GenomeNet

Database: RefSeq
Entry: NP_001300740
LinkDB: NP_001300740
Original site: NP_001300740 
LOCUS       NP_001300740            2634 aa            linear   VRT 27-JAN-2019
DEFINITION  inositol 1,4,5-trisphosphate receptor type 3 [Danio rerio].
ACCESSION   NP_001300740
VERSION     NP_001300740.1
DBSOURCE    REFSEQ: accession NM_001313811.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Cyprinidae; Danio.
REFERENCE   1  (residues 1 to 2634)
  AUTHORS   Henke K, Daane JM, Hawkins MB, Dooley CM, Busch-Nentwich EM,
            Stemple DL and Harris MP.
  TITLE     Genetic Screen for Postembryonic Development in the Zebrafish
            (Danio rerio): Dominant Mutations Affecting Adult Form
  JOURNAL   Genetics 207 (2), 609-623 (2017)
   PUBMED   28835471
REFERENCE   2  (residues 1 to 2634)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2634)
  AUTHORS   Yartseva V, Takacs CM, Vejnar CE, Lee MT and Giraldez AJ.
  TITLE     RESA identifies mRNA-regulatory sequences at high resolution
  JOURNAL   Nat. Methods 14 (2), 201-207 (2017)
   PUBMED   28024160
REFERENCE   4  (residues 1 to 2634)
  AUTHORS   Albasanz JL, Santana S, Guzman-Sanchez F, Leon D, Burgos JS and
            Martin M.
  TITLE     2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates
            Metabotropic Glutamate 5 Receptors Endogenously Expressed in
            Zebrafish Brain
  JOURNAL   ACS Chem Neurosci 7 (12), 1690-1697 (2016)
   PUBMED   27635438
REFERENCE   5  (residues 1 to 2634)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2634)
  AUTHORS   Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris
            PC, Torres VE and Ehrlich BE.
  TITLE     Polycystin-2 mutations lead to impaired calcium cycling in the
            heart and predispose to dilated cardiomyopathy
  JOURNAL   J. Mol. Cell. Cardiol. 58, 199-208 (2013)
   PUBMED   23376035
REFERENCE   7  (residues 1 to 2634)
  AUTHORS   Bohne A, Darras A, D'Cotta H, Baroiller JF, Galiana-Arnoux D and
            Volff JN.
  TITLE     The vertebrate makorin ubiquitin ligase gene family has been shaped
            by large-scale duplication and retroposition from an ancestral
            gonad-specific, maternal-effect gene
  JOURNAL   BMC Genomics 11, 721 (2010)
   PUBMED   21172006
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 2634)
  AUTHORS   Sato Y, Hashiguchi Y and Nishida M.
  TITLE     Temporal pattern of loss/persistence of duplicate genes involved in
            signal transduction and metabolic pathways after teleost-specific
            genome duplication
  JOURNAL   BMC Evol. Biol. 9, 127 (2009)
   PUBMED   19500364
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 2634)
  AUTHORS   Petko JA, Kabbani N, Frey C, Woll M, Hickey K, Craig M, Canfield VA
            and Levenson R.
  TITLE     Proteomic and functional analysis of NCS-1 binding proteins reveals
            novel signaling pathways required for inner ear development in
            zebrafish
  JOURNAL   BMC Neurosci 10, 27 (2009)
   PUBMED   19320994
  REMARK    GeneRIF: findings reveal a novel signalling pathway involved in
            development of the semicircular canal system, and suggest a
            previously unrecognized role for NCS-1 in mitochondrial function
            via its association with several mitochondrial proteins.
            Publication Status: Online-Only
REFERENCE   10 (residues 1 to 2634)
  AUTHORS   Ashworth R, Devogelaere B, Fabes J, Tunwell RE, Koh KR, De Smedt H
            and Patel S.
  TITLE     Molecular and functional characterization of inositol trisphosphate
            receptors during early zebrafish development
  JOURNAL   J. Biol. Chem. 282 (19), 13984-13993 (2007)
   PUBMED   17331947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX784023.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     Protein         1..2634
                     /product="inositol 1,4,5-trisphosphate receptor type 3"
                     /note="inositol 1,4,5-triphosphate receptor, type 3"
                     /calculated_mol_wt=301641
     Region          6..226
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:285871"
     Region          233..289
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          235..428
                     /region_name="MIR"
                     /note="MIR domain; pfam02815"
                     /db_xref="CDD:280906"
     Region          296..>333
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          471..661
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:279676"
     Region          1168..1310
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:279676"
