GenomeNet

Database: RefSeq
Entry: NP_001258297
LinkDB: NP_001258297
Original site: NP_001258297 
LOCUS       NP_001258297             537 aa            linear   PRI 25-JUN-2018
DEFINITION  prostaglandin G/H synthase 1 isoform 6 [Homo sapiens].
ACCESSION   NP_001258297
VERSION     NP_001258297.1
DBSOURCE    REFSEQ: accession NM_001271368.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 537)
  AUTHORS   O'Sullivan MJ, Gabriel E, Panariti A, Park CY, Ijpma G, Fredberg
            JJ, Lauzon AM and Martin JG.
  TITLE     Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent Endogenous
            Reduction in Airway Smooth Muscle Contractile Phenotype
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 57 (6), 683-691 (2017)
   PUBMED   28708434
  REMARK    GeneRIF: Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent
            Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
REFERENCE   2  (residues 1 to 537)
  AUTHORS   Qin N, Zhang SP, Reitz TL, Mei JM and Flores CM.
  TITLE     Cloning, expression, and functional characterization of human
            cyclooxygenase-1 splicing variants: evidence for intron 1 retention
  JOURNAL   J. Pharmacol. Exp. Ther. 315 (3), 1298-1305 (2005)
   PUBMED   16141368
  REMARK    GeneRIF: Cloning, expression, and functional characterization of
            COX1 splicing variants were performed; there is evidence for intron
            retention.
REFERENCE   3  (residues 1 to 537)
  AUTHORS   Dinchuk,J.E., Liu,R.Q. and Trzaskos,J.M.
  TITLE     COX-3: in the wrong frame in mind
  JOURNAL   Immunol. Lett. 86 (1), 121 (2003)
   PUBMED   12600754
REFERENCE   4  (residues 1 to 537)
  AUTHORS   Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS
            and Simmons DL.
  TITLE     COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and
            other analgesic/antipyretic drugs: cloning, structure, and
            expression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (21), 13926-13931 (2002)
   PUBMED   12242329
  REMARK    GeneRIF: cloning, structure and expression of the COX-3 isozyme
REFERENCE   5  (residues 1 to 537)
  AUTHORS   Plant MH and Laneuville O.
  TITLE     Characterization of a novel transcript of prostaglandin
            endoperoxide H synthase 1 with a tissue-specific profile of
            expression
  JOURNAL   Biochem. J. 344 Pt 3, 677-685 (1999)
   PUBMED   10585854
REFERENCE   6  (residues 1 to 537)
  AUTHORS   Picot D, Loll PJ and Garavito RM.
  TITLE     The X-ray crystal structure of the membrane protein prostaglandin
            H2 synthase-1
  JOURNAL   Nature 367 (6460), 243-249 (1994)
   PUBMED   8121489
  REMARK    GeneRIF: Prostaglandin G/H synthase is a moonlighting protein that
            functions both as a peroxidase as well as a cyclooxygenase.
REFERENCE   7  (residues 1 to 537)
  AUTHORS   Diaz A, Reginato AM and Jimenez SA.
  TITLE     Alternative splicing of human prostaglandin G/H synthase mRNA and
            evidence of differential regulation of the resulting transcripts by
            transforming growth factor beta 1, interleukin 1 beta, and tumor
            necrosis factor alpha
  JOURNAL   J. Biol. Chem. 267 (15), 10816-10822 (1992)
   PUBMED   1587858
REFERENCE   8  (residues 1 to 537)
  AUTHORS   Takahashi Y, Ueda N, Yoshimoto T, Yamamoto S, Yokoyama C, Miyata A,
            Tanabe T, Fuse I, Hattori A and Shibata A.
  TITLE     Immunoaffinity purification and cDNA cloning of human platelet
            prostaglandin endoperoxide synthase (cyclooxygenase)
  JOURNAL   Biochem. Biophys. Res. Commun. 182 (2), 433-438 (1992)
   PUBMED   1734857
REFERENCE   9  (residues 1 to 537)
  AUTHORS   Funk CD, Funk LB, Kennedy ME, Pong AS and Fitzgerald GA.
  TITLE     Human platelet/erythroleukemia cell prostaglandin G/H synthase:
            cDNA cloning, expression, and gene chromosomal assignment
  JOURNAL   FASEB J. 5 (9), 2304-2312 (1991)
   PUBMED   1907252
REFERENCE   10 (residues 1 to 537)
  AUTHORS   Yokoyama C and Tanabe T.
  TITLE     Cloning of human gene encoding prostaglandin endoperoxide synthase
            and primary structure of the enzyme
  JOURNAL   Biochem. Biophys. Res. Commun. 165 (2), 888-894 (1989)
   PUBMED   2512924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK308222.1, AL162424.20,
            AK295221.1, AL359636.17 and AI813317.1.
            
            Summary: This is one of two genes encoding similar enzymes that
            catalyze the conversion of arachinodate to prostaglandin. The
            encoded protein regulates angiogenesis in endothelial cells, and is
            inhibited by nonsteroidal anti-inflammatory drugs such as aspirin.
            Based on its ability to function as both a cyclooxygenase and as a
            peroxidase, the encoded protein has been identified as a
            moonlighting protein. The protein may promote cell proliferation
            during tumor progression. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (7) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start site, compared to variant 1. The primary ORF can be
            translated due to a combination of reinitiation and leaky scanning.
