GenomeNet

Database: RefSeq
Entry: NP_002240
LinkDB: NP_002240
Original site: NP_002240 
LOCUS       NP_002240                731 aa            linear   PRI 25-JUN-2018
DEFINITION  small conductance calcium-activated potassium channel protein 3
            isoform a [Homo sapiens].
ACCESSION   NP_002240
VERSION     NP_002240.3
DBSOURCE    REFSEQ: accession NM_002249.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 731)
  AUTHORS   Gueguinou M, Crottes D, Chantome A, Rapetti-Mauss R,
            Potier-Cartereau M, Clarysse L, Girault A, Fourbon Y, Jezequel P,
            Guerin-Charbonnel C, Fromont G, Martin P, Pellissier B, Schiappa R,
            Chamorey E, Mignen O, Uguen A, Borgese F, Vandier C and Soriani O.
  TITLE     The SigmaR1 chaperone drives breast and colorectal cancer cell
            migration by tuning SK3-dependent Ca(2+) homeostasis
  JOURNAL   Oncogene 36 (25), 3640-3647 (2017)
   PUBMED   28114279
  REMARK    GeneRIF: Analyses of tissue microarray from colorectal cancer
            patients showed higher SigmaR1 expression levels in cancer samples
            and a correlation with tumor grade. Moreover, the exploration of a
            cohort of 4937 breast cancer patients indicated that high
            expression of SigmaR1 and Orai1 channels was significantly
            correlated to a lower overall survival
REFERENCE   2  (residues 1 to 731)
  AUTHORS   Yang M, Camara AKS, Aldakkak M, Kwok WM and Stowe DF.
  TITLE     Identity and function of a cardiac mitochondrial small conductance
            Ca(2+)-activated K(+) channel splice variant
  JOURNAL   Biochim. Biophys. Acta 1858 (6), 442-458 (2017)
   PUBMED   28342809
  REMARK    GeneRIF: A splice variant SK3.2 was found in ventricular myocyte
            mitochondria and its mRNA expression was studied.
REFERENCE   3  (residues 1 to 731)
  AUTHORS   Gueguinou M, Harnois T, Crottes D, Uguen A, Deliot N, Gambade A,
            Chantome A, Haelters JP, Jaffres PA, Jourdan ML, Weber G, Soriani
            O, Bougnoux P, Mignen O, Bourmeyster N, Constantin B, Lecomte T,
            Vandier C and Potier-Cartereau M.
  TITLE     SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell
            migration: a novel opportunity to modulate anti-EGFR mAb action by
            the alkyl-lipid Ohmline
  JOURNAL   Oncotarget 7 (24), 36168-36184 (2016)
   PUBMED   27102434
  REMARK    GeneRIF: Data indicate that the inhibition of the Store Operated
            Calcium Entry (SOCE)-dependent colon cancer cell migration through
            SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a
            strategy to modulate Anti-EGFR mAb action in metastatic colorectal
            cancer (mCRC).
REFERENCE   4  (residues 1 to 731)
  AUTHORS   Koot BG, Alders M, Verheij J, Beuers U and Cobben JM.
  TITLE     A de novo mutation in KCNN3 associated with autosomal dominant
            idiopathic non-cirrhotic portal hypertension
  JOURNAL   J. Hepatol. 64 (4), 974-977 (2016)
   PUBMED   26658685
  REMARK    GeneRIF: KCNN3 gene encodes small conductance calcium-activated
            potassium (SK) channel 3
REFERENCE   5  (residues 1 to 731)
  AUTHORS   Ortega A, Tarazon E, Rosello-Lleti E, Gil-Cayuela C, Lago F,
            Gonzalez-Juanatey JR, Cinca J, Jorge E, Martinez-Dolz L, Portoles M
            and Rivera M.
  TITLE     Patients with Dilated Cardiomyopathy and Sustained Monomorphic
            Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes
            and CACNG8-Linked Left Ventricular Dysfunction
  JOURNAL   PLoS ONE 10 (12), e0145518 (2015)
   PUBMED   26710323
  REMARK    GeneRIF: Patients with Dilated Cardiomyopathy and Sustained
            Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and
            KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 731)
  AUTHORS   Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn
            F, Grissmer S and Morris-Rosendahl DJ.
  TITLE     An apamin- and scyllatoxin-insensitive isoform of the human SK3
            channel
  JOURNAL   Mol. Pharmacol. 65 (3), 788-801 (2004)
   PUBMED   14978258
REFERENCE   7  (residues 1 to 731)
  AUTHORS   Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman
            R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy
            KG, Gargus JJ, Gutman GA and Navon R.
  TITLE     hKCa3/KCNN3 potassium channel gene: association of longer CAG
            repeats with schizophrenia in Israeli Ashkenazi Jews, expression in
            human tissues and localization to chromosome 1q21
  JOURNAL   Mol. Psychiatry 4 (3), 254-260 (1999)
   PUBMED   10395215
REFERENCE   8  (residues 1 to 731)
  AUTHORS   Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH,
            Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ
            and Gargus JJ.
  TITLE     Isolation of a novel potassium channel gene hSKCa3 containing a
            polymorphic CAG repeat: a candidate for schizophrenia and bipolar
            disorder?
  JOURNAL   Mol. Psychiatry 3 (1), 32-37 (1998)
   PUBMED   9491810
REFERENCE   9  (residues 1 to 731)
  AUTHORS   Imbert G, Saudou F, Yvert G, Devys D, Trottier Y, Garnier JM, Weber
            C, Mandel JL, Cancel G, Abbas N, Durr A, Didierjean O, Stevanin G,
            Agid Y and Brice A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat. Genet. 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   10 (residues 1 to 731)
  AUTHORS   Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J
            and Adelman JP.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ251016.1, BC042147.1,
            AL606500.8 and AW135188.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 27, 2006 this sequence version replaced NP_002240.2.
            
            Summary: Action potentials in vertebrate neurons are followed by an
            afterhyperpolarization (AHP) that may persist for several seconds
            and may have profound consequences for the firing pattern of the
            neuron. Each component of the AHP is kinetically distinct and is
            mediated by different calcium-activated potassium channels. This
            gene belongs to the KCNN family of potassium channels. It encodes
            an integral membrane protein that forms a voltage-independent
            calcium-activated channel, which is thought to regulate neuronal
            excitability by contributing to the slow component of synaptic AHP.
            This gene contains two CAG repeat regions in the coding sequence.
