GenomeNet

Database: RefSeq
Entry: NP_002991
LinkDB: NP_002991
Original site: NP_002991 
LOCUS       NP_002991                280 aa            linear   PRI 11-NOV-2018
DEFINITION  succinate dehydrogenase [ubiquinone] iron-sulfur subunit,
            mitochondrial precursor [Homo sapiens].
ACCESSION   NP_002991
VERSION     NP_002991.2
DBSOURCE    REFSEQ: accession NM_003000.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 280)
  AUTHORS   Yamanaka M, Shiga K, Fujiwara S, Mizuguchi Y, Yasuda S, Ishizawa K,
            Saiki Y, Higashi K, Ogawa T, Kimura N and Horii A.
  TITLE     A Novel SDHB IVS2-2A>C Mutation Is Responsible for Hereditary
            Pheochromocytoma/Paraganglioma Syndrome
  JOURNAL   Tohoku J. Exp. Med. 245 (2), 99-105 (2018)
   PUBMED   29925701
  REMARK    GeneRIF: newly identified IVS2-2A>C mutation in SDHB is responsible
            for Hereditary Pheochromocytoma/Paraganglioma Syndrome.
REFERENCE   2  (residues 1 to 280)
  AUTHORS   Samuel N, Ejaz R, Silver J, Ezzat S, Cusimano RJ and Kim RH.
  TITLE     Primary mediastinal paraganglioma associated with a familial
            variant in the succinate dehydrogenase B subunit gene
  JOURNAL   J Surg Oncol 117 (2), 160-162 (2018)
   PUBMED   28891197
  REMARK    GeneRIF: Mutation in the SDHB gene is associated with mediastinal
            paraganglioma.
REFERENCE   3  (residues 1 to 280)
  AUTHORS   Dhir M, Li W, Hogg ME, Bartlett DL, Carty SE, McCoy KL, Challinor
            SM and Yip L.
  TITLE     Clinical Predictors of Malignancy in Patients with Pheochromocytoma
            and Paraganglioma
  JOURNAL   Ann. Surg. Oncol. 24 (12), 3624-3630 (2017)
   PUBMED   28884434
  REMARK    GeneRIF: Germline SDHB mutation is associated with Pheochromocytoma
            and Paraganglioma.
REFERENCE   4  (residues 1 to 280)
  AUTHORS   Fujita,Y., Watanabe,T., Ogawa,R., Ishida,I., Seike,M., Shichi,H.,
            Nakamura,S., Hino,Y., Chihara,K. and Iida,K.
  TITLE     [A Case of Familial Paraganglioma with a Mutation in the SDHB Gene]
  JOURNAL   Nippon Naika Gakkai Zasshi 105 (10), 2034-2040 (2016)
   PUBMED   30178964
  REMARK    GeneRIF: Mutation is detected in the SDHB gene both mother and a
            child
REFERENCE   5  (residues 1 to 280)
  AUTHORS   Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E,
            Skoldberg F, Husebye ES, Eng C and Maher ER.
  TITLE     Gene mutations in the succinate dehydrogenase subunit SDHB cause
            susceptibility to familial pheochromocytoma and to familial
            paraganglioma
  JOURNAL   Am. J. Hum. Genet. 69 (1), 49-54 (2001)
   PUBMED   11404820
  REMARK    Erratum:[Am J Hum Genet 2002 Feb;70(2):565]
REFERENCE   6  (residues 1 to 280)
  AUTHORS   Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M and
            Scheffler IE.
  TITLE     Structural organization of the gene encoding the human iron-sulfur
            subunit of succinate dehydrogenase
  JOURNAL   Gene 159 (2), 249-253 (1995)
   PUBMED   7622059
REFERENCE   7  (residues 1 to 280)
  AUTHORS   Fridell RA, Harding LS, Bogerd HP and Cullen BR.
  TITLE     Identification of a novel human zinc finger protein that
            specifically interacts with the activation domain of lentiviral Tat
            proteins
  JOURNAL   Virology 209 (2), 347-357 (1995)
   PUBMED   7778269
REFERENCE   8  (residues 1 to 280)
  AUTHORS   Else,T., Greenberg,S. and Fishbein,L.
  TITLE     Hereditary Paraganglioma-Pheochromocytoma Syndromes
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301715
REFERENCE   9  (residues 1 to 280)
  AUTHORS   Kita K, Oya H, Gennis RB, Ackrell BA and Kasahara M.
  TITLE     Human complex II (succinate-ubiquinone oxidoreductase): cDNA
            cloning of iron sulfur (Ip) subunit of liver mitochondria
  JOURNAL   Biochem. Biophys. Res. Commun. 166 (1), 101-108 (1990)
   PUBMED   2302193
REFERENCE   10 (residues 1 to 280)
  AUTHORS   Gould SJ, Subramani S and Scheffler IE.