            The encoded isoform (6) is shorter and has a distinct N-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 8121489
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     Protein         1..537
                     /product="prostaglandin G/H synthase 1 isoform 6"
                     /EC_number="1.14.99.1"
                     /note="PGH synthase 1; cyclooxygenase-1; prostaglandin H2
                     synthase 1; prostaglandin-endoperoxide synthase 1
                     (prostaglandin G/H synthase and cyclooxygenase)"
                     /calculated_mol_wt=61799
     variation       1
                     /replace="t"
                     /db_xref="dbSNP:753115165"
     variation       4
                     /replace="l"
                     /db_xref="dbSNP:141836062"
     variation       4
                     /replace="p"
                     /db_xref="dbSNP:1433342545"
     variation       4
                     /replace="s"
                     /db_xref="dbSNP:1160235906"
     Region          8..44
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     variation       9
                     /replace="l"
                     /db_xref="dbSNP:780151632"
     variation       11
                     /replace="c"
                     /db_xref="dbSNP:1253575866"
     variation       12
                     /replace="y"
                     /db_xref="dbSNP:146798706"
     variation       13
                     /replace="f"
                     /db_xref="dbSNP:754929199"
     variation       13
                     /replace="n"
                     /db_xref="dbSNP:1341497045"
     variation       14
                     /replace="l"
                     /db_xref="dbSNP:866976183"
     variation       15
                     /replace="f"
                     /db_xref="dbSNP:1355943489"
     variation       16
                     /replace="q"
                     /db_xref="dbSNP:3842788"
     variation       17
                     /replace="h"
                     /db_xref="dbSNP:1324797084"
     variation       20
                     /replace="v"
                     /db_xref="dbSNP:748082558"
     variation       21
                     /replace="f"
                     /db_xref="dbSNP:769519064"
     variation       23
                     /replace="c"
                     /db_xref="dbSNP:368356508"
     variation       23
                     /replace="h"
                     /db_xref="dbSNP:145719684"
     variation       24
                     /replace="f"
                     /db_xref="dbSNP:138230380"
     variation       25
                     /replace="c"
                     /db_xref="dbSNP:201276316"
     variation       25
                     /replace="g"
                     /db_xref="dbSNP:199814600"
     variation       28
                     /replace="c"
                     /db_xref="dbSNP:767143547"
     variation       28
                     /replace="h"
                     /db_xref="dbSNP:3842789"
     variation       30
                     /replace="r"
                     /db_xref="dbSNP:762435435"
     variation       32
                     /replace="d"
                     /db_xref="dbSNP:201078942"
     variation       34
                     /replace="i"
                     /db_xref="dbSNP:765660071"
     variation       34
                     /replace="t"
                     /db_xref="dbSNP:143346502"
     variation       35
                     /replace="c"
                     /db_xref="dbSNP:1485800508"
     variation       35
                     /replace="h"
                     /db_xref="dbSNP:200993905"
     variation       36
                     /replace="a"
                     /db_xref="dbSNP:1166179022"
     variation       36
                     /replace="k"
                     /db_xref="dbSNP:201806874"
     variation       36
                     /replace="t"
                     /db_xref="dbSNP:751654725"
     variation       37
                     /replace="s"
                     /db_xref="dbSNP:754946174"
     variation       38
                     /replace="f"
                     /db_xref="dbSNP:781262401"
     variation       39
                     /replace="s"
                     /db_xref="dbSNP:748027439"
     variation       40
                     /replace="s"
                     /db_xref="dbSNP:199631305"
     variation       43
                     /replace="c"
                     /db_xref="dbSNP:3842790"
     variation       43
                     /replace="g"
                     /db_xref="dbSNP:202069102"
     variation       44
                     /replace="p"
                     /db_xref="dbSNP:749083530"
     variation       46
                     /replace="p"
                     /db_xref="dbSNP:1178685836"
     variation       46
                     /replace="r"
                     /db_xref="dbSNP:530984736"
     variation       46
                     /replace="s"
                     /db_xref="dbSNP:143357990"
     variation       47
                     /replace="s"
                     /db_xref="dbSNP:200851241"
     variation       48
                     /replace="l"
                     /db_xref="dbSNP:1207859726"
     variation       49
                     /replace="*"
                     /db_xref="dbSNP:201623077"
     variation       49
                     /replace="g"
                     /db_xref="dbSNP:1235555836"
     variation       50
                     /replace="n"
                     /db_xref="dbSNP:1433965237"
     variation       53
                     /replace="l"
                     /db_xref="dbSNP:201201408"
     variation       53
                     /replace="r"
                     /db_xref="dbSNP:1045763183"
     variation       53
                     /replace="w"
                     /db_xref="dbSNP:181947887"
     variation       55
                     /replace="s"
                     /db_xref="dbSNP:770420419"
     variation       57
                     /replace="q"
                     /db_xref="dbSNP:202202847"
     variation       57
                     /replace="r"
                     /db_xref="dbSNP:374417599"
     variation       58
                     /replace="s"
                     /db_xref="dbSNP:570181723"
     variation       59
                     /replace="r"
                     /db_xref="dbSNP:1281575509"
     variation       60
                     /replace="t"
                     /db_xref="dbSNP:774902601"
     variation       61
                     /replace="p"
                     /db_xref="dbSNP:759721849"
     variation       62
                     /replace="f"
                     /db_xref="dbSNP:200293390"
     variation       63
                     /replace="t"
                     /db_xref="dbSNP:767772589"
     Region          64..513
                     /region_name="prostaglandin_endoperoxide_synthase"
                     /note="Animal prostaglandin endoperoxide synthase and
                     related bacterial proteins; cd09816"
                     /db_xref="CDD:188648"
     variation       64
                     /replace="y"
                     /db_xref="dbSNP:370137933"
     variation       65
                     /replace="c"
                     /db_xref="dbSNP:1349486095"
     variation       66
                     /replace="l"
                     /db_xref="dbSNP:1055346421"
     variation       67
                     /replace="f"
                     /db_xref="dbSNP:752758224"
     variation       67
                     /replace="l"
                     /db_xref="dbSNP:760807033"
     variation       67
                     /replace="p"
                     /db_xref="dbSNP:1282806042"
     variation       68
                     /replace="a"
                     /db_xref="dbSNP:1435665295"
     variation       69
                     /replace="g"
                     /db_xref="dbSNP:781386246"
     variation       69
                     /replace="h"
                     /db_xref="dbSNP:201416961"
     variation       69
                     /replace="r"
                     /db_xref="dbSNP:1352297092"
     variation       69
                     /replace="y"
                     /db_xref="dbSNP:1206379293"
     variation       70
                     /replace="r"
                     /db_xref="dbSNP:753672636"
     variation       71
                     /replace="c"
                     /db_xref="dbSNP:200494275"
     variation       71
                     /replace="h"
                     /db_xref="dbSNP:185497478"
     variation       71
                     /replace="r"
                     /db_xref="dbSNP:1479065588"
     variation       72
                     /replace="*"
                     /db_xref="dbSNP:201321920"