            It was thought that expansion of one or both of these repeats could
            lead to an increased susceptibility to schizophrenia or bipolar
            disorder, but studies indicate that this is probably not the case.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (1) encodes isoform a (also known
            as SK3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ251016.1, SRR1803615.98226.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     Protein         1..731
                     /product="small conductance calcium-activated potassium
                     channel protein 3 isoform a"
                     /note="SKCa 3; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3; small
                     conductance calcium-activated potassium channel 3;
                     potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 3"
                     /calculated_mol_wt=81255
     variation       3
                     /replace="i"
                     /db_xref="dbSNP:879156430"
     variation       5
                     /replace="g"
                     /db_xref="dbSNP:764241408"
     variation       5
                     /replace="r"
                     /db_xref="dbSNP:1314820187"
     variation       5
                     /replace="v"
                     /db_xref="dbSNP:753975074"
     variation       6
                     /replace="r"
                     /db_xref="dbSNP:1178786642"
     variation       7
                     /replace="l"
                     /db_xref="dbSNP:1384879010"
     variation       8
                     /replace="h"
                     /db_xref="dbSNP:1334562631"
     variation       10
                     /replace="l"
                     /db_xref="dbSNP:775784556"
     variation       10
                     /replace="p"
                     /db_xref="dbSNP:760919650"
     variation       10
                     /replace="s"
                     /db_xref="dbSNP:1290475271"
     variation       11
                     /replace="e"
                     /db_xref="dbSNP:1379965875"
     variation       11
                     /replace="r"
                     /db_xref="dbSNP:1451894666"
     variation       12
                     /replace="l"
                     /db_xref="dbSNP:1005929642"
     variation       16
                     /replace="e"
                     /db_xref="dbSNP:749427507"
     variation       17
                     /replace="r"
                     /db_xref="dbSNP:773375470"
     variation       19
                     /replace="p"
                     /db_xref="dbSNP:1164271804"
     variation       21
                     /replace="r"
                     /db_xref="dbSNP:772303802"
     variation       24
                     /replace="p"
                     /db_xref="dbSNP:759985849"
     variation       25
                     /replace="s"
                     /db_xref="dbSNP:774720187"
     variation       26
                     /replace="f"
                     /db_xref="dbSNP:1448092120"
     variation       26
                     /replace="s"
                     /db_xref="dbSNP:771529884"
     variation       27
                     /replace="g"
                     /db_xref="dbSNP:1264279183"
     variation       28
                     /replace="e"
                     /db_xref="dbSNP:1487086082"
     variation       28
                     /replace="y"
                     /db_xref="dbSNP:748752195"
     variation       29
                     /replace="a"
                     /db_xref="dbSNP:1270230401"
     variation       29
                     /replace="e"
                     /db_xref="dbSNP:1360685161"
     variation       29
                     /replace="q"
                     /db_xref="dbSNP:777429243"
     Region          30..41
                     /region_name="polyglutamine repeats"
                     /note="12Q repeat"
     variation       30
                     /replace="k"
                     /db_xref="dbSNP:1246286082"
     variation       30
                     /replace="q"
                     /db_xref="dbSNP:1360893418"
     variation       31
                     /replace="p"
                     /db_xref="dbSNP:893433935"
     variation       32
                     /replace="h"
                     /db_xref="dbSNP:1243961995"
     variation       33
                     /replace="-"
                     /db_xref="dbSNP:756917944"
     variation       33
                     /replace="k"
                     /db_xref="dbSNP:1297421328"
     variation       33
                     /replace="q"
                     /db_xref="dbSNP:769528792"
     variation       34
                     /replace="-"
                     /db_xref="dbSNP:764662697"
     variation       34
                     /replace="q"
                     /db_xref="dbSNP:1380366868"
     variation       35
                     /replace="a"
                     /db_xref="dbSNP:758287149"
     variation       36
                     /replace="-"
                     /db_xref="dbSNP:1344022582"
     variation       36
                     /replace="-"
                     /db_xref="dbSNP:887608589"
     variation       36
                     /replace="e"
                     /db_xref="dbSNP:1256783509"
     variation       37
                     /replace="-"
                     /db_xref="dbSNP:763649325"
     variation       37
                     /replace="k"
                     /db_xref="dbSNP:747821668"
     variation       37
                     /replace="p"
                     /db_xref="dbSNP:1303946886"
     variation       37
                     /replace="q"
                     /db_xref="dbSNP:1053870402"
     variation       38
                     /replace="-"
                     /db_xref="dbSNP:1191457063"
     variation       38
                     /replace="-"
                     /db_xref="dbSNP:1278067583"
     variation       38
                     /replace="h"
                     /db_xref="dbSNP:749969403"
     variation       39
                     /replace="-"
                     /db_xref="dbSNP:746772658"
     variation       39
                     /replace="q"
                     /db_xref="dbSNP:544278583"
     variation       40
                     /replace="-"
                     /db_xref="dbSNP:748310679"
     variation       40
                     /replace="k"
                     /db_xref="dbSNP:1476022991"
     variation       41
                     /replace="-"
                     /db_xref="dbSNP:753586364"
     variation       41
                     /replace="-"
                     /db_xref="dbSNP:780092269"
     variation       41
                     /replace="p"
                     /db_xref="dbSNP:754693972"
     variation       41
                     /replace="q"
                     /db_xref="dbSNP:1371336812"
     variation       41
                     /replace="q"
                     /db_xref="dbSNP:754856463"
     variation       41
                     /replace="qqq"
                     /db_xref="dbSNP:1188508653"
     variation       42
                     /replace="l"
                     /db_xref="dbSNP:996595936"
     variation       43
                     /replace="r"
                     /db_xref="dbSNP:746888428"
     variation       44
                     /replace="a"
                     /db_xref="dbSNP:759985669"
     variation       44
                     /replace="l"
                     /db_xref="dbSNP:1270057106"
     variation       44
                     /replace="p"
                     /db_xref="dbSNP:779840436"
     variation       44
                     /replace="t"
                     /db_xref="dbSNP:1300925892"
     variation       45
                     /replace="q"
                     /db_xref="dbSNP:1490755760"
     variation       46
                     /replace="a"
                     /db_xref="dbSNP:1208768473"
     variation       46
                     /replace="e"
                     /db_xref="dbSNP:576968004"
     variation       47
                     /replace="p"
                     /db_xref="dbSNP:1216758997"
     variation       47
                     /replace="q"
                     /db_xref="dbSNP:1252956526"
     variation       47
                     /replace="s"
                     /db_xref="dbSNP:189948752"
     variation       48
                     /replace="l"
                     /db_xref="dbSNP:1283694613"
     variation       48
                     /replace="s"
                     /db_xref="dbSNP:1339522227"
     variation       50
                     /replace="a"
                     /db_xref="dbSNP:1406977167"
     variation       50
                     /replace="v"
                     /db_xref="dbSNP:1316618694"
     variation       51
                     /replace="l"
                     /db_xref="dbSNP:756235732"
     variation       51
                     /replace="p"
                     /db_xref="dbSNP:1410650511"
     variation       51
                     /replace="s"
                     /db_xref="dbSNP:764182244"
     variation       52
                     /replace="*"
                     /db_xref="dbSNP:1398754600"
     variation       52
                     /replace="r"
                     /db_xref="dbSNP:1166623724"
     variation       53
                     /replace="q"
                     /db_xref="dbSNP:1465575240"
     variation       54
                     /replace="h"
                     /db_xref="dbSNP:1430408879"
     variation       54
                     /replace="p"
                     /db_xref="dbSNP:1202131602"
     variation       55
                     /replace="l"
                     /db_xref="dbSNP:1481196243"
     variation       55
                     /replace="p"
                     /db_xref="dbSNP:752885057"
     variation       56
                     /replace="r"
                     /db_xref="dbSNP:1244673804"
     variation       57
                     /replace="p"
                     /db_xref="dbSNP:767851503"
     variation       57
                     /replace="r"
                     /db_xref="dbSNP:1285216395"
     variation       58
                     /replace="l"
                     /db_xref="dbSNP:1437869897"
     variation       59
                     /replace="q"
                     /db_xref="dbSNP:759810374"
     variation       61
