LOCUS NP_001277144 445 aa linear PRI 27-APR-2025
DEFINITION C-terminal-binding protein 2 isoform 1 [Homo sapiens].
ACCESSION NP_001277144 XP_005269620
VERSION NP_001277144.1
DBSOURCE REFSEQ: accession NM_001290215.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 445)
AUTHORS Pastoors,D., Havermans,M., Mulet-Lazaro,R., Brian,D., Noort,W.,
Grasel,J., Hoogenboezem,R., Smeenk,L., Demmers,J.A.A., Milsom,M.D.,
Enver,T., Groen,R.W.J., Bindels,E. and Delwel,R.
TITLE Oncogene EVI1 drives acute myeloid leukemia via a targetable
interaction with CTBP2
JOURNAL Sci Adv 10 (20), eadk9076 (2024)
PUBMED 38748792
REMARK GeneRIF: Oncogene EVI1 drives acute myeloid leukemia via a
targetable interaction with CTBP2.
REFERENCE 2 (residues 1 to 445)
AUTHORS Cheung,C.H.Y., Cheng,C.K., Leung,K.T., Zhang,C., Ho,C.Y., Luo,X.,
Kam,A.Y.F., Xia,T., Wan,T.S.K., Pitts,H.A., Chan,N.P.H.,
Cheung,J.S., Wong,R.S.M., Zhang,X.B. and Ng,M.H.L.
TITLE C-terminal binding protein 2 is a novel tumor suppressor targeting
the MYC-IRF4 axis in multiple myeloma
JOURNAL Blood Adv 8 (9), 2217-2234 (2024)
PUBMED 38457926
REMARK GeneRIF: C-terminal binding protein 2 is a novel tumor suppressor
targeting the MYC-IRF4 axis in multiple myeloma.
REFERENCE 3 (residues 1 to 445)
AUTHORS Li,K., Chen,J., Zhang,C., Cheng,M., Chen,S., Song,W., Yang,C.,
Ling,R., Chen,Z., Wang,X., Xiong,G., Ma,J., Zhu,Y., Yuan,Q.,
Liu,Q., Peng,L., Chen,Q. and Chen,D.
TITLE The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head
and neck squamous cell carcinoma
JOURNAL J Clin Invest 133 (20), e170173 (2023)
PUBMED 37643007
REMARK GeneRIF: The CTBP2-PCIF1 complex regulates m6Am modification of
mRNA in head and neck squamous cell carcinoma.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 445)
AUTHORS Sekiya,M., Ma,Y., Kainoh,K., Saito,K., Yamazaki,D., Tsuyuzaki,T.,
Chen,W., Adi Putri,P.I.P., Ohno,H., Miyamoto,T., Takeuchi,Y.,
Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
Motomura,K., Matsuzaka,T., Murata,K., Mizuno,S., Takahashi,S. and
Shimano,H.
TITLE Loss of CtBP2 may be a mechanistic link between metabolic
derangements and progressive impairment of pancreatic beta cell
function
JOURNAL Cell Rep 42 (8), 112914 (2023)
PUBMED 37557182
REMARK GeneRIF: Loss of CtBP2 may be a mechanistic link between metabolic
derangements and progressive impairment of pancreatic beta cell
function.
REFERENCE 5 (residues 1 to 445)
AUTHORS Saito,K., Sekiya,M., Kainoh,K., Yoshino,R., Hayashi,A., Han,S.I.,
Araki,M., Ohno,H., Takeuchi,Y., Tsuyuzaki,T., Yamazaki,D.,
Wanpei,C., Hada,L., Watanabe,S., Paramita Adi Putri,P.I.,
Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
Miyamoto,T., Matsuzaka,T. and Shimano,H.
TITLE Obesity-induced metabolic imbalance allosterically modulates CtBP2
to inhibit PPAR-alpha transcriptional activity
JOURNAL J Biol Chem 299 (7), 104890 (2023)
PUBMED 37286039
REMARK GeneRIF: Obesity-induced metabolic imbalance allosterically
modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
REFERENCE 6 (residues 1 to 445)
AUTHORS Holmes,M., Turner,J., Fox,A., Chisholm,O., Crossley,M. and Chong,B.
TITLE hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
and modulates GATA-mediated activation
JOURNAL J Biol Chem 274 (33), 23491-23498 (1999)
PUBMED 10438528
REFERENCE 7 (residues 1 to 445)
AUTHORS Sewalt,R.G., Gunster,M.J., van der Vlag,J., Satijn,D.P. and
Otte,A.P.
