GenomeNet

Database: RefSeq
Entry: NP_001268704
LinkDB: NP_001268704
Original site: NP_001268704 
LOCUS       NP_001268704            1234 aa            linear   PRI 14-MAR-2023
DEFINITION  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform i
            [Homo sapiens].
ACCESSION   NP_001268704 XP_005260414
VERSION     NP_001268704.1
DBSOURCE    REFSEQ: accession NM_001281775.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1234)
  AUTHORS   Adhikary S, Singh V, Choudhari R, Yang B, Adhikari S, Ramos EI,
            Chaudhuri S, Roy S, Gadad SS and Das C.
  TITLE     ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal
            differentiation
  JOURNAL   Cell Death Dis 13 (9), 766 (2022)
   PUBMED   36064715
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1234)
  AUTHORS   Dias KR, Carlston CM, Blok LER, De Hayr L, Nawaz U, Evans CA,
            Bayrak-Toydemir P, Htun S, Zhu Y, Ma A, Lynch SA, Moorwood C, Stals
            K, Ellard S, Bainbridge MN, Friedman J, Pappas JG, Rabin R, Nowak
            CB, Douglas J, Wilson TE, Guillen Sacoto MJ, Mullegama SV,
            Palculict TB, Kirk EP, Pinner JR, Edwards M, Montanari F, Graziano
            C, Pippucci T, Dingmann B, Glass I, Mefford HC, Shimoji T, Suzuki
            T, Yamakawa K, Streff H, Schaaf CP, Slavotinek AM, Voineagu I,
            Carey JC, Buckley MF, Schenck A, Harvey RJ and Roscioli T.
  TITLE     De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations
  JOURNAL   Genet Med 24 (9), 1952-1966 (2022)
   PUBMED   35916866
  REMARK    GeneRIF: De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations.
REFERENCE   3  (residues 1 to 1234)
  AUTHORS   Benz C, Ali M, Krystkowiak I, Simonetti L, Sayadi A, Mihalic F,
            Kliche J, Andersson E, Jemth P, Davey NE and Ivarsson Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (residues 1 to 1234)
  AUTHORS   Choi S, Lee KW, Koh HH, Park S, Yeo SY, Joh JW, Choi MS, Kim SH,
            Park CK and Ha SY.
  TITLE     Validation of ZMYND8 as a new treatment target in hepatocellular
            carcinoma
  JOURNAL   J Cancer Res Clin Oncol 147 (12), 3517-3534 (2021)
   PUBMED   34462784
  REMARK    GeneRIF: Validation of ZMYND8 as a new treatment target in
            hepatocellular carcinoma.
REFERENCE   5  (residues 1 to 1234)
  AUTHORS   Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y,
            Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A,
            Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB,
            Bernt KM, Berger SL and Shi J.
  TITLE     ZMYND8-regulated IRF8 transcription axis is an acute myeloid
            leukemia dependency
  JOURNAL   Mol Cell 81 (17), 3604-3622 (2021)
   PUBMED   34358447
  REMARK    GeneRIF: ZMYND8-regulated IRF8 transcription axis is an acute
            myeloid leukemia dependency.
REFERENCE   6  (residues 1 to 1234)
  AUTHORS   Nelson D, Yoshida EM, Paulson MS, Hengen PN, Ge D, Kanwar B,
            McNally J, Pang PS, Subramanian GM, McHutchison JG, Urbanek P,
            Lawitz E and Urban TJ.
  TITLE     Genome-wide association study to characterize serum bilirubin
            elevations in patients with HCV treated with GS-9256, an HCV NS3
            serine protease inhibitor
  JOURNAL   Antivir Ther 19 (7), 679-686 (2014)
   PUBMED   24503447
REFERENCE   7  (residues 1 to 1234)
  AUTHORS   Miles RR, Crockett DK, Lim MS and Elenitoba-Johnson KS.
  TITLE     Analysis of BCL6-interacting proteins by tandem mass spectrometry
  JOURNAL   Mol Cell Proteomics 4 (12), 1898-1909 (2005)
   PUBMED   16147992
REFERENCE   8  (residues 1 to 1234)
  AUTHORS   Westendorf JJ and Koka S.
  TITLE     Identification of FHOD1-binding proteins and mechanisms of
            FHOD1-regulated actin dynamics
  JOURNAL   J Cell Biochem 92 (1), 29-41 (2004)
   PUBMED   15095401
REFERENCE   9  (residues 1 to 1234)
  AUTHORS   Eichmuller S, Usener D, Dummer R, Stein A, Thiel D and Schadendorf
            D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   10 (residues 1 to 1234)
  AUTHORS   Fossey SC, Kuroda S, Price JA, Pendleton JK, Freedman BI and Bowden
            DW.
  TITLE     Identification and characterization of PRKCBP1, a candidate
            RACK-like protein
  JOURNAL   Mamm Genome 11 (10), 919-925 (2000)
   PUBMED   11003709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC362133.1, DQ368673.1,
            AL022342.7, DR422399.1, BC146802.1 and AI275390.1.
            
            On Aug 31, 2013 this sequence version replaced XP_005260414.1.
            