                     /replace="l"
                     /db_xref="dbSNP:766732370"
     variation       61
                     /replace="p"
                     /db_xref="dbSNP:763583178"
     variation       63
                     /replace="h"
                     /db_xref="dbSNP:772796174"
     variation       63
                     /replace="p"
                     /db_xref="dbSNP:769402185"
     variation       64
                     /replace="-"
                     /db_xref="dbSNP:774556523"
     variation       64
                     /replace="p"
                     /db_xref="dbSNP:1455162416"
     variation       64
                     /replace="q"
                     /db_xref="dbSNP:747696814"
     variation       65
                     /replace="a"
                     /db_xref="dbSNP:1356816364"
     variation       65
                     /replace="q"
                     /db_xref="dbSNP:1343108054"
     variation       66
                     /replace="-"
                     /db_xref="dbSNP:1329458989"
     variation       66
                     /replace="i"
                     /db_xref="dbSNP:1274433929"
     variation       66
                     /replace="l"
                     /db_xref="dbSNP:768411824"
     variation       66
                     /replace="p"
                     /db_xref="dbSNP:1337554036"
     variation       66
                     /replace="p"
                     /db_xref="dbSNP:776143138"
     variation       66
                     /replace="pqqq"
                     /db_xref="dbSNP:773041948"
     Region          67..80
                     /region_name="polyglutamine repeats"
                     /note="14Q repeat"
     variation       68
                     /replace="*"
                     /db_xref="dbSNP:1446693141"
     variation       68
                     /replace="pqqqqq"
                     /db_xref="dbSNP:766931119"
     variation       68
                     /replace="q"
                     /db_xref="dbSNP:1407524932"
     variation       69
                     /replace="hqqq"
                     /db_xref="dbSNP:1468522805"
     variation       71
                     /replace="h"
                     /db_xref="dbSNP:1424950921"
     variation       71
                     /replace="rqq"
                     /db_xref="dbSNP:763512217"
     variation       72
                     /replace="-"
                     /db_xref="dbSNP:1468975273"
     variation       72
                     /replace="h"
                     /db_xref="dbSNP:1470314237"
     variation       72
                     /replace="l"
                     /db_xref="dbSNP:1171568672"
     variation       72
                     /replace="lqqqq"
                     /db_xref="dbSNP:773426876"
     variation       73
                     /replace="*"
                     /db_xref="dbSNP:1234097850"
     variation       73
                     /replace="-"
                     /db_xref="dbSNP:1213222049"
     variation       73
                     /replace="l"
                     /db_xref="dbSNP:1056798872"
     variation       74
                     /replace="-"
                     /db_xref="dbSNP:1265613567"
     variation       74
                     /replace="hqqqqq"
                     /db_xref="dbSNP:1457236819"
     variation       75
                     /replace="-"
                     /db_xref="dbSNP:1439902314"
     variation       75
                     /replace="h"
                     /db_xref="dbSNP:938630908"
     variation       76
                     /replace="*"
                     /db_xref="dbSNP:1243725158"
     variation       76
                     /replace="-"
                     /db_xref="dbSNP:1183042636"
     variation       76
                     /replace="hqqq"
                     /db_xref="dbSNP:748222393"
     variation       77
                     /replace="-"
                     /db_xref="dbSNP:1363622883"
     variation       78
                     /replace="*"
                     /db_xref="dbSNP:1259562582"
     variation       78
                     /replace="-"
                     /db_xref="dbSNP:1471870235"
     variation       78
                     /replace="h"
                     /db_xref="dbSNP:539996528"
     variation       79
                     /replace="-"
                     /db_xref="dbSNP:1167759314"
     variation       79
                     /replace="rqqqq"
                     /db_xref="dbSNP:746397332"
     variation       80
                     /replace="-"
                     /db_xref="dbSNP:58327065"
     variation       80
                     /replace="-"
                     /db_xref="dbSNP:748855613"
     variation       80
                     /replace="p"
                     /db_xref="dbSNP:572995536"
     variation       80
                     /replace="q"
                     /db_xref="dbSNP:927281361"
     variation       80
                     /replace="qq"
                     /db_xref="dbSNP:3831942"
     variation       80
                     /replace="qq"
                     /db_xref="dbSNP:56352724"
     variation       80
                     /replace="qqq"
                     /db_xref="dbSNP:1205505198"
     variation       80
                     /replace="qqqqq"
                     /db_xref="dbSNP:1468522805"
     variation       80
                     /replace="qqqqq"
                     /db_xref="dbSNP:746397332"
     variation       81
                     /replace="aaaaaa"
                     /db_xref="dbSNP:3831942"
     variation       81
                     /replace="p"
                     /db_xref="dbSNP:1427217789"
     variation       81
                     /replace="q"
                     /db_xref="dbSNP:866882425"
     variation       82
                     /replace="p"
                     /db_xref="dbSNP:1440440765"
     variation       82
                     /replace="p"
                     /db_xref="dbSNP:756828006"
     variation       82
                     /replace="q"
                     /db_xref="dbSNP:779901170"
     variation       83
                     /replace="q"
                     /db_xref="dbSNP:866979236"
     variation       84
                     /replace="s"
                     /db_xref="dbSNP:1277660019"
     variation       85
                     /replace="l"
                     /db_xref="dbSNP:372000131"
     variation       86
                     /replace="f"
                     /db_xref="dbSNP:1353192884"
     variation       87
                     /replace="q"
                     /db_xref="dbSNP:758285173"
     variation       88
                     /replace="l"
                     /db_xref="dbSNP:554535092"
     variation       89
                     /replace="a"
                     /db_xref="dbSNP:1383654511"
     variation       90
                     /replace="e"
                     /db_xref="dbSNP:778862958"
     variation       90
                     /replace="h"
                     /db_xref="dbSNP:756182511"
     variation       91
                     /replace="l"
                     /db_xref="dbSNP:1242966390"
     variation       92
                     /replace="e"
                     /db_xref="dbSNP:1210768047"
     variation       92
                     /replace="q"
                     /db_xref="dbSNP:1358893571"
     variation       93
                     /replace="r"
                     /db_xref="dbSNP:752884227"
     variation       94
                     /replace="q"
                     /db_xref="dbSNP:767581747"
     variation       95
                     /replace="p"
                     /db_xref="dbSNP:751832980"
     variation       95
                     /replace="r"
                     /db_xref="dbSNP:1381820560"
     variation       95
                     /replace="t"
                     /db_xref="dbSNP:1462133434"
     variation       96
                     /replace="f"
                     /db_xref="dbSNP:1272864491"
     variation       96
                     /replace="v"
                     /db_xref="dbSNP:766786050"
     variation       98
                     /replace="s"
                     /db_xref="dbSNP:1395492090"
     variation       99
                     /replace="d"
                     /db_xref="dbSNP:1185273667"
     variation       99
                     /replace="g"
                     /db_xref="dbSNP:1482243090"
     variation       99
                     /replace="s"
                     /db_xref="dbSNP:1385346526"
     variation       100
                     /replace="l"
                     /db_xref="dbSNP:1324086038"
     variation       100
                     /replace="l"
                     /db_xref="dbSNP:763457140"
     variation       101
                     /replace="p"
                     /db_xref="dbSNP:773819304"
     variation       102
                     /replace="h"
                     /db_xref="dbSNP:914714232"
     variation       106
                     /replace="t"
                     /db_xref="dbSNP:201079149"
     variation       107
                     /replace="a"
                     /db_xref="dbSNP:1216207825"
     variation       107
                     /replace="v"
                     /db_xref="dbSNP:956420912"
     variation       109
                     /replace="s"
                     /db_xref="dbSNP:1213530983"
     variation       110
                     /replace="a"
                     /db_xref="dbSNP:768125954"
     variation       110
                     /replace="d"
                     /db_xref="dbSNP:575111668"
     variation       110
                     /replace="t"
                     /db_xref="dbSNP:1360176552"
     variation       111
                     /replace="p"
                     /db_xref="dbSNP:369288709"
     variation       112
                     /replace="a"
                     /db_xref="dbSNP:143130189"
     variation       112
                     /replace="r"
                     /db_xref="dbSNP:1433386175"
     variation       113
                     /replace="f"
                     /db_xref="dbSNP:753256170"
     variation       113
                     /replace="l"
                     /db_xref="dbSNP:973416823"
     variation       113
                     /replace="s"
                     /db_xref="dbSNP:1455401613"
     variation       114
                     /replace="t"
