LOCUS NP_001275648 764 aa linear PRI 19-NOV-2023
DEFINITION signal transducer and activator of transcription 5A isoform 2 [Homo
sapiens].
ACCESSION NP_001275648 XP_005257679
VERSION NP_001275648.1
DBSOURCE REFSEQ: accession NM_001288719.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 764)
AUTHORS Yin L, Xu J, Wu W, Niu M, Li Z, Zhu F and Xu K.
TITLE Dual inhibition of STAT3 and STAT5 may overcome imatinib resistance
in chronic myeloid leukemia
JOURNAL Hematology 28 (1), 2224625 (2023)
PUBMED 37345979
REMARK GeneRIF: Dual inhibition of STAT3 and STAT5 may overcome imatinib
resistance in chronic myeloid leukemia.
REFERENCE 2 (residues 1 to 764)
AUTHORS Wan P, He X, Han Y, Wang L and Yuan Z.
TITLE Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance
of breast cancer cells via promoting miR-182 transcription
JOURNAL Chem Biol Drug Des 102 (1), 14-25 (2023)
PUBMED 36905318
REMARK GeneRIF: Stat5 inhibits NLRP3-mediated pyroptosis to enhance
chemoresistance of breast cancer cells via promoting miR-182
transcription.
REFERENCE 3 (residues 1 to 764)
AUTHORS Son A, Meylan F, Gomez-Rodriguez J, Kaul Z, Sylvester M, Falduto
GH, Vazquez E, Haque T, Kitakule MM, Wang C, Manthiram K, Qi CF,
Cheng J, Gurram RK, Zhu J, Schwartzberg P, Milner JD,
Frischmeyer-Guerrerio PA and Schwartz DM.
TITLE Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent
innate-like function of TH9 cells to promote allergic inflammation
JOURNAL Nat Immunol 24 (6), 1036-1048 (2023)
PUBMED 37106040
REMARK GeneRIF: Dynamic chromatin accessibility licenses STAT5- and
STAT6-dependent innate-like function of TH9 cells to promote
allergic inflammation.
Erratum:[Nat Immunol. 2023 Oct 11;:. PMID: 37821709]
REFERENCE 4 (residues 1 to 764)
AUTHORS Wang S, Fan R, Gao H, Ma X, Wu Y, Xing Y, Wang Y and Jia Y.
TITLE STAT5A modulates gastric cancer progression via upregulation of
CD44
JOURNAL Genomics 115 (3), 110638 (2023)
PUBMED 37196931
REMARK GeneRIF: STAT5A modulates gastric cancer progression via
upregulation of CD44.
REFERENCE 5 (residues 1 to 764)
AUTHORS Smith MR, Satter LRF and Vargas-Hernandez A.
TITLE STAT5b: A master regulator of key biological pathways
JOURNAL Front Immunol 13, 1025373 (2023)
PUBMED 36755813
REMARK GeneRIF: STAT5b: A master regulator of key biological pathways.
Review article
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 764)
AUTHORS Kirken RA, Rui H, Malabarba MG, Howard OM, Kawamura M, O'Shea JJ
and Farrar WL.
TITLE Activation of JAK3, but not JAK1, is critical for IL-2-induced
proliferation and STAT5 recruitment by a COOH-terminal region of
the IL-2 receptor beta-chain
JOURNAL Cytokine 7 (7), 689-700 (1995)
PUBMED 8580378
REFERENCE 7 (residues 1 to 764)
AUTHORS Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, Shibuya K,
Ortaldo JR, Gupta S, Chen YQ, Giri JD et al.
TITLE Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus
kinases by interleukins 2 and 15
JOURNAL Proc Natl Acad Sci U S A 92 (19), 8705-8709 (1995)
PUBMED 7568001
REFERENCE 8 (residues 1 to 764)
AUTHORS Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L,
Yamauchi A, Bloom ET, Mietz J, John S et al.
TITLE The role of shared receptor motifs and common Stat proteins in the
generation of cytokine pleiotropy and redundancy by IL-2, IL-4,
IL-7, IL-13, and IL-15
JOURNAL Immunity 2 (4), 331-339 (1995)
PUBMED 7719938
REFERENCE 9 (residues 1 to 764)
AUTHORS Hou J, Schindler U, Henzel WJ, Wong SC and McKnight SL.
TITLE Identification and purification of human Stat proteins activated in
response to interleukin-2
JOURNAL Immunity 2 (4), 321-329 (1995)
PUBMED 7719937
REFERENCE 10 (residues 1 to 764)
AUTHORS Gouilleux F, Wakao H, Mundt M and Groner B.
TITLE Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a
prerequisite for DNA binding and induction of transcription
JOURNAL EMBO J 13 (18), 4361-4369 (1994)
PUBMED 7925280
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DQ471288.1, AB208972.1 and
BC027036.1.