     variation       72
                     /replace="r"
                     /db_xref="dbSNP:758111962"
     variation       75
                     /replace="d"
                     /db_xref="dbSNP:1408353678"
     variation       76
                     /replace="s"
                     /db_xref="dbSNP:1412713473"
     variation       77
                     /replace="f"
                     /db_xref="dbSNP:189207093"
     variation       78
                     /replace="h"
                     /db_xref="dbSNP:1401551468"
     variation       80
                     /replace="i"
                     /db_xref="dbSNP:1440603985"
     variation       80
                     /replace="t"
                     /db_xref="dbSNP:780776712"
     variation       83
                     /replace="*"
                     /db_xref="dbSNP:200837579"
     variation       83
                     /replace="q"
                     /db_xref="dbSNP:5787"
     variation       84
                     /replace="d"
                     /db_xref="dbSNP:1016323395"
     variation       84
                     /replace="k"
                     /db_xref="dbSNP:1006330625"
     variation       85
                     /replace="i"
                     /db_xref="dbSNP:1320749717"
     variation       86
                     /replace="f"
                     /db_xref="dbSNP:575538701"
     variation       86
                     /replace="l"
                     /db_xref="dbSNP:539608410"
     variation       87
                     /replace="t"
                     /db_xref="dbSNP:1156905767"
     variation       87
                     /replace="v"
                     /db_xref="dbSNP:759948709"
     variation       88
                     /replace="c"
                     /db_xref="dbSNP:200028534"
     variation       88
                     /replace="h"
                     /db_xref="dbSNP:775618916"
     variation       88
                     /replace="r"
                     /db_xref="dbSNP:200663390"
     variation       90
                     /replace="v"
                     /db_xref="dbSNP:374026737"
     Site            order(91,179,319,322..323,327,329,355,359,361,455,459,
                     463..464,467..468,471)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:188648"
     variation       92
                     /replace="k"
                     /db_xref="dbSNP:1294196498"
     variation       92
                     /replace="t"
                     /db_xref="dbSNP:147532493"
     variation       94
                     /replace="c"
                     /db_xref="dbSNP:117122585"
     variation       94
                     /replace="h"
                     /db_xref="dbSNP:754563323"
     variation       95
                     /replace="s"
                     /db_xref="dbSNP:1264696246"
     variation       96
                     /replace="k"
                     /db_xref="dbSNP:778096193"
     variation       96
                     /replace="s"
                     /db_xref="dbSNP:767254405"
     Site            order(99,101..103,110..114,116,203,293..297,300..301,304,
                     307..308,311,341..348,474..475,478..482,484..486,488..489)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:188648"
     variation       99
                     /replace="p"
                     /db_xref="dbSNP:749706336"
     variation       100
                     /replace="c"
                     /db_xref="dbSNP:1355711160"
     variation       101
                     /replace="g"
                     /db_xref="dbSNP:755712939"
     variation       101
                     /replace="p"
                     /db_xref="dbSNP:755582076"
     variation       101
                     /replace="t"
                     /db_xref="dbSNP:147795437"
     variation       102
                     /replace="h"
                     /db_xref="dbSNP:1207199723"
     variation       102
                     /replace="p"
                     /db_xref="dbSNP:112033264"
     variation       103
                     /replace="i"
                     /db_xref="dbSNP:1186152883"
     variation       103
                     /replace="p"
                     /db_xref="dbSNP:779702921"
     variation       105
                     /replace="n"
                     /db_xref="dbSNP:1258506719"
     variation       109
                     /replace="g"
                     /db_xref="dbSNP:954849919"
     variation       111
                     /replace="i"
                     /db_xref="dbSNP:758946951"
     variation       111
                     /replace="v"
                     /db_xref="dbSNP:202111485"
     variation       113
                     /replace="l"
                     /db_xref="dbSNP:201463029"
     variation       113
                     /replace="r"
                     /db_xref="dbSNP:137938866"
     variation       114
                     /replace="e"
                     /db_xref="dbSNP:768757555"
     variation       114
                     /replace="k"
                     /db_xref="dbSNP:1006117739"
     variation       115
                     /replace="s"
                     /db_xref="dbSNP:776846682"
     variation       115
                     /replace="y"
                     /db_xref="dbSNP:1318856680"
     variation       116
                     /replace="l"
                     /db_xref="dbSNP:748974760"
     variation       116
                     /replace="y"
                     /db_xref="dbSNP:769870166"
     variation       117
                     /replace="f"
                     /db_xref="dbSNP:542535309"
     variation       118
                     /replace="n"
                     /db_xref="dbSNP:368871343"
     variation       119
                     /replace="m"
                     /db_xref="dbSNP:1013587209"
     Site            order(122,173,177,181,184..186,269,356,359..362,365,381,
                     383..384,387)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:188648"
     variation       123
                     /replace="s"
                     /db_xref="dbSNP:771040023"
     variation       124
                     /replace="c"
                     /db_xref="dbSNP:1379029876"
     variation       124
                     /replace="h"
                     /db_xref="dbSNP:10306140"
     variation       126
                     /replace="l"
                     /db_xref="dbSNP:746349627"
     variation       129
                     /replace="g"
                     /db_xref="dbSNP:1465507375"
     variation       129
                     /replace="v"
                     /db_xref="dbSNP:1392661217"
     variation       131
                     /replace="e"
                     /db_xref="dbSNP:767216209"
     variation       131
                     /replace="t"
                     /db_xref="dbSNP:969506010"
     variation       132
                     /replace="g"
                     /db_xref="dbSNP:147131934"
     variation       135
                     /replace="i"
                     /db_xref="dbSNP:1208057929"
     variation       135
                     /replace="s"
                     /db_xref="dbSNP:1436650713"
     variation       136
                     /replace="t"
                     /db_xref="dbSNP:760264793"
     variation       137
                     /replace="i"
                     /db_xref="dbSNP:201412045"
     variation       137
                     /replace="t"
                     /db_xref="dbSNP:1195588804"
     variation       137
                     /replace="v"
                     /db_xref="dbSNP:1483666446"
     variation       139
                     /replace="n"
                     /db_xref="dbSNP:139521520"
     variation       139
                     /replace="t"
                     /db_xref="dbSNP:753398325"
     variation       140
                     /replace="e"
                     /db_xref="dbSNP:758897801"
     variation       141
                     /replace="g"
                     /db_xref="dbSNP:1320214413"
     variation       143
                     /replace="-"
                     /db_xref="dbSNP:772106353"
     variation       144
                     /replace="e"
                     /db_xref="dbSNP:1272870519"
     variation       144
                     /replace="q"
                     /db_xref="dbSNP:1348149589"
     variation       145
                     /replace="l"
                     /db_xref="dbSNP:1320290573"
     variation       146
                     /replace="t"
                     /db_xref="dbSNP:778206736"
     variation       147
                     /replace="e"
                     /db_xref="dbSNP:749523355"
     variation       150
                     /replace="f"
                     /db_xref="dbSNP:757344876"
