LOCUS NP_001287752 599 aa linear PRI 19-MAR-2023
DEFINITION PR domain zinc finger protein 5 isoform 2 [Homo sapiens].
ACCESSION NP_001287752 XP_005262763
VERSION NP_001287752.1
DBSOURCE REFSEQ: accession NM_001300823.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 599)
AUTHORS Ren Y, Wang Y, Fang L, Ma M, Ge L, Su C, Xin L, He J, Yang J and
Liu X.
TITLE Deregulation of PRDM5 promotes cell proliferation by regulating
JAK/STAT signaling pathway through SOCS1 in human lung
adenocarcinoma
JOURNAL Cancer Med 12 (4), 4568-4578 (2023)
PUBMED 36127737
REMARK GeneRIF: Deregulation of PRDM5 promotes cell proliferation by
regulating JAK/STAT signaling pathway through SOCS1 in human lung
adenocarcinoma.
REFERENCE 2 (residues 1 to 599)
AUTHORS Guo J, Yang Q, Wei S, Shao J, Zhao T, Guo L, Liu J, Chen J and Wang
G.
TITLE Low expression of PRDM5 predicts poor prognosis of esophageal
squamous cell carcinoma
JOURNAL BMC Cancer 22 (1), 745 (2022)
PUBMED 35799142
REMARK GeneRIF: Low expression of PRDM5 predicts poor prognosis of
esophageal squamous cell carcinoma.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 599)
AUTHORS Zhang C, Liu Z, Sheng Y, Wu B, Song Y, Ye G, Qi Y and Zhao S.
TITLE PRDM5 suppresses oesophageal squamous carcinoma cells and modulates
14-3-3zeta/Akt signalling pathway
JOURNAL Clin Exp Pharmacol Physiol 49 (3), 370-379 (2022)
PUBMED 34757658
REMARK GeneRIF: PRDM5 suppresses oesophageal squamous carcinoma cells and
modulates 14-3-3zeta/Akt signalling pathway.
REFERENCE 4 (residues 1 to 599)
AUTHORS Dhooge T, Van Damme T, Syx D, Mosquera LM, Nampoothiri S,
Radhakrishnan A, Simsek-Kiper PO, Utine GE, Bonduelle M, Migeotte
I, Essawi O, Ceylaner S, Al Kindy A, Tinkle B, Symoens S and
Malfait F.
TITLE More than meets the eye: Expanding and reviewing the clinical and
mutational spectrum of brittle cornea syndrome
JOURNAL Hum Mutat 42 (6), 711-730 (2021)
PUBMED 33739556
REMARK GeneRIF: More than meets the eye: Expanding and reviewing the
clinical and mutational spectrum of brittle cornea syndrome.
Review article
REFERENCE 5 (residues 1 to 599)
AUTHORS Wang X, Chang H, Gao G, Su B, Deng Q, Zhou H, Wang Q, Lin Y and
Ding Y.
TITLE Silencing of PRDM5 increases cell proliferation and inhibits cell
apoptosis in glioma
JOURNAL Int J Neurosci 131 (2), 144-153 (2021)
PUBMED 32083978
REMARK GeneRIF: Silencing of PRDM5 increases cell proliferation and
inhibits cell apoptosis in glioma.
REFERENCE 6 (residues 1 to 599)
AUTHORS Duan Z, Person RE, Lee HH, Huang S, Donadieu J, Badolato R, Grimes
HL, Papayannopoulou T and Horwitz MS.
TITLE Epigenetic regulation of protein-coding and microRNA genes by the
Gfi1-interacting tumor suppressor PRDM5
JOURNAL Mol Cell Biol 27 (19), 6889-6902 (2007)
PUBMED 17636019
REMARK GeneRIF: Results identify PRDM5, which acts as a sequence-specific,
DNA binding transcription factor that targets
hematopoiesis-associated protein-coding and microRNA genes, some of
which are targets of Gfi1.
REFERENCE 7 (residues 1 to 599)
AUTHORS Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M,
Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y,
Imai K, Itoh F and Tokino T.
TITLE PRDM5 identified as a target of epigenetic silencing in colorectal
and gastric cancer
JOURNAL Clin Cancer Res 13 (16), 4786-4794 (2007)
PUBMED 17699856
REMARK GeneRIF: Data suggest that epigenetic alteration of PRDM5 (e.g.,
methylation of its 5'-CpG island or trimethylation of Lys(27) of
histone H3) likely plays a key role in the progression of
gastrointestinal cancers and may be a useful molecular marker.
