                     /db_xref="dbSNP:770923059"
     variation       139
                     /replace="q"
                     /db_xref="dbSNP:1024570279"
     variation       140
                     /replace="k"
                     /db_xref="dbSNP:778987310"
     variation       142
                     /replace="a"
                     /db_xref="dbSNP:745422986"
     variation       143
                     /replace="m"
                     /db_xref="dbSNP:771585066"
     variation       143
                     /replace="q"
                     /db_xref="dbSNP:1219522144"
     variation       144
                     /replace="r"
                     /db_xref="dbSNP:1316503803"
     variation       145
                     /replace="q"
                     /db_xref="dbSNP:371010069"
     variation       145
                     /replace="w"
                     /db_xref="dbSNP:200649158"
     variation       146
                     /replace="i"
                     /db_xref="dbSNP:1484498158"
     variation       147
                     /replace="m"
                     /db_xref="dbSNP:1424703433"
     variation       147
                     /replace="v"
                     /db_xref="dbSNP:769028657"
     variation       148
                     /replace="n"
                     /db_xref="dbSNP:188993222"
     variation       149
                     /replace="n"
                     /db_xref="dbSNP:1488331662"
     variation       151
                     /replace="e"
                     /db_xref="dbSNP:139263584"
     variation       152
                     /replace="d"
                     /db_xref="dbSNP:909163184"
     variation       152
                     /replace="v"
                     /db_xref="dbSNP:1420953232"
     variation       153
                     /replace="l"
                     /db_xref="dbSNP:765802481"
     variation       155
                     /replace="q"
                     /db_xref="dbSNP:201527082"
     variation       155
                     /replace="r"
                     /db_xref="dbSNP:35553988"
     variation       155
                     /replace="w"
                     /db_xref="dbSNP:375232467"
     variation       156
                     /replace="e"
                     /db_xref="dbSNP:767880620"
     variation       157
                     /replace="a"
                     /db_xref="dbSNP:4331"
     variation       157
                     /replace="v"
                     /db_xref="dbSNP:1374995262"
     variation       158
                     /replace="l"
                     /db_xref="dbSNP:1300293916"
     variation       158
                     /replace="l"
                     /db_xref="dbSNP:368447908"
     variation       160
                     /replace="s"
                     /db_xref="dbSNP:199785479"
     variation       161
                     /replace="*"
                     /db_xref="dbSNP:933390771"
     variation       163
                     /replace="l"
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     variation       309
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     variation       344
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     variation       358
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     variation       358
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     variation       360
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     variation       361
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     variation       361
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     variation       361
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     variation       362
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     variation       365
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     variation       366
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     variation       368
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     variation       369
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     variation       369
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     variation       370
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     variation       370
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     variation       372
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     variation       374
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     variation       375
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     variation       376
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     variation       377
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     variation       377
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     variation       378
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     variation       379
                     /replace="q"
                     /db_xref="dbSNP:143507892"
     variation       379
                     /replace="r"
                     /db_xref="dbSNP:922132884"
     variation       379
                     /replace="w"
                     /db_xref="dbSNP:772888815"
     variation       380
                     /replace="g"
                     /db_xref="dbSNP:780072379"
     variation       381
                     /replace="v"
                     /db_xref="dbSNP:766716582"
     variation       382
                     /replace="v"
                     /db_xref="dbSNP:774748647"
     variation       383
                     /replace="r"
                     /db_xref="dbSNP:759966983"