     variation       150
                     /replace="l"
                     /db_xref="dbSNP:185705486"
     variation       151
                     /replace="l"
                     /db_xref="dbSNP:1368219687"
     variation       153
                     /replace="c"
                     /db_xref="dbSNP:745776199"
     variation       153
                     /replace="h"
                     /db_xref="dbSNP:202052201"
     variation       154
                     /replace="c"
                     /db_xref="dbSNP:775345298"
     variation       154
                     /replace="h"
                     /db_xref="dbSNP:199832794"
     variation       155
                     /replace="f"
                     /db_xref="dbSNP:768447613"
     variation       156
                     /replace="l"
                     /db_xref="dbSNP:1406854955"
     variation       156
                     /replace="l"
                     /db_xref="dbSNP:776210328"
     variation       158
                     /replace="w"
                     /db_xref="dbSNP:761476597"
     variation       160
                     /replace="t"
                     /db_xref="dbSNP:3842792"
     variation       163
                     /replace="a"
                     /db_xref="dbSNP:1296358400"
     variation       163
                     /replace="r"
                     /db_xref="dbSNP:1342618257"
     variation       164
                     /replace="d"
                     /db_xref="dbSNP:907158454"
     variation       165
                     /replace="p"
                     /db_xref="dbSNP:760063671"
     variation       165
                     /replace="t"
                     /db_xref="dbSNP:577686184"
     variation       166
                     /replace="k"
                     /db_xref="dbSNP:767966650"
     variation       166
                     /replace="r"
                     /db_xref="dbSNP:1291264280"
     variation       167
                     /replace="s"
                     /db_xref="dbSNP:201523045"
     variation       169
                     /replace="n"
                     /db_xref="dbSNP:202141502"
     variation       169
                     /replace="s"
                     /db_xref="dbSNP:756477134"
     variation       170
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     variation       170
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     variation       173
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     variation       174
                     /replace="l"
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     variation       175
                     /replace="l"
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     variation       179
                     /replace="l"
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     variation       180
                     /replace="i"
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     variation       180
                     /replace="t"
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     variation       181
                     /replace="l"
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     variation       181
                     /replace="y"
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     variation       186
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     variation       187
                     /replace="c"
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     variation       188
                     /replace="g"
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     variation       190
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     variation       192
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     variation       192
                     /replace="h"
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     variation       195
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     variation       196
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     variation       197
                     /replace="g"
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     variation       197
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     variation       198
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     variation       199
                     /replace="g"
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     variation       200
                     /replace="h"
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     variation       200
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     variation       201
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     variation       201
                     /replace="r"
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     variation       203
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     variation       204
                     /replace="f"
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     variation       204
                     /replace="l"
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     variation       205
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     variation       206
                     /replace="h"
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     variation       207
                     /replace="v"
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     variation       208
                     /replace="f"
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     variation       208
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     variation       209
                     /replace="g"
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     variation       210
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     variation       211
                     /replace="k"
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     variation       211
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     variation       212
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     variation       213
                     /replace="e"
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     variation       214
                     /replace="c"
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     variation       214
                     /replace="h"
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     variation       215
                     /replace="p"
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     variation       215
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     variation       217
                     /replace="q"
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     variation       218
                     /replace="l"
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     variation       218
                     /replace="l"
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     variation       218
                     /replace="p"
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     variation       219
                     /replace="q"
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     variation       219
                     /replace="w"
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     variation       220
                     /replace="f"
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     variation       220
                     /replace="l"
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     variation       221
                     /replace="y"
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     variation       222
                     /replace="r"
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     variation       223
                     /replace="g"
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     variation       223
                     /replace="y"
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     variation       224
                     /replace="e"
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     variation       225
                     /replace="k"
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     variation       226
                     /replace="l"
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     variation       227
                     /replace="e"
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     variation       227
                     /replace="k"
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     variation       229
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     variation       230
                     /replace="m"
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     variation       230
                     /replace="v"
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     variation       231