            Summary: The protein encoded by this gene is a receptor for
            activated C-kinase (RACK) protein. The encoded protein has been
            shown to bind in vitro to activated protein kinase C beta I. In
            addition, this protein is a cutaneous T-cell lymphoma-associated
            antigen. Finally, the protein contains a bromodomain and two zinc
            fingers, and is thought to be a transcriptional regulator. Multiple
            transcript variants encoding several different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (9) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (i) is longer, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225857.1, DQ368673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471951.7/ ENSP00000420095.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     Protein         1..1234
                     /product="MYND-type zinc finger-containing chromatin
                     reader ZMYND8 isoform i"
                     /note="CTCL tumor antigen se14-3; RACK like clone 7;
                     protein kinase C-binding protein 1; predicted protein of
                     HQ2893; zinc finger MYND domain-containing protein 8;
                     cutaneous T-cell lymphoma-associated antigen se14-3;
                     transcription coregulator ZMYND8; MYND-type zinc
                     finger-containing chromatin reader ZMYND8"
                     /calculated_mol_wt=137037
     Region          <24..153
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          110..150
                     /region_name="PHD_PRKCBP1"
                     /note="PHD finger found in protein kinase C-binding
                     protein 1 (PRKCBP1); cd15538"
                     /db_xref="CDD:277013"
     Site            order(110,119..123,127,145)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277013"
     Region          171..269
                     /region_name="Bromo_RACK7"
                     /note="Bromodomain, RACK7_like subfamily. RACK7 (also
                     called human protein kinase C-binding protein) was
                     identified as a potential tumor suppressor genes, it
                     shares domain architecture with BS69/ZMYND11; both have
                     been implicated in the regulation of cellular...; cd05508"
                     /db_xref="CDD:99940"
     Site            order(197,202,205,244,248,254)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99940"
     Region          292..382
                     /region_name="PWWP_PRKCBP1"
                     /note="PWWP domain found in protein kinase C-binding
                     protein 1 (PRKCBP1) and similar proteins; cd20160"
                     /db_xref="CDD:438988"
     Site            order(294,298)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:438988"
     Site            order(304,306,354,356,360..361)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438988"
     Site            order(305,307..308,327,329..332,334,355..358)
                     /site_type="other"
                     /note="regulatory protein binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438988"
     Site            order(308,311,327)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438988"
     Site            309..312
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438988"
     Region          442..640
                     /region_name="DUF3544"
                     /note="Domain of unknown function (DUF3544); pfam12064"
                     /db_xref="CDD:432301"
     Region          <622..>780
                     /region_name="TFIIF_alpha"
                     /note="Transcription initiation factor IIF, alpha subunit
                     (TFIIF-alpha); pfam05793"
                     /db_xref="CDD:310411"
     Region          <975..1044
                     /region_name="ATP-synt_Fo_b"
                     /note="F-type ATP synthase, membrane subunit b; cd06503"
                     /db_xref="CDD:349951"
     Region          1048..1082
                     /region_name="zf-MYND"
                     /note="MYND finger; pfam01753"
                     /db_xref="CDD:426410"
     CDS             1..1234
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /coded_by="NM_001281775.3:30..3734"
                     /note="isoform i is encoded by transcript variant 9"
                     /db_xref="CCDS:CCDS63306.1"
                     /db_xref="GeneID:23613"
                     /db_xref="HGNC:HGNC:9397"
                     /db_xref="MIM:615713"
ORIGIN      
        1 mhpqslaeee ikteqevveg mdistrskdp gsaertaqkr kfpspphssn ghspqdtsts
       61 pikkkkkpgl lnsnnkeqse lrhgpfyymk qplttdpvdv vpqdgrndfy cwvchregqv
      121 lccelcprvy hakclrltse pegdwfcpec ekitvaecie tqskamtmlt ieqlsyllkf
      181 aiqkmkqpgt dafqkpvple qhpdyaeyif hpmdlctlek nakkkmygct eafladakwi
      241 lhnciiyngg nhkltqiakv vikicehemn eievcpecyl aacqkrdnwf cepcsnphpl
      301 vwaklkgfpf wpakalrdkd gqvdarffgq hdrawvpinn cylmskeipf svkktksifn
      361 samqemevyv enirrkfgvf nyspfrtpyt pnsqyqmlld ptnpsagtak idkqekvkln
      421 fdmtaspkil mskpvlsggt grrislsdmp rspmstnssv htgsdveqda ekkatsshfs
      481 aseesmdfld kstaspastk tgqagslsgs pkpfspqlsa pittktdkts ttgsilnlnl
      541 drskaemdlk elsesvqqqs tpvplispkr qirsrfqlnl dktiesckaq lgineisedv
      601 ytavehsdse dseksdssds eyisddeqks knepedtedk egcqmdkeps avkkkpkptn
      661 pveikeelks tspasekadp gavkdkaspe pekdfsekak psphpikdkl kgkdetdspt
      721 vhlgldsdse selvidlged hsgregrknk kepkepspkq dvvgktppst tvgshsppet
      781 pvltrssaqt saagatatts tsstvtvtap apaatgspvk kqrpllpket apavqrvvwn
      841 ssskfqtssq kwhmqkmqrq qqqqqqqnqq qqpqssqgtr yqtrqavkav qqkeitqsps
      901 tstitlvtst qssplvtssg smstlvssvn adlpiatasa dvaadiakyt skmmdaikgt
      961 mteiyndlsk nttgstiaei rrlrieiekl qwlhqqelse mkhnleltma emrqsleqer
     1021 drliaevkkq lelekqqavd etkkkqwcan ckkeaifycc wntsycdypc qqahwpehmk
     1081 sctqsatapq qeadaevnte tlnkssqgss sstqsapset asaskekets aekskesgst
     1141 ldlsgsretp ssillgsnqg svskrcdkqp ayaptttdhq phpnypaqky hsrsnkssws
     1201 ssdekrgstr sdhntststk sllpkesrld tfwd
//
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