     variation       383
                     /replace="s"
                     /db_xref="dbSNP:767594429"
     Site            order(384..386,414..415,418,442,488,542..544,549,551)
                     /site_type="active"
                     /db_xref="CDD:188999"
     variation       384
                     /replace="h"
                     /db_xref="dbSNP:148024347"
     variation       385
                     /replace="a"
                     /db_xref="dbSNP:367799203"
     variation       385
                     /replace="d"
                     /db_xref="dbSNP:764275894"
     variation       385
                     /replace="t"
                     /db_xref="dbSNP:756159839"
     variation       386
                     /replace="l"
                     /db_xref="dbSNP:1420430019"
     variation       386
                     /replace="s"
                     /db_xref="dbSNP:758161582"
     variation       387
                     /replace="p"
                     /db_xref="dbSNP:779833433"
     variation       389
                     /replace="n"
                     /db_xref="dbSNP:1354629347"
     variation       392
                     /replace="d"
                     /db_xref="dbSNP:746934582"
     variation       392
                     /replace="n"
                     /db_xref="dbSNP:532039424"
     variation       393
                     /replace="g"
                     /db_xref="dbSNP:781271191"
     variation       393
                     /replace="s"
                     /db_xref="dbSNP:937878555"
     variation       395
                     /replace="y"
                     /db_xref="dbSNP:913463914"
     variation       396
                     /replace="f"
                     /db_xref="dbSNP:747700760"
     variation       397
                     /replace="q"
                     /db_xref="dbSNP:554004241"
     variation       397
                     /replace="w"
                     /db_xref="dbSNP:769406157"
     variation       400
                     /replace="r"
                     /db_xref="dbSNP:375442845"
     variation       401
                     /replace="c"
                     /db_xref="dbSNP:761107328"
     variation       401
                     /replace="g"
                     /db_xref="dbSNP:1318768216"
     variation       401
                     /replace="y"
                     /db_xref="dbSNP:1346738730"
     variation       403
                     /replace="i"
                     /db_xref="dbSNP:1439040577"
     variation       403
                     /replace="t"
                     /db_xref="dbSNP:768632989"
     variation       404
                     /replace="m"
                     /db_xref="dbSNP:141750591"
     variation       407
                     /replace="d"
                     /db_xref="dbSNP:868230881"
     variation       409
                     /replace="l"
                     /db_xref="dbSNP:1041542720"
     variation       409
                     /replace="l"
                     /db_xref="dbSNP:761795254"
     variation       409
                     /replace="p"
                     /db_xref="dbSNP:931669958"
     variation       410
                     /replace="v"
                     /db_xref="dbSNP:3730044"
     variation       411
                     /replace="v"
                     /db_xref="dbSNP:1343201751"
     variation       412
                     /replace="p"
                     /db_xref="dbSNP:1218838386"
     variation       413
                     /replace="h"
                     /db_xref="dbSNP:369689246"
     variation       413
                     /replace="y"
                     /db_xref="dbSNP:1285477249"
     Site            order(414,418,442)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188999"
     variation       414
                     /replace="h"
                     /db_xref="dbSNP:767378617"
     variation       414
                     /replace="r"
                     /db_xref="dbSNP:1315238107"
     variation       415
                     /replace="k"
                     /db_xref="dbSNP:752685131"
     variation       416
                     /replace="i"
                     /db_xref="dbSNP:1227030637"
     variation       416
                     /replace="r"
                     /db_xref="dbSNP:1468555557"
     variation       417
                     /replace="s"
                     /db_xref="dbSNP:756019276"
     variation       418
                     /replace="d"
                     /db_xref="dbSNP:1244440863"
     variation       418
                     /replace="h"
                     /db_xref="dbSNP:373198685"
     variation       418
                     /replace="r"
                     /db_xref="dbSNP:771384705"
     variation       419
                     /replace="i"
                     /db_xref="dbSNP:75067113"
     variation       419
                     /replace="v"
                     /db_xref="dbSNP:753450698"
     variation       421
                     /replace="h"
                     /db_xref="dbSNP:778562737"
     variation       423
                     /replace="i"
                     /db_xref="dbSNP:1395070641"
     variation       423
                     /replace="v"
                     /db_xref="dbSNP:745486055"
     variation       424
                     /replace="k"
                     /db_xref="dbSNP:772433710"
     variation       425
                     /replace="c"
                     /db_xref="dbSNP:1325658187"
     variation       425
                     /replace="y"
                     /db_xref="dbSNP:146046369"
