LOCUS NP_001243638 196 aa linear PRI 13-AUG-2020
DEFINITION anaphase-promoting complex subunit 10 isoform 2 [Homo sapiens].
ACCESSION NP_001243638
VERSION NP_001243638.1
DBSOURCE REFSEQ: accession NM_001256709.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 196)
AUTHORS Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J
and Wang JB.
TITLE A novel function of anaphase promoting complex subunit 10 in tumor
progression in non-small cell lung cancer
JOURNAL Cell Cycle 18 (9), 1019-1032 (2019)
PUBMED 31023143
REMARK GeneRIF: APC10 was overexpressed in non-small cell lung cancer cell
lines compared to human bronchial epithelial cell lines. APC10 was
shown to interact with GAC; knocking down APC10 downregulated
glutamine metabolism to induce autophagy, resulting in effective
inhibition of the proliferation and migration of non-small cell
lung cancer cells.
REFERENCE 2 (residues 1 to 196)
AUTHORS He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H,
Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung
T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu
D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram
MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J,
Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y,
Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T,
Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto
K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK,
Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke
KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T and Qi L.
TITLE Meta-analysis of genome-wide association studies of adult height in
East Asians identifies 17 novel loci
JOURNAL Hum. Mol. Genet. 24 (6), 1791-1800 (2015)
PUBMED 25429064
REFERENCE 3 (residues 1 to 196)
AUTHORS Mansfeld J, Collin P, Collins MO, Choudhary JS and Pines J.
TITLE APC15 drives the turnover of MCC-CDC20 to make the spindle assembly
checkpoint responsive to kinetochore attachment
JOURNAL Nat. Cell Biol. 13 (10), 1234-1243 (2011)
PUBMED 21926987
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 196)
AUTHORS Izawa D and Pines J.
TITLE How APC/C-Cdc20 changes its substrate specificity in mitosis
JOURNAL Nat. Cell Biol. 13 (3), 223-233 (2011)
PUBMED 21336306
REMARK GeneRIF: Cdc20 requires APC3 and APC8 to bind and activate the
APC/C when the spindle assembly checkpoint is satisfied, but only
APC8 when active, and APC10 is crucial for the destruction of
cyclin B1 and securin, but not cyclin A
Erratum:[Nat Cell Biol. 2011 May;13(5):633]
REFERENCE 5 (residues 1 to 196)
AUTHORS Buschhorn BA, Petzold G, Galova M, Dube P, Kraft C, Herzog F, Stark
H and Peters JM.
TITLE Substrate binding on the APC/C occurs between the coactivator Cdh1
and the processivity factor Doc1
JOURNAL Nat. Struct. Mol. Biol. 18 (1), 6-13 (2011)
PUBMED 21186364
REMARK GeneRIF: Substrates are recruited to the Anaphase-promoting complex
by binding to a bipartite substrate receptor composed of Cdh1 and
Doc1.
REFERENCE 6 (residues 1 to 196)
AUTHORS Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA,
Stockinger W, Nimpf J and Herz J.
TITLE Interactions of the low density lipoprotein receptor gene family
with cytosolic adaptor and scaffold proteins suggest diverse
biological functions in cellular communication and signal
transduction
JOURNAL J. Biol. Chem. 275 (33), 25616-25624 (2000)
PUBMED 10827173
REFERENCE 7 (residues 1 to 196)
AUTHORS Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M and Peters JM.
TITLE Mitotic regulation of the APC activator proteins CDC20 and CDH1
JOURNAL Mol. Biol. Cell 11 (5), 1555-1569 (2000)
PUBMED 10793135
REFERENCE 8 (residues 1 to 196)
AUTHORS Lukas C, Sorensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters
JM, Bartek J and Lukas J.
TITLE Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
rearrangement of the anaphase-promoting complex
JOURNAL Nature 401 (6755), 815-818 (1999)
PUBMED 10548110
REFERENCE 9 (residues 1 to 196)
AUTHORS Kurasawa Y and Todokoro K.
TITLE Identification of human APC10/Doc1 as a subunit of anaphase
promoting complex
JOURNAL Oncogene 18 (37), 5131-5137 (1999)
PUBMED 10498862
REFERENCE 10 (residues 1 to 196)
AUTHORS Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
Schleiffer A, Nasmyth K, Mann M and Peters JM.
TITLE Characterization of the DOC1/APC10 subunit of the yeast and the
human anaphase-promoting complex
JOURNAL J. Biol. Chem. 274 (20), 14500-14507 (1999)
PUBMED 10318877
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BF693880.1, AL080090.1, BG494966.1 and AC097649.3.
Summary: ANAPC10 is a core subunit of the anaphase-promoting
complex (APC), or cyclosome, a ubiquitin protein ligase that is
essential for progression through the cell cycle. APC initiates
sister chromatid separation by ubiquitinating the anaphase
inhibitor securin (PTTG1; MIM 604147) and triggers exit from
mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the
activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940)
(summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by
OMIM, Feb 2011].
Transcript Variant: This variant (5) differs in the 5' UTR and
initiates translation at an alternate start codon, compared to
variant 1. The encoded isoform (2) is longer and has a distinct
N-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BG494966.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..196
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q31.21"
Protein 1..196
/product="anaphase-promoting complex subunit 10 isoform 2"
/note="cyclosome subunit 10"
/calculated_mol_wt=22292
Region 15..194
/region_name="ANAPC10"
/note="Anaphase-promoting complex, subunit 10 (APC10);
pfam03256"
/db_xref="CDD:281274"
Site order(64,91,98,100,163)
/site_type="other"
/note="putative ligand binding site [chemical binding]"
/db_xref="CDD:176484"
CDS 1..196
/gene="ANAPC10"
/gene_synonym="APC10; DOC1"
/coded_by="NM_001256709.2:198..788"
/note="isoform 2 is encoded by transcript variant 5"
/db_xref="GeneID:10393"
/db_xref="HGNC:HGNC:24077"
/db_xref="MIM:613745"
ORIGIN
1 mggvketnil kmttpnktpp gadpkqlert gtvreigsqa vwslssckpg fgvdqlrddn
61 letywqsdgs qphlvniqfr rkttvktlci yadyksdesy tpskisvrvg nnfhnlqeir
121 qlelvepsgw ihvpltdnhk kptrtfmiqi avlanhqngr dthmrqikiy tpveessigk
181 fprcttidfm myrsir
//