                     /db_xref="dbSNP:1174068382"
     variation       115
                     /replace="n"
                     /db_xref="dbSNP:1295917259"
     variation       115
                     /replace="s"
                     /db_xref="dbSNP:1374652315"
     variation       116
                     /replace="c"
                     /db_xref="dbSNP:1418719086"
     variation       116
                     /replace="p"
                     /db_xref="dbSNP:76110919"
     variation       116
                     /replace="s"
                     /db_xref="dbSNP:770872750"
     variation       117
                     /replace="p"
                     /db_xref="dbSNP:75265898"
     variation       117
                     /replace="t"
                     /db_xref="dbSNP:781367114"
     variation       118
                     /replace="t"
                     /db_xref="dbSNP:371733237"
     variation       119
                     /replace="i"
                     /db_xref="dbSNP:1187063315"
     variation       119
                     /replace="n"
                     /db_xref="dbSNP:751781187"
     variation       123
                     /replace="s"
                     /db_xref="dbSNP:1017264241"
     variation       125
                     /replace="g"
                     /db_xref="dbSNP:1297113065"
     variation       127
                     /replace="d"
                     /db_xref="dbSNP:1322174628"
     variation       127
                     /replace="g"
                     /db_xref="dbSNP:560686817"
     variation       131
                     /replace="d"
                     /db_xref="dbSNP:367772161"
     variation       134
                     /replace="e"
                     /db_xref="dbSNP:750875567"
     variation       134
                     /replace="n"
                     /db_xref="dbSNP:374255471"
     variation       136
                     /replace="f"
                     /db_xref="dbSNP:762384927"
     variation       136
                     /replace="s"
                     /db_xref="dbSNP:142488101"
     variation       137
                     /replace="f"
                     /db_xref="dbSNP:753245766"
     variation       140
                     /replace="f"
                     /db_xref="dbSNP:1393475084"
     variation       142
                     /replace="i"
                     /db_xref="dbSNP:1274261491"
     variation       144
                     /replace="t"
                     /db_xref="dbSNP:763639345"
     variation       145
                     /replace="t"
                     /db_xref="dbSNP:760144428"
     variation       148
                     /replace="v"
                     /db_xref="dbSNP:1277979256"
     variation       150
                     /replace="g"
                     /db_xref="dbSNP:775203978"
     variation       152
                     /replace="d"
                     /db_xref="dbSNP:771770139"
     variation       154
                     /replace="g"
                     /db_xref="dbSNP:759272043"
     variation       154
                     /replace="q"
                     /db_xref="dbSNP:774140951"
     variation       154
                     /replace="r"
                     /db_xref="dbSNP:770817586"
     variation       155
                     /replace="h"
                     /db_xref="dbSNP:372419327"
     variation       158
                     /replace="v"
                     /db_xref="dbSNP:768747077"
     variation       159
                     /replace="s"
                     /db_xref="dbSNP:747120477"
     variation       160
                     /replace="p"
                     /db_xref="dbSNP:780406060"
     variation       161
                     /replace="p"
                     /db_xref="dbSNP:1165458934"
     variation       162
                     /replace="m"
                     /db_xref="dbSNP:1009453212"
     variation       162
                     /replace="v"
                     /db_xref="dbSNP:958234152"
     variation       163
                     /replace="q"
                     /db_xref="dbSNP:750750797"
     variation       164
                     /replace="q"
                     /db_xref="dbSNP:1031992441"
     variation       164
                     /replace="r"
                     /db_xref="dbSNP:1488174086"
     variation       164
                     /replace="w"
                     /db_xref="dbSNP:1189715733"
     variation       165
                     /replace="r"
                     /db_xref="dbSNP:779450172"
     variation       166
                     /replace="d"
                     /db_xref="dbSNP:757613552"
     variation       166
                     /replace="g"
                     /db_xref="dbSNP:1024976098"
     Site            167
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P58391};
                     propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       168
                     /replace="k"
                     /db_xref="dbSNP:764576115"
     variation       168
                     /replace="s"
                     /db_xref="dbSNP:754341660"
     variation       169
                     /replace="a"
                     /db_xref="dbSNP:1257788771"
     variation       169
                     /replace="np"
                     /db_xref="dbSNP:1224562601"
     variation       171
                     /replace="t"
                     /db_xref="dbSNP:760220645"
     variation       173
                     /replace="i"
                     /db_xref="dbSNP:752220674"
     variation       174
                     /replace="t"
                     /db_xref="dbSNP:1384723020"
     variation       175
                     /replace="i"
                     /db_xref="dbSNP:1161185513"
     variation       175
                     /replace="v"
                     /db_xref="dbSNP:767093909"
     variation       176
                     /replace="n"
                     /db_xref="dbSNP:759220737"
     variation       177
                     /replace="s"
                     /db_xref="dbSNP:774086047"
     variation       178
                     /replace="y"
                     /db_xref="dbSNP:368827258"
     variation       179
                     /replace="k"
                     /db_xref="dbSNP:1364361025"
     variation       179
                     /replace="r"
                     /db_xref="dbSNP:538727884"
     variation       181
                     /replace="r"
                     /db_xref="dbSNP:1169663679"
     variation       182
                     /replace="c"
                     /db_xref="dbSNP:1319927570"
     variation       182
                     /replace="g"
                     /db_xref="dbSNP:1470077766"
     variation       184
                     /replace="v"
                     /db_xref="dbSNP:1386570811"
     variation       185
                     /replace="l"
                     /db_xref="dbSNP:773192197"
     variation       186
                     /replace="k"
                     /db_xref="dbSNP:148154578"
     variation       191
                     /replace="l"
                     /db_xref="dbSNP:1190754931"
     variation       192
                     /replace="s"
                     /db_xref="dbSNP:1432832525"
     variation       198
                     /replace="l"
                     /db_xref="dbSNP:747052272"
     variation       200
                     /replace="*"
                     /db_xref="dbSNP:775716344"
     variation       200
                     /replace="e"
                     /db_xref="dbSNP:772377511"
     variation       201
                     /replace="a"
                     /db_xref="dbSNP:143830956"
     variation       203
                     /replace="t"
                     /db_xref="dbSNP:1309754714"
     variation       204
                     /replace="e"
                     /db_xref="dbSNP:1254645580"
     variation       204
                     /replace="g"
                     /db_xref="dbSNP:749672556"
     variation       204
                     /replace="k"
                     /db_xref="dbSNP:757638842"
     variation       207
                     /replace="l"
                     /db_xref="dbSNP:778285818"
     variation       207
                     /replace="t"
                     /db_xref="dbSNP:1230596389"
     variation       209
                     /replace="q"
                     /db_xref="dbSNP:752167486"
     variation       209
                     /replace="r"
                     /db_xref="dbSNP:756586810"
     variation       213
                     /replace="l"
                     /db_xref="dbSNP:571325361"
     variation       213
                     /replace="s"
                     /db_xref="dbSNP:767038800"
     variation       214
                     /replace="g"
                     /db_xref="dbSNP:751179183"
     variation       215
                     /replace="n"
                     /db_xref="dbSNP:766011548"
     variation       216
                     /replace="l"
                     /db_xref="dbSNP:1465726985"
     variation       216
                     /replace="t"
                     /db_xref="dbSNP:1056344278"
     variation       217
                     /replace="l"
                     /db_xref="dbSNP:1245831928"
     variation       217
                     /replace="p"
                     /db_xref="dbSNP:764611548"
     variation       218
                     /replace="d"
                     /db_xref="dbSNP:762791737"
     variation       219
                     /replace="t"
                     /db_xref="dbSNP:571743632"
     variation       220
                     /replace="g"
                     /db_xref="dbSNP:1487370991"
     variation       220
                     /replace="l"
                     /db_xref="dbSNP:1160705864"
     variation       220
                     /replace="v"
                     /db_xref="dbSNP:772893514"
     variation       221
                     /replace="v"
                     /db_xref="dbSNP:765155011"
     variation       223
                     /replace="f"
                     /db_xref="dbSNP:1008394410"
     variation       223
                     /replace="s"
                     /db_xref="dbSNP:761873426"
     variation       224
                     /replace="q"
                     /db_xref="dbSNP:775661147"
     variation       224
                     /replace="r"
