LOCUS NP_001188616 2118 aa linear INV 26-DEC-2023
DEFINITION paralytic, isoform U [Drosophila melanogaster].
ACCESSION NP_001188616
VERSION NP_001188616.1
DBLINK BioProject: PRJNA164
BioSample: SAMN02803731
DBSOURCE REFSEQ: accession NM_001201687.1
KEYWORDS RefSeq.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 2118)
AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
Strelets,V., Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: Impact of
High-Throughput Data
JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015)
PUBMED 26109357
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 2118)
AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: The
Rule-Benders
JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015)
PUBMED 26109356
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 2118)
AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
TITLE The Release 6 reference sequence of the Drosophila melanogaster
genome
JOURNAL Genome Res 25 (3), 445-458 (2015)
PUBMED 25589440
REFERENCE 4 (residues 1 to 2118)
AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
TITLE Sequence finishing and mapping of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1625-1628 (2007)
PUBMED 17569867
REFERENCE 5 (residues 1 to 2118)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
TITLE The Release 5.1 annotation of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1586-1591 (2007)
PUBMED 17569856
REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE 6 (residues 1 to 2118)
AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
Ashburner,M. and Anxolabehere,D.
TITLE Combined evidence annotation of transposable elements in genome
sequences
JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005)
PUBMED 16110336
REFERENCE 7 (residues 1 to 2118)
AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
Celniker,S.E., Rubin,G.M. and Karpen,G.H.
TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly
JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002)
PUBMED 12537574
REFERENCE 8 (residues 1 to 2118)
AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
Rubin,G.M., Ashburner,M. and Celniker,S.E.
TITLE The transposable elements of the Drosophila melanogaster
euchromatin: a genomics perspective
JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002)
PUBMED 12537573
REFERENCE 9 (residues 1 to 2118)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REFERENCE 10 (residues 1 to 2118)
AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
Gibbs,R.A. and Rubin,G.M.
TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence
JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002)
PUBMED 12537568
REFERENCE 11 (residues 1 to 2118)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REFERENCE 12 (residues 1 to 2118)
AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
Smith,E., Yu,C. and Rubin,G.
CONSRTM Berkeley Drosophila Genome Project
TITLE Drosophila melanogaster release 4 sequence
JOURNAL Unpublished
REFERENCE 13 (residues 1 to 2118)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 14 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 15 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 16 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 17 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 18 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 19 (residues 1 to 2118)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 20 (residues 1 to 2118)
AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
Park,S., Svirskas,R. and Karpen,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 21 (residues 1 to 2118)
AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
Svirskas,R. and Rubin,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 22 (residues 1 to 2118)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
CONSRTM Drosophila Heterochromatin Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE 23 (residues 1 to 2118)
AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The
reference sequence is identical to ADV37698.
##Genome-Annotation-Data-START##
Annotation Provider :: FlyBase
Annotation Status :: Full annotation
Annotation Version :: Release 6.54
URL :: http://flybase.org
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..2118
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
/chromosome="X"
/genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
Protein 1..2118
/product="paralytic, isoform U"
/name="CG9907 gene product from transcript CG9907-RU"
/note="CG9907-PU; para-PU; bang sensitive;
voltage-sensitive sodium channel; shudderer; bang
senseless; bangsenseless; voltage gated sodium ion
channel; paralyzed; Out-cold; Out cold; smell-blind;
smellblind; paralytic; bang-senseless"
/calculated_mol_wt=237645
Region 34..>103
/region_name="PNISR"
/note="Arginine/serine-rich protein PNISR; pfam15996"
/db_xref="CDD:435058"
Region 152..436
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Region 555..740
/region_name="Na_trans_cytopl"
/note="Cytoplasmic domain of voltage-gated Na+ ion
channel; pfam11933"
/db_xref="CDD:432199"
Region 817..1028
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Region 1054..1283
/region_name="Na_trans_assoc"
/note="Sodium ion transport-associated; pfam06512"
/db_xref="CDD:428983"
Region 1287..1558
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Region 1548..1600
/region_name="Na_channel_gate"
/note="Inactivation gate of the voltage-gated sodium
channel alpha subunits; cd13433"
/db_xref="CDD:240441"
Site 1563..1566
/site_type="other"
/note="putative hydrophobic latch"
/db_xref="CDD:240441"
Region 1608..1858
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Region 1869..1916
/region_name="GPHH"
/note="Voltage-dependent L-type calcium channel,
IQ-associated; pfam16905"
/db_xref="CDD:435642"
CDS 1..2118
/gene="para"
/locus_tag="Dmel_CG9907"
/gene_synonym="bas; bss; CG9907; Dmel\CG9907; DmNav;
DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da;
l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; Para;
para13-5; sbl; sbl-1; Scn1alpha; Shu; Shudderer; VSSC"
/coded_by="NM_001201687.1:269..6625"
/db_xref="FLYBASE:FBpp0292688"
/db_xref="GeneID:32619"
/db_xref="FLYBASE:FBgn0285944"
ORIGIN
1 mtedsdsise eerslfrpft reslvqieqr iaaehekqke lerkraegev pqygrkkkqk
61 eiryddeded egpqpdptle qgvpipvrlq gsfppelast pledidpyys nvltfvvvsk
121 gkdifrfsas kamwmldpfn pirrvaiyil vhplfslfii ttilvncilm impttptves
181 teviftgiyt fesavkvmar gfilcpftyl rdawnwldfv vialayvtmg idlgnlaalr
241 tfrvlralkt vaivpglkti vgaviesvkn lrdviiltmf slsvfalmgl qiymgvltqk
301 cikkfpldgs wgnltdenwd yhnrnssnwy sedegisfpl cgnisgagqc dddyvclqgf
361 gpnpnygyts fdsfgwafls afrlmtqdfw edlyqlvlra agpwhmlffi viiflgsfyl
421 vnlilaivam sydelqkkae eeeaaeeeai reaeeaaaak aakleerana qaqaaadaaa
481 aeeaalhpem aksptyscis yelfvggekg nddnnkekms irsveveses vsviqrqpap
541 ttahqatkvr kvsttslslp gspfnirrgs rsshkytirn grgrfgipgs drkplvlsty
601 qdaqqhlpya ddsnavtpms eengaiivpv yygnlgsrhs sytshqsris ytshgdllgg
661 mavmgvstmt kesklrnrnt rnqsvgatng gttcldtnhk ldhrdyeigl ectdeagkik
721 hhdnpfiepv qtqtvvdmkd vmvlndiieq aagrhsrasd rgvsvyyfpt edddedgptf
781 kdkalevilk gidvfcvwdc cwvwlkfqew vslivfdpfv elfitlcivv ntmfmamdhh
841 dmnkemervl ksgnyfftat faieatmklm amspkyyfqe gwnifdfiiv alsllelgle
901 gvqglsvlrs frllrvfkla kswptlnlli simgrtmgal gnltfvlcii ififavmgmq
961 lfgknyhdhk drfpdgdlpr wnftdfmhsf mivfrvlcge wiesmwdcmy vgdvscipff
1021 latvvignlv vlnlflalll snfgssslsa ptadndtnki aeafnrigrf kswvkrniad
1081 cfklirnklt nqisdqpsgk gvcrcisaeh gdnelelghd eiladglikk gikeqtqlev
1141 aigdgmefti hgdmknnkpk kskylnnatd ddtasinsyg shknrpfkde shkgsaetme
1201 geekrdaske dlgldeelde egeceegpld gdiiihahde dildeypadc cpdsyykkfp
1261 ilagdddspf wqgwgnlrlk tfqlienkyf etavitmilm sslalaledv hlpqrpilqd
1321 ilyymdrift vifflemlik wlalgfkvyf tnawcwldfv ivmvslinfv aslvgaggiq
1381 afktmrtlra lrplramsrm qgmrvvvnal vqaipsifnv llvclifwli faimgvqlfa
1441 gkyfkcedmn gtklsheiip nrnaceseny twvnsamnfd hvgnaylclf qvatfkgwiq
1501 imndaidsre vdkqpiretn iymylyfvff iifgsfftln lfigviidnf neqkkkaggs
1561 lemfmtedqk kyynamkkmg skkplkaipr prwrpqaivf eivtdkkfdi iimlfiglnm
1621 ftmtldryda sdtynavldy lnaifvvifs secllkifal ryhyfiepwn lfdvvvvils
1681 ilglvlsdii ekyfvsptll rvvrvakvgr vlrlvkgakg irtllfalam slpalfnicl
1741 llflvmfifa ifgmsffmhv keksgindvy nfktfgqsmi llfqmstsag wdgvldaiin
1801 eeacdppdnd kgypgncgsa tvgitfllsy lvisflivin myiavileny sqatedvqeg
1861 ltdddydmyy eiwqqfdpeg tqyirydqls efldvleppl qihkpnkyki ismdipicrg
1921 dlmycvdild altkdffark gnpieetgei geiaarpdte gyepvsstlw rqreeycarl
1981 iqhawrkhka rgegggsfep dtdhgdggdp dagdpapdea tdgdapaggd gsvngtaega
2041 adadesnvns pgedaaaaaa aaaaaaaagt ttagspgags agrqtavlve sdgfvtkngh
2101 kvvihsrsps itsrtadv
//