                     /replace="p"
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     variation       232
                     /replace="n"
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     variation       233
                     /replace="r"
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     variation       234
                     /replace="a"
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     variation       235
                     /replace="n"
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     variation       236
                     /replace="*"
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     variation       237
                     /replace="l"
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     variation       237
                     /replace="p"
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     variation       238
                     /replace="p"
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     variation       239
                     /replace="l"
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     variation       239
                     /replace="s"
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     variation       241
                     /replace="a"
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     variation       241
                     /replace="k"
                     /db_xref="dbSNP:200090968"
     variation       242
                     /replace="k"
                     /db_xref="dbSNP:757063530"
     variation       243
                     /replace="a"
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     variation       243
                     /replace="v"
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     variation       244
                     /replace="p"
                     /db_xref="dbSNP:201739321"
     variation       244
                     /replace="s"
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     variation       245
                     /replace="v"
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     variation       246
                     /replace="f"
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     variation       246
                     /replace="l"
                     /db_xref="dbSNP:779689927"
     variation       247
                     /replace="i"
                     /db_xref="dbSNP:746589741"
     variation       248
                     /replace="r"
                     /db_xref="dbSNP:199965305"
     variation       248
                     /replace="y"
                     /db_xref="dbSNP:756576489"
     variation       249
                     /replace="c"
                     /db_xref="dbSNP:201244156"
     variation       249
                     /replace="y"
                     /db_xref="dbSNP:771236340"
     variation       250
                     /replace="p"
                     /db_xref="dbSNP:1198350921"
     variation       250
                     /replace="s"
                     /db_xref="dbSNP:774725068"
     variation       251
                     /replace="q"
                     /db_xref="dbSNP:200024359"
     variation       251
                     /replace="r"
                     /db_xref="dbSNP:202218991"
     variation       254
                     /replace="l"
                     /db_xref="dbSNP:200825574"
     variation       254
                     /replace="p"
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     variation       255
                     /replace="h"
                     /db_xref="dbSNP:201651122"
     variation       255
                     /replace="p"
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     variation       256
                     /replace="q"
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     variation       256
                     /replace="r"
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     variation       257
                     /replace="n"
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     variation       257
                     /replace="s"
                     /db_xref="dbSNP:762682480"
     variation       259
                     /replace="i"
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     variation       262
                     /replace="d"
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     variation       262
                     /replace="g"
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     variation       264
                     /replace="q"
                     /db_xref="dbSNP:1292860855"
     variation       270
                     /replace="l"
                     /db_xref="dbSNP:1367041659"
     variation       270
                     /replace="p"
                     /db_xref="dbSNP:754452041"
     variation       272
                     /replace="l"
                     /db_xref="dbSNP:780588469"
     variation       273
                     /replace="i"
                     /db_xref="dbSNP:1218412685"
     variation       273
                     /replace="t"
                     /db_xref="dbSNP:754302638"
     variation       277
                     /replace="m"
                     /db_xref="dbSNP:200209212"
     variation       277
                     /replace="t"
                     /db_xref="dbSNP:199769305"
     variation       279
                     /replace="*"
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     variation       280
                     /replace="l"
                     /db_xref="dbSNP:1205890009"
     variation       281
                     /replace="c"
                     /db_xref="dbSNP:780267925"
     variation       281
                     /replace="h"
                     /db_xref="dbSNP:60893133"
     variation       281
                     /replace="r"
                     /db_xref="dbSNP:1405079720"
     variation       282
                     /replace="*"
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     variation       282
                     /replace="e"
                     /db_xref="dbSNP:570341040"
     variation       283
                     /replace="y"
                     /db_xref="dbSNP:1477254696"
     variation       284
                     /replace="n"
                     /db_xref="dbSNP:201788310"
     variation       285
                     /replace="c"
                     /db_xref="dbSNP:200336506"
     variation       285
                     /replace="h"
                     /db_xref="dbSNP:201325322"
     variation       286
                     /replace="v"
                     /db_xref="dbSNP:199790847"
     variation       288
                     /replace="g"
                     /db_xref="dbSNP:200721326"
     variation       288
                     /replace="n"
                     /db_xref="dbSNP:941053201"
     variation       288
                     /replace="v"
                     /db_xref="dbSNP:985418713"
     variation       289
                     /replace="l"
                     /db_xref="dbSNP:534966394"
     variation       292
                     /replace="a"
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     variation       292
                     /replace="v"
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     variation       293
                     /replace="e"
                     /db_xref="dbSNP:201374825"
     variation       293
                     /replace="k"
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     variation       294
                     /replace="h"
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     variation       294
                     /replace="l"
                     /db_xref="dbSNP:201316771"
     variation       294
                     /replace="y"
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     variation       295
                     /replace="p"
                     /db_xref="dbSNP:145581212"
     variation       296
                     /replace="i"
                     /db_xref="dbSNP:780314550"
     variation       296
                     /replace="t"
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     variation       298
                     /replace="d"
                     /db_xref="dbSNP:200834586"
     variation       298
                     /replace="g"
                     /db_xref="dbSNP:4836884"
     variation       298
                     /replace="s"
                     /db_xref="dbSNP:1320384776"
     variation       299
                     /replace="n"
                     /db_xref="dbSNP:748308378"
     variation       300
                     /replace="e"
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     variation       300
                     /replace="hptwgde"