                     /db_xref="dbSNP:1426139473"
     variation       227
                     /replace="n"
                     /db_xref="dbSNP:371916177"
     variation       227
                     /replace="s"
                     /db_xref="dbSNP:772255794"
     variation       228
                     /replace="d"
                     /db_xref="dbSNP:776341018"
     variation       229
                     /replace="a"
                     /db_xref="dbSNP:771073279"
     variation       229
                     /replace="t"
                     /db_xref="dbSNP:1048393434"
     variation       229
                     /replace="v"
                     /db_xref="dbSNP:753446081"
     variation       230
                     /replace="q"
                     /db_xref="dbSNP:374308005"
     variation       230
                     /replace="y"
                     /db_xref="dbSNP:1037654791"
     variation       231
                     /replace="l"
                     /db_xref="dbSNP:778033980"
     variation       232
                     /replace="t"
                     /db_xref="dbSNP:1246605230"
     variation       233
                     /replace="l"
                     /db_xref="dbSNP:756598163"
     variation       234
                     /replace="f"
                     /db_xref="dbSNP:748634554"
     variation       235
                     /replace="n"
                     /db_xref="dbSNP:937986284"
     variation       235
                     /replace="r"
                     /db_xref="dbSNP:781691180"
     variation       236
                     /replace="h"
                     /db_xref="dbSNP:754478127"
     variation       236
                     /replace="n"
                     /db_xref="dbSNP:1300202445"
     variation       240
                     /replace="a"
                     /db_xref="dbSNP:751123937"
     variation       241
                     /replace="q"
                     /db_xref="dbSNP:926645633"
     variation       242
                     /replace="d"
                     /db_xref="dbSNP:982123538"
     variation       242
                     /replace="s"
                     /db_xref="dbSNP:1300219992"
     variation       243
                     /replace="h"
                     /db_xref="dbSNP:1367281245"
     variation       245
                     /replace="p"
                     /db_xref="dbSNP:1187483246"
     variation       245
                     /replace="y"
                     /db_xref="dbSNP:1329183587"
     variation       246
                     /replace="v"
                     /db_xref="dbSNP:765994411"
     variation       247
                     /replace="d"
                     /db_xref="dbSNP:1409684244"
     variation       248
                     /replace="i"
                     /db_xref="dbSNP:757990006"
     variation       249
                     /replace="t"
                     /db_xref="dbSNP:558590709"
     variation       250
                     /replace="t"
                     /db_xref="dbSNP:534102990"
     variation       251
                     /replace="i"
                     /db_xref="dbSNP:567068548"
     variation       252
                     /replace="n"
                     /db_xref="dbSNP:1209955323"
     variation       252
                     /replace="s"
                     /db_xref="dbSNP:776706655"
     variation       253
                     /replace="n"
                     /db_xref="dbSNP:1263564251"
     variation       254
                     /replace="asstt"
                     /db_xref="dbSNP:1243984703"
     variation       255
                     /replace="f"
                     /db_xref="dbSNP:913727371"
     variation       255
                     /replace="s"
                     /db_xref="dbSNP:35646025"
     variation       256
                     /replace="l"
                     /db_xref="dbSNP:370649072"
     variation       258
                     /replace="a"
                     /db_xref="dbSNP:759634001"
     variation       259
                     /replace="n"
                     /db_xref="dbSNP:1398382827"
     variation       260
                     /replace="k"
                     /db_xref="dbSNP:774300198"
     variation       262
                     /replace="e"
                     /db_xref="dbSNP:1319511626"
     variation       266
                     /replace="l"
                     /db_xref="dbSNP:771147595"
     variation       267
                     /replace="g"
                     /db_xref="dbSNP:376039172"
     variation       271
                     /replace="r"
                     /db_xref="dbSNP:1251615007"
     variation       272
                     /replace="h"
                     /db_xref="dbSNP:1053624354"
     variation       272
                     /replace="r"
                     /db_xref="dbSNP:1388703408"
     Region          273..380
                     /region_name="SK_channel"
                     /note="Calcium-activated SK potassium channel; pfam03530"
                     /db_xref="CDD:281522"
     variation       273
                     /replace="k"
                     /db_xref="dbSNP:957968000"
     variation       273
                     /replace="r"
                     /db_xref="dbSNP:773536080"
     variation       274
                     /replace="r"
                     /db_xref="dbSNP:770116460"
     variation       276
                     /replace="l"
                     /db_xref="dbSNP:781652495"
     variation       276
                     /replace="p"
                     /db_xref="dbSNP:748575212"
     variation       281
                     /replace="r"
                     /db_xref="dbSNP:374076091"
     variation       282
                     /replace="q"
                     /db_xref="dbSNP:1262083332"
     variation       283
                     /replace="m"
                     /db_xref="dbSNP:934809617"
     variation       284
                     /replace="s"
                     /db_xref="dbSNP:746447168"
     variation       284
                     /replace="t"
                     /db_xref="dbSNP:1485515951"
     variation       286
                     /replace="c"
                     /db_xref="dbSNP:1264668634"
     variation       286
                     /replace="h"
                     /db_xref="dbSNP:779459677"
     variation       287
                     /replace="a"
                     /db_xref="dbSNP:548585313"
     Site            288..308
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       288
                     /replace="l"
                     /db_xref="dbSNP:1318600047"
     variation       292
                     /replace="v"
                     /db_xref="dbSNP:750020974"
     variation       293
                     /replace="l"
                     /db_xref="dbSNP:778666134"
     variation       295
                     /replace="v"
                     /db_xref="dbSNP:757106174"
     variation       297
                     /replace="f"
                     /db_xref="dbSNP:1182555704"
     variation       300
                     /replace="t"
                     /db_xref="dbSNP:753701554"
     variation       302
                     /replace="i"
                     /db_xref="dbSNP:764058022"
     variation       302
                     /replace="t"
                     /db_xref="dbSNP:1413202740"
     variation       303
                     /replace="d"
                     /db_xref="dbSNP:1329360033"
     variation       304
                     /replace="i"
                     /db_xref="dbSNP:760728518"
     variation       304
                     /replace="l"
                     /db_xref="dbSNP:879107575"
     variation       307
                     /replace="g"
                     /db_xref="dbSNP:751611611"
     variation       308
                     /replace="l"
                     /db_xref="dbSNP:766351743"
     variation       312
                     /replace="d"
                     /db_xref="dbSNP:748029142"
     variation       312
                     /replace="v"
                     /db_xref="dbSNP:1473194402"
     variation       314
                     /replace="v"
                     /db_xref="dbSNP:1227114832"
     Site            315..335
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       315
                     /replace="l"
                     /db_xref="dbSNP:142476638"
     variation       316
                     /replace="l"
                     /db_xref="dbSNP:754945314"
     variation       316
                     /replace="s"
                     /db_xref="dbSNP:750426969"
     variation       317
                     /replace="l"
                     /db_xref="dbSNP:1342035493"
     variation       318
                     /replace="v"
                     /db_xref="dbSNP:765321692"
     variation       319
                     /replace="l"
                     /db_xref="dbSNP:369164690"
     variation       320
                     /replace="k"
                     /db_xref="dbSNP:1429357039"
     variation       321
                     /replace="y"
                     /db_xref="dbSNP:757374968"
     variation       324
                     /replace="s"
                     /db_xref="dbSNP:1305948105"
     variation       326
                     /replace="s"
                     /db_xref="dbSNP:1315413625"
     variation       328
                     /replace="i"
                     /db_xref="dbSNP:918297653"
     variation       335
                     /replace="i"
                     /db_xref="dbSNP:754028439"
     variation       336
                     /replace="t"
                     /db_xref="dbSNP:764366056"
     variation       338
                     /replace="h"
                     /db_xref="dbSNP:1416889386"
     variation       339
                     /replace="a"
                     /db_xref="dbSNP:1171173045"
     variation       339
                     /replace="i"
                     /db_xref="dbSNP:760891294"
     variation       340
                     /replace="c"
                     /db_xref="dbSNP:775927958"
     variation       340
                     /replace="h"
                     /db_xref="dbSNP:760112555"
     variation       342
                     /replace="i"
                     /db_xref="dbSNP:1391743478"
     variation       342
                     /replace="v"
