LOCUS NP_001277144 445 aa linear PRI 25-FEB-2019
DEFINITION C-terminal-binding protein 2 isoform 1 [Homo sapiens].
ACCESSION NP_001277144 XP_005269620
VERSION NP_001277144.1
DBSOURCE REFSEQ: accession NM_001290215.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 445)
AUTHORS Liu X, Zhu C, Li J, Xu F, Huang G, Xu L and Zhang B.
TITLE HBV Upregulates CtBP2 Expression via the X Gene
JOURNAL Biomed Res Int 2018, 6960573 (2018)
PUBMED 30151388
REMARK GeneRIF: HBV may be involved in the occurrence and development of
hepatocellular carcinoma by upregulating CtBP2 expression.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 445)
AUTHORS Shi H, Mao Y, Ju Q, Wu Y, Bai W, Wang P, Zhang Y and Jiang M.
TITLE C-terminal binding protein2 mediates cisplatin chemoresistance in
esophageal cancer cells via the inhibition of apoptosis
JOURNAL Int. J. Oncol. 53 (1), 167-176 (2018)
PUBMED 29658564
REMARK GeneRIF: the present study indicated that CtBP2 reduced the
susceptibility of ECA109 cells to cisplatin by regulating the
expression of apoptosis-related proteins, suggesting that it may be
a promising therapeutic target in esophageal squamous cell
carcinoma in the future.
REFERENCE 3 (residues 1 to 445)
AUTHORS Bellesis AG, Jecrois AM, Hayes JA, Schiffer CA and Royer WE Jr.
TITLE Assembly of human C-terminal binding protein (CtBP) into tetramers
JOURNAL J. Biol. Chem. 293 (23), 9101-9112 (2018)
PUBMED 29700119
REMARK GeneRIF: Here, multi-angle light scattering (MALS) data established
the NAD(+)- and NADH-dependent assembly of CtBP1 and CtBP2 into
tetramers.
REFERENCE 4 (residues 1 to 445)
AUTHORS Liu DZ, Zhao H, Zou QG and Ma QJ.
TITLE MiR-338 suppresses cell proliferation and invasion by targeting
CTBP2 in glioma
JOURNAL Cancer Biomark 20 (3), 289-297 (2017)
PUBMED 28826173
REMARK GeneRIF: Results indicated that CTBP2 was direct target of
miR-338-5p in glioma cells. CTBP2 silencing can rescued the
phenotype changes induced by miR-338-5p inhibitor on cell
proliferation and invasion in glioma.
REFERENCE 5 (residues 1 to 445)
AUTHORS Xuan Q, Zhong X, Li W, Mo Z, Huang Y and Hu Y.
TITLE CtBP2 is associated with angiogenesis and regulates the apoptosis
of prostate cancer cells
JOURNAL Oncol. Rep. 38 (2), 1259-1267 (2017)
PUBMED 28677795
REMARK GeneRIF: High CTBP2 expression is associated with prostate cancer.
REFERENCE 6 (residues 1 to 445)
AUTHORS Holmes M, Turner J, Fox A, Chisholm O, Crossley M and Chong B.
TITLE hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
and modulates GATA-mediated activation
JOURNAL J. Biol. Chem. 274 (33), 23491-23498 (1999)
PUBMED 10438528
REFERENCE 7 (residues 1 to 445)
AUTHORS Sewalt RG, Gunster MJ, van der Vlag J, Satijn DP and Otte AP.
TITLE C-Terminal binding protein is a transcriptional repressor that
interacts with a specific class of vertebrate Polycomb proteins
JOURNAL Mol. Cell. Biol. 19 (1), 777-787 (1999)
PUBMED 9858600
REFERENCE 8 (residues 1 to 445)
AUTHORS Turner J and Crossley M.
TITLE Cloning and characterization of mCtBP2, a co-repressor that
associates with basic Kruppel-like factor and other mammalian
transcriptional regulators
JOURNAL EMBO J. 17 (17), 5129-5140 (1998)
PUBMED 9724649
REFERENCE 9 (residues 1 to 445)
AUTHORS Katsanis N and Fisher EM.