     Region          1838..1943
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:285630"
     Region          2151..>2340
                     /region_name="glyco_rpt_poly"
                     /note="oligosaccharide repeat unit polymerase; TIGR04370"
                     /db_xref="CDD:275163"
     Region          2151..>2184
                     /region_name="PAP2_like"
                     /note="PAP2_like proteins, a super-family of histidine
                     phosphatases and vanadium haloperoxidases, includes type 2
                     phosphatidic acid phosphatase or lipid phosphate
                     phosphatase (LPP), Glucose-6-phosphatase,
                     Phosphatidylglycerophosphatase B and bacterial acid...;
                     cl00474"
                     /db_xref="CDD:294324"
     Region          <2277..2474
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:278921"
     CDS             1..2634
                     /gene="itpr3"
                     /gene_synonym="si:dkey-163f12.8"
                     /coded_by="NM_001313811.1:396..8300"
                     /db_xref="GeneID:794666"
                     /db_xref="ZFIN:ZDB-GENE-070605-1"
ORIGIN      
        1 msdsassflh igdivslyae gtvngfistl glvddrcvve pasgdlenpp kkfrdclfkv
       61 ypmnrysaqk qfwkakqakh ekdkigdmvl lqklqhaanl eqkqndaenk kvhgdvvkyg
      121 sviqllhmks nkyltvnkrl palleknamr vtldgtgneg swlfiqpfwk lrangdnvvv
      181 gdkvilnpvn agqplhassy elpdhsgcke insvnsntsw kislfmmfsd hkdevlkggd
      241 vvrlfhaeqe kfltcdeyks klhvflrttl rqsatsatss nalwevevvh hdpcrggagh
      301 wnslyrfkhl atgnylaaee npgykensnd ievdssrikr slgerikykl vavphgndia
      361 slfeldpttl qktdsfvprn syvrfrhlct ntwiqstnip idideerpir lmlgtcptke
      421 dkeafaivsv pvmeirdldf andaslmlst vvekfkygfl spndrryaik lledvvffvv
      481 dqlnngqpal evsmnkpnre rqklmreqni lkqifgiika pfkergddpp lltleelsdq
      541 kyllyqymlr lcyrvlrhsq edyrknqeyi akqfgmmqsq igydilaedt itallhnnrk
      601 llekhitkte vetfvslvrk nreprfldyl sdlcvsnnva ipvtqelick cvlnaknqdi
      661 lmkterraak esqhtseyle efgdedevwl iwsekenenh eksirqlaqe arqgnvhden
      721 vltyyryqlk lfarmcfdrq ylaidviskq ldielislcm mdetlpfdlr asfcrlmlha
      781 hvdrdpqelv tpikfarlwt eiptsisikd ydshldysrd nkknkfantm afmeeylnnv
      841 liddlpfane eknkltyevv slarhliyfg fysffellrl trtllgiidc tpsnasinpl
      901 fnddgsgknv rrsihgmgqm mstmvlnrkp slfsapgrtg dsqvgskdsi dtqditvmdt
      961 klkileilqf ilsvrldyrl sfllsvfkke fvdvypmeda dathhtehea sinlqhigeq
     1021 aeamfgigkg nsilevddeg grmflrvlih limhdypplv sgalqllfkh fsqrqevlht
     1081 fkqvqllist qdvdnykhik rdldllrtmv ekselwvikk sssggdgkkd kkdkkepeav
     1141 speeeadskk qtteksnesy qnvkeilerl nkmcssgvfk kqqrllknmg ahkvmldllq
     1201 isydrndtkm leiikythlf lqkfctgnle nqallhkhln lfltprllea etmqqifsnn
     1261 fqlcseises vlhhfihcla tqgrhiqyln flhtiikaeg kyvkkcqdmi mteltsagdd
     1321 vvvlytddts fntmvelmtq sregvkddsp lryhislvel laacaegknv yteikctsll
     1381 pleemvkvit hedcitevki ayvnfvnhcy vdtevemkei ytsnhiwklf enftvdmarv
     1441 csnrekrmsd pvlekyviqv vldtvtaffs spfsenstst eahhttvkql lqstmrlldc
     1501 pwlqpqqkvq vescirtlav ttksrsiplp veleahvnmm lshsnsltls rsshsnksms
     1561 rltrpaaptn pwdykniiek lqdiintlee rvmplvnael svlvdvlhqp ellflegtda
     1621 rsrcesggfi skliqhtkal mnsdeklcik vlrtlqemli reldfdekgf alrkvllqny
     1681 lynnkknika elvehaggae gerdwltvaa lqcrldkegg tklftdlits tknekifqes
     1741 iqlaiclleg gnteiqnsfy klmmgdnkse kffkvlndrm knaqldikst vsvnvgemsn
     1801 kakddkdlet ggvssfgqpe pqpeqqevet emgpsvtimk pilrflqllc enhnqdlqnf
     1861 lriqnnktny nlvsetlqfl dimcgsttgg lgllglyine nnvelitqtl etlteycqgp
     1921 cqenqtcivs hecngidiit alilndispl cryrmelvlq lkdnasklll almesrhdse
     1981 naerilfnlr prelvelikk aylqegecke gevsprevgh niyilalqla rhnkvlltll
     2041 kpvkkikeee eesissmlnl nkqqeeeked plehydrqta qieivredrs meqivfpvhp
     2101 iceflteesk frvfttteqd eqgskvtnff eqtsflhnem ewqkklrsmp vlywfsrrms
     2161 lwgtisfnla vfinliialf yphdsghsgs idsslllmgf wcfaglavlg llfkrygfqs
     2221 ltvaitlrci yhfgigptll llgalnlink ivylvsfvgn ngtfimgyka mvmdveflyh
     2281 vayvltsslg lfvheffysi llfdliyree tlfnviksvt rngrsillta vlaiilvylf
     2341 sivgflflrn dfimevdhla spapgdtesf msscssdgid cteetgllap aededntera
     2401 cdtllmciit vlnhglrngg gvgdvlrkps kneplfparv vydllfyfiv iiivlnlifg
     2461 viidtfadlr sekqkkeevl kttcficgle rdkfdnktvs feehiklehn iwnylyfivl
     2521 ireknktdyt gpesyvalmi knknldwfpr mqamslvvtd gdgeqnemrn lqdrlsstmk
     2581 vvtqltsqlt elkeqmteqr krrqrmgfvd vqsgsnpgmp vppspaggnq vyka
//
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