LOCUS NP_001239217 1019 aa linear ROD 25-APR-2025
DEFINITION 2-oxoglutarate dehydrogenase complex component E1 isoform 4 [Mus
musculus].
ACCESSION NP_001239217
VERSION NP_001239217.1
DBSOURCE REFSEQ: accession NM_001252288.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 1019)
AUTHORS Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
TITLE Metabolic rewiring of macrophages by epidermal-derived lactate
promotes sterile inflammation in the murine skin
JOURNAL EMBO J 43 (7), 1113-1134 (2024)
PUBMED 38418556
REFERENCE 2 (residues 1 to 1019)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 3 (residues 1 to 1019)
AUTHORS Zhong,Y., Gao,Y., Zhou,D., Ma,X., Chen,H., Xu,Y., Yang,W. and Yu,X.
TITLE Structural basis for the activity and regulation of human
alpha-ketoglutarate dehydrogenase revealed by Cryo-EM
JOURNAL Biochem Biophys Res Commun 602, 120-126 (2022)
PUBMED 35272141
REFERENCE 4 (residues 1 to 1019)
AUTHORS Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
TITLE LONP1-mediated mitochondrial quality control safeguards metabolic
shifts in heart development
JOURNAL Development 149 (6) (2022)
PUBMED 35237793
REFERENCE 5 (residues 1 to 1019)
AUTHORS Andrade,J., Shi,C., Costa,A.S.H., Choi,J., Kim,J.,
Doddaballapur,A., Sugino,T., Ong,Y.T., Castro,M., Zimmermann,B.,
Kaulich,M., Guenther,S., Wilhelm,K., Kubota,Y., Braun,T., Koh,G.Y.,
Grosso,A.R., Frezza,C. and Potente,M.
TITLE Control of endothelial quiescence by FOXO-regulated metabolites
JOURNAL Nat Cell Biol 23 (4), 413-423 (2021)
PUBMED 33795871
REFERENCE 6 (residues 1 to 1019)
AUTHORS Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
TITLE Integrated analysis of protein composition, tissue diversity, and
gene regulation in mouse mitochondria
JOURNAL Cell 115 (5), 629-640 (2003)
PUBMED 14651853
REFERENCE 7 (residues 1 to 1019)
AUTHORS Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
TITLE Targeting a complex transcriptome: the construction of the mouse
full-length cDNA encyclopedia
JOURNAL Genome Res 13 (6B), 1273-1289 (2003)
PUBMED 12819125
REFERENCE 8 (residues 1 to 1019)
AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
TITLE BayGenomics: a resource of insertional mutations in mouse embryonic
stem cells
JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003)
PUBMED 12520002
REFERENCE 9 (residues 1 to 1019)
AUTHORS Udaka,K., Tsomides,T.J., Walden,P., Fukusen,N. and Eisen,H.N.
TITLE A ubiquitous protein is the source of naturally occurring peptides
that are recognized by a CD8+ T-cell clone
JOURNAL Proc Natl Acad Sci U S A 90 (23), 11272-11276 (1993)
PUBMED 8248240
REFERENCE 10 (residues 1 to 1019)
AUTHORS Udaka,K., Tsomides,T.J. and Eisen,H.N.
TITLE A naturally occurring peptide recognized by alloreactive CD8+
cytotoxic T lymphocytes in association with a class I MHC protein
JOURNAL Cell 69 (6), 989-998 (1992)
PUBMED 1606619
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY782774.1, BY785860.1, BC049104.1, AK147289.1 and AL607152.21.
Transcript Variant: This variant (5) differs in the 5' UTR exon and
lacks an in-frame coding exon, compared to variant 1. The resulting
isoform (4) lacks an internal segment, compared to isoform 1.
Variants 5 and 9 encode the same isoform (4).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC049104.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849377
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1019
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 3.94 cM"
Protein 1..1019
/product="2-oxoglutarate dehydrogenase complex component
E1 isoform 4"
/EC_number="1.2.4.2"
/note="2-oxoglutarate dehydrogenase, mitochondrial;
OGDC-E1; alpha-KGDH-E1; thiamine diphosphate
(ThDP)-dependent 2-oxoglutarate dehydrogenase;
2-oxoglutarate dehydrogenase complex component E1;
alpha-ketoglutarate dehydrogenase; oxoglutarate
dehydrogenase (lipoamide)"
/calculated_mol_wt=115897
Region 49..1012
/region_name="SucA"
/note="2-oxoglutarate dehydrogenase complex, dehydrogenase
(E1) component, and related enzymes [Energy production and
conversion]; COG0567"
/db_xref="CDD:440333"
CDS 1..1019
/gene="Ogdh"
/gene_synonym="2210403E04Rik; 2210412K19Rik; d1401; E1o;
mKIAA4192; OGDH-E1"
/coded_by="NM_001252288.1:184..3243"
/note="isoform 4 is encoded by transcript variant 5"
/db_xref="CCDS:CCDS56759.1"
/db_xref="GeneID:18293"
/db_xref="MGI:MGI:1098267"
ORIGIN
1 mfhlrtcaak lrpltasqtv ktfsqnkpaa irtfqqircy sapvaaepfl sgtssnyvee
61 mycawlenpk svhkswdiff rntnagappg tayqsplsls rsslatmaha qslveaqpnv
121 dklvedhlav qslirayqvr ghhiakldpl giscvnfdda pvtvssnvgf yglhesdldk
181 vfhlptttfi ggqepalplr eiirrlemay cqhigvefmf indleqcqwi rqkfetpgim
241 qftneekrtl larlvrstrf eeflqrkwss ekrfglegce vlipalktii dmssangvdy
301 vimgmphrgr lnvlanvirk eleqifcqfd skleaadegs gdmkyhlgmy hrrinrvtdr
361 nitlslvanp shleaadpvv mgktkaeqfy cgdtegkkvm sillhgdaaf agqgivyetf
421 hlsdlpsytt hgtvhvvvnn qigfttdprm arsspyptdv arvvnapifh vnsddpeavm
481 yvckvaaewr ntfhkdvvvd lvcyrrnghn emdepmftqp lmykqirkqk pvlqkyaell
541 vsqgvvnqpe yeeeiskydk iceeaftrsk dekilhikhw ldspwpgfft ldgqprsmtc
601 pstgleedvl fhigkvassv pvenftihgg lsrilktrre lvtnrtvdwa laeymafgsl
661 lkegihvrls gqdvergtfs hrhhvlhdqn vdkrtcipmn hlwpnqapyt vcnsslseyg
721 vlgfelgfam aspnalvlwe aqfgdfnnma qciidqficp gqakwvrqng ivlllphgme
781 gmgpehssar perflqmcnd dpdvlpdlqe enfdinqlyd cnwivvncst pgnffhvlrr
841 qillpfrkpl ivftpksllr hpeartsfde mlpgthfqrv ipengpaaqd phkvkrllfc
901 tgkvyydltr erkarnmeee vaitrieqls pfpfdlllke aqkypnaela wcqeehknqg
961 yydyvkprlr ttidrakpvw yagrdpaaap atgnkkthlt elqrfldtaf dldafkkfs
//