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     variation       301
                     /replace="s"
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     variation       305
                     /replace="k"
                     /db_xref="dbSNP:543848883"
     variation       305
                     /replace="t"
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     variation       307
                     /replace="c"
                     /db_xref="dbSNP:201808321"
     variation       307
                     /replace="h"
                     /db_xref="dbSNP:978684239"
     variation       307
                     /replace="r"
                     /db_xref="dbSNP:1181007153"
     variation       310
                     /replace="l"
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     variation       311
                     /replace="t"
                     /db_xref="dbSNP:1425553917"
     variation       313
                     /replace="e"
                     /db_xref="dbSNP:145832816"
     variation       314
                     /replace="a"
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     variation       315
                     /replace="m"
                     /db_xref="dbSNP:1313769659"
     variation       316
                     /replace="r"
                     /db_xref="dbSNP:3842799"
     variation       319
                     /replace="i"
                     /db_xref="dbSNP:776168492"
     variation       319
                     /replace="t"
                     /db_xref="dbSNP:200953830"
     variation       319
                     /replace="v"
                     /db_xref="dbSNP:1237507833"
     variation       320
                     /replace="g"
                     /db_xref="dbSNP:796503758"
     variation       320
                     /replace="k"
                     /db_xref="dbSNP:1234735937"
     variation       321
                     /replace="d"
                     /db_xref="dbSNP:766866338"
     variation       321
                     /replace="k"
                     /db_xref="dbSNP:537966176"
     variation       322
                     /replace="y"
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     variation       323
                     /replace="e"
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     variation       323
                     /replace="m"
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     variation       324
                     /replace="q"
                     /db_xref="dbSNP:1467324103"
     variation       325
                     /replace="q"
                     /db_xref="dbSNP:1327882473"
     variation       327
                     /replace="n"
                     /db_xref="dbSNP:755242638"
     variation       332
                     /replace="h"
                     /db_xref="dbSNP:893235391"
     variation       332
                     /replace="k"
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     variation       334
                     /replace="r"
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     variation       336
                     /replace="e"
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     variation       340
                     /replace="l"
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     variation       341
                     /replace="f"
                     /db_xref="dbSNP:201018159"
     variation       342
                     /replace="d"
                     /db_xref="dbSNP:777974312"
     variation       342
                     /replace="s"
                     /db_xref="dbSNP:202234148"
     variation       343
                     /replace="i"
                     /db_xref="dbSNP:898928989"
     variation       344
                     /replace="h"
                     /db_xref="dbSNP:1309870814"
     variation       347
                     /replace="l"
                     /db_xref="dbSNP:754729293"
     variation       348
                     /replace="c"
                     /db_xref="dbSNP:749385976"
     variation       348
                     /replace="h"
                     /db_xref="dbSNP:757213251"
     variation       349
                     /replace="k"
                     /db_xref="dbSNP:1315825691"
     variation       350
                     /replace="c"
                     /db_xref="dbSNP:745829594"
     variation       350
                     /replace="h"
                     /db_xref="dbSNP:1273597287"
     variation       351
                     /replace="t"
                     /db_xref="dbSNP:1305962442"
     variation       353
                     /replace="l"
                     /db_xref="dbSNP:200451116"
     variation       353
                     /replace="r"
                     /db_xref="dbSNP:1198174544"
     variation       354
                     /replace="e"
                     /db_xref="dbSNP:771816850"
     variation       355
                     /replace="f"
                     /db_xref="dbSNP:577580485"
     variation       356
                     /replace="s"
                     /db_xref="dbSNP:201913038"
     variation       357
                     /replace="h"
                     /db_xref="dbSNP:1345922404"
     variation       357
                     /replace="r"
                     /db_xref="dbSNP:201487422"
     variation       359
                     /replace="y"
                     /db_xref="dbSNP:1256318228"
     variation       360
                     /replace="h"
                     /db_xref="dbSNP:553787268"
     variation       360
                     /replace="r"
                     /db_xref="dbSNP:773784546"
     variation       363
                     /replace="p"
                     /db_xref="dbSNP:1464361690"
     variation       363
                     /replace="r"
                     /db_xref="dbSNP:1033598858"
     variation       364
                     /replace="s"
                     /db_xref="dbSNP:778554144"
     variation       364
                     /replace="v"
                     /db_xref="dbSNP:761165659"
     variation       366
                     /replace="p"
                     /db_xref="dbSNP:1404257203"
     variation       366
                     /replace="t"
                     /db_xref="dbSNP:769362378"
     variation       368
                     /replace="p"
                     /db_xref="dbSNP:774674911"
     variation       371
                     /replace="i"
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     variation       371
                     /replace="t"
                     /db_xref="dbSNP:1377938676"
     variation       372
                     /replace="g"
                     /db_xref="dbSNP:1401279487"
     variation       372
                     /replace="s"
                     /db_xref="dbSNP:143030223"
     variation       372
                     /replace="v"
                     /db_xref="dbSNP:1167123015"
     variation       373
                     /replace="r"
                     /db_xref="dbSNP:201552344"
     variation       374
                     /replace="s"
                     /db_xref="dbSNP:751514710"
     variation       375
                     /replace="r"
                     /db_xref="dbSNP:1411445405"
     variation       376
                     /replace="i"
                     /db_xref="dbSNP:1383364119"
     variation       377
                     /replace="i"
                     /db_xref="dbSNP:1013695541"
     variation       377
                     /replace="t"
                     /db_xref="dbSNP:781075207"
     variation       377
                     /replace="v"
                     /db_xref="dbSNP:754721873"
     variation       378
                     /replace="a"
                     /db_xref="dbSNP:1026557269"
     variation       379
                     /replace="h"
                     /db_xref="dbSNP:1452541125"
     variation       379
                     /replace="p"
                     /db_xref="dbSNP:1215254123"
     variation       379
                     /replace="r"
                     /db_xref="dbSNP:922186878"
     variation       380
                     /replace="h"
                     /db_xref="dbSNP:200049829"
     variation       381
                     /replace="v"
                     /db_xref="dbSNP:5792"
     variation       382
                     /replace="l"
                     /db_xref="dbSNP:1353509748"
     variation       383
                     /replace="l"
                     /db_xref="dbSNP:200856477"
     variation       383
                     /replace="q"
                     /db_xref="dbSNP:1261502092"
     variation       385
                     /replace="a"
                     /db_xref="dbSNP:1344793798"
     variation       386