  TITLE     Use of the DNA polymerase chain reaction for homology probing:
            isolation of partial cDNA or genomic clones encoding the
            iron-sulfur protein of succinate dehydrogenase from several species
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (6), 1934-1938 (1989)
   PUBMED   2494655
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2556]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007840.2, BF796275.1 and
            BU554163.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 28, 2006 this sequence version replaced NP_002991.1.
            
            Summary: Complex II of the respiratory chain, which is specifically
            involved in the oxidation of succinate, carries electrons from FADH
            to CoQ. The complex is composed of four nuclear-encoded subunits
            and is localized in the mitochondrial inner membrane. The
            iron-sulfur subunit is highly conserved and contains three
            cysteine-rich clusters which may comprise the iron-sulfur centers
            of the enzyme. Sporadic and familial mutations in this gene result
            in paragangliomas and pheochromocytoma, and support a link between
            mitochondrial dysfunction and tumorigenesis. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.327377.1, U17248.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 2302193; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     Protein         1..280
                     /product="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial precursor"
                     /EC_number="1.3.5.1"
                     /note="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial; iron-sulfur subunit of complex II;
                     succinate dehydrogenase complex, subunit B, iron sulfur
                     (Ip)"
                     /calculated_mol_wt=28808
     transit_peptide 1..28
                     /calculated_mol_wt=2840
     variation       1
                     /replace="i"
                     /db_xref="dbSNP:1131691061"
     variation       1
                     /replace="l"
                     /db_xref="dbSNP:1131691049"
     variation       2
                     /replace="v"
                     /db_xref="dbSNP:199948437"
     variation       3
                     /replace="a"
                     /db_xref="dbSNP:1350879010"
     variation       3
                     /replace="g"
                     /db_xref="dbSNP:11203289"
     variation       3
                     /replace="t"
                     /db_xref="dbSNP:765429934"
     variation       4
                     /replace="g"
                     /db_xref="dbSNP:776656866"
     variation       4
                     /replace="v"
                     /db_xref="dbSNP:768683606"
     Region          5..271
                     /region_name="PLN00129"
                     /note="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit"
                     /db_xref="CDD:215067"
     variation       5
                     /replace="g"
                     /db_xref="dbSNP:760565241"
     variation       5
                     /replace="i"
                     /db_xref="dbSNP:962717797"
     variation       5
                     /replace="v"
                     /db_xref="dbSNP:1182998682"
     variation       6
                     /replace="a"
                     /db_xref="dbSNP:2746462"
     variation       6
                     /replace="s"
                     /db_xref="dbSNP:1472284221"
     variation       6
                     /replace="v"
                     /db_xref="dbSNP:1249560928"
     variation       7
                     /replace="f"
                     /db_xref="dbSNP:745664191"
     variation       7
                     /replace="l"
                     /db_xref="dbSNP:147815442"
     variation       7
                     /replace="p"
                     /db_xref="dbSNP:778776844"
     variation       8
                     /replace="f"
                     /db_xref="dbSNP:199848267"
     variation       8
                     /replace="l"
                     /db_xref="dbSNP:1060503767"
     variation       8
                     /replace="p"
                     /db_xref="dbSNP:777447369"
     variation       8
                     /replace="s"
                     /db_xref="dbSNP:148738139"
     variation       9
                     /replace="*"
                     /db_xref="dbSNP:786203800"
     variation       9
                     /replace="v"
                     /db_xref="dbSNP:1060503768"
     variation       10
                     /replace="s"
                     /db_xref="dbSNP:1024111417"
     variation       11
                     /replace="c"
                     /db_xref="dbSNP:200868378"
     variation       11
                     /replace="h"
                     /db_xref="dbSNP:111430410"
     variation       11
                     /replace="r"
                     /db_xref="dbSNP:146399542"
     variation       12
                     /replace="p"
                     /db_xref="dbSNP:1293365726"
     variation       12
                     /replace="r"
                     /db_xref="dbSNP:754024341"
     variation       12
                     /replace="r"
                     /db_xref="dbSNP:761996626"
     variation       13
                     /replace="l"
                     /db_xref="dbSNP:201745731"
     variation       13
                     /replace="w"
                     /db_xref="dbSNP:1052232356"
     variation       14
                     /replace="l"
                     /db_xref="dbSNP:764089231"
     variation       14
                     /replace="p"
                     /db_xref="dbSNP:760753435"
     variation       15
                     /replace="a"
                     /db_xref="dbSNP:764875162"
     variation       15
                     /replace="h"
                     /db_xref="dbSNP:1131691056"
     variation       15
                     /replace="s"
                     /db_xref="dbSNP:794728951"
     variation       15
                     /replace="t"
