GenomeNet

Database: RefSeq
Entry: NP_001229476
LinkDB: NP_001229476
Original site: NP_001229476 
LOCUS       NP_001229476             110 aa            linear   PRI 25-JUL-2020
DEFINITION  anaphase-promoting complex subunit 16 isoform 1 [Homo sapiens].
ACCESSION   NP_001229476
VERSION     NP_001229476.1
DBSOURCE    REFSEQ: accession NM_001242547.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M,
            Stemmann O and Choudhary C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden R,
            Brown NG, Frye JJ, Peters JM and Schulman BA.
  TITLE     Structure of an APC3-APC16 complex: insights into assembly of the
            anaphase-promoting complex/cyclosome
  JOURNAL   J. Mol. Biol. 427 (8), 1748-1764 (2015)
   PUBMED   25490258
  REMARK    GeneRIF: The structures show how one APC16 binds asymmetrically to
            the symmetric APC3 dimer and, together with biochemistry and prior
            data, explain how APC16 recruits APC7 to APC3.
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L,
            Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T,
            Earnshaw WC and Rappsilber J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM,
            Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C,
            Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM,
            Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S,
            Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F,
            Mechtler K, Hyman AA and Peters JM.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Cui XY, Chen JX, Liu BW, Xiao LY and Fang DZ.
  TITLE     Identification of a novel gene, MSAG, regulated by high levels of
            glucose and insulin
  JOURNAL   Biochemistry Mosc. 74 (1), 22-28 (2009)
   PUBMED   19232044
  REMARK    GeneRIF: The predicted protein encoded by MSAG contains 110 amino
            acids and has a theoretical molecular weight of 11667.04 and an
            isoelectric point of 4.91 (MSAG).
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
            Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm. Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF
            Jr and Laurie GW.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L,
            Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE,
            Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles
            J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD,
            Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H,
            Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,
            Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee
            CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner
            L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S,
            Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E,
            Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C,
            Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK,
            Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird
            G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE,
            McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson
            T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan
            S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou
            T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore
            N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J,
            Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead
            SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK,
            Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T,
            Doucette-Stamm L, Beck S, Smith DR and Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD511334.1, AL607035.12 and CD724246.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1, and encodes isoform 1. Variants 1-3 encode
            the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.855464.1,
                                           SRR7410570.464496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     Protein         1..110
                     /product="anaphase-promoting complex subunit 16 isoform 1"
                     /note="metabolic syndrome-associated protein; cyclosome
                     subunit 16; centromere protein 27"
                     /calculated_mol_wt=11536
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000244|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q96DE5.1)"
     Region          27..106
                     /region_name="ANAPC16"
                     /note="Anaphase Promoting Complex Subunit 16; pfam17256"
                     /db_xref="CDD:339972"
     CDS             1..110
                     /gene="ANAPC16"
                     /gene_synonym="APC16; bA570G20.3; C10orf104; CENP-27;
                     MSAG"
                     /coded_by="NM_001242547.2:89..421"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS7314.1"
                     /db_xref="GeneID:119504"
                     /db_xref="HGNC:HGNC:26976"
                     /db_xref="MIM:613427"
ORIGIN      
        1 maassssssa ggvsgssvtg sgfsvsdlap prkalftypk gagemledgs erflcesvfs
       61 yqvastlkqv khdqqvarme klaglveele adewrfkpie qllgftpssg
//
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