LOCUS NP_001293142 870 aa linear PRI 22-SEP-2023
DEFINITION thrombospondin-4 isoform b [Homo sapiens].
ACCESSION NP_001293142
VERSION NP_001293142.1
DBSOURCE REFSEQ: accession NM_001306213.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 870)
AUTHORS Maemets-Allas K, Klaas M, Cardenas-Leon CG, Arak T, Kankuri E and
Jaks V.
TITLE Stimulation with THBS4 activates pathways that regulate
proliferation, migration and inflammation in primary human
keratinocytes
JOURNAL Biochem Biophys Res Commun 642, 97-106 (2023)
PUBMED 36566568
REMARK GeneRIF: Stimulation with THBS4 activates pathways that regulate
proliferation, migration and inflammation in primary human
keratinocytes.
REFERENCE 2 (residues 1 to 870)
AUTHORS Andres Sastre E, Maly K, Zhu M, Witte-Bouma J, Trompet D, Bohm AM,
Brachvogel B, van Nieuwenhoven CA, Maes C, van Osch GJVM, Zaucke F
and Farrell E.
TITLE Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage
during endochondral bone formation and repair
JOURNAL Bone 150, 115999 (2021)
PUBMED 33971315
REMARK GeneRIF: Spatiotemporal distribution of thrombospondin-4 and -5 in
cartilage during endochondral bone formation and repair.
REFERENCE 3 (residues 1 to 870)
AUTHORS He L, Wang W, Shi H, Jiang C, Yao H, Zhang Y, Qian W and Lin R.
TITLE THBS4/integrin alpha2 axis mediates BM-MSCs to promote angiogenesis
in gastric cancer associated with chronic Helicobacter pylori
infection
JOURNAL Aging (Albany NY) 13 (15), 19375-19396 (2021)
PUBMED 34390328
REMARK GeneRIF: THBS4/integrin alpha2 axis mediates BM-MSCs to promote
angiogenesis in gastric cancer associated with chronic Helicobacter
pylori infection.
REFERENCE 4 (residues 1 to 870)
AUTHORS Harada J, Miyata Y, Araki K, Matsuda T, Nagashima Y, Mukae Y,
Mitsunari K, Matsuo T, Ohba K, Mochizuki Y and Sakai H.
TITLE Pathological Significance and Prognostic Roles of Thrombospondin-3,
4 and 5 in Bladder Cancer
JOURNAL In Vivo 35 (3), 1693-1701 (2021)
PUBMED 33910854
REMARK GeneRIF: Pathological Significance and Prognostic Roles of
Thrombospondin-3, 4 and 5 in Bladder Cancer.
REFERENCE 5 (residues 1 to 870)
AUTHORS Newton G, Weremowicz S, Morton CC, Jenkins NA, Gilbert DJ, Copeland
NG and Lawler J.
TITLE The thrombospondin-4 gene
JOURNAL Mamm Genome 10 (10), 1010-1016 (1999)
PUBMED 10501972
REFERENCE 6 (residues 1 to 870)
AUTHORS Arber S and Caroni P.
TITLE Thrombospondin-4, an extracellular matrix protein expressed in the
developing and adult nervous system promotes neurite outgrowth
JOURNAL J Cell Biol 131 (4), 1083-1094 (1995)
PUBMED 7490284
REMARK GeneRIF: The functional analysis of the rat counterpart.
REFERENCE 7 (residues 1 to 870)
AUTHORS Lawler J, McHenry K, Duquette M and Derick L.
TITLE Characterization of human thrombospondin-4
JOURNAL J Biol Chem 270 (6), 2809-2814 (1995)
PUBMED 7852353
REFERENCE 8 (residues 1 to 870)
AUTHORS Adams JC and Lawler J.
TITLE Cell-type specific adhesive interactions of skeletal myoblasts with
thrombospondin-1
JOURNAL Mol Biol Cell 5 (4), 423-437 (1994)
PUBMED 7519904
REFERENCE 9 (residues 1 to 870)
AUTHORS Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K and
DeSimone DW.
TITLE Identification and characterization of thrombospondin-4, a new
member of the thrombospondin gene family
JOURNAL J Cell Biol 120 (4), 1059-1067 (1993)
PUBMED 8432726
REFERENCE 10 (residues 1 to 870)
AUTHORS McLaren,K.M.
TITLE Immunohistochemical localisation of thrombospondin in human
megakaryocytes and platelets
JOURNAL J Clin Pathol 36 (2), 197-199 (1983)
PUBMED 6338048
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC342285.1, DC310687.1,
DC376500.1 and BC050456.1.
