LOCUS NP_001242928 2169 aa linear ROD 25-APR-2025
DEFINITION voltage-dependent L-type calcium channel subunit alpha-1C isoform 7
[Mus musculus].
ACCESSION NP_001242928
VERSION NP_001242928.1
DBSOURCE REFSEQ: accession NM_001255999.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 2169)
AUTHORS Fang,L.P., Lin,C.H., Medlej,Y., Zhao,R., Chang,H.F., Guo,Q., Wu,Z.,
Su,Y., Zhao,N., Gobbo,D., Wyatt,A., Wahl,V., Fiore,F., Tu,S.M.,
Boehm,U., Huang,W., Bian,S., Agarwal,A., Lauterbach,M.A., Yi,C.,
Niu,J., Scheller,A., Kirchhoff,F. and Bai,X.
TITLE Oligodendrocyte precursor cells facilitate neuronal lysosome
release
JOURNAL Nat Commun 16 (1), 1175 (2025)
PUBMED 39885146
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 2169)
AUTHORS Matsui,M., Lynch,L.E., Distefano,I., Galante,A., Gade,A.R.,
Wang,H.G., Gomez-Banoy,N., Towers,P., Sinden,D.S., Wei,E.Q.,
Barnett,A.S., Johnson,K., Lima,R., Rubio-Navarro,A., Li,A.K.,
Marx,S.O., McGraw,T.E., Thornton,P.S., Timothy,K.W., Lo,J.C. and
Pitt,G.S.
TITLE Multiple beta cell-independent mechanisms drive hypoglycemia in
Timothy syndrome
JOURNAL Nat Commun 15 (1), 8980 (2024)
PUBMED 39420001
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 2169)
AUTHORS Chevalier,N.R., Zig,L., Gomis,A., Amedzrovi Agbesi,R.J., El
Merhie,A., Pontoizeau,L., Le Parco,I., Rouach,N., Arnoux,I., de
Santa Barbara,P. and Faure,S.
TITLE Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact
on smooth muscle differentiation
JOURNAL Commun Biol 7 (1), 1277 (2024)
PUBMED 39375515
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 2169)
AUTHORS Loganathan,S., Menegaz,D., Delling,J.P., Eder,M. and Deussing,J.M.
TITLE Cacna1c deficiency in forebrain glutamatergic neurons alters
behavior and hippocampal plasticity in female mice
JOURNAL Transl Psychiatry 14 (1), 421 (2024)
PUBMED 39370418
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 2169)
AUTHORS Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
TITLE Loss of connectin novex-3 leads to heart dysfunction associated
with impaired cardiomyocyte proliferation and abnormal nuclear
mechanics
JOURNAL Sci Rep 14 (1), 13727 (2024)
PUBMED 38877142
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 2169)
AUTHORS Chaudhari,N.
TITLE A single nucleotide deletion in the skeletal muscle-specific
calcium channel transcript of muscular dysgenesis (mdg) mice
JOURNAL J Biol Chem 267 (36), 25636-25639 (1992)
PUBMED 1281468
REFERENCE 7 (residues 1 to 2169)
AUTHORS Chin,H., Krall,M., Kim,H.L., Kozak,C.A. and Mock,B.
TITLE The gene for the alpha 1 subunit of the skeletal muscle
dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse
chromosome 1
JOURNAL Genomics 14 (4), 1089-1091 (1992)
PUBMED 1335956
REFERENCE 8 (residues 1 to 2169)
AUTHORS Ma,W.J., Holz,R.W. and Uhler,M.D.
TITLE Expression of a cDNA for a neuronal calcium channel alpha 1 subunit
enhances secretion from adrenal chromaffin cells
JOURNAL J Biol Chem 267 (32), 22728-22732 (1992)
PUBMED 1385406
REFERENCE 9 (residues 1 to 2169)
AUTHORS Perez-Reyes,E., Wei,X.Y., Castellano,A. and Birnbaumer,L.
TITLE Molecular diversity of L-type calcium channels. Evidence for
alternative splicing of the transcripts of three non-allelic genes
JOURNAL J Biol Chem 265 (33), 20430-20436 (1990)
PUBMED 2173707
REFERENCE 10 (residues 1 to 2169)
AUTHORS Vasseur,M., Debuyser,A. and Joffre,M.
TITLE Sensitivity of pancreatic beta cell to calcium channel blockers. An
electrophysiologic study of verapamil and nifedipine
JOURNAL Fundam Clin Pharmacol 1 (2), 95-113 (1987)
PUBMED 3315915
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK052162.1, FM872411.1 and AC036121.11.