                     /db_xref="dbSNP:775049811"
     variation       344
                     /replace="l"
                     /db_xref="dbSNP:767904708"
     variation       345
                     /replace="f"
                     /db_xref="dbSNP:140455860"
     variation       346
                     /replace="m"
                     /db_xref="dbSNP:1291721595"
     variation       347
                     /replace="i"
                     /db_xref="dbSNP:752112611"
     variation       348
                     /replace="n"
                     /db_xref="dbSNP:1397836050"
     variation       349
                     /replace="n"
                     /db_xref="dbSNP:1131820"
     variation       349
                     /replace="s"
                     /db_xref="dbSNP:767055276"
     variation       350
                     /replace="g"
                     /db_xref="dbSNP:1174250735"
     variation       350
                     /replace="s"
                     /db_xref="dbSNP:772849147"
     variation       351
                     /replace="a"
                     /db_xref="dbSNP:540117403"
     variation       351
                     /replace="t"
                     /db_xref="dbSNP:1453830866"
     variation       351
                     /replace="v"
                     /db_xref="dbSNP:1238782069"
     variation       355
                     /replace="r"
                     /db_xref="dbSNP:1362265064"
     variation       355
                     /replace="r"
                     /db_xref="dbSNP:769288919"
     variation       359
                     /replace="g"
                     /db_xref="dbSNP:751983692"
     variation       359
                     /replace="s"
                     /db_xref="dbSNP:761545559"
     variation       360
                     /replace="h"
                     /db_xref="dbSNP:1250219419"
     variation       360
                     /replace="y"
                     /db_xref="dbSNP:913636248"
     variation       361
                     /replace="k"
                     /db_xref="dbSNP:776194606"
     variation       362
                     /replace="h"
                     /db_xref="dbSNP:1484455009"
     variation       363
                     /replace="n"
                     /db_xref="dbSNP:768464858"
     variation       364
                     /replace="l"
                     /db_xref="dbSNP:1051614"
     variation       365
                     /replace="c"
                     /db_xref="dbSNP:772001209"
     Site            366..386
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       370
                     /replace="l"
                     /db_xref="dbSNP:1327116224"
     variation       371
                     /replace="l"
                     /db_xref="dbSNP:1034183876"
     variation       372
                     /replace="l"
                     /db_xref="dbSNP:1254657878"
     variation       373
                     /replace="c"
                     /db_xref="dbSNP:144038732"
     variation       374
                     /replace="a"
                     /db_xref="dbSNP:1374628109"
     variation       374
                     /replace="t"
                     /db_xref="dbSNP:777932235"
     variation       375
                     /replace="v"
                     /db_xref="dbSNP:756198528"
     variation       378
                     /replace="v"
                     /db_xref="dbSNP:1396346957"
     variation       380
                     /replace="g"
                     /db_xref="dbSNP:371681362"
     variation       381
                     /replace="k"
                     /db_xref="dbSNP:76610518"
     variation       382
                     /replace="h"
                     /db_xref="dbSNP:1434354109"
     variation       383
                     /replace="r"
                     /db_xref="dbSNP:1361240179"
     variation       387
                     /replace="m"
                     /db_xref="dbSNP:766922504"
     variation       387
                     /replace="t"
                     /db_xref="dbSNP:749900768"
     variation       388
                     /replace="a"
                     /db_xref="dbSNP:1051615"
     variation       388
                     /replace="p"
                     /db_xref="dbSNP:1363677459"
     variation       389
                     /replace="h"
                     /db_xref="dbSNP:764779145"
     variation       389
                     /replace="r"
                     /db_xref="dbSNP:1425854361"
     variation       390
                     /replace="l"
                     /db_xref="dbSNP:761267826"
     variation       391
                     /replace="a"
                     /db_xref="dbSNP:776340934"
     variation       392
                     /replace="f"
                     /db_xref="dbSNP:1193516138"
     variation       392
                     /replace="y"
                     /db_xref="dbSNP:979389317"
     variation       393
                     /replace="f"
                     /db_xref="dbSNP:1485181152"
     variation       393
                     /replace="s"
                     /db_xref="dbSNP:1263244075"
     variation       394
                     /replace="y"
                     /db_xref="dbSNP:141600491"
     variation       396
                     /replace="p"
                     /db_xref="dbSNP:1260034815"
     variation       396
                     /replace="t"
                     /db_xref="dbSNP:760404240"
     variation       397
                     /replace="s"
                     /db_xref="dbSNP:575280266"
     variation       397
                     /replace="y"
                     /db_xref="dbSNP:775295714"
     variation       398
                     /replace="q"
                     /db_xref="dbSNP:771961515"
     variation       398
                     /replace="w"
                     /db_xref="dbSNP:557073337"
     variation       399
                     /replace="a"
                     /db_xref="dbSNP:748238359"
     variation       399
                     /replace="t"
                     /db_xref="dbSNP:1341414549"
     variation       399
                     /replace="v"
                     /db_xref="dbSNP:368720064"
     variation       401
                     /replace="a"
                     /db_xref="dbSNP:755251545"
     variation       401
                     /replace="t"
                     /db_xref="dbSNP:781422166"
     variation       402
                     /replace="h"
                     /db_xref="dbSNP:267598058"
     variation       404
                     /replace="d"
                     /db_xref="dbSNP:780585604"
     variation       404
                     /replace="h"
                     /db_xref="dbSNP:375440538"
     Site            405..425
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       406
                     /replace="v"
                     /db_xref="dbSNP:1026329597"
     variation       407
                     /replace="l"
                     /db_xref="dbSNP:372161618"
     variation       409
                     /replace="l"
                     /db_xref="dbSNP:1423836003"
     variation       414
                     /replace="c"
                     /db_xref="dbSNP:750909377"
     variation       414
                     /replace="r"
                     /db_xref="dbSNP:765730337"
     variation       415
                     /replace="l"
                     /db_xref="dbSNP:756777418"
     variation       417
                     /replace="l"
                     /db_xref="dbSNP:1210347815"
     variation       418
                     /replace="i"
                     /db_xref="dbSNP:1489445780"
     variation       420
                     /replace="*"
                     /db_xref="dbSNP:753301038"
     variation       420
                     /replace="q"
                     /db_xref="dbSNP:1408630129"
     variation       421
                     /replace="f"
                     /db_xref="dbSNP:1232399226"
     variation       422
                     /replace="i"
                     /db_xref="dbSNP:75503830"
     variation       423
                     /replace="l"
                     /db_xref="dbSNP:1336554824"
     variation       427
                     /replace="q"
                     /db_xref="dbSNP:763697141"
     variation       427
                     /replace="r"
                     /db_xref="dbSNP:760343159"
     variation       429
                     /replace="f"
                     /db_xref="dbSNP:368437227"
     variation       430
                     /replace="t"
                     /db_xref="dbSNP:146684021"
     variation       432
                     /replace="t"
                     /db_xref="dbSNP:1325913224"
     variation       433
                     /replace="s"
                     /db_xref="dbSNP:2271117"
     variation       435
                     /replace="c"
                     /db_xref="dbSNP:1326312153"
     variation       435
                     /replace="r"
                     /db_xref="dbSNP:759396427"
     variation       437
                     /replace="i"
                     /db_xref="dbSNP:374269558"
     variation       438
                     /replace="r"
                     /db_xref="dbSNP:770791170"
     variation       443
                     /replace="i"
                     /db_xref="dbSNP:748196476"
     variation       447
                     /replace="t"
                     /db_xref="dbSNP:1426240316"
     variation       448
                     /replace="c"
                     /db_xref="dbSNP:1172301675"
     variation       448
                     /replace="h"
                     /db_xref="dbSNP:777143484"
     variation       453
                     /replace="m"
                     /db_xref="dbSNP:1474256642"
     variation       453
                     /replace="t"
                     /db_xref="dbSNP:370594487"
     Site            454..474
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       456
                     /replace="t"
                     /db_xref="dbSNP:963507754"
     variation       458
                     /replace="c"
                     /db_xref="dbSNP:559302379"
     variation       460
                     /replace="d"
                     /db_xref="dbSNP:1199012884"
     variation       463
                     /replace="l"
                     /db_xref="dbSNP:534181337"