Summary: The protein encoded by this gene belongs to the
thrombospondin protein family. Thrombospondin family members are
adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix
interactions. This protein forms a pentamer and can bind to heparin
and calcium. It is involved in local signaling in the developing
and adult nervous system, and it contributes to spinal
sensitization and neuropathic pain states. This gene is activated
during the stromal response to invasive breast cancer. It may also
play a role in inflammatory responses in Alzheimer's disease.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Apr 2015].
Transcript Variant: This variant (3) contains alternate 5' exon
structure, and it thus differs in the 5' UTR and initiates
translation at a downstream in-frame start codon, compared to
variant 1. The encoded isoform (b) is shorter at the N-terminus,
compared to isoform a. Variants 2, 3 and 4 all encode isoform b.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038196.687617.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..870
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q14.1"
Protein 1..870
/product="thrombospondin-4 isoform b"
/calculated_mol_wt=95875
Region <1..101
/region_name="LamG"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; cl22861"
/db_xref="CDD:451433"
Region 128..171
/region_name="coiled coil"
/note="coiled coil [structural motif]"
/db_xref="CDD:293926"
Region 128..171
/region_name="TSP-4cc"
/note="Coiled coil region of thrombospondin-4 (TSP-4);
cd16080"
/db_xref="CDD:293926"
Site order(128..133,135..140,143,145..147,149..151,153..154,
156..161,163..165,167..170)
/site_type="other"
/note="oligomer interface [polypeptide binding]"
/db_xref="CDD:293926"
Site order(139,150,153)
/site_type="other"
/note="chemical substrate binding site [chemical binding]"
/db_xref="CDD:293926"
Region 199..229
/region_name="EGF"
/note="EGF-like domain; pfam00008"
/db_xref="CDD:394967"
Region 235..269
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site order(235,238,252)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region 288..322
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site order(288,291,305)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region 405..440
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 405..440
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275366"
Region 441..463
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275366"
Region 464..499
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275365"
Region 500..522
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275365"
Region 523..560
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275365"
Region 524..560
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 561..600
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275366"
Region 601..635
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 601..632
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275365"
Region 654..851
/region_name="TSP_C"
/note="Thrombospondin C-terminal region; pfam05735"
/db_xref="CDD:428609"
CDS 1..870
/gene="THBS4"
/gene_synonym="TSP-4; TSP4"
/coded_by="NM_001306213.2:363..2975"
/note="isoform b is encoded by transcript variant 3"
/db_xref="CCDS:CCDS78027.1"
/db_xref="GeneID:7060"
/db_xref="HGNC:HGNC:11788"
/db_xref="MIM:600715"
ORIGIN
1 mgrlnkailr ylkndgkvhl vvfnnlqlad grrhrillrl snlqrgagsl elyldciqvd
61 svhnlprafa gpsqkpetie lrtfqrkpqd fleelklvvr gslfqvaslq dcflqqsepl
121 aatgtgdfnr qflgqmtqln qllgevkdll rqqvketsfl rntiaecqac gplkfqsptp
181 stvvppappa pptrpprrcd snpcfrgvqc tdsrdgfqcg pcpegytgng itcidvdeck
241 yhpcypgvhc inlspgfrcd acpvgftgpm vqgvgisfak snkqvctdid ecrngacvpn
301 sicvntlgsy rcgpckpgyt gdqirgckae rncrnpelnp csvnaqciee rqgdvtcvcg
361 vgwagdgyic gkdvdidsyp deelpcsarn ckkdnckyvp nsgqedadrd gigdacdeda
421 dgdgilneqd ncvlihnvdq rnsdkdifgd acdnclsvln ndqkdtdgdg rgdacdddmd
481 gdgiknildn cpkfpnrdqr dkdgdgvgda cdscpdvsnp nqsdvdndlv gdscdtnqds
541 dgdghqdstd ncptvinsaq ldtdkdgigd ecdddddndg ipdlvppgpd ncrlvpnpaq
601 edsnsdgvgd icesdfdqdq vidridvcpe naevtltdfr ayqtvvldpe gdaqidpnwv
661 vlnqgmeivq tmnsdpglav gytafngvdf egtfhvntqt dddyagfifg yqdsssfyvv
721 mwkqteqtyw qatpfravae pgiqlkavks ktgpgehlrn slwhtgdtsd qvrllwkdsr
781 nvgwkdkvsy rwflqhrpqv gyirvrfyeg selvadsgvt idttmrggrl gvfcfsqeni
841 iwsnlkyrcn dtipedfqef qtqnfdrfdn
//