     variation       428
                     /replace="l"
                     /db_xref="dbSNP:1436102382"
     variation       429
                     /replace="-"
                     /db_xref="dbSNP:746977732"
     variation       429
                     /replace="l"
                     /db_xref="dbSNP:377280373"
     variation       433
                     /replace="k"
                     /db_xref="dbSNP:747362596"
     variation       435
                     /replace="v"
                     /db_xref="dbSNP:769272334"
     variation       436
                     /replace="a"
                     /db_xref="dbSNP:1041524189"
     variation       438
                     /replace="p"
                     /db_xref="dbSNP:147806836"
     variation       439
                     /replace="a"
                     /db_xref="dbSNP:540734174"
     variation       439
                     /replace="s"
                     /db_xref="dbSNP:571848794"
     variation       440
                     /replace="f"
                     /db_xref="dbSNP:1350437085"
     variation       441
                     /replace="q"
                     /db_xref="dbSNP:144751624"
     variation       441
                     /replace="r"
                     /db_xref="dbSNP:773600140"
     variation       442
                     /replace="e"
                     /db_xref="dbSNP:1253480175"
     variation       443
                     /replace="t"
                     /db_xref="dbSNP:1471502216"
     variation       444
                     /replace="t"
                     /db_xref="dbSNP:4976"
     variation       445
                     /replace="g"
                     /db_xref="dbSNP:752593254"
     variation       445
                     /replace="r"
                     /db_xref="dbSNP:1418273122"
     variation       446
                     /replace="d"
                     /db_xref="dbSNP:373427509"
     variation       446
                     /replace="g"
                     /db_xref="dbSNP:1200211350"
     variation       447
                     /replace="l"
                     /db_xref="dbSNP:764129854"
     variation       449
                     /replace="t"
                     /db_xref="dbSNP:201529811"
     variation       450
                     /replace="f"
                     /db_xref="dbSNP:753672462"
     variation       451
                     /replace="a"
                     /db_xref="dbSNP:1489092015"
     variation       452
                     /replace="a"
                     /db_xref="dbSNP:1372691116"
     variation       452
                     /replace="m"
                     /db_xref="dbSNP:377550847"
     variation       453
                     /replace="s"
                     /db_xref="dbSNP:756826166"
     variation       453
                     /replace="y"
                     /db_xref="dbSNP:1170915014"
     variation       454
                     /replace="m"
                     /db_xref="dbSNP:778331848"
     variation       454
                     /replace="t"
                     /db_xref="dbSNP:750092571"
     variation       455
                     /replace="s"
                     /db_xref="dbSNP:758105347"
     variation       456
                     /replace="n"
                     /db_xref="dbSNP:374679629"
     variation       458
                     /replace="l"
                     /db_xref="dbSNP:1355072990"
     variation       459
                     /replace="h"
                     /db_xref="dbSNP:768882213"
     variation       459
                     /replace="p"
                     /db_xref="dbSNP:747442787"
     variation       461
                     /replace="l"
                     /db_xref="dbSNP:781732987"
     variation       462
                     /replace="k"
                     /db_xref="dbSNP:142947404"
     variation       463
                     /replace="l"
                     /db_xref="dbSNP:769998393"
     variation       463
                     /replace="p"
                     /db_xref="dbSNP:1258035065"
     variation       464
                     /replace="l"
                     /db_xref="dbSNP:773367295"
     variation       465
                     /replace="n"
                     /db_xref="dbSNP:1368193999"
     variation       466
                     /replace="t"
                     /db_xref="dbSNP:749362077"
     variation       467
                     /replace="-"
                     /db_xref="dbSNP:768525377"
     variation       467
                     /replace="e"
                     /db_xref="dbSNP:771342124"
     variation       470
                     /replace="s"
                     /db_xref="dbSNP:150690061"
     variation       471
                     /replace="d"
                     /db_xref="dbSNP:200011052"
     variation       471
                     /replace="n"
                     /db_xref="dbSNP:140980792"
     variation       472
                     /replace="k"
                     /db_xref="dbSNP:761601299"
     variation       473
                     /replace="h"
                     /db_xref="dbSNP:762473590"
     variation       474
                     /replace="g"
                     /db_xref="dbSNP:1313627969"
     variation       475
                     /replace="v"
                     /db_xref="dbSNP:765835019"
     variation       476
                     /replace="d"
                     /db_xref="dbSNP:751226904"
     variation       476
                     /replace="s"
                     /db_xref="dbSNP:935304784"
     variation       477
