GenomeNet

Database: RefSeq
Entry: NP_001305296
LinkDB: NP_001305296
Original site: NP_001305296 
LOCUS       NP_001305296             219 aa            linear   PRI 30-APR-2025
DEFINITION  anaphase-promoting complex subunit 10 isoform 5 [Homo sapiens].
ACCESSION   NP_001305296 XP_011529824
VERSION     NP_001305296.1
DBSOURCE    REFSEQ: accession NM_001318367.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 219)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   2  (residues 1 to 219)
  AUTHORS   Wang,Y., Han,T., Gan,M., Guo,M., Xie,C., Jin,J., Zhang,S., Wang,P.,
            Cao,J. and Wang,J.B.
  TITLE     A novel function of anaphase promoting complex subunit 10 in tumor
            progression in non-small cell lung cancer
  JOURNAL   Cell Cycle 18 (9), 1019-1032 (2019)
   PUBMED   31023143
  REMARK    GeneRIF: APC10 was overexpressed in non-small cell lung cancer cell
            lines compared to human bronchial epithelial cell lines. APC10 was
            shown to interact with GAC; knocking down APC10 downregulated
            glutamine metabolism to induce autophagy, resulting in effective
            inhibition of the proliferation and migration of non-small cell
            lung cancer cells.
REFERENCE   3  (residues 1 to 219)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (residues 1 to 219)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   5  (residues 1 to 219)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   6  (residues 1 to 219)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   7  (residues 1 to 219)
  AUTHORS   Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
            Peters,J.M.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol Biol Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   8  (residues 1 to 219)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   9  (residues 1 to 219)
  AUTHORS   Kurasawa,Y. and Todokoro,K.
  TITLE     Identification of human APC10/Doc1 as a subunit of anaphase
            promoting complex
  JOURNAL   Oncogene 18 (37), 5131-5137 (1999)
   PUBMED   10498862
REFERENCE   10 (residues 1 to 219)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI913723.1, AC096757.3, AB012109.1, AC097649.3 and AW025455.1.
            
            On Jan 5, 2016 this sequence version replaced XP_011529824.1.
            
            Summary: ANAPC10 is a core subunit of the anaphase-promoting
            complex (APC), or cyclosome, a ubiquitin protein ligase that is
            essential for progression through the cell cycle. APC initiates
            sister chromatid separation by ubiquitinating the anaphase
            inhibitor securin (PTTG1; MIM 604147) and triggers exit from
            mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the
            activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940)
            (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by
            OMIM, Feb 2011].
            
            Transcript Variant: This variant (10) contains an alternate 5'
            terminal exon compared to variant 1. This difference results in a
            distinct 5' UTR, translation initiation at an alternate start
            codon, and a novel 5' coding region compared to variant 1. The
            encoded isoform (5) is longer and has a distinct N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI913723.1, SRR18074969.3292745.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     Protein         1..219
                     /product="anaphase-promoting complex subunit 10 isoform 5"
                     /note="cyclosome subunit 10"
                     /calculated_mol_wt=25101
     Region          38..217
                     /region_name="ANAPC10"
                     /note="Anaphase-promoting complex, subunit 10 (APC10);
                     pfam03256"
                     /db_xref="CDD:367420"
     Site            order(87,114,121,123,186)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176484"
     CDS             1..219
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /coded_by="NM_001318367.2:49..708"
                     /note="isoform 5 is encoded by transcript variant 10"
                     /db_xref="GeneID:10393"
                     /db_xref="HGNC:HGNC:24077"
                     /db_xref="MIM:613745"
ORIGIN      
        1 mrstflewas yslqnleaif ltlssmvray nilkmttpnk tppgadpkql ertgtvreig
       61 sqavwslssc kpgfgvdqlr ddnletywqs dgsqphlvni qfrrkttvkt lciyadyksd
      121 esytpskisv rvgnnfhnlq eirqlelvep sgwihvpltd nhkkptrtfm iqiavlanhq
      181 ngrdthmrqi kiytpveess igkfprctti dfmmyrsir
//
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