LOCUS NP_001229476 110 aa linear PRI 27-APR-2025
DEFINITION anaphase-promoting complex subunit 16 isoform 1 [Homo sapiens].
ACCESSION NP_001229476
VERSION NP_001229476.1
DBSOURCE REFSEQ: accession NM_001242547.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 110)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 110)
AUTHORS Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
Barisic,M., Stemmann,O. and Choudhary,C.
TITLE Deletion of APC7 or APC16 Allows Proliferation of Human Cells
without the Spindle Assembly Checkpoint
JOURNAL Cell Rep 25 (9), 2317-2328 (2018)
PUBMED 30485802
REMARK GeneRIF: the contribution of the anaphase-promoting
complex/cyclosome subunits APC7 and APC16 to APC/C composition and
function in human cells.
REFERENCE 3 (residues 1 to 110)
AUTHORS Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
and Rape,M.
TITLE Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
and Protein Quality Control
JOURNAL Cell 171 (4), 918-933 (2017)
PUBMED 29033132
REFERENCE 4 (residues 1 to 110)
AUTHORS Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
Skehel,M. and Barford,D.
TITLE Molecular mechanism of APC/C activation by mitotic phosphorylation
JOURNAL Nature 533 (7602), 260-264 (2016)
PUBMED 27120157
REFERENCE 5 (residues 1 to 110)
AUTHORS Yamaguchi,M., Yu,S., Qiao,R., Weissmann,F., Miller,D.J.,
VanderLinden,R., Brown,N.G., Frye,J.J., Peters,J.M. and
Schulman,B.A.
TITLE Structure of an APC3-APC16 complex: insights into assembly of the
anaphase-promoting complex/cyclosome
JOURNAL J Mol Biol 427 (8), 1748-1764 (2015)
PUBMED 25490258
REMARK GeneRIF: The structures show how one APC16 binds asymmetrically to
the symmetric APC3 dimer and, together with biochemistry and prior
data, explain how APC16 recruits APC7 to APC3.
REFERENCE 6 (residues 1 to 110)
AUTHORS Cui,X.Y., Chen,J.X., Liu,B.W., Xiao,L.Y. and Fang,D.Z.
TITLE Identification of a novel gene, MSAG, regulated by high levels of
glucose and insulin
JOURNAL Biochemistry (Mosc) 74 (1), 22-28 (2009)
PUBMED 19232044
REMARK GeneRIF: The predicted protein encoded by MSAG contains 110 amino
acids and has a theoretical molecular weight of 11667.04 and an
isoelectric point of 4.91 (MSAG).
REFERENCE 7 (residues 1 to 110)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 8 (residues 1 to 110)
AUTHORS Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
Frierson,H.F. Jr. and Laurie,G.W.
TITLE The lacrimal gland transcriptome is an unusually rich source of
rare and poorly characterized gene transcripts
JOURNAL Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
PUBMED 15851553
REFERENCE 9 (residues 1 to 110)
AUTHORS Castro,A., Bernis,C., Vigneron,S., Labbe,J.C. and Lorca,T.
TITLE The anaphase-promoting complex: a key factor in the regulation of
cell cycle
JOURNAL Oncogene 24 (3), 314-325 (2005)
PUBMED 15678131
REMARK Review article
REFERENCE 10 (residues 1 to 110)
AUTHORS Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
TITLE The DNA sequence and comparative analysis of human chromosome 10
JOURNAL Nature 429 (6990), 375-381 (2004)
PUBMED 15164054
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CD511334.1, AL607035.12 and CD724246.1.
Transcript Variant: This variant (3) differs in the 5' UTR,
compared to variant 1, and encodes isoform 1. Variants 1-3 encode
the same protein (isoform 1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.855464.1,
SRR7410570.464496.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..110
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22.1"
Protein 1..110
/product="anaphase-promoting complex subunit 16 isoform 1"
/note="metabolic syndrome-associated protein; cyclosome
subunit 16; centromere protein 27"
/calculated_mol_wt=11536
Region 1..29
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q96DE5.1)"
Site 2
/site_type="acetylation"
/note="N-acetylalanine.
/evidence=ECO:0007744|PubMed:22814378; propagated from
UniProtKB/Swiss-Prot (Q96DE5.1)"
Region 27..106
/region_name="ANAPC16"
/note="Anaphase-promoting complex, subunit 16; pfam17256"
/db_xref="CDD:435817"
CDS 1..110
/gene="ANAPC16"
/gene_synonym="APC16; bA570G20.3; C10orf104; CENP-27;
MSAG"
/coded_by="NM_001242547.2:89..421"
/note="isoform 1 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS7314.1"
/db_xref="GeneID:119504"
/db_xref="HGNC:HGNC:26976"
/db_xref="MIM:613427"
ORIGIN
1 maassssssa ggvsgssvtg sgfsvsdlap prkalftypk gagemledgs erflcesvfs
61 yqvastlkqv khdqqvarme klaglveele adewrfkpie qllgftpssg
//
