LOCUS NP_001268711 1136 aa linear PRI 14-MAR-2023
DEFINITION MYND-type zinc finger-containing chromatin reader ZMYND8 isoform p
[Homo sapiens].
ACCESSION NP_001268711 XP_005260429
VERSION NP_001268711.1
DBSOURCE REFSEQ: accession NM_001281782.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1136)
AUTHORS Adhikary S, Singh V, Choudhari R, Yang B, Adhikari S, Ramos EI,
Chaudhuri S, Roy S, Gadad SS and Das C.
TITLE ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal
differentiation
JOURNAL Cell Death Dis 13 (9), 766 (2022)
PUBMED 36064715
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 1136)
AUTHORS Dias KR, Carlston CM, Blok LER, De Hayr L, Nawaz U, Evans CA,
Bayrak-Toydemir P, Htun S, Zhu Y, Ma A, Lynch SA, Moorwood C, Stals
K, Ellard S, Bainbridge MN, Friedman J, Pappas JG, Rabin R, Nowak
CB, Douglas J, Wilson TE, Guillen Sacoto MJ, Mullegama SV,
Palculict TB, Kirk EP, Pinner JR, Edwards M, Montanari F, Graziano
C, Pippucci T, Dingmann B, Glass I, Mefford HC, Shimoji T, Suzuki
T, Yamakawa K, Streff H, Schaaf CP, Slavotinek AM, Voineagu I,
Carey JC, Buckley MF, Schenck A, Harvey RJ and Roscioli T.
TITLE De Novo ZMYND8 variants result in an autosomal dominant
neurodevelopmental disorder with cardiac malformations
JOURNAL Genet Med 24 (9), 1952-1966 (2022)
PUBMED 35916866
REMARK GeneRIF: De Novo ZMYND8 variants result in an autosomal dominant
neurodevelopmental disorder with cardiac malformations.
REFERENCE 3 (residues 1 to 1136)
AUTHORS Benz C, Ali M, Krystkowiak I, Simonetti L, Sayadi A, Mihalic F,
Kliche J, Andersson E, Jemth P, Davey NE and Ivarsson Y.
TITLE Proteome-scale mapping of binding sites in the unstructured regions
of the human proteome
JOURNAL Mol Syst Biol 18 (1), e10584 (2022)
PUBMED 35044719
REFERENCE 4 (residues 1 to 1136)
AUTHORS Choi S, Lee KW, Koh HH, Park S, Yeo SY, Joh JW, Choi MS, Kim SH,
Park CK and Ha SY.
TITLE Validation of ZMYND8 as a new treatment target in hepatocellular
carcinoma
JOURNAL J Cancer Res Clin Oncol 147 (12), 3517-3534 (2021)
PUBMED 34462784
REMARK GeneRIF: Validation of ZMYND8 as a new treatment target in
hepatocellular carcinoma.
REFERENCE 5 (residues 1 to 1136)
AUTHORS Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y,
Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A,
Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB,
Bernt KM, Berger SL and Shi J.
TITLE ZMYND8-regulated IRF8 transcription axis is an acute myeloid
leukemia dependency
JOURNAL Mol Cell 81 (17), 3604-3622 (2021)
PUBMED 34358447
REMARK GeneRIF: ZMYND8-regulated IRF8 transcription axis is an acute
myeloid leukemia dependency.
REFERENCE 6 (residues 1 to 1136)
AUTHORS Nelson D, Yoshida EM, Paulson MS, Hengen PN, Ge D, Kanwar B,
McNally J, Pang PS, Subramanian GM, McHutchison JG, Urbanek P,
Lawitz E and Urban TJ.
TITLE Genome-wide association study to characterize serum bilirubin
elevations in patients with HCV treated with GS-9256, an HCV NS3
serine protease inhibitor
JOURNAL Antivir Ther 19 (7), 679-686 (2014)
PUBMED 24503447
REFERENCE 7 (residues 1 to 1136)
AUTHORS Miles RR, Crockett DK, Lim MS and Elenitoba-Johnson KS.
