LOCUS NP_001243638 196 aa linear PRI 30-APR-2025
DEFINITION anaphase-promoting complex subunit 10 isoform 2 [Homo sapiens].
ACCESSION NP_001243638
VERSION NP_001243638.1
DBSOURCE REFSEQ: accession NM_001256709.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 196)
AUTHORS Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
TITLE A homozygous loss-of-function mutation in FBXO43 causes human
non-obstructive azoospermia
JOURNAL Clin Genet 101 (1), 55-64 (2022)
PUBMED 34595750
REFERENCE 2 (residues 1 to 196)
AUTHORS Wang,Y., Han,T., Gan,M., Guo,M., Xie,C., Jin,J., Zhang,S., Wang,P.,
Cao,J. and Wang,J.B.
TITLE A novel function of anaphase promoting complex subunit 10 in tumor
progression in non-small cell lung cancer
JOURNAL Cell Cycle 18 (9), 1019-1032 (2019)
PUBMED 31023143
REMARK GeneRIF: APC10 was overexpressed in non-small cell lung cancer cell
lines compared to human bronchial epithelial cell lines. APC10 was
shown to interact with GAC; knocking down APC10 downregulated
glutamine metabolism to induce autophagy, resulting in effective
inhibition of the proliferation and migration of non-small cell
lung cancer cells.
REFERENCE 3 (residues 1 to 196)
AUTHORS Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
and Rape,M.
TITLE Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
and Protein Quality Control
JOURNAL Cell 171 (4), 918-933 (2017)
PUBMED 29033132
REFERENCE 4 (residues 1 to 196)
AUTHORS Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
Skehel,M. and Barford,D.
TITLE Molecular mechanism of APC/C activation by mitotic phosphorylation
JOURNAL Nature 533 (7602), 260-264 (2016)
PUBMED 27120157
REFERENCE 5 (residues 1 to 196)
AUTHORS He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
TITLE Meta-analysis of genome-wide association studies of adult height in
East Asians identifies 17 novel loci
JOURNAL Hum Mol Genet 24 (6), 1791-1800 (2015)
PUBMED 25429064
REFERENCE 6 (residues 1 to 196)
AUTHORS Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
TITLE Interactions of the low density lipoprotein receptor gene family
with cytosolic adaptor and scaffold proteins suggest diverse
biological functions in cellular communication and signal
transduction
JOURNAL J Biol Chem 275 (33), 25616-25624 (2000)
PUBMED 10827173
REFERENCE 7 (residues 1 to 196)
AUTHORS Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
Peters,J.M.
TITLE Mitotic regulation of the APC activator proteins CDC20 and CDH1
JOURNAL Mol Biol Cell 11 (5), 1555-1569 (2000)
PUBMED 10793135
REFERENCE 8 (residues 1 to 196)
AUTHORS Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
Peters,J.M., Bartek,J. and Lukas,J.
TITLE Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
rearrangement of the anaphase-promoting complex
JOURNAL Nature 401 (6755), 815-818 (1999)
PUBMED 10548110
REFERENCE 9 (residues 1 to 196)
AUTHORS Kurasawa,Y. and Todokoro,K.
TITLE Identification of human APC10/Doc1 as a subunit of anaphase
promoting complex
JOURNAL Oncogene 18 (37), 5131-5137 (1999)
PUBMED 10498862
REFERENCE 10 (residues 1 to 196)
AUTHORS Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
TITLE Characterization of the DOC1/APC10 subunit of the yeast and the
human anaphase-promoting complex
JOURNAL J Biol Chem 274 (20), 14500-14507 (1999)
PUBMED 10318877
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BF693880.1, AL080090.1, BG494966.1 and AC097649.3.
Summary: ANAPC10 is a core subunit of the anaphase-promoting
complex (APC), or cyclosome, a ubiquitin protein ligase that is
essential for progression through the cell cycle. APC initiates
sister chromatid separation by ubiquitinating the anaphase
inhibitor securin (PTTG1; MIM 604147) and triggers exit from
mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the
activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940)
(summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by
OMIM, Feb 2011].
Transcript Variant: This variant (5) differs in the 5' UTR and
initiates translation at an alternate start codon, compared to
variant 1. The encoded isoform (2) is longer and has a distinct
N-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BG494966.1, SRR14243140.6501165.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..196
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q31.21"
Protein 1..196
/product="anaphase-promoting complex subunit 10 isoform 2"
/note="cyclosome subunit 10"
/calculated_mol_wt=22292
Region 15..194
/region_name="ANAPC10"
/note="Anaphase-promoting complex, subunit 10 (APC10);
pfam03256"
/db_xref="CDD:367420"
Site order(64,91,98,100,163)
/site_type="other"
/note="putative ligand binding site [chemical binding]"
/db_xref="CDD:176484"
CDS 1..196
/gene="ANAPC10"
/gene_synonym="APC10; DOC1"
/coded_by="NM_001256709.2:198..788"
/note="isoform 2 is encoded by transcript variant 5"
/db_xref="GeneID:10393"
/db_xref="HGNC:HGNC:24077"
/db_xref="MIM:613745"
ORIGIN
1 mggvketnil kmttpnktpp gadpkqlert gtvreigsqa vwslssckpg fgvdqlrddn
61 letywqsdgs qphlvniqfr rkttvktlci yadyksdesy tpskisvrvg nnfhnlqeir
121 qlelvepsgw ihvpltdnhk kptrtfmiqi avlanhqngr dthmrqikiy tpveessigk
181 fprcttidfm myrsir
//
