GenomeNet

Database: RefSeq
Entry: NP_001243637
LinkDB: NP_001243637
Original site: NP_001243637 
LOCUS       NP_001243637             185 aa            linear   PRI 13-AUG-2020
DEFINITION  anaphase-promoting complex subunit 10 isoform 1 [Homo sapiens].
ACCESSION   NP_001243637
VERSION     NP_001243637.1
DBSOURCE    REFSEQ: accession NM_001256708.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 185)
  AUTHORS   Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J
            and Wang JB.
  TITLE     A novel function of anaphase promoting complex subunit 10 in tumor
            progression in non-small cell lung cancer
  JOURNAL   Cell Cycle 18 (9), 1019-1032 (2019)
   PUBMED   31023143
  REMARK    GeneRIF: APC10 was overexpressed in non-small cell lung cancer cell
            lines compared to human bronchial epithelial cell lines. APC10 was
            shown to interact with GAC; knocking down APC10 downregulated
            glutamine metabolism to induce autophagy, resulting in effective
            inhibition of the proliferation and migration of non-small cell
            lung cancer cells.
REFERENCE   2  (residues 1 to 185)
  AUTHORS   He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H,
            Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung
            T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu
            D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram
            MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J,
            Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y,
            Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T,
            Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto
            K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK,
            Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke
            KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T and Qi L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum. Mol. Genet. 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   3  (residues 1 to 185)
  AUTHORS   Mansfeld J, Collin P, Collins MO, Choudhary JS and Pines J.
  TITLE     APC15 drives the turnover of MCC-CDC20 to make the spindle assembly
            checkpoint responsive to kinetochore attachment
  JOURNAL   Nat. Cell Biol. 13 (10), 1234-1243 (2011)
   PUBMED   21926987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 185)
  AUTHORS   Izawa D and Pines J.
  TITLE     How APC/C-Cdc20 changes its substrate specificity in mitosis
  JOURNAL   Nat. Cell Biol. 13 (3), 223-233 (2011)
   PUBMED   21336306
  REMARK    GeneRIF: Cdc20 requires APC3 and APC8 to bind and activate the
            APC/C when the spindle assembly checkpoint is satisfied, but only
            APC8 when active, and APC10 is crucial for the destruction of
            cyclin B1 and securin, but not cyclin A
            Erratum:[Nat Cell Biol. 2011 May;13(5):633]
REFERENCE   5  (residues 1 to 185)
  AUTHORS   Buschhorn BA, Petzold G, Galova M, Dube P, Kraft C, Herzog F, Stark
            H and Peters JM.
  TITLE     Substrate binding on the APC/C occurs between the coactivator Cdh1
            and the processivity factor Doc1
  JOURNAL   Nat. Struct. Mol. Biol. 18 (1), 6-13 (2011)
   PUBMED   21186364
  REMARK    GeneRIF: Substrates are recruited to the Anaphase-promoting complex
            by binding to a bipartite substrate receptor composed of Cdh1 and
            Doc1.
REFERENCE   6  (residues 1 to 185)
  AUTHORS   Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA,
            Stockinger W, Nimpf J and Herz J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J. Biol. Chem. 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   7  (residues 1 to 185)
  AUTHORS   Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M and Peters JM.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol. Biol. Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   8  (residues 1 to 185)
  AUTHORS   Lukas C, Sorensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters
            JM, Bartek J and Lukas J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   9  (residues 1 to 185)
  AUTHORS   Kurasawa Y and Todokoro K.
  TITLE     Identification of human APC10/Doc1 as a subunit of anaphase
            promoting complex
  JOURNAL   Oncogene 18 (37), 5131-5137 (1999)
   PUBMED   10498862
REFERENCE   10 (residues 1 to 185)
  AUTHORS   Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
            Schleiffer A, Nasmyth K, Mann M and Peters JM.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J. Biol. Chem. 274 (20), 14500-14507 (1999)
   PUBMED   10318877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096757.3, BU567906.1, CV023091.1 and AC097649.3.
            
            Summary: ANAPC10 is a core subunit of the anaphase-promoting
            complex (APC), or cyclosome, a ubiquitin protein ligase that is
            essential for progression through the cell cycle. APC initiates
            sister chromatid separation by ubiquitinating the anaphase
            inhibitor securin (PTTG1; MIM 604147) and triggers exit from
            mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the
            activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940)
            (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by
            OMIM, Feb 2011].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.323893.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     Protein         1..185
                     /product="anaphase-promoting complex subunit 10 isoform 1"
                     /note="cyclosome subunit 10"
                     /calculated_mol_wt=21121
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000244|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9UM13.1)"
     Region          4..183
                     /region_name="ANAPC10"
                     /note="Anaphase-promoting complex, subunit 10 (APC10);
                     pfam03256"
                     /db_xref="CDD:308727"
     Site            order(53,80,87,89,152)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176484"
     Site            169
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8K2H6; propagated from
                     UniProtKB/Swiss-Prot (Q9UM13.1)"
     CDS             1..185
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /coded_by="NM_001256708.2:349..906"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS43273.1"
                     /db_xref="GeneID:10393"
                     /db_xref="HGNC:HGNC:24077"
                     /db_xref="MIM:613745"
ORIGIN      
        1 mttpnktppg adpkqlertg tvreigsqav wslssckpgf gvdqlrddnl etywqsdgsq
       61 phlvniqfrr kttvktlciy adyksdesyt pskisvrvgn nfhnlqeirq lelvepsgwi
      121 hvpltdnhkk ptrtfmiqia vlanhqngrd thmrqikiyt pveessigkf prcttidfmm
      181 yrsir
//
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