                     /replace="v"
                     /db_xref="dbSNP:4977"
     variation       478
                     /replace="p"
                     /db_xref="dbSNP:1351048530"
     variation       478
                     /replace="v"
                     /db_xref="dbSNP:989584821"
     variation       480
                     /replace="k"
                     /db_xref="dbSNP:1210514649"
     variation       481
                     /replace="i"
                     /db_xref="dbSNP:767184799"
     variation       481
                     /replace="l"
                     /db_xref="dbSNP:144926742"
     variation       482
                     /replace="a"
                     /db_xref="dbSNP:1007334111"
     variation       482
                     /replace="t"
                     /db_xref="dbSNP:569898686"
     variation       483
                     /replace="l"
                     /db_xref="dbSNP:756512070"
     variation       484
                     /replace="d"
                     /db_xref="dbSNP:778470338"
     variation       484
                     /replace="g"
                     /db_xref="dbSNP:1458584759"
     variation       484
                     /replace="n"
                     /db_xref="dbSNP:1197014458"
     variation       486
                     /replace="i"
                     /db_xref="dbSNP:754344947"
     variation       486
                     /replace="v"
                     /db_xref="dbSNP:1458035301"
     variation       487
                     /replace="t"
                     /db_xref="dbSNP:773695336"
     variation       488
                     /replace="l"
                     /db_xref="dbSNP:778802598"
     variation       489
                     /replace="i"
                     /db_xref="dbSNP:745951639"
     variation       490
                     /replace="l"
                     /db_xref="dbSNP:1384728709"
     variation       490
                     /replace="s"
                     /db_xref="dbSNP:747724861"
     variation       491
                     /replace="f"
                     /db_xref="dbSNP:1300081096"
     variation       493
                     /replace="c"
                     /db_xref="dbSNP:1382876528"
     variation       493
                     /replace="h"
                     /db_xref="dbSNP:1342469069"
     variation       494
                     /replace="l"
                     /db_xref="dbSNP:189373608"
     variation       495
                     /replace="a"
                     /db_xref="dbSNP:1322398043"
     variation       495
                     /replace="i"
                     /db_xref="dbSNP:147763588"
     variation       495
                     /replace="v"
                     /db_xref="dbSNP:371996217"
     variation       496
                     /replace="n"
                     /db_xref="dbSNP:571910640"
     variation       497
                     /replace="k"
                     /db_xref="dbSNP:769531227"
     variation       498
                     /replace="*"
                     /db_xref="dbSNP:773163752"
     variation       499
                     /replace="c"
                     /db_xref="dbSNP:762807750"
     variation       499
                     /replace="h"
                     /db_xref="dbSNP:141139841"
     variation       500
                     /replace="*"
                     /db_xref="dbSNP:1266895232"
     variation       501
                     /replace="r"
                     /db_xref="dbSNP:1164187187"
     variation       502
                     /replace="l"
                     /db_xref="dbSNP:534480370"
     variation       504
                     /replace="g"
                     /db_xref="dbSNP:375039288"
     variation       505
                     /replace="e"
                     /db_xref="dbSNP:752369560"
     variation       506
                     /replace="c"
                     /db_xref="dbSNP:1472584106"
     variation       506
                     /replace="n"
                     /db_xref="dbSNP:1166034708"
     variation       507
                     /replace="v"
                     /db_xref="dbSNP:761139845"
     variation       510
                     /replace="k"
                     /db_xref="dbSNP:1455896148"
     variation       512
                     /replace="y"
                     /db_xref="dbSNP:1292602898"
     variation       514
                     /replace="h"
                     /db_xref="dbSNP:764489358"
     variation       517
                     /replace="*"
                     /db_xref="dbSNP:1411245193"
     variation       518
                     /replace="s"
                     /db_xref="dbSNP:768017942"
     variation       520
                     /replace="g"
                     /db_xref="dbSNP:754412363"
     variation       525
                     /replace="v"
                     /db_xref="dbSNP:775421383"
     variation       526
                     /replace="l"
                     /db_xref="dbSNP:757051176"
     variation       527
                     /replace="c"
                     /db_xref="dbSNP:1040513482"
     variation       528
                     /replace="t"
                     /db_xref="dbSNP:145349565"
     variation       529
                     /replace="p"
                     /db_xref="dbSNP:771498675"
     variation       529
                     /replace="t"
                     /db_xref="dbSNP:745776314"
     variation       530
                     /replace="a"
                     /db_xref="dbSNP:1458829834"
     variation       530
                     /replace="s"