TITLE C-Terminal binding protein is a transcriptional repressor that
interacts with a specific class of vertebrate Polycomb proteins
JOURNAL Mol Cell Biol 19 (1), 777-787 (1999)
PUBMED 9858600
REFERENCE 8 (residues 1 to 445)
AUTHORS Turner,J. and Crossley,M.
TITLE Cloning and characterization of mCtBP2, a co-repressor that
associates with basic Kruppel-like factor and other mammalian
transcriptional regulators
JOURNAL EMBO J 17 (17), 5129-5140 (1998)
PUBMED 9724649
REFERENCE 9 (residues 1 to 445)
AUTHORS Katsanis,N. and Fisher,E.M.
TITLE A novel C-terminal binding protein (CTBP2) is closely related to
CTBP1, an adenovirus E1A-binding protein, and maps to human
chromosome 21q21.3
JOURNAL Genomics 47 (2), 294-299 (1998)
PUBMED 9479502
REFERENCE 10 (residues 1 to 445)
AUTHORS Schaeper,U., Boyd,J.M., Verma,S., Uhlmann,E., Subramanian,T. and
Chinnadurai,G.
TITLE Molecular cloning and characterization of a cellular phosphoprotein
that interacts with a conserved C-terminal domain of adenovirus E1A
involved in negative modulation of oncogenic transformation
JOURNAL Proc Natl Acad Sci U S A 92 (23), 10467-10471 (1995)
PUBMED 7479821
REMARK Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY147073.1, AK290390.1 and
AL731571.3.
On Mar 1, 2014 this sequence version replaced XP_005269620.1.
Summary: This gene produces alternative transcripts encoding two
distinct proteins. One protein is a transcriptional repressor,
while the other isoform is a major component of specialized
synapses known as synaptic ribbons. Both proteins contain a NAD+
binding domain similar to NAD+-dependent 2-hydroxyacid
dehydrogenases. A portion of the 3' untranslated region was used to
map this gene to chromosome 21q21.3; however, it was noted that
similar loci elsewhere in the genome are likely. Blast analysis
shows that this gene is present on chromosome 10. Several
transcript variants encoding two different isoforms have been found
for this gene. [provided by RefSeq, Feb 2014].
Transcript Variant: This variant (5) contains a distinct 5' UTR and
5' CDS, compared to variant 2. Variants 1, 3, 4, and 5-8 all encode
the same isoform (1), which has a distinct N-terminus that is 540
aa shorter than the N-terminus of isoform 2. The protein is thought
to bind to the C-terminus of the adenovirus E1A proteins. Studies
in mice suggest that this protein is involved in transcriptional
repression.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290390.1, SRR14372080.1458172.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..445
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26.13"
Protein 1..445
/product="C-terminal-binding protein 2 isoform 1"
/note="ribeye"
/calculated_mol_wt=48814
Site 22
/site_type="methylation"
/note="Asymmetric dimethylarginine.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (P56545.1)"
Region 34..352
/region_name="CtBP_dh"
/note="C-terminal binding protein (CtBP),
D-isomer-specific 2-hydroxyacid dehydrogenases related
repressor; cd05299"
/db_xref="CDD:240624"
Site order(103,106..107,272,321,324)
/site_type="other"
/note="ligand binding site [chemical binding]"
/db_xref="CDD:240624"
Site order(106,134,186..187,189..191,209..213,242..244,246,249,
270..272,296..297,321,323..324)
/site_type="other"
/note="NAD binding site [chemical binding]"
/db_xref="CDD:240624"
Region 414..445
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P56545.1)"
Site 428
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (P56545.1)"
CDS 1..445
/gene="CTBP2"
/coded_by="NM_001290215.3:349..1686"
/note="isoform 1 is encoded by transcript variant 5"
/db_xref="CCDS:CCDS7643.1"
/db_xref="GeneID:1488"
/db_xref="HGNC:HGNC:2495"
/db_xref="MIM:602619"
ORIGIN
1 malvdkhkvk rqrldriceg irpqimngpl hprplvalld grdctvempi lkdlatvafc
61 daqstqeihe kvlneavgam myhtitltre dlekfkalrv ivrigsgydn vdikaagelg
121 iavcnipsaa veetadstic hilnlyrrnt wlyqalregt rvqsveqire vasgaarirg
181 etlgligfgr tgqavavrak afgfsvifyd pylqdgiers lgvqrvytlq dllyqsdcvs
241 lhcnlnehnh hlindftikq mrqgaflvna argglvdeka laqalkegri rgaaldvhes
301 epfsfaqgpl kdapnlictp htawyseqas lemreaaate irraitgrip eslrncvnke
361 ffvtsapwsv idqqaihpel ngatyryppg ivgvapgglp aamegiipgg ipvthnlptv
421 ahpsqapspn qptkhgdnre hpneq
//