     variation       464
                     /replace="l"
                     /db_xref="dbSNP:367863664"
     variation       465
                     /replace="v"
                     /db_xref="dbSNP:1212995083"
     variation       466
                     /replace="c"
                     /db_xref="dbSNP:182790998"
     variation       467
                     /replace="s"
                     /db_xref="dbSNP:1039861886"
     Region          468..547
                     /region_name="Ion_trans_2"
                     /note="Ion channel; pfam07885"
                     /db_xref="CDD:285168"
     variation       468
                     /replace="i"
                     /db_xref="dbSNP:138364260"
     variation       470
                     /replace="l"
                     /db_xref="dbSNP:746274298"
     variation       470
                     /replace="v"
                     /db_xref="dbSNP:758828575"
     variation       473
                     /replace="m"
                     /db_xref="dbSNP:1480926694"
     variation       473
                     /replace="t"
                     /db_xref="dbSNP:757709658"
     variation       473
                     /replace="v"
                     /db_xref="dbSNP:779417955"
     variation       476
                     /replace="*"
                     /db_xref="dbSNP:753340296"
     variation       477
                     /replace="t"
                     /db_xref="dbSNP:763573215"
     variation       478
                     /replace="i"
                     /db_xref="dbSNP:148925371"
     variation       483
                     /replace="r"
                     /db_xref="dbSNP:763234530"
     variation       484
                     /replace="d"
                     /db_xref="dbSNP:773593953"
     variation       485
                     /replace="h"
                     /db_xref="dbSNP:1236133765"
     variation       486
                     /replace="a"
                     /db_xref="dbSNP:1462534450"
     variation       489
                     /replace="d"
                     /db_xref="dbSNP:576034957"
     variation       489
                     /replace="n"
                     /db_xref="dbSNP:1248925587"
     variation       490
                     /replace="i"
                     /db_xref="dbSNP:1279183438"
     variation       492
                     /replace="g"
                     /db_xref="dbSNP:748636403"
     variation       492
                     /replace="s"
                     /db_xref="dbSNP:777239113"
     variation       495
                     /replace="p"
                     /db_xref="dbSNP:1444271102"
     variation       496
                     /replace="s"
                     /db_xref="dbSNP:1162711477"
     variation       502
                     /replace="f"
                     /db_xref="dbSNP:1009320885"
     variation       502
                     /replace="s"
                     /db_xref="dbSNP:768050294"
     variation       507
                     /replace="f"
                     /db_xref="dbSNP:866256648"
     variation       510
                     /replace="y"
                     /db_xref="dbSNP:746589982"
     variation       511
                     /replace="g"
                     /db_xref="dbSNP:1213428541"
     variation       512
                     /replace="d"
                     /db_xref="dbSNP:779516843"
     variation       513
                     /replace="i"
                     /db_xref="dbSNP:890496198"
     variation       514
                     /replace="v"
                     /db_xref="dbSNP:932772948"
     variation       515
                     /replace="p"
                     /db_xref="dbSNP:557553959"
     variation       515
                     /replace="s"
                     /db_xref="dbSNP:758076087"
     variation       518
                     /replace="h"
                     /db_xref="dbSNP:778873040"
     variation       518
                     /replace="y"
                     /db_xref="dbSNP:1463698061"
     Site            523..543
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     variation       523
                     /replace="i"
                     /db_xref="dbSNP:757157532"
     variation       528
                     /replace="g"
                     /db_xref="dbSNP:545239721"
     variation       530
                     /replace="t"
                     /db_xref="dbSNP:200867139"
     variation       531
                     /replace="g"
                     /db_xref="dbSNP:1208033012"
     variation       538
                     /replace="v"
                     /db_xref="dbSNP:1346561867"
     variation       540
                     /replace="a"
                     /db_xref="dbSNP:766456980"
     variation       541
                     /replace="a"
                     /db_xref="dbSNP:112703022"
     variation       541
                     /replace="m"
                     /db_xref="dbSNP:1326148732"
     variation       541
                     /replace="v"
                     /db_xref="dbSNP:1241117849"
     variation       543
                     /replace="v"
                     /db_xref="dbSNP:758516858"
     variation       544
                     /replace="*"
                     /db_xref="dbSNP:1468182036"
     variation       544
                     /replace="q"
                     /db_xref="dbSNP:1306111529"
     variation       545
                     /replace="k"
                     /db_xref="dbSNP:750643072"
     variation       548
                     /replace="h"
                     /db_xref="dbSNP:1164856301"
     variation       549
                     /replace="i"
                     /db_xref="dbSNP:1385797740"
     variation       550
                     /replace="k"
                     /db_xref="dbSNP:762109698"
     variation       550
                     /replace="t"
                     /db_xref="dbSNP:765504126"
     variation       551
                     /replace="a"
                     /db_xref="dbSNP:777061224"
     variation       553
                     /replace="m"
                     /db_xref="dbSNP:764469884"
     variation       554
                     /replace="h"
                     /db_xref="dbSNP:761267551"
     variation       554
                     /replace="y"
                     /db_xref="dbSNP:1363915899"
     variation       556
                     /replace="h"
                     /db_xref="dbSNP:1168754175"
     variation       559
                     /replace="l"
                     /db_xref="dbSNP:775910318"
     Region          561..637
                     /region_name="Calmodulin-binding. {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGI6.1)"
     Region          561..633
                     /region_name="CaMBD"
                     /note="Calmodulin binding domain; pfam02888"
                     /db_xref="CDD:280961"
     variation       561
                     /replace="e"
                     /db_xref="dbSNP:1363553372"
     variation       562
                     /replace="t"
                     /db_xref="dbSNP:1329820923"
     variation       563
                     /replace="q"
                     /db_xref="dbSNP:1165985485"
     variation       567
                     /replace="q"
                     /db_xref="dbSNP:935918876"
     variation       567
                     /replace="r"
                     /db_xref="dbSNP:372547701"
     variation       568
                     /replace="v"
                     /db_xref="dbSNP:779042876"
     variation       572
                     /replace="a"
                     /db_xref="dbSNP:757503744"
     variation       573
                     /replace="a"
                     /db_xref="dbSNP:1159622035"
     variation       574
                     /replace="n"
                     /db_xref="dbSNP:754103274"
     variation       579
                     /replace="t"
                     /db_xref="dbSNP:572788586"
     variation       581
                     /replace="l"
                     /db_xref="dbSNP:1373126082"
     variation       583
                     /replace="h"
                     /db_xref="dbSNP:1194766988"
     variation       589
                     /replace="l"
                     /db_xref="dbSNP:560866177"
     variation       590
                     /replace="r"
                     /db_xref="dbSNP:1260911238"
     variation       592
                     /replace="f"
                     /db_xref="dbSNP:1331357011"
     variation       592
                     /replace="t"
                     /db_xref="dbSNP:952407124"
     variation       593
                     /replace="d"
                     /db_xref="dbSNP:768149702"
     variation       594
                     /replace="q"
                     /db_xref="dbSNP:759048436"
     variation       594
                     /replace="r"
                     /db_xref="dbSNP:1435063037"
     Region          595..673
                     /region_name="Prefoldin"
                     /note="Prefoldin is a hexameric molecular chaperone
                     complex, found in both eukaryotes and archaea, that binds
                     and stabilizes newly synthesized polypeptides allowing
                     them to fold correctly. The complex contains two alpha and
                     four beta subunits, the two subunits...; cl09111"
                     /db_xref="CDD:298833"
     variation       595
                     /replace="t"
                     /db_xref="dbSNP:1213266406"
     variation       597
                     /replace="l"
                     /db_xref="dbSNP:774027041"
     variation       597
                     /replace="v"
                     /db_xref="dbSNP:1253317603"
     variation       604
                     /replace="f"
                     /db_xref="dbSNP:770655498"
     variation       605
                     /replace="l"
                     /db_xref="dbSNP:145724994"
     variation       607
                     /replace="a"
                     /db_xref="dbSNP:1302512240"
     variation       611
                     /replace="l"
                     /db_xref="dbSNP:41270947"
     variation       613
                     /replace="s"
                     /db_xref="dbSNP:150313898"
     variation       614
                     /replace="i"
                     /db_xref="dbSNP:371805423"
     variation       614