TITLE Analysis of BCL6-interacting proteins by tandem mass spectrometry
JOURNAL Mol Cell Proteomics 4 (12), 1898-1909 (2005)
PUBMED 16147992
REFERENCE 8 (residues 1 to 1136)
AUTHORS Westendorf JJ and Koka S.
TITLE Identification of FHOD1-binding proteins and mechanisms of
FHOD1-regulated actin dynamics
JOURNAL J Cell Biochem 92 (1), 29-41 (2004)
PUBMED 15095401
REFERENCE 9 (residues 1 to 1136)
AUTHORS Eichmuller S, Usener D, Dummer R, Stein A, Thiel D and Schadendorf
D.
TITLE Serological detection of cutaneous T-cell lymphoma-associated
antigens
JOURNAL Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
PUBMED 11149944
REFERENCE 10 (residues 1 to 1136)
AUTHORS Fossey SC, Kuroda S, Price JA, Pendleton JK, Freedman BI and Bowden
DW.
TITLE Identification and characterization of PRKCBP1, a candidate
RACK-like protein
JOURNAL Mamm Genome 11 (10), 919-925 (2000)
PUBMED 11003709
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC362133.1, DQ368678.1,
AL022342.7, DR422399.1, BC146802.1 and AI275390.1.
On Aug 31, 2013 this sequence version replaced XP_005260429.1.
Summary: The protein encoded by this gene is a receptor for
activated C-kinase (RACK) protein. The encoded protein has been
shown to bind in vitro to activated protein kinase C beta I. In
addition, this protein is a cutaneous T-cell lymphoma-associated
antigen. Finally, the protein contains a bromodomain and two zinc
fingers, and is thought to be a transcriptional regulator. Multiple
transcript variants encoding several different isoforms have been
found for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (16) uses an alternate in-frame
splice site and lacks an in-frame exon in the central coding
region, compared to variant 1. The encoded isoform (p) is shorter,
compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DQ368678.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1136
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q13.12"
Protein 1..1136
/product="MYND-type zinc finger-containing chromatin
reader ZMYND8 isoform p"
/note="CTCL tumor antigen se14-3; RACK like clone 7;
protein kinase C-binding protein 1; predicted protein of
HQ2893; zinc finger MYND domain-containing protein 8;
cutaneous T-cell lymphoma-associated antigen se14-3;
transcription coregulator ZMYND8; MYND-type zinc
finger-containing chromatin reader ZMYND8"
/calculated_mol_wt=125631
Region <24..128
/region_name="TNG2"
/note="Chromatin remodeling protein, contains PhD zinc
finger [Chromatin structure and dynamics]; COG5034"
/db_xref="CDD:227367"
Region 85..125
/region_name="PHD_PRKCBP1"
/note="PHD finger found in protein kinase C-binding
protein 1 (PRKCBP1); cd15538"
/db_xref="CDD:277013"
Site order(85,94..98,102,120)
/site_type="other"
/note="putative histone H3 binding site [polypeptide
binding]"
/db_xref="CDD:277013"
Region 146..244
/region_name="Bromo_RACK7"
/note="Bromodomain, RACK7_like subfamily. RACK7 (also
called human protein kinase C-binding protein) was
identified as a potential tumor suppressor genes, it
shares domain architecture with BS69/ZMYND11; both have
