LOCUS NP_001423 169 aa linear PRI 16-SEP-2023
DEFINITION proepiregulin preproprotein [Homo sapiens].
ACCESSION NP_001423
VERSION NP_001423.1
DBSOURCE REFSEQ: accession NM_001432.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 169)
AUTHORS Liu X, Qin L, Li W and Fei F.
TITLE MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation
and metastasis of human multiple myeloma cells
JOURNAL Acta Biochim Pol 70 (2), 389-393 (2023)
PUBMED 37329522
REMARK GeneRIF: MicroRNA-1179 targets Epiregulin (EREG) regulates the
proliferation and metastasis of human multiple myeloma cells.
REFERENCE 2 (residues 1 to 169)
AUTHORS Zheng,L., Wang,X.I., Chen,S., Moosvi,A.M., Wan,D.Q. and Zhang,S.
TITLE Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and
ER: A Diagnostic Pitfall
JOURNAL Int J Gynecol Pathol 42 (3), 234-240 (2023)
PUBMED 36730878
REMARK GeneRIF: Two Cases of Biphasic Synovial Sarcoma With Expression of
PAX8 and ER: A Diagnostic Pitfall.
REFERENCE 3 (residues 1 to 169)
AUTHORS Zhang L, Nan F, Yang L, Dong Y and Tian Y.
TITLE Differentially expressed EREG and SPP1 are independent prognostic
markers in cervical squamous cell carcinoma
JOURNAL J Obstet Gynaecol Res 48 (7), 1848-1858 (2022)
PUBMED 35491469
REMARK GeneRIF: Differentially expressed EREG and SPP1 are independent
prognostic markers in cervical squamous cell carcinoma.
REFERENCE 4 (residues 1 to 169)
AUTHORS Zhang Y, Qiu F, Ye T, Lee SH, Xu J, Jia L, Zeng R, Wang X, Hu X,
Yan X, Li H, Lu Y, Wang X, Jiang R and Xu W.
TITLE Epiregulin increases stemness-associated genes expression and
promotes chemoresistance of non-small cell lung cancer via ERK
signaling
JOURNAL Stem Cell Res Ther 13 (1), 197 (2022)
PUBMED 35551652
REMARK GeneRIF: Epiregulin increases stemness-associated genes expression
and promotes chemoresistance of non-small cell lung cancer via ERK
signaling.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 169)
AUTHORS Kumbrink J, Li P, Pok-Udvari A, Klauschen F, Kirchner T and Jung A.
TITLE p130Cas Is Correlated with EREG Expression and a Prognostic Factor
Depending on Colorectal Cancer Stage and Localization Reducing
FOLFIRI Efficacy
JOURNAL Int J Mol Sci 22 (22), 12364 (2021)
PUBMED 34830244
REMARK GeneRIF: p130Cas Is Correlated with EREG Expression and a
Prognostic Factor Depending on Colorectal Cancer Stage and
Localization Reducing FOLFIRI Efficacy.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 169)
AUTHORS Riese DJ 2nd and Cullum RL.
TITLE Epiregulin: roles in normal physiology and cancer
JOURNAL Semin Cell Dev Biol 28, 49-56 (2014)
PUBMED 24631357
REMARK Review article
REFERENCE 7 (residues 1 to 169)
AUTHORS Riese DJ 2nd, Komurasaki T, Plowman GD and Stern DF.
TITLE Activation of ErbB4 by the bifunctional epidermal growth factor
family hormone epiregulin is regulated by ErbB2
JOURNAL J Biol Chem 273 (18), 11288-11294 (1998)
PUBMED 9556621
REFERENCE 8 (residues 1 to 169)
AUTHORS Shelly M, Pinkas-Kramarski R, Guarino BC, Waterman H, Wang LM,
Lyass L, Alimandi M, Kuo A, Bacus SS, Pierce JH, Andrews GC and
Yarden Y.
TITLE Epiregulin is a potent pan-ErbB ligand that preferentially
activates heterodimeric receptor complexes
JOURNAL J Biol Chem 273 (17), 10496-10505 (1998)
PUBMED 9553109
REFERENCE 9 (residues 1 to 169)
AUTHORS Komurasaki T, Toyoda H, Uchida D and Morimoto S.
TITLE Epiregulin binds to epidermal growth factor receptor and ErbB-4 and
induces tyrosine phosphorylation of epidermal growth factor
receptor, ErbB-2, ErbB-3 and ErbB-4
JOURNAL Oncogene 15 (23), 2841-2848 (1997)
PUBMED 9419975
REFERENCE 10 (residues 1 to 169)
AUTHORS Toyoda H, Komurasaki T, Uchida D and Morimoto S.
TITLE Distribution of mRNA for human epiregulin, a differentially
expressed member of the epidermal growth factor family
JOURNAL Biochem J 326 (Pt 1) (Pt 1), 69-75 (1997)
PUBMED 9337852
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from D30783.1 and AC021180.6.
Summary: This gene encodes a secreted peptide hormone and member of
the epidermal growth factor (EGF) family of proteins. The encoded
protein is a ligand of the epidermal growth factor receptor (EGFR)
and the structurally related erb-b2 receptor tyrosine kinase 4
(ERBB4). The encoded protein may be involved in a wide range of
biological processes including inflammation, wound healing, oocyte
maturation, and cell proliferation. Additionally, the encoded
protein may promote the progression of cancers of various human
tissues. [provided by RefSeq, Jul 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D30783.1, BC136404.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1966682, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000244869.3/ ENSP00000244869.2
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..169
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q13.3"
Protein 1..169
/product="proepiregulin preproprotein"
/note="proepiregulin"
/calculated_mol_wt=15889
sig_peptide 1..29
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O14944.1)"
/calculated_mol_wt=3173
mat_peptide 30..169
/product="Proepiregulin. /id=PRO_0000302800"
/note="propagated from UniProtKB/Swiss-Prot (O14944.1)"
/calculated_mol_wt=15889
Site 47
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O14944.1)"
mat_peptide 63..108
/product="Epiregulin. /id=PRO_0000007557"
/note="propagated from UniProtKB/Swiss-Prot (O14944.1)"
/calculated_mol_wt=5275
Region <64..148
/region_name="PHA03099"
/note="epidermal growth factor-like protein (EGF-like
protein); Provisional"
/db_xref="CDD:165381"
Site 120..140
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (O14944.1)"
CDS 1..169
/gene="EREG"
/gene_synonym="Ep; EPR; ER"
/coded_by="NM_001432.3:165..674"
/db_xref="CCDS:CCDS3564.1"
/db_xref="GeneID:2069"
/db_xref="HGNC:HGNC:3443"
/db_xref="MIM:602061"
ORIGIN
1 mtagrrmeml cagrvpalll clgfhllqav lsttvipsci pgessdncta lvqtednprv
61 aqvsitkcss dmngyclhgq ciylvdmsqn ycrcevgytg vrcehffltv hqplskeyva
121 ltviliilfl itvvgstyyf crwyrnrksk epkkeyervt sgdpelpqv
//