                     /replace="v"
                     /db_xref="dbSNP:764812946"
     variation       615
                     /replace="k"
                     /db_xref="dbSNP:1172634446"
     variation       615
                     /replace="r"
                     /db_xref="dbSNP:201207460"
     variation       616
                     /replace="l"
                     /db_xref="dbSNP:1389378310"
     variation       622
                     /replace="n"
                     /db_xref="dbSNP:776442774"
     variation       624
                     /replace="e"
                     /db_xref="dbSNP:768533962"
     variation       626
                     /replace="n"
                     /db_xref="dbSNP:746927647"
     variation       629
                     /replace="v"
                     /db_xref="dbSNP:1436062687"
     variation       632
                     /replace="a"
                     /db_xref="dbSNP:1414628428"
     variation       638
                     /replace="i"
                     /db_xref="dbSNP:950244144"
     variation       638
                     /replace="t"
                     /db_xref="dbSNP:757871783"
     variation       641
                     /replace="l"
                     /db_xref="dbSNP:749908433"
     variation       646
                     /replace="s"
                     /db_xref="dbSNP:927916560"
     variation       648
                     /replace="q"
                     /db_xref="dbSNP:1423319449"
     variation       648
                     /replace="r"
                     /db_xref="dbSNP:764907068"
     variation       650
                     /replace="v"
                     /db_xref="dbSNP:761396508"
     variation       652
                     /replace="l"
                     /db_xref="dbSNP:1173956185"
     variation       652
                     /replace="l"
                     /db_xref="dbSNP:917524524"
     variation       652
                     /replace="r"
                     /db_xref="dbSNP:1469459005"
     variation       655
                     /replace="e"
                     /db_xref="dbSNP:776316771"
     variation       656
                     /replace="t"
                     /db_xref="dbSNP:1474235878"
     variation       660
                     /replace="e"
                     /db_xref="dbSNP:991708080"
     variation       661
                     /replace="l"
                     /db_xref="dbSNP:763846307"
     variation       661
                     /replace="s"
                     /db_xref="dbSNP:1217131264"
     variation       662
                     /replace="r"
                     /db_xref="dbSNP:1449279449"
     variation       663
                     /replace="l"
                     /db_xref="dbSNP:760531110"
     variation       665
                     /replace="d"
                     /db_xref="dbSNP:1204872676"
     variation       666
                     /replace="h"
                     /db_xref="dbSNP:61811431"
     variation       667
                     /replace="t"
                     /db_xref="dbSNP:562479403"
     variation       668
                     /replace="s"
                     /db_xref="dbSNP:543914524"
     variation       671
                     /replace="t"
                     /db_xref="dbSNP:201738401"
     variation       672
                     /replace="t"
                     /db_xref="dbSNP:773185644"
     variation       674
                     /replace="p"
                     /db_xref="dbSNP:748347248"
     variation       674
                     /replace="q"
                     /db_xref="dbSNP:1431362926"
     variation       674
                     /replace="t"
                     /db_xref="dbSNP:1283136274"
     variation       676
                     /replace="l"
                     /db_xref="dbSNP:564861358"
     variation       677
                     /replace="i"
                     /db_xref="dbSNP:374819006"
     variation       678
                     /replace="a"
                     /db_xref="dbSNP:747394806"
     variation       678
                     /replace="v"
                     /db_xref="dbSNP:371429880"
     variation       679
                     /replace="d"
                     /db_xref="dbSNP:1345912022"
     variation       680
                     /replace="n"
                     /db_xref="dbSNP:1218890443"
     variation       682
                     /replace="c"
                     /db_xref="dbSNP:1209698715"
     variation       682
                     /replace="h"
                     /db_xref="dbSNP:1167358894"
     variation       682
                     /replace="r"
                     /db_xref="dbSNP:1278239029"
     variation       684
                     /replace="r"
                     /db_xref="dbSNP:1489335578"
     variation       687
                     /replace="-"
                     /db_xref="dbSNP:149440400"
     variation       687
                     /replace="q"
                     /db_xref="dbSNP:762020489"
     variation       688
                     /replace="l"
                     /db_xref="dbSNP:1217963475"
     variation       689
                     /replace="l"
                     /db_xref="dbSNP:1263174399"
     variation       689
                     /replace="l"
                     /db_xref="dbSNP:867367933"
     variation       690
                     /replace="s"
                     /db_xref="dbSNP:540307843"
     variation       691
                     /replace="a"
                     /db_xref="dbSNP:1417221707"
     variation       692
                     /replace="i"
                     /db_xref="dbSNP:758862833"
     variation       692
                     /replace="v"
                     /db_xref="dbSNP:1445634628"
     variation       693
                     /replace="t"
                     /db_xref="dbSNP:1476448239"
     variation       694
                     /replace="d"
                     /db_xref="dbSNP:1240792645"
     variation       695
                     /replace="t"
                     /db_xref="dbSNP:756664099"
     variation       696
                     /replace="q"
                     /db_xref="dbSNP:377688678"
     variation       696
                     /replace="r"
                     /db_xref="dbSNP:1469177913"
     variation       696
                     /replace="w"
                     /db_xref="dbSNP:1193116792"
     variation       697
                     /replace="d"
                     /db_xref="dbSNP:1381597874"
     variation       697
                     /replace="r"
                     /db_xref="dbSNP:374192381"
     variation       701
                     /replace="s"
                     /db_xref="dbSNP:978522766"
     variation       701
                     /replace="v"
                     /db_xref="dbSNP:756801201"
     variation       702
                     /replace="v"
                     /db_xref="dbSNP:914885726"
     variation       703
                     /replace="d"
                     /db_xref="dbSNP:1214606699"
     variation       705
                     /replace="s"
                     /db_xref="dbSNP:753486219"
     variation       707
                     /replace="i"
                     /db_xref="dbSNP:1268293186"
     variation       708
                     /replace="a"
                     /db_xref="dbSNP:967553480"
     variation       708
                     /replace="l"
                     /db_xref="dbSNP:763748485"
     variation       709
                     /replace="i"
                     /db_xref="dbSNP:1459697235"
     variation       709
                     /replace="v"
                     /db_xref="dbSNP:200865416"
     variation       710
                     /replace="s"
                     /db_xref="dbSNP:752464816"
     variation       711
                     /replace="n"
                     /db_xref="dbSNP:1435992851"
     variation       714
                     /replace="t"
                     /db_xref="dbSNP:76925601"
     variation       716
                     /replace="d"
                     /db_xref="dbSNP:920992562"
     variation       716
                     /replace="f"
                     /db_xref="dbSNP:764160677"
     variation       719
                     /replace="t"
                     /db_xref="dbSNP:1168502986"
     variation       722
                     /replace="l"
                     /db_xref="dbSNP:774384644"
     variation       723
                     /replace="t"
                     /db_xref="dbSNP:769754241"
     variation       724
                     /replace="a"
                     /db_xref="dbSNP:201808409"
     variation       724
                     /replace="l"
                     /db_xref="dbSNP:144072589"
     variation       724
                     /replace="p"
                     /db_xref="dbSNP:199920438"
     variation       725
                     /replace="n"
                     /db_xref="dbSNP:996024923"
     variation       727
                     /replace="n"
                     /db_xref="dbSNP:574750243"
     variation       729
                     /replace="s"
                     /db_xref="dbSNP:371063589"
     CDS             1..731
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3"
                     /coded_by="NM_002249.5:315..2510"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30880.1"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
ORIGIN      
        1 mdtsghfhds gvgdldedpk cpcpssgdeq qqqqqqqqqq qppppappaa pqqplgpslq
       61 pqppqlqqqq qqqqqqqqqq pphplsqlaq lqsqpvhpgl lhssptafra ppssnstail
      121 hpssrqgsql nlndhllghs psstatsgpg ggsrhrqasp lvhrrdsnpf teiamsscky
      181 sggvmkplsr lsasrrnlie aetegqplql fspsnppeiv issrednhah qtllhhpnat
      241 hnhqhagtta ssttfpkank rknqnigykl ghrralfekr krlsdyalif gmfgivvmvi
      301 etelswglys kdsmfslalk clislstiil lgliiayhtr evqlfvidng addwriamty
      361 erilyislem lvcaihpipg eykffwtarl afsytpsrae advdiilsip mflrlyliar
      421 vmllhsklft dassrsigal nkinfntrfv mktlmticpg tvllvfsisl wiiaawtvrv
      481 ceryhdqqdv tsnflgamwl isitflsigy gdmvphtycg kgvclltgim gagctalvva
      541 vvarkleltk aekhvhnfmm dtqltkrikn aaanvlretw liykhtkllk kidhakvrkh
      601 qrkflqaihq lrsvkmeqrk lsdqantlvd lskmqnvmyd litelndrse dlekqigsle
      661 sklehltasf nslplliadt lrqqqqqlls aiieargvsv avgtthtpis dspigvssts
      721 fptpytssss c
//
DBGET integrated database retrieval system