TITLE A novel C-terminal binding protein (CTBP2) is closely related to
CTBP1, an adenovirus E1A-binding protein, and maps to human
chromosome 21q21.3
JOURNAL Genomics 47 (2), 294-299 (1998)
PUBMED 9479502
REFERENCE 10 (residues 1 to 445)
AUTHORS Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T and
Chinnadurai G.
TITLE Molecular cloning and characterization of a cellular phosphoprotein
that interacts with a conserved C-terminal domain of adenovirus E1A
involved in negative modulation of oncogenic transformation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (23), 10467-10471 (1995)
PUBMED 7479821
REMARK Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY147073.1, AK290390.1 and
AL731571.3.
On Mar 1, 2014 this sequence version replaced XP_005269620.1.
Summary: This gene produces alternative transcripts encoding two
distinct proteins. One protein is a transcriptional repressor,
while the other isoform is a major component of specialized
synapses known as synaptic ribbons. Both proteins contain a NAD+
binding domain similar to NAD+-dependent 2-hydroxyacid
dehydrogenases. A portion of the 3' untranslated region was used to
map this gene to chromosome 21q21.3; however, it was noted that
similar loci elsewhere in the genome are likely. Blast analysis
shows that this gene is present on chromosome 10. Several
transcript variants encoding two different isoforms have been found
for this gene. [provided by RefSeq, Feb 2014].
Transcript Variant: This variant (5) contains a distinct 5' UTR and
5' CDS, compared to variant 2. Variants 1, 3, 4, and 5-8 all encode
the same isoform (1), which has a distinct N-terminus that is 540
aa shorter than the N-terminus of isoform 2. The protein is thought
to bind to the C-terminus of the adenovirus E1A proteins. Studies
in mice suggest that this protein is involved in transcriptional
repression.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290390.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..445
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26.13"
Protein 1..445
/product="C-terminal-binding protein 2 isoform 1"
/note="ribeye"
/calculated_mol_wt=48814
Site 22
/site_type="methylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}; propagated from
UniProtKB/Swiss-Prot (P56545.1)"
Region 34..352
/region_name="CtBP_dh"
/note="C-terminal binding protein (CtBP),
D-isomer-specific 2-hydroxyacid dehydrogenases related
repressor; cd05299"
/db_xref="CDD:240624"
Site order(103,106..107,272,321,324)
/site_type="other"
/note="ligand binding site [chemical binding]"
/db_xref="CDD:240624"
Site order(106,134,186..187,189..191,209..213,242..244,246,249,
270..272,296..297,321,323..324)
/site_type="other"
/note="NAD binding site [chemical binding]"
/db_xref="CDD:240624"
Site order(272,301,321)
/site_type="active"
/note="catalytic site [active]"
/db_xref="CDD:240624"
Site 428
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P56545.1)"
CDS 1..445
/gene="CTBP2"
/coded_by="NM_001290215.2:690..2027"
/note="isoform 1 is encoded by transcript variant 5"
/db_xref="CCDS:CCDS7643.1"
/db_xref="GeneID:1488"
/db_xref="HGNC:HGNC:2495"
/db_xref="MIM:602619"
ORIGIN
1 malvdkhkvk rqrldriceg irpqimngpl hprplvalld grdctvempi lkdlatvafc
61 daqstqeihe kvlneavgam myhtitltre dlekfkalrv ivrigsgydn vdikaagelg
121 iavcnipsaa veetadstic hilnlyrrnt wlyqalregt rvqsveqire vasgaarirg
181 etlgligfgr tgqavavrak afgfsvifyd pylqdgiers lgvqrvytlq dllyqsdcvs
241 lhcnlnehnh hlindftikq mrqgaflvna argglvdeka laqalkegri rgaaldvhes
301 epfsfaqgpl kdapnlictp htawyseqas lemreaaate irraitgrip eslrncvnke
361 ffvtsapwsv idqqaihpel ngatyryppg ivgvapgglp aamegiipgg ipvthnlptv
421 ahpsqapspn qptkhgdnre hpneq
//