                     /replace="m"
                     /db_xref="dbSNP:186089151"
     variation       387
                     /replace="e"
                     /db_xref="dbSNP:748870472"
     variation       387
                     /replace="g"
                     /db_xref="dbSNP:77027063"
     variation       387
                     /replace="n"
                     /db_xref="dbSNP:1371451731"
     variation       389
                     /replace="f"
                     /db_xref="dbSNP:1462203829"
     variation       389
                     /replace="i"
                     /db_xref="dbSNP:1374814910"
     variation       390
                     /replace="k"
                     /db_xref="dbSNP:770569428"
     variation       393
                     /replace="g"
                     /db_xref="dbSNP:1235877514"
     variation       393
                     /replace="q"
                     /db_xref="dbSNP:776082208"
     variation       393
                     /replace="r"
                     /db_xref="dbSNP:1182115085"
     variation       394
                     /replace="q"
                     /db_xref="dbSNP:1376665437"
     variation       395
                     /replace="t"
                     /db_xref="dbSNP:747538111"
     variation       396
                     /replace="q"
                     /db_xref="dbSNP:202077552"
     variation       396
                     /replace="r"
                     /db_xref="dbSNP:201622021"
     variation       398
                     /replace="a"
                     /db_xref="dbSNP:1283730016"
     variation       398
                     /replace="q"
                     /db_xref="dbSNP:1465093387"
     variation       401
                     /replace="n"
                     /db_xref="dbSNP:1329184423"
     variation       401
                     /replace="s"
                     /db_xref="dbSNP:1378013115"
     variation       404
                     /replace="c"
                     /db_xref="dbSNP:200149499"
     variation       404
                     /replace="h"
                     /db_xref="dbSNP:762967410"
     variation       405
                     /replace="e"
                     /db_xref="dbSNP:5793"
     variation       406
                     /replace="k"
                     /db_xref="dbSNP:1308012947"
     variation       409
                     /replace="t"
                     /db_xref="dbSNP:202202331"
     variation       409
                     /replace="v"
                     /db_xref="dbSNP:201169549"
     variation       410
                     /replace="q"
                     /db_xref="dbSNP:1330672296"
     variation       411
                     /replace="t"
                     /db_xref="dbSNP:1222076748"
     variation       412
                     /replace="h"
                     /db_xref="dbSNP:1016563469"
     variation       413
                     /replace="i"
                     /db_xref="dbSNP:1265465621"
     variation       413
                     /replace="i"
                     /db_xref="dbSNP:766471508"
     variation       414
                     /replace="-"
                     /db_xref="dbSNP:1449147743"
     variation       414
                     /replace="s"
                     /db_xref="dbSNP:3842800"
     variation       415
                     /replace="f"
                     /db_xref="dbSNP:1216603398"
     variation       415
                     /replace="s"
                     /db_xref="dbSNP:1250076225"
     variation       417
                     /replace="e"
                     /db_xref="dbSNP:1481347182"
     variation       418
                     /replace="l"
                     /db_xref="dbSNP:141224237"
     variation       419
                     /replace="i"
                     /db_xref="dbSNP:5794"
     variation       420
                     /replace="e"
                     /db_xref="dbSNP:1026348451"
     variation       421
                     /replace="e"
                     /db_xref="dbSNP:764002862"
     variation       421
                     /replace="g"
                     /db_xref="dbSNP:1305615443"
     variation       422
                     /replace="n"
                     /db_xref="dbSNP:753499997"
     variation       423
                     /replace="a"
                     /db_xref="dbSNP:1356670240"
     variation       423
                     /replace="q"
                     /db_xref="dbSNP:1365802832"
     variation       424
                     /replace="i"
                     /db_xref="dbSNP:757008796"
     variation       425
                     /replace="a"
                     /db_xref="dbSNP:778555893"
     variation       425
                     /replace="v"
                     /db_xref="dbSNP:1487722775"
     variation       427
                     /replace="k"
                     /db_xref="dbSNP:971134486"
     variation       431
                     /replace="l"
                     /db_xref="dbSNP:1243678325"
     variation       431
                     /replace="l"
                     /db_xref="dbSNP:1486061390"
     variation       431
                     /replace="s"
                     /db_xref="dbSNP:1471982931"
     variation       432
                     /replace="c"
                     /db_xref="dbSNP:1365921984"
     variation       435
                     /replace="i"
                     /db_xref="dbSNP:1241156217"
     variation       435
                     /replace="t"
                     /db_xref="dbSNP:745438240"
     variation       437
                     /replace="a"
                     /db_xref="dbSNP:3842802"
     variation       437
                     /replace="v"
                     /db_xref="dbSNP:200550102"
     variation       438
                     /replace="l"
                     /db_xref="dbSNP:748628931"
     variation       439
                     /replace="e"
                     /db_xref="dbSNP:1250312297"
     variation       442
                     /replace="p"
                     /db_xref="dbSNP:3842803"
     variation       442
                     /replace="s"
                     /db_xref="dbSNP:770158186"
     variation       444
                     /replace="l"
                     /db_xref="dbSNP:989628881"
     variation       445
                     /replace="p"
                     /db_xref="dbSNP:368538672"
     variation       449
                     /replace="c"
                     /db_xref="dbSNP:200589866"
     variation       449
                     /replace="v"
                     /db_xref="dbSNP:1431869316"
     variation       453
                     /replace="p"
                     /db_xref="dbSNP:201964215"
     variation       454
                     /replace="v"
                     /db_xref="dbSNP:1302806115"
     variation       455
                     /replace="s"
                     /db_xref="dbSNP:915395645"
     variation       456
                     /replace="g"
                     /db_xref="dbSNP:756237235"
     variation       458
                     /replace="s"
                     /db_xref="dbSNP:1315208727"
     variation       459
                     /replace="l"
                     /db_xref="dbSNP:1352321780"
     variation       459
                     /replace="t"
                     /db_xref="dbSNP:368573797"
     variation       460
                     /replace="t"
                     /db_xref="dbSNP:199886942"
     variation       461
                     /replace="e"
                     /db_xref="dbSNP:201356005"
     variation       462
                     /replace="t"
                     /db_xref="dbSNP:201812915"
     variation       463
                     /replace="v"
                     /db_xref="dbSNP:1403280214"
     variation       464
                     /replace="s"
                     /db_xref="dbSNP:373931629"
     variation       465
                     /replace="h"
                     /db_xref="dbSNP:200975278"
     variation       465
                     /replace="s"
                     /db_xref="dbSNP:145989297"
     variation       467
                     /replace="f"
                     /db_xref="dbSNP:866722757"
     variation       467
                     /replace="s"
                     /db_xref="dbSNP:267602116"
     variation       468
                     /replace="f"
                     /db_xref="dbSNP:1184126734"
     variation       468
                     /replace="l"
                     /db_xref="dbSNP:1453546499"
     variation       469
                     /replace="r"
                     /db_xref="dbSNP:137963114"
     variation       470
                     /replace="g"
                     /db_xref="dbSNP:1410396010"
     variation       470
