LOCUS NP_001231533 536 aa linear PRI 29-MAY-2023
DEFINITION dihydropyrimidinase-related protein 2 isoform 3 [Homo sapiens].
ACCESSION NP_001231533
VERSION NP_001231533.1
DBSOURCE REFSEQ: accession NM_001244604.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 536)
AUTHORS Brustovetsky T, Khanna R and Brustovetsky N.
TITLE CRMP2 Participates in Regulating Mitochondrial Morphology and
Motility in Alzheimer's Disease
JOURNAL Cells 12 (9), 1287 (2023)
PUBMED 37174687
REMARK GeneRIF: CRMP2 Participates in Regulating Mitochondrial Morphology
and Motility in Alzheimer's Disease.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 536)
AUTHORS Suzuki H, Li S, Tokutomi T, Takeuchi C, Takahashi M, Yamada M,
Okuno H, Miya F, Takenouchi T, Numabe H, Kosaki K and Ohshima T.
TITLE De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with
intellectual disabilities and documentation of functional relevance
through zebrafish rescue and cellular transfection experiments
JOURNAL Hum Mol Genet 31 (24), 4173-4182 (2022)
PUBMED 35861646
REMARK GeneRIF: De novo non-synonymous DPYSL2 (CRMP2) variants in two
patients with intellectual disabilities and documentation of
functional relevance through zebrafish rescue and cellular
transfection experiments.
REFERENCE 3 (residues 1 to 536)
AUTHORS Jin Y, Bian S, Wang H, Mo J, Fei H, Li L, Chen T and Jiang H.
TITLE CRMP2 derived from cancer associated fibroblasts facilitates
progression of ovarian cancer via HIF-1alpha-glycolysis signaling
pathway
JOURNAL Cell Death Dis 13 (8), 675 (2022)
PUBMED 35927239
REMARK GeneRIF: CRMP2 derived from cancer associated fibroblasts
facilitates progression of ovarian cancer via HIF-1alpha-glycolysis
signaling pathway.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 536)
AUTHORS Abu Rmaileh A, Solaimuthu B, Khatib A, Lavi S, Tanna M, Hayashi A,
Ben Yosef M, Lichtenstein M, Pillar N and Shaul YD.
TITLE DPYSL2 interacts with JAK1 to mediate breast cancer cell migration
JOURNAL J Cell Biol 221 (7) (2022)
PUBMED 35575798
REMARK GeneRIF: DPYSL2 interacts with JAK1 to mediate breast cancer cell
migration.
REFERENCE 5 (residues 1 to 536)
AUTHORS Soutar MP, Thornhill P, Cole AR and Sutherland C.
TITLE Increased CRMP2 phosphorylation is observed in Alzheimer's disease;
does this tell us anything about disease development?
JOURNAL Curr Alzheimer Res 6 (3), 269-278 (2009)
PUBMED 19519308
REMARK Review article
REFERENCE 6 (residues 1 to 536)
AUTHORS Gu Y and Ihara Y.
TITLE Evidence that collapsin response mediator protein-2 is involved in
the dynamics of microtubules
JOURNAL J Biol Chem 275 (24), 17917-17920 (2000)
PUBMED 10770920
REFERENCE 7 (residues 1 to 536)
AUTHORS Gu Y, Hamajima N and Ihara Y.
TITLE Neurofibrillary tangle-associated collapsin response mediator
protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518,
and Ser-522
JOURNAL Biochemistry 39 (15), 4267-4275 (2000)
PUBMED 10757975
REFERENCE 8 (residues 1 to 536)
AUTHORS Kitamura K, Takayama M, Hamajima N, Nakanishi M, Sasaki M, Endo Y,
Takemoto T, Kimura H, Iwaki M and Nonaka M.
TITLE Characterization of the human dihydropyrimidinase-related protein 2
(DRP-2) gene
JOURNAL DNA Res 6 (5), 291-297 (1999)
PUBMED 10574455
REFERENCE 9 (residues 1 to 536)
AUTHORS Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M and Nonaka M.