On Jan 1, 2014 this sequence version replaced XP_005257679.1.
Summary: The protein encoded by this gene is a member of the STAT
family of transcription factors. In response to cytokines and
growth factors, STAT family members are phosphorylated by the
receptor associated kinases, and then form homo- or heterodimers
that translocate to the cell nucleus where they act as
transcription activators. This protein is activated by, and
mediates the responses of many cell ligands, such as IL2, IL3, IL7
GM-CSF, erythropoietin, thrombopoietin, and different growth
hormones. Activation of this protein in myeloma and lymphoma
associated with a TEL/JAK2 gene fusion is independent of cell
stimulus and has been shown to be essential for tumorigenesis. The
mouse counterpart of this gene is found to induce the expression of
BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this
gene in cells. Alternatively spliced transcript variants have been
found for this gene. [provided by RefSeq, Dec 2013].
Transcript Variant: This variant (3) lacks an in-frame coding exon
in the 5' region compared to variant 1. The resulting shorter
isoform (2) lacks an internal protein segment compared to isoform
1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK301457.1, SRR7346977.1606697.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..764
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.2"
Protein 1..764
/product="signal transducer and activator of transcription
5A isoform 2"
/note="epididymis secretory sperm binding protein"
/calculated_mol_wt=86818
Region 4..>95
/region_name="STAT_int"
/note="STAT protein, protein interaction domain;
pfam02865"
/db_xref="CDD:427024"
Region 109..300
/region_name="STAT5_CCD"
/note="Coiled-coil domain of Signal Transducer and
Activator of Transcription 5 (STAT5); cd16855"
/db_xref="CDD:341080"
Site order(112..135,195..221,245..266)
/site_type="other"
/note="coiled-coil motif"
/db_xref="CDD:341080"
Site order(137,140,144,147,151,257,261,268)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:341080"
Region 302..459
/region_name="STAT5_DBD"
/note="DNA-binding domain of Signal Transducer and
Activator of Transcription 5 (STAT5); cd16849"
/db_xref="CDD:341087"
Site order(315,331..336,338,368..369,372,387..388,392,419,
423..424)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:341087"
Region 543..682
/region_name="SH2_STAT5a"
/note="Src homology 2 (SH2) domain found in signal
transducer and activator of transcription (STAT) 5a
proteins; cd10421"
/db_xref="CDD:198284"
Site order(570,588,612,614)
/site_type="other"
/note="phosphotyrosine binding pocket [polypeptide
binding]"
/db_xref="CDD:198284"
Site order(613,629)
/site_type="other"
/note="hydrophobic binding pocket [polypeptide binding]"
/db_xref="CDD:198284"
Site order(623..624,669)
/site_type="other"
/note="homodimer interface [polypeptide binding]"
/db_xref="CDD:198284"
CDS 1..764
/gene="STAT5A"
/gene_synonym="MGF; STAT5"
/coded_by="NM_001288719.2:112..2406"
/note="isoform 2 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS74067.1"
/db_xref="GeneID:6776"
/db_xref="HGNC:HGNC:11366"
/db_xref="MIM:601511"
ORIGIN
1 magwiqaqql qgdalrqmqv lygqhfpiev rhylaqwies qpwdaidldn pqdraqatql
61 leglvqelqk kaehqvgedg fllkiklghy atqlqcsspa gilvdamsqk hlqinqtfee
121 lrlvtqdten elkklqqtqe yfiiqyqesl riqaqfaqla qlspqerlsr etalqqkqvs
181 leawlqreaq tlqqyrvela ekhqktlqll rkqqtiildd eliqwkrrqq lagnggppeg
241 sldvlqswce klaeiiwqnr qqirraehlc qqlpipgpve emlaevnati tdiisalvts
301 tfiiekqppq vlktqtkfaa tvrllvggkl nvhmnppqvk atiiseqqak sllknentrn
361 ecsgeilnnc cvmeyhqatg tlsahfrnms lkrikradrr gaesvteekf tvlfesqfsv
421 gsnelvfqvk tlslpvvviv hgsqdhnata tvlwdnafae pgrvpfavpd kvlwpqlcea
481 lnmkfkaevq snrgltkenl vflaqklfnn ssshledysg lsvswsqfnr enlpgwnytf
541 wqwfdgvmev lkkhhkphwn dgailgfvnk qqahdllink pdgtfllrfs dseiggitia
601 wkfdspernl wnlkpfttrd fsirsladrl gdlsyliyvf pdrpkdevfs kyytpvlaka
661 vdgyvkpqik qvvpefvnas adaggssaty mdqapspavc pqapynmypq npdhvldqdg
721 efdldetmdv arhveellrr pmdsldsrls ppaglftsar gsls
//