been implicated in the regulation of cellular...; cd05508"
/db_xref="CDD:99940"
Site order(172,177,180,219,223,229)
/site_type="other"
/note="putative acetyllysine binding site [chemical
binding]"
/db_xref="CDD:99940"
Region 267..357
/region_name="PWWP_PRKCBP1"
/note="PWWP domain found in protein kinase C-binding
protein 1 (PRKCBP1) and similar proteins; cd20160"
/db_xref="CDD:438988"
Site order(269,273)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:438988"
Site order(279,281,329,331,335..336)
/site_type="other"
/note="putative DNA binding site [nucleotide binding]"
/db_xref="CDD:438988"
Site order(280,282..283,302,304..307,309,330..333)
/site_type="other"
/note="regulatory protein binding site [polypeptide
binding]"
/db_xref="CDD:438988"
Site order(283,286,302)
/site_type="other"
/note="putative methyl-histone binding site [polypeptide
binding]"
/db_xref="CDD:438988"
Site 284..287
/site_type="other"
/note="PWWP sequence motif"
/db_xref="CDD:438988"
Region 417..615
/region_name="DUF3544"
/note="Domain of unknown function (DUF3544); pfam12064"
/db_xref="CDD:432301"
Region <597..>755
/region_name="TFIIF_alpha"
/note="Transcription initiation factor IIF, alpha subunit
(TFIIF-alpha); pfam05793"
/db_xref="CDD:310411"
Region <867..946
/region_name="ATP-synt_Fo_b"
/note="F-type ATP synthase, membrane subunit b; cd06503"
/db_xref="CDD:349951"
Region 950..984
/region_name="zf-MYND"
/note="MYND finger; pfam01753"
/db_xref="CDD:426410"
CDS 1..1136
/gene="ZMYND8"
/gene_synonym="PRKCBP1; PRO2893; RACK7"
/coded_by="NM_001281782.3:30..3440"
/note="isoform p is encoded by transcript variant 16"
/db_xref="CCDS:CCDS63305.1"
/db_xref="GeneID:23613"
/db_xref="HGNC:HGNC:9397"
/db_xref="MIM:615713"
ORIGIN
1 mhpqslaeee ikteqevveg mdistrskdp gsaertaqkr kfpspphssn ghspqdtsts
61 pikkkkkpgl lnsnnkeqdg rndfycwvch regqvlccel cprvyhakcl rltsepegdw
121 fcpecekitv aecietqska mtmltieqls yllkfaiqkm kqpgtdafqk pvpleqhpdy
181 aeyifhpmdl ctleknakkk mygcteafla dakwilhnci iynggnhklt qiakvvikic
241 ehemneievc pecylaacqk rdnwfcepcs nphplvwakl kgfpfwpaka lrdkdgqvda
301 rffgqhdraw vpinncylms keipfsvkkt ksifnsamqe mevyvenirr kfgvfnyspf
361 rtpytpnsqy qmlldptnps agtakidkqe kvklnfdmta spkilmskpv lsggtgrris
421 lsdmprspms tnssvhtgsd veqdaekkat sshfsasees mdfldkstas pastktgqag
481 slsgspkpfs pqlsapittk tdktsttgsi lnlnldrska emdlkelses vqqqstpvpl
541 ispkrqirsr fqlnldktie sckaqlgine isedvytave hsdsedseks dssdseyisd
601 deqksknepe dtedkegcqm dkepsavkkk pkptnpveik eelkstspas ekadpgavkd
661 kaspepekdf sekakpsphp ikdklkgkde tdsptvhlgl dsdseselvi dlgedhsgre
721 grknkkepke pspkqdvvgk tppsttvgsh sppetpvltr ssaqtsaaga tattstsstv
781 tvtapapaat gspvkkqrpl lpketapavq rvvwnsstvq qkeitqspst stitlvtstq
841 ssplvtssgs mstlvssvna dlpiatasad vaadiakyts kirrlrieie klqwlhqqel
901 semkhnlelt maemrqsleq erdrliaevk kqlelekqqa vdetkkkqwc anckkeaify
961 ccwntsycdy pcqqahwpeh mksctqsata pqqeadaevn tetlnkssqg sssstqsaps
1021 etasaskeke tsaekskesg stldlsgsre tpssillgsn qgsvskrcdk qpayaptttd
1081 hqphpnypaq kyhsrsnkss wsssdekrgs trsdhntsts tksllpkesr ldtfwd
//