                     /db_xref="dbSNP:1447215842"
     variation       531
                     /replace="p"
                     /db_xref="dbSNP:1339023151"
     variation       533
                     /replace="t"
                     /db_xref="dbSNP:144974035"
     variation       534
                     /replace="q"
                     /db_xref="dbSNP:746517733"
     variation       535
                     /replace="d"
                     /db_xref="dbSNP:768468260"
     variation       535
                     /replace="g"
                     /db_xref="dbSNP:776400866"
     variation       536
                     /replace="d"
                     /db_xref="dbSNP:1269279770"
     variation       537
                     /replace="l"
                     /db_xref="dbSNP:1465879181"
     variation       538
                     /replace="d"
                     /db_xref="dbSNP:762107963"
     variation       541
                     /replace="a"
                     /db_xref="dbSNP:773598878"
     variation       541
                     /replace="d"
                     /db_xref="dbSNP:565263717"
     variation       544
                     /replace="h"
                     /db_xref="dbSNP:192029734"
     variation       544
                     /replace="y"
                     /db_xref="dbSNP:1192509168"
     variation       547
                     /replace="s"
                     /db_xref="dbSNP:200201337"
     variation       548
                     /replace="s"
                     /db_xref="dbSNP:149084065"
     variation       549
                     /replace="m"
                     /db_xref="dbSNP:373319603"
     variation       550
                     /replace="t"
                     /db_xref="dbSNP:1455545095"
     variation       551
                     /replace="y"
                     /db_xref="dbSNP:1396260507"
     variation       552
                     /replace="l"
                     /db_xref="dbSNP:567659245"
     variation       554
                     /replace="t"
                     /db_xref="dbSNP:202056228"
     variation       555
                     /replace="a"
                     /db_xref="dbSNP:566409012"
     variation       555
                     /replace="t"
                     /db_xref="dbSNP:747412511"
     variation       556
                     /replace="l"
                     /db_xref="dbSNP:776634959"
     variation       559
                     /replace="a"
                     /db_xref="dbSNP:754265941"
     variation       559
                     /replace="d"
                     /db_xref="dbSNP:1458534207"
     variation       561
                     /replace="s"
                     /db_xref="dbSNP:748236790"
     variation       562
                     /replace="s"
                     /db_xref="dbSNP:1385800001"
     variation       563
                     /replace="l"
                     /db_xref="dbSNP:538659872"
     variation       563
                     /replace="p"
                     /db_xref="dbSNP:759423545"
     variation       564
                     /replace="*"
                     /db_xref="dbSNP:1406482731"
     variation       565
                     /replace="a"
                     /db_xref="dbSNP:767177049"
     variation       565
                     /replace="l"
                     /db_xref="dbSNP:775501006"
     variation       565
                     /replace="p"
                     /db_xref="dbSNP:376216920"
     variation       568
                     /replace="i"
                     /db_xref="dbSNP:756739847"
     variation       568
                     /replace="t"
                     /db_xref="dbSNP:753388395"
     variation       568
                     /replace="v"
                     /db_xref="dbSNP:376826294"
     variation       571
                     /replace="m"
                     /db_xref="dbSNP:764893306"
     variation       572
                     /replace="m"
                     /db_xref="dbSNP:12709442"
     variation       572
                     /replace="t"
                     /db_xref="dbSNP:141429845"
     variation       573
                     /replace="d"
                     /db_xref="dbSNP:1396533675"
     variation       573
                     /replace="g"
                     /db_xref="dbSNP:982649386"
     variation       574
                     /replace="r"
                     /db_xref="dbSNP:1210452594"
     variation       575
                     /replace="l"
                     /db_xref="dbSNP:1264163829"
     variation       575
                     /replace="s"
                     /db_xref="dbSNP:1295931503"
     variation       578
                     /replace="i"
                     /db_xref="dbSNP:780228220"
     variation       578
                     /replace="s"
                     /db_xref="dbSNP:747389681"
     variation       579
                     /replace="d"
                     /db_xref="dbSNP:777388821"
     variation       579
                     /replace="s"
                     /db_xref="dbSNP:755506668"
     variation       580
                     /replace="l"
                     /db_xref="dbSNP:748284095"
     variation       580
                     /replace="p"
                     /db_xref="dbSNP:1343107612"
     variation       580
                     /replace="s"
                     /db_xref="dbSNP:769941358"
     variation       581
                     /replace="t"
                     /db_xref="dbSNP:773596097"
     variation       582
                     /replace="v"
                     /db_xref="dbSNP:201870045"
