GenomeNet

Database: RefSeq
Entry: NP_001277143
LinkDB: NP_001277143
Original site: NP_001277143 
LOCUS       NP_001277143             445 aa            linear   PRI 26-FEB-2019
DEFINITION  C-terminal-binding protein 2 isoform 1 [Homo sapiens].
ACCESSION   NP_001277143
VERSION     NP_001277143.1
DBSOURCE    REFSEQ: accession NM_001290214.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 445)
  AUTHORS   Liu X, Zhu C, Li J, Xu F, Huang G, Xu L and Zhang B.
  TITLE     HBV Upregulates CtBP2 Expression via the X Gene
  JOURNAL   Biomed Res Int 2018, 6960573 (2018)
   PUBMED   30151388
  REMARK    GeneRIF: HBV may be involved in the occurrence and development of
            hepatocellular carcinoma by upregulating CtBP2 expression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 445)
  AUTHORS   Shi H, Mao Y, Ju Q, Wu Y, Bai W, Wang P, Zhang Y and Jiang M.
  TITLE     C-terminal binding protein2 mediates cisplatin chemoresistance in
            esophageal cancer cells via the inhibition of apoptosis
  JOURNAL   Int. J. Oncol. 53 (1), 167-176 (2018)
   PUBMED   29658564
  REMARK    GeneRIF: the present study indicated that CtBP2 reduced the
            susceptibility of ECA109 cells to cisplatin by regulating the
            expression of apoptosis-related proteins, suggesting that it may be
            a promising therapeutic target in esophageal squamous cell
            carcinoma in the future.
REFERENCE   3  (residues 1 to 445)
  AUTHORS   Bellesis AG, Jecrois AM, Hayes JA, Schiffer CA and Royer WE Jr.
  TITLE     Assembly of human C-terminal binding protein (CtBP) into tetramers
  JOURNAL   J. Biol. Chem. 293 (23), 9101-9112 (2018)
   PUBMED   29700119
  REMARK    GeneRIF: Here, multi-angle light scattering (MALS) data established
            the NAD(+)- and NADH-dependent assembly of CtBP1 and CtBP2 into
            tetramers.
REFERENCE   4  (residues 1 to 445)
  AUTHORS   Liu DZ, Zhao H, Zou QG and Ma QJ.
  TITLE     MiR-338 suppresses cell proliferation and invasion by targeting
            CTBP2 in glioma
  JOURNAL   Cancer Biomark 20 (3), 289-297 (2017)
   PUBMED   28826173
  REMARK    GeneRIF: Results indicated that CTBP2 was direct target of
            miR-338-5p in glioma cells. CTBP2 silencing can rescued the
            phenotype changes induced by miR-338-5p inhibitor on cell
            proliferation and invasion in glioma.
REFERENCE   5  (residues 1 to 445)
  AUTHORS   Xuan Q, Zhong X, Li W, Mo Z, Huang Y and Hu Y.
  TITLE     CtBP2 is associated with angiogenesis and regulates the apoptosis
            of prostate cancer cells
  JOURNAL   Oncol. Rep. 38 (2), 1259-1267 (2017)
   PUBMED   28677795
  REMARK    GeneRIF: High CTBP2 expression is associated with prostate cancer.
REFERENCE   6  (residues 1 to 445)
  AUTHORS   Holmes M, Turner J, Fox A, Chisholm O, Crossley M and Chong B.
  TITLE     hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
            and modulates GATA-mediated activation
  JOURNAL   J. Biol. Chem. 274 (33), 23491-23498 (1999)
   PUBMED   10438528
REFERENCE   7  (residues 1 to 445)
  AUTHORS   Sewalt RG, Gunster MJ, van der Vlag J, Satijn DP and Otte AP.
  TITLE     C-Terminal binding protein is a transcriptional repressor that
            interacts with a specific class of vertebrate Polycomb proteins
  JOURNAL   Mol. Cell. Biol. 19 (1), 777-787 (1999)
   PUBMED   9858600
REFERENCE   8  (residues 1 to 445)
  AUTHORS   Turner J and Crossley M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J. 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   9  (residues 1 to 445)
  AUTHORS   Katsanis N and Fisher EM.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   10 (residues 1 to 445)
  AUTHORS   Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T and
            Chinnadurai G.
  TITLE     Molecular cloning and characterization of a cellular phosphoprotein
            that interacts with a conserved C-terminal domain of adenovirus E1A
            involved in negative modulation of oncogenic transformation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (23), 10467-10471 (1995)
   PUBMED   7479821
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM712328.1, BC052276.1 and
            AL731571.3.
            
            Summary: This gene produces alternative transcripts encoding two
            distinct proteins. One protein is a transcriptional repressor,
            while the other isoform is a major component of specialized
            synapses known as synaptic ribbons. Both proteins contain a NAD+
            binding domain similar to NAD+-dependent 2-hydroxyacid
            dehydrogenases. A portion of the 3' untranslated region was used to
            map this gene to chromosome 21q21.3; however, it was noted that
            similar loci elsewhere in the genome are likely. Blast analysis
            shows that this gene is present on chromosome 10. Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (4) contains a distinct 5' UTR and
            5' CDS, compared to variant 2. Variants 1, 3, 4, and 5-8 all encode
            the same isoform (1), which has a distinct N-terminus that is 540
            aa shorter than the N-terminus of isoform 2. The protein is thought
            to bind to the C-terminus of the adenovirus E1A proteins. Studies
            in mice suggest that this protein is involved in transcriptional
            repression.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052276.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     Protein         1..445
                     /product="C-terminal-binding protein 2 isoform 1"
                     /note="ribeye"
                     /calculated_mol_wt=48814
     Site            22
                     /site_type="methylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Asymmetric dimethylarginine.
                     {ECO:0000244|PubMed:24129315}; propagated from
                     UniProtKB/Swiss-Prot (P56545.1)"
     Region          34..352
                     /region_name="CtBP_dh"
                     /note="C-terminal binding protein (CtBP),
                     D-isomer-specific 2-hydroxyacid dehydrogenases related
                     repressor; cd05299"
                     /db_xref="CDD:240624"
     Site            order(103,106..107,272,321,324)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:240624"
     Site            order(106,134,186..187,189..191,209..213,242..244,246,249,
                     270..272,296..297,321,323..324)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:240624"
     Site            order(272,301,321)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:240624"
     Site            428
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P56545.1)"
     CDS             1..445
                     /gene="CTBP2"
                     /coded_by="NM_001290214.2:426..1763"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS7643.1"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
ORIGIN      
        1 malvdkhkvk rqrldriceg irpqimngpl hprplvalld grdctvempi lkdlatvafc
       61 daqstqeihe kvlneavgam myhtitltre dlekfkalrv ivrigsgydn vdikaagelg
      121 iavcnipsaa veetadstic hilnlyrrnt wlyqalregt rvqsveqire vasgaarirg
      181 etlgligfgr tgqavavrak afgfsvifyd pylqdgiers lgvqrvytlq dllyqsdcvs
      241 lhcnlnehnh hlindftikq mrqgaflvna argglvdeka laqalkegri rgaaldvhes
      301 epfsfaqgpl kdapnlictp htawyseqas lemreaaate irraitgrip eslrncvnke
      361 ffvtsapwsv idqqaihpel ngatyryppg ivgvapgglp aamegiipgg ipvthnlptv
      421 ahpsqapspn qptkhgdnre hpneq
//
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