TITLE A novel gene family defined by human dihydropyrimidinase and three
related proteins with differential tissue distribution
JOURNAL Gene 180 (1-2), 157-163 (1996)
PUBMED 8973361
REFERENCE 10 (residues 1 to 536)
AUTHORS Goshima Y, Nakamura F, Strittmatter P and Strittmatter SM.
TITLE Collapsin-induced growth cone collapse mediated by an intracellular
protein related to UNC-33
JOURNAL Nature 376 (6540), 509-514 (1995)
PUBMED 7637782
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP222303.1, AK299077.1,
BX463316.2, AC015564.13 and BC056408.1.
Summary: This gene encodes a member of the collapsin response
mediator protein family. Collapsin response mediator proteins form
homo- and hetero-tetramers and facilitate neuron guidance, growth
and polarity. The encoded protein promotes microtubule assembly and
is required for Sema3A-mediated growth cone collapse, and also
plays a role in synaptic signaling through interactions with
calcium channels. This gene has been implicated in multiple
neurological disorders, and hyperphosphorylation of the encoded
protein may play a key role in the development of Alzheimer's
disease. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. [provided by
RefSeq, Sep 2011].
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
portion of the 5' coding region and initiates translation at a
downstream, in-frame start codon, compared to variant 1. The
encoded isoform (3) has a shorter N-terminus, compared to isoform
1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803617.133392.1,
SRR1803613.66143.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1970526, SAMEA2145245
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..536
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p21.2"
Protein 1..536
/product="dihydropyrimidinase-related protein 2 isoform 3"
/note="dihydropyrimidinase-related protein 2; collapsin
response mediator protein hCRMP-2; unc-33-like
phosphoprotein 2"
/calculated_mol_wt=58032
Region 1..430
/region_name="D-HYD"
/note="D-hydantoinases (D-HYD) also called
dihydropyrimidases (DHPase) and related proteins; DHPases
are a family of enzymes that catalyze the reversible
hydrolytic ring opening of the amide bond in five- or
six-membered cyclic diamides, like dihydropyrimidine...;
cd01314"
/db_xref="CDD:238639"
Site order(8..9,144,165,168,171,194,198,202,205,232..233,
235..236,354,359,364)
/site_type="other"
/note="tetramer interface [polypeptide binding]"
/db_xref="CDD:238639"
Site order(37,39,129,162,218,296)
/site_type="active"
/db_xref="CDD:238639"
CDS 1..536
/gene="DPYSL2"
/gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
ULIP-2; ULIP2"
/coded_by="NM_001244604.2:199..1809"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS59096.1"
/db_xref="GeneID:1808"
/db_xref="HGNC:HGNC:3014"
/db_xref="MIM:602463"
ORIGIN
1 medglikqig enlivpggvk tieahsrmvi pggidvhtrf qmpdqgmtsa ddffqgtkaa
61 laggttmiid hvvpepgtsl laafdqwrew adsksccdys lhvdisewhk giqeemealv
121 kdhgvnsflv ymafkdrfql tdcqiyevls virdigaiaq vhaengdiia eeqqrildlg
181 itgpeghvls rpeeveaeav nraitianqt ncplyitkvm skssaeviaq arkkgtvvyg
241 epitaslgtd gshywsknwa kaaafvtspp lspdpttpdf lnsllscgdl qvtgsahctf
301 ntaqkavgkd nftlipegtn gteermsviw dkavvtgkmd enqfvavtst naakvfnlyp
361 rkgriavgsd adlviwdpds vktisakthn ssleynifeg mecrgsplvv isqgkivled
421 gtlhvtegsg ryiprkpfpd fvykrikars rlaelrgvpr glydgpvcev svtpktvtpa
481 ssaktspakq qappvrnlhq sgfslsgaqi ddniprrttq rivappggra nitslg
//