Transcript Variant: This variant (7) has multiple differences in
the coding region but maintains the reading frame, compared to
variant 1. This variant encodes isoform 7, which is the same length
as isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FM872411.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2169
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="6"
/map="6 55.86 cM"
Protein 1..2169
/product="voltage-dependent L-type calcium channel subunit
alpha-1C isoform 7"
/note="voltage-dependent L-type calcium channel subunit
alpha-1C; skeletal muscle-specific calcium channel;
calcium channel voltage-dependent alpha1c subunit;
neuronal voltage-gated calcium channel alpha 1C subunit;
brain class C; voltage-gated calcium channel subunit alpha
Cav1.2"
/calculated_mol_wt=243378
Region 153..446
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:459842"
Region 553..794
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:459842"
Region 929..1206
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:459842"
Region 1248..1517
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:459842"
Region 1526..1579
/region_name="GPHH"
/note="Voltage-dependent L-type calcium channel,
IQ-associated; pfam16905"
/db_xref="CDD:465306"
Region 1589..1663
/region_name="Ca_chan_IQ"
/note="Voltage gated calcium channel IQ domain; pfam08763"
/db_xref="CDD:462591"
Region 1683..2118
/region_name="CAC1F_C"
/note="Voltage-gated calcium channel subunit alpha,
C-term; pfam16885"
/db_xref="CDD:465298"
CDS 1..2169
/gene="Cacna1c"
/gene_synonym="Cav1.2; Cchl1a1; D930026N18Rik; MBC;
MELC-CC"
/coded_by="NM_001255999.2:179..6688"
/note="isoform 7 is encoded by transcript variant 7"
/db_xref="CCDS:CCDS80594.1"
/db_xref="GeneID:12288"
/db_xref="MGI:MGI:103013"
ORIGIN
1 mirafvqpst ppyqplsshs seeterkfkg kvvheaqlnc fyispggsny gsprpahanm
61 nanaaaglap ehiptpgaal swqaaidaar qaklmgsagn atistvsstq rkrqqygkpk
121 kqggttatrp prallcltlk npirracisi vewkpfeiii lltifancva laiyipfped
181 dsnatnsnle rveylfliif tveaflkvia ygllfhpnay lrngwnlldf iivvvglfsa
241 ileqatkadg analggkgag fdvkalrafr vlrplrlvsg vpslqvvlns iikamvpllh
301 iallvlfvii iyaiiglelf mgkmhktcyn qegiidvpae edpspcalet ghgrqcqngt
361 vckpgwdgpk hgitnfdnfa famltvfqci tmegwtdvly wmqdamgyel pwvyfvslvi
421 fgsffvlnlv lgvlsgefsk erekakargd fqklrekqql eedlkgyldw itqaedidpe
481 nedegmdedk prnmsmptse tesvntenva ggdiegencg arlahrisks kfsrywrrwn
541 rfcrrkcraa vksnvfywlv iflvflntlt iasehynqph wltevqdtan kallalftae
601 mllkmyslgl qayfvslfnr fdcfivcggi letilvetki msplgisvlr cvrllrifki
661 trywnslsnl vasllnsvrs iaslllllfl fiiifsllgm qlfggkfnfd emqtrrstfd
721 nfpqslltvf qiltgedwns vmydgimayg gpsfpgmlvc iyfiilficg nyillnvfla
781 iavdnladae sltsaqkeee eekerkklar taspekkqev mekpaveesk eekielksit
841 adgesppttk inmddlqpse nedksphsnp dtageedeee pempvgprpr plselhlkek
901 avpmpeasaf fifspnnrfr lqchrivndt iftnlilffi llssislaae dpvqhtsfrn
961 hilfyfdivf ttiftieial kmtaygaflh kgsfcrnyfn ildllvvsvs lisfgiqssa
1021 invvkilrvl rvlrplrain rakglkhvvq cvfvairtig nivivttllq fmfacigvql
1081 fkgklytcsd sskqteaeck gnyitykdge vdhpiiqprs wenskfdfdn vlaammalft
1141 vstfegwpel lyrsidshte dkgpiynyrv eisiffiiyi iiiaffmmni fvgfvivtfq
1201 eqgeqeyknc eldknqrqcv eyalkarplr ryipknqhqy kvwyvvnsty feylmfvlil
1261 lnticlamqh ygqsclfkia mnilnmlftg lftvemilkl iafkpkgyfs dpwnvfdfli
1321 vigsiidvil setnpaehtq cspsmsaeen srisitffrl frvmrlvkll srgegirtll
1381 wtfiksfqal pyvallivml ffiyavigmq vfgkialndt teinrnnnfq tfpqavlllf
1441 rcatgeawqd imlacmpgkk capesepsns tegetpcgss favfyfisfy mlcafliinl
1501 fvavimdnfd yltrdwsilg phhldefkri waeydpeakg rikhldvvtl lrriqpplgf
1561 gklcphrvac krlvsmnmpl nsdgtvmfna tlfalvrtal riktegnleq aneelraiik
1621 kiwkrtsmkl ldqvvppagd devtvgkfya tfliqeyfrk fkkrkeqglv gkpsqrnals
1681 lqaglrtlhd igpeirrais gdltaeeeld kamkeavsaa seddifrrag glfgnhvtyy
1741 qsdsrgnfpq tfatqrplhi nktgnnqadt espsheklvd stftpssyss tgsnaninna
1801 nntalgrfph pagysstvst veghgpplsp avrvqeaawk lsskrchsre sqgatvnqei
1861 fpdetrsvrm seeaeycsep sllstdmfsy qedehrqltc peedkreiqp spkrsflrsa
1921 slgrrasfhl eclkrqkdqg gdisqktalp lhlvhhqala vaglspllqr shspttfprp
1981 cptppvtpgs rgrplrpipt lrlegaesse klnssfpsih csswseetta csgsssmarr
2041 arpvsltvps qagapgrqfh gsasslveav liseglgqfa qdpkfievtt qeladacdmt
2101 ieemenaadn ilsggaqqsp ngtllpfvnc rdpgqdrava pedescayal grgrseeala
2161 dsrsyvsnl
//