                     /replace="s"
                     /db_xref="dbSNP:763949437"
     variation       470
                     /replace="v"
                     /db_xref="dbSNP:201947942"
     variation       472
                     /replace="r"
                     /db_xref="dbSNP:1489045261"
     variation       473
                     /replace="g"
                     /db_xref="dbSNP:542367354"
     variation       473
                     /replace="r"
                     /db_xref="dbSNP:200460276"
     variation       474
                     /replace="n"
                     /db_xref="dbSNP:1480766361"
     variation       475
                     /replace="l"
                     /db_xref="dbSNP:146883047"
     variation       475
                     /replace="t"
                     /db_xref="dbSNP:201184369"
     variation       476
                     /replace="m"
                     /db_xref="dbSNP:1401653841"
     variation       477
                     /replace="c"
                     /db_xref="dbSNP:750057735"
     variation       477
                     /replace="g"
                     /db_xref="dbSNP:202195652"
     variation       478
                     /replace="p"
                     /db_xref="dbSNP:757880106"
     variation       479
                     /replace="l"
                     /db_xref="dbSNP:753219685"
     variation       479
                     /replace="p"
                     /db_xref="dbSNP:374665506"
     variation       480
                     /replace="a"
                     /db_xref="dbSNP:1196962987"
     variation       481
                     /replace="s"
                     /db_xref="dbSNP:778094724"
     variation       481
                     /replace="y"
                     /db_xref="dbSNP:139976672"
     variation       482
                     /replace="*"
                     /db_xref="dbSNP:562053731"
     variation       484
                     /replace="l"
                     /db_xref="dbSNP:200295924"
     variation       484
                     /replace="p"
                     /db_xref="dbSNP:1218265301"
     variation       485
                     /replace="g"
                     /db_xref="dbSNP:1205494988"
     variation       486
                     /replace="t"
                     /db_xref="dbSNP:746100280"
     variation       488
                     /replace="g"
                     /db_xref="dbSNP:201417140"
     variation       489
                     /replace="g"
                     /db_xref="dbSNP:760637830"
     variation       489
                     /replace="s"
                     /db_xref="dbSNP:775470716"
     variation       490
                     /replace="k"
                     /db_xref="dbSNP:199842281"
     variation       491
                     /replace="a"
                     /db_xref="dbSNP:1433740420"
     variation       491
                     /replace="l"
                     /db_xref="dbSNP:1202443510"
     variation       492
                     /replace="a"
                     /db_xref="dbSNP:1234825191"
     variation       492
                     /replace="a"
                     /db_xref="dbSNP:1470667063"
     variation       493
                     /replace="f"
                     /db_xref="dbSNP:776714887"
     variation       495
                     /replace="l"
                     /db_xref="dbSNP:143433344"
     variation       495
                     /replace="t"
                     /db_xref="dbSNP:201061676"
     variation       498
                     /replace="m"
                     /db_xref="dbSNP:201084893"
     variation       498
                     /replace="t"
                     /db_xref="dbSNP:199581775"
     variation       500
                     /replace="i"
                     /db_xref="dbSNP:201003047"
     variation       505
                     /replace="i"
                     /db_xref="dbSNP:765893652"
     variation       506
                     /replace="s"
                     /db_xref="dbSNP:1330375990"
     variation       507
                     /replace="v"
                     /db_xref="dbSNP:751086028"
     variation       508
                     /replace="n"
                     /db_xref="dbSNP:200353943"
     variation       509
                     /replace="s"
                     /db_xref="dbSNP:201486676"
     variation       509
                     /replace="t"
                     /db_xref="dbSNP:528026128"
     variation       510
                     /replace="n"
                     /db_xref="dbSNP:199627452"
     variation       512
                     /replace="y"
                     /db_xref="dbSNP:1277491951"
     variation       513
                     /replace="a"
                     /db_xref="dbSNP:377391709"
     variation       514
                     /replace="y"
                     /db_xref="dbSNP:1216239570"
     variation       515
                     /replace="i"
                     /db_xref="dbSNP:533328230"
     variation       516
                     /replace="f"
                     /db_xref="dbSNP:267602117"
     variation       518
                     /replace="c"
                     /db_xref="dbSNP:1003968567"
     variation       518
                     /replace="h"
                     /db_xref="dbSNP:200664060"
     variation       520
                     /replace="l"
                     /db_xref="dbSNP:201836968"
     variation       520
                     /replace="p"
                     /db_xref="dbSNP:200095172"
     variation       520
                     /replace="s"
                     /db_xref="dbSNP:920517405"
     variation       522
                     /replace="s"
                     /db_xref="dbSNP:200742375"
     variation       522
                     /replace="v"
                     /db_xref="dbSNP:560719076"
     variation       523
                     /replace="g"
                     /db_xref="dbSNP:1237745930"
     variation       523
                     /replace="n"
                     /db_xref="dbSNP:1474752028"
     variation       524
                     /replace="q"
                     /db_xref="dbSNP:1216965769"
     variation       525
                     /replace="v"
                     /db_xref="dbSNP:1170116574"
     variation       527
                     /replace="r"
                     /db_xref="dbSNP:1258368286"
     variation       528
                     /replace="s"
                     /db_xref="dbSNP:776662441"
     variation       529
                     /replace="t"
                     /db_xref="dbSNP:1423400795"
     variation       529
                     /replace="v"
                     /db_xref="dbSNP:1300938986"
     variation       531
                     /replace="k"
                     /db_xref="dbSNP:201753794"
     variation       532
                     /replace="*"
                     /db_xref="dbSNP:769682753"
     variation       532
                     /replace="q"
                     /db_xref="dbSNP:1022456315"
     variation       532
                     /replace="r"
                     /db_xref="dbSNP:1324460875"
     variation       534
                     /replace="f"
                     /db_xref="dbSNP:772933961"
     variation       534
                     /replace="s"
                     /db_xref="dbSNP:762656955"
     variation       535
                     /replace="a"
                     /db_xref="dbSNP:1340193221"
     variation       535
                     /replace="t"
                     /db_xref="dbSNP:766010151"
     variation       536
                     /replace="e"
                     /db_xref="dbSNP:527896215"
     CDS             1..537
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /coded_by="NM_001271368.1:604..2217"
                     /note="isoform 6 is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS59520.1"
                     /db_xref="GeneID:5742"
                     /db_xref="HGNC:HGNC:9604"
                     /db_xref="MIM:176805"
ORIGIN      
        1 mrkprlmnpc cyypcqhqgi cvrfgldryq cdctrtgysg pnctipglwt wlrnslrpsp
       61 sfthfllthg rwfwefvnat firemlmrlv ltvrsnlips pptynsahdy iswesfsnvs
      121 yytrilpsvp kdcptpmgtk gkkqlpdaql larrfllrrk fipdpqgtnl mfaffaqhft
      181 hqffktsgkm gpgftkalgh gvdlghiygd nlerqyqlrl fkdgklkyqv ldgemyppsv
      241 eeapvlmhyp rgippqsqma vgqevfgllp glmlyatlwl rehnrvcdll kaehptwgde
      301 qlfqttrlil igetikivie eyvqqlsgyf lqlkfdpell fgvqfqyrnr iamefnhlyh
      361 whplmpdsfk igggrnmdhh ilhvavdvir esremrlqpf neyrkrfgmk pytsfqelvg
      421 ekemaaelee lygdidalef ypglllekch pnsifgesmi eigapfslkg llgnpicspe
      481 ywkpstfgge vgfnivktat lkklvclntk tcpyvsfrvp dasqddgpav erpstel
//
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