     variation       583
                     /replace="l"
                     /db_xref="dbSNP:1257665286"
     variation       585
                     /replace="y"
                     /db_xref="dbSNP:771913893"
     variation       586
                     /replace="l"
                     /db_xref="dbSNP:775204602"
     variation       588
                     /replace="l"
                     /db_xref="dbSNP:369760270"
     variation       588
                     /replace="p"
                     /db_xref="dbSNP:140280723"
     variation       590
                     /replace="l"
                     /db_xref="dbSNP:1390560241"
     variation       591
                     /replace="a"
                     /db_xref="dbSNP:1291258688"
     variation       591
                     /replace="d"
                     /db_xref="dbSNP:1168139461"
     variation       594
                     /replace="g"
                     /db_xref="dbSNP:1353694784"
     variation       594
                     /replace="h"
                     /db_xref="dbSNP:538166970"
     variation       595
                     /replace="a"
                     /db_xref="dbSNP:1304453464"
     variation       595
                     /replace="m"
                     /db_xref="dbSNP:12720742"
     variation       595
                     /replace="t"
                     /db_xref="dbSNP:138240046"
     variation       596
                     /replace="*"
                     /db_xref="dbSNP:766053859"
     variation       597
                     /replace="d"
                     /db_xref="dbSNP:996589954"
     variation       597
                     /replace="n"
                     /db_xref="dbSNP:1271336698"
     variation       597
                     /replace="t"
                     /db_xref="dbSNP:574717474"
     variation       598
                     /replace="e"
                     /db_xref="dbSNP:781769416"
     variation       598
                     /replace="k"
                     /db_xref="dbSNP:149590791"
     variation       599
                     /replace="l"
                     /db_xref="dbSNP:890761035"
     variation       599
                     /replace="p"
                     /db_xref="dbSNP:1451027689"
     variation       600
                     /replace="h"
                     /db_xref="dbSNP:144312383"
     variation       600
                     /replace="r"
                     /db_xref="dbSNP:757974064"
     variation       602
                     /replace="*"
                     /db_xref="dbSNP:534095139"
     variation       602
                     /replace="d"
                     /db_xref="dbSNP:1248102885"
     variation       604
                     /replace="l"
                     /db_xref="dbSNP:749373274"
     variation       604
                     /replace="p"
                     /db_xref="dbSNP:140941300"
     variation       605
                     /replace="g"
                     /db_xref="dbSNP:1433516779"
     variation       605
                     /replace="s"
                     /db_xref="dbSNP:1418538736"
     variation       607
                     /replace="l"
                     /db_xref="dbSNP:779175881"
     variation       607
                     /replace="p"
                     /db_xref="dbSNP:111576990"
     variation       607
                     /replace="s"
                     /db_xref="dbSNP:144888208"
     variation       608
                     /replace="q"
                     /db_xref="dbSNP:867518041"
     variation       609
                     /replace="h"
                     /db_xref="dbSNP:776554544"
     variation       609
                     /replace="y"
                     /db_xref="dbSNP:866250489"
     variation       610
                     /replace="n"
                     /db_xref="dbSNP:1033103629"
     variation       610
                     /replace="t"
                     /db_xref="dbSNP:761685671"
     variation       611
                     /replace="*"
                     /db_xref="dbSNP:769710002"
     variation       612
                     /replace="a"
                     /db_xref="dbSNP:772778762"
     variation       612
                     /replace="k"
                     /db_xref="dbSNP:762495578"
     variation       612
                     /replace="t"
                     /db_xref="dbSNP:751171602"
     variation       613
                     /replace="l"
                     /db_xref="dbSNP:121912703"
     variation       613
                     /replace="p"
                     /db_xref="dbSNP:201117207"
     variation       613
                     /replace="s"
                     /db_xref="dbSNP:967933744"
     variation       614
                     /replace="s"
                     /db_xref="dbSNP:753269825"
     variation       615
                     /replace="f"
                     /db_xref="dbSNP:756742824"
     variation       615
                     /replace="s"
                     /db_xref="dbSNP:778419134"
     variation       616
                     /replace="t"
                     /db_xref="dbSNP:959741765"
     variation       616
                     /replace="v"
                     /db_xref="dbSNP:1241356540"
     variation       617
                     /replace="c"
                     /db_xref="dbSNP:750545791"
     variation       617
                     /replace="l"
                     /db_xref="dbSNP:372282664"
     variation       617
                     /replace="r"
                     /db_xref="dbSNP:375754441"
     variation       618