REFERENCE 8 (residues 1 to 599)
AUTHORS Deng Q and Huang S.
TITLE PRDM5 is silenced in human cancers and has growth suppressive
activities
JOURNAL Oncogene 23 (28), 4903-4910 (2004)
PUBMED 15077163
REMARK GeneRIF: PRDM5 caused G2/M arrest and apoptosis upon infection of
tumor cells. These results suggest that inactivation of PRDM5 may
play a role in carcinogenesis.
REFERENCE 9 (residues 1 to 599)
AUTHORS Xiao B, Wilson JR and Gamblin SJ.
TITLE SET domains and histone methylation
JOURNAL Curr Opin Struct Biol 13 (6), 699-705 (2003)
PUBMED 14675547
REMARK Review article
REFERENCE 10 (residues 1 to 599)
AUTHORS Jiang GL and Huang S.
TITLE The yin-yang of PR-domain family genes in tumorigenesis
JOURNAL Histol Histopathol 15 (1), 109-117 (2000)
PUBMED 10668202
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC104795.1, AC104068.3 and
AC025741.5.
On Jul 15, 2014 this sequence version replaced XP_005262763.1.
Summary: The protein encoded by this gene is a transcription factor
of the PR-domain protein family. It contains a PR-domain and
multiple zinc finger motifs. Transcription factors of the PR-domain
family are known to be involved in cell differentiation and
tumorigenesis. [provided by RefSeq, Jul 2008].
Sequence Note:.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC121037.1, SRR11853561.22560.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..599
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q27"
Protein 1..599
/product="PR domain zinc finger protein 5 isoform 2"
/EC_number="2.1.1.-"
/note="PR domain zinc finger protein 5; PR domain
containing 5; PR domain 5"
/calculated_mol_wt=69731
Region 2..128
/region_name="PR-SET_PRDM5"
/note="PR-SET domain found in PR domain zinc finger
protein 5 (PRDM5) and similar proteins; cd19190"
/db_xref="CDD:380967"
Site order(19..21,38,55..59,70,83..87,89,98..99,123..124)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:380967"
Site order(19..21,55..56,83..87,89,123)
/site_type="other"
/note="putative SAM binding site"
/db_xref="CDD:380967"
Region 169..190
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 174..589
/region_name="COG5048"
/note="FOG: Zn-finger [General function prediction only]"
/db_xref="CDD:227381"
Region 201..221
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 233..256
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 266..286
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 291..311
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 319..339
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(324,326,328,330..331,334..335,338,352,354,358..359,
362..363,366,380,382,384,386..387,390..391,394)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 347..367
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 375..395
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 403..420
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 432..452
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 460..480
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(465,467,469,471..472,475..476,479,493,495,499..500,
503..504,507,521,523,525,527..528,531..532,535)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 488..508
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 516..536
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 544..564
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 573..594
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
CDS 1..599
/gene="PRDM5"
/gene_synonym="BCS2; PFM2"
/coded_by="NM_001300823.2:119..1918"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS75188.1"
/db_xref="GeneID:11107"
/db_xref="HGNC:HGNC:9349"
/db_xref="MIM:614161"
ORIGIN
1 mlgmyvpdrf slkssrvqdg mglytarrvr kgekfgpfag ekrmpedlde nmdyrlmwev
61 rgskgevlyi ldatnprhsn wlrfvheaps qeqknlaaiq egenifylav edietdtell
121 igyldsdmea eeeeqqimtv ikegevensr rqstagrkdr lgckedyacp qcessftsed
181 ilaehlqtlh qkpteekefk ckncgkkfpv kqalqrhfeq hqetcrgdar fvckadscgk
241 rlkskdalkr hqenvhtgdp kkklicsvcn kkcssasslq ehrkiheifd cqecmkkfis
301 anqlkrhmit hsekrpynce icnksfkrld qvgahkvihs edkpykcklc gkgfahrnvy
361 knhkkthsee rpfqceecka lfrtpfslqr hllihnsert fkchhcdatf krkdtlnvhv
421 qvvherhkky rcelcnkafv tpsvlrshkk thtgekekic pycgqkfass gtlrvhirsh
481 tgerpyqcpy cekgfskndg lkmhirthtr ekpykcsecs kafsqkrgld ehkrthtgek
541 pfqcdvcdla fslkkmlirh kmthnpnrpl aecqfchkkf trndylkvhm dnihgvads
//
