LOCUS NP_001229476 110 aa linear PRI 25-JUL-2020
DEFINITION anaphase-promoting complex subunit 16 isoform 1 [Homo sapiens].
ACCESSION NP_001229476
VERSION NP_001229476.1
DBSOURCE REFSEQ: accession NM_001242547.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 110)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 110)
AUTHORS Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M,
Stemmann O and Choudhary C.
TITLE Deletion of APC7 or APC16 Allows Proliferation of Human Cells
without the Spindle Assembly Checkpoint
JOURNAL Cell Rep 25 (9), 2317-2328 (2018)
PUBMED 30485802
REMARK GeneRIF: the contribution of the anaphase-promoting
complex/cyclosome subunits APC7 and APC16 to APC/C composition and
function in human cells.
REFERENCE 3 (residues 1 to 110)
AUTHORS Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden R,
Brown NG, Frye JJ, Peters JM and Schulman BA.
TITLE Structure of an APC3-APC16 complex: insights into assembly of the
anaphase-promoting complex/cyclosome
JOURNAL J. Mol. Biol. 427 (8), 1748-1764 (2015)
PUBMED 25490258
REMARK GeneRIF: The structures show how one APC16 binds asymmetrically to
the symmetric APC3 dimer and, together with biochemistry and prior
data, explain how APC16 recruits APC7 to APC3.
REFERENCE 4 (residues 1 to 110)
AUTHORS Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L,
Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T,
Earnshaw WC and Rappsilber J.
TITLE The protein composition of mitotic chromosomes determined using
multiclassifier combinatorial proteomics
JOURNAL Cell 142 (5), 810-821 (2010)
PUBMED 20813266
REFERENCE 5 (residues 1 to 110)
AUTHORS Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM,
Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C,
Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM,
Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S,
Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F,
Mechtler K, Hyman AA and Peters JM.
TITLE Systematic analysis of human protein complexes identifies
chromosome segregation proteins
JOURNAL Science 328 (5978), 593-599 (2010)
PUBMED 20360068
REFERENCE 6 (residues 1 to 110)
AUTHORS Cui XY, Chen JX, Liu BW, Xiao LY and Fang DZ.
TITLE Identification of a novel gene, MSAG, regulated by high levels of
glucose and insulin
JOURNAL Biochemistry Mosc. 74 (1), 22-28 (2009)
PUBMED 19232044
REMARK GeneRIF: The predicted protein encoded by MSAG contains 110 amino
acids and has a theoretical molecular weight of 11667.04 and an
isoelectric point of 4.91 (MSAG).
REFERENCE 7 (residues 1 to 110)
AUTHORS Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 8 (residues 1 to 110)
AUTHORS Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF
Jr and Laurie GW.
TITLE The lacrimal gland transcriptome is an unusually rich source of
rare and poorly characterized gene transcripts
JOURNAL Invest. Ophthalmol. Vis. Sci. 46 (5), 1572-1580 (2005)
PUBMED 15851553
REFERENCE 9 (residues 1 to 110)
AUTHORS Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L,
Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE,
Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles
J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD,
Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H,
Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,
Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee
CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner
L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S,
Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E,
Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C,
Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK,
Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird
G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE,
McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson
T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan
S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou
T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore
N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J,
Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead
SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK,
Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T,
Doucette-Stamm L, Beck S, Smith DR and Rogers J.
TITLE The DNA sequence and comparative analysis of human chromosome 10
JOURNAL Nature 429 (6990), 375-381 (2004)
PUBMED 15164054
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CD511334.1, AL607035.12 and CD724246.1.
Transcript Variant: This variant (3) differs in the 5' UTR,
compared to variant 1, and encodes isoform 1. Variants 1-3 encode
the same protein (isoform 1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.855464.1,
SRR7410570.464496.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..110
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22.1"
Protein 1..110
/product="anaphase-promoting complex subunit 16 isoform 1"
/note="metabolic syndrome-associated protein; cyclosome
subunit 16; centromere protein 27"
/calculated_mol_wt=11536
Site 2
/site_type="acetylation"
/note="N-acetylalanine.
/evidence=ECO:0000244|PubMed:22814378; propagated from
UniProtKB/Swiss-Prot (Q96DE5.1)"
Region 27..106
/region_name="ANAPC16"
/note="Anaphase Promoting Complex Subunit 16; pfam17256"
/db_xref="CDD:339972"
CDS 1..110
/gene="ANAPC16"
/gene_synonym="APC16; bA570G20.3; C10orf104; CENP-27;
MSAG"
/coded_by="NM_001242547.2:89..421"
/note="isoform 1 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS7314.1"
/db_xref="GeneID:119504"
/db_xref="HGNC:HGNC:26976"
/db_xref="MIM:613427"
ORIGIN
1 maassssssa ggvsgssvtg sgfsvsdlap prkalftypk gagemledgs erflcesvfs
61 yqvastlkqv khdqqvarme klaglveele adewrfkpie qllgftpssg
//