                     /replace="l"
                     /db_xref="dbSNP:1474601688"
     variation       618
                     /replace="s"
                     /db_xref="dbSNP:1167676961"
     variation       621
                     /replace="l"
                     /db_xref="dbSNP:751737727"
     variation       621
                     /replace="p"
                     /db_xref="dbSNP:755904563"
     variation       622
                     /replace="l"
                     /db_xref="dbSNP:1334187394"
     variation       624
                     /replace="e"
                     /db_xref="dbSNP:749019292"
     variation       624
                     /replace="g"
                     /db_xref="dbSNP:777561376"
     variation       625
                     /replace="s"
                     /db_xref="dbSNP:757286547"
     variation       626
                     /replace="s"
                     /db_xref="dbSNP:367916721"
     variation       627
                     /replace="c"
                     /db_xref="dbSNP:1226490350"
     variation       627
                     /replace="h"
                     /db_xref="dbSNP:781198085"
     variation       627
                     /replace="r"
                     /db_xref="dbSNP:372143589"
     variation       628
                     /replace="i"
                     /db_xref="dbSNP:372416620"
     variation       629
                     /replace="i"
                     /db_xref="dbSNP:1261338191"
     variation       630
                     /replace="f"
                     /db_xref="dbSNP:963984458"
     variation       630
                     /replace="l"
                     /db_xref="dbSNP:531181910"
     variation       633
                     /replace="l"
                     /db_xref="dbSNP:768181342"
     variation       634
                     /replace="a"
                     /db_xref="dbSNP:777124668"
     variation       635
                     /replace="v"
                     /db_xref="dbSNP:1193002337"
     variation       636
                     /replace="ld"
                     /db_xref="dbSNP:780845846"
     variation       637
                     /replace="a"
                     /db_xref="dbSNP:770384980"
     variation       637
                     /replace="v"
                     /db_xref="dbSNP:762056936"
     variation       638
                     /replace="*"
                     /db_xref="dbSNP:1174820268"
     variation       639
                     /replace="e"
                     /db_xref="dbSNP:56038824"
     variation       640
                     /replace="a"
                     /db_xref="dbSNP:773663364"
     variation       641
                     /replace="c"
                     /db_xref="dbSNP:763049172"
     variation       641
                     /replace="h"
                     /db_xref="dbSNP:766377685"
     variation       641
                     /replace="r"
                     /db_xref="dbSNP:751789079"
     variation       642
                     /replace="m"
                     /db_xref="dbSNP:759857038"
     variation       642
                     /replace="v"
                     /db_xref="dbSNP:767628762"
     variation       643
                     /replace="d"
                     /db_xref="dbSNP:1434928128"
     variation       643
                     /replace="g"
                     /db_xref="dbSNP:753706300"
     variation       643
                     /replace="s"
                     /db_xref="dbSNP:1347084405"
     variation       644
                     /replace="*"
                     /db_xref="dbSNP:1282502522"
     variation       644
                     /replace="p"
                     /db_xref="dbSNP:756978461"
     variation       644
                     /replace="q"
                     /db_xref="dbSNP:1239908508"
     variation       648
                     /replace="l"
                     /db_xref="dbSNP:1262562180"
     variation       649
                     /replace="f"
                     /db_xref="dbSNP:1348880297"
     variation       651
                     /replace="d"
                     /db_xref="dbSNP:778929865"
     variation       651
                     /replace="g"
                     /db_xref="dbSNP:1309203619"
     variation       652
                     /replace="i"
                     /db_xref="dbSNP:144242912"
     variation       653
                     /replace="a"
                     /db_xref="dbSNP:1197920248"
     variation       653
                     /replace="t"
                     /db_xref="dbSNP:757997489"
     variation       654
                     /replace="l"
                     /db_xref="dbSNP:369306676"
     variation       654
                     /replace="l"
                     /db_xref="dbSNP:746513914"
     variation       655
                     /replace="l"
                     /db_xref="dbSNP:768399209"
     variation       655
                     /replace="p"
                     /db_xref="dbSNP:1179455074"
     variation       656
                     /replace="i"
                     /db_xref="dbSNP:780690514"
     variation       656
                     /replace="v"
                     /db_xref="dbSNP:748570561"
     variation       657
                     /replace="a"
                     /db_xref="dbSNP:1452608632"
     variation       657
                     /replace="g"
                     /db_xref="dbSNP:770016471"
     variation       657
                     /replace="t"
                     /db_xref="dbSNP:1425238764"
     variation       658
                     /replace="t"
                     /db_xref="dbSNP:1054697649"
     variation       660
                     /replace="g"
                     /db_xref="dbSNP:1473244016"
     variation       661
                     /replace="-"
                     /db_xref="dbSNP:1367232864"
     variation       662
                     /replace="s"
                     /db_xref="dbSNP:1402919954"
     variation       664
                     /replace="p"
                     /db_xref="dbSNP:4980"
     variation       664
                     /replace="w"
                     /db_xref="dbSNP:568401628"
     variation       666
                     /replace="f"
                     /db_xref="dbSNP:1042056760"
     variation       666
                     /replace="s"
                     /db_xref="dbSNP:1393052928"
     variation       668
                     /replace="v"
                     /db_xref="dbSNP:1268051765"
     variation       669
                     /replace="c"
                     /db_xref="dbSNP:375527470"
     variation       669
                     /replace="h"
                     /db_xref="dbSNP:1333987335"
     variation       669
                     /replace="r"
                     /db_xref="dbSNP:1238643055"
     variation       671
                     /replace="c"
                     /db_xref="dbSNP:4364"
     variation       671
                     /replace="p"
                     /db_xref="dbSNP:767828019"
     variation       671
                     /replace="r"
                     /db_xref="dbSNP:1220775181"
     variation       672
                     /replace="g"
                     /db_xref="dbSNP:1291502122"
     variation       674
                     /replace="h"
                     /db_xref="dbSNP:1481281618"
     variation       674
                     /replace="r"
                     /db_xref="dbSNP:1004296792"
     variation       675
                     /replace="q"
                     /db_xref="dbSNP:12720745"
     variation       675
                     /replace="w"
                     /db_xref="dbSNP:752812293"
     variation       676
                     /replace="h"
                     /db_xref="dbSNP:1217507273"
     variation       677
                     /replace="s"
                     /db_xref="dbSNP:1417948787"
     variation       678
                     /replace="h"
                     /db_xref="dbSNP:1013454628"
     variation       678
                     /replace="y"
                     /db_xref="dbSNP:765069550"
     variation       679
                     /replace="r"
                     /db_xref="dbSNP:1422356094"
     variation       680
                     /replace="l"
                     /db_xref="dbSNP:886053226"
     variation       681
                     /replace="*"
                     /db_xref="dbSNP:1162756119"
     variation       681
                     /replace="r"
                     /db_xref="dbSNP:4981"
     variation       682
                     /replace="f"
                     /db_xref="dbSNP:750229908"
     variation       683
                     /replace="c"
                     /db_xref="dbSNP:1024799181"
     variation       684
                     /replace="f"
                     /db_xref="dbSNP:1394448757"
     variation       684
                     /replace="s"
                     /db_xref="dbSNP:780111755"
     variation       685
                     /replace="d"
                     /db_xref="dbSNP:1244045213"
     variation       685
                     /replace="g"
                     /db_xref="dbSNP:1385347177"
     variation       685
                     /replace="k"
                     /db_xref="dbSNP:751134637"
     variation       686
                     /replace="v"
                     /db_xref="dbSNP:1314816029"
     variation       687
                     /replace="e"
                     /db_xref="dbSNP:4365"
     variation       688
                     /replace="l"
                     /db_xref="dbSNP:1207267524"
     variation       689
                     /replace="k"
                     /db_xref="dbSNP:1016285379"
     variation       690
                     /replace="h"
                     /db_xref="dbSNP:1250173627"
     variation       691
                     /replace="s"
                     /db_xref="dbSNP:1480573228"
     CDS             1..691
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /coded_by="NM_001178057.1:52..2127"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS54155.1"
                     /db_xref="GeneID:1636"
                     /db_xref="HGNC:HGNC:2707"
                     /db_xref="MIM:106180"
ORIGIN      
        1 mgqgwatagl psllflllcy ghpllvpsqe asqqvtvthg tssqattssq ttthqatahq
       61 tsaqspnlvt deaeaskfve eydrtsqvvw neyaeanwny ntnittetsk illqknmqia
      121 nhtlkygtqa rkfdvnqlqn ttikriikkv qdleraalpa qeleeynkil ldmettysva
      181 tvchpngscl qlepdltnvm atsrkyedll wawegwrdka grailqfypk yvelinqaar
      241 lngyvdagds wrsmyetpsl eqdlerlfqe lqplylnlha yvrralhrhy gaqhinlegp
      301 ipahllgnmw aqtwsniydl vvpfpsapsm dtteamlkqg wtprrmfkea ddfftslgll
      361 pvppefwnks mlekptdgre vvchasawdf yngkdfrikq cttvnledlv vahhemghiq
      421 yfmqykdlpv alreganpgf heaigdvlal svstpkhlhs lnllsseggs dehdinflmk
      481 maldkiafip fsylvdqwrw rvfdgsitke nynqewwslr lkyqglcppv prtqgdfdpg
      541 akfhipssvp yirtamklgf srpwpeamql itgqpnmsas amlsyfkpll dwlrtenelh
      601 geklgwpqyn wtpnsarseg plpdsgrvsf lgldldaqqa rvgqwlllfl giallvatlg
      661 lsqrlfsirh rslhrhshgp qfgsevelrh s
//
DBGET integrated database retrieval system