                     /db_xref="dbSNP:1409902974"
     variation       15
                     /replace="v"
                     /db_xref="dbSNP:796475064"
     variation       16
                     /replace="a"
                     /db_xref="dbSNP:1433760506"
     variation       16
                     /replace="r"
                     /db_xref="dbSNP:775350144"
     variation       17
                     /replace="a"
                     /db_xref="dbSNP:1060503756"
     variation       17
                     /replace="i"
                     /db_xref="dbSNP:138979875"
     variation       17
                     /replace="t"
                     /db_xref="dbSNP:550555402"
     variation       18
                     /replace="l"
                     /db_xref="dbSNP:759446168"
     variation       19
                     /replace="d"
                     /db_xref="dbSNP:1207765873"
     variation       19
                     /replace="g"
                     /db_xref="dbSNP:1326601709"
     variation       21
                     /replace="t"
                     /db_xref="dbSNP:774266782"
     variation       22
                     /replace="c"
                     /db_xref="dbSNP:772853861"
     variation       22
                     /replace="f"
                     /db_xref="dbSNP:141230910"
     variation       24
                     /replace="p"
                     /db_xref="dbSNP:878854580"
     variation       25
                     /replace="a"
                     /db_xref="dbSNP:200329668"
     variation       25
                     /replace="g"
                     /db_xref="dbSNP:1131691057"
     variation       25
                     /replace="p"
                     /db_xref="dbSNP:768101924"
     variation       27
                     /replace="*"
                     /db_xref="dbSNP:74315369"
     variation       27
                     /replace="q"
                     /db_xref="dbSNP:373976827"
     variation       28
                     /replace="g"
                     /db_xref="dbSNP:1337602604"
     mat_peptide     29..280
                     /product="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial"
                     /calculated_mol_wt=28808
     variation       30
                     /replace="q"
                     /db_xref="dbSNP:749662497"
     variation       30
                     /replace="r"
                     /db_xref="dbSNP:747198089"
     variation       32
                     /replace="a"
                     /db_xref="dbSNP:1484330671"
     variation       33
                     /replace="t"
                     /db_xref="dbSNP:777898500"
     variation       34
                     /replace="g"
                     /db_xref="dbSNP:867908217"
     variation       35
                     /replace="i"
                     /db_xref="dbSNP:1331420052"
     variation       36
                     /replace="t"
                     /db_xref="dbSNP:1204932232"
     variation       36
                     /replace="v"
                     /db_xref="dbSNP:1337800267"
     variation       37
                     /replace="l"
                     /db_xref="dbSNP:1324983452"
     variation       37
                     /replace="s"
                     /db_xref="dbSNP:761180960"
     variation       38
                     /replace="c"
                     /db_xref="dbSNP:202119350"
     variation       38
                     /replace="h"
                     /db_xref="dbSNP:143058777"
     variation       38
                     /replace="p"
                     /db_xref="dbSNP:398123690"
     variation       41
                     /replace="k"
                     /db_xref="dbSNP:137877851"
     variation       42
                     /replace="l"
                     /db_xref="dbSNP:767667150"
     variation       42
                     /replace="l"
                     /db_xref="dbSNP:878854572"
     variation       44
                     /replace="r"
                     /db_xref="dbSNP:864321639"
     variation       44
                     /replace="v"
                     /db_xref="dbSNP:200418115"
     variation       45
                     /replace="y"
                     /db_xref="dbSNP:1351034939"
     variation       46
                     /replace="*"
                     /db_xref="dbSNP:74315370"
     variation       46
                     /replace="q"
                     /db_xref="dbSNP:772551056"
     variation       46
                     /replace="r"
                     /db_xref="dbSNP:1392672185"
     variation       47
                     /replace="*"
                     /db_xref="dbSNP:1060503762"
     variation       47
                     /replace="*"
                     /db_xref="dbSNP:1163621416"
     variation       48
                     /replace="v"
                     /db_xref="dbSNP:202101384"
     variation       50
                     /replace="g"
                     /db_xref="dbSNP:201219456"
     variation       50
                     /replace="h"
                     /db_xref="dbSNP:1060503765"
     Site            51
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q9CQA3};
                     propagated from UniProtKB/Swiss-Prot (P21912.3)"
     variation       52
                     /replace="a"
                     /db_xref="dbSNP:1459423949"
     variation       52
                     /replace="p"
                     /db_xref="dbSNP:1183722041"
     variation       52
                     /replace="v"
                     /db_xref="dbSNP:878854573"
     variation       53
                     /replace="e"
                     /db_xref="dbSNP:34916635"
     variation       55
                     /replace="t"
                     /db_xref="dbSNP:764843485"
     Site            55
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q9CQA3};
                     propagated from UniProtKB/Swiss-Prot (P21912.3)"
     variation       56
                     /replace="y"
                     /db_xref="dbSNP:786202100"
     variation       57
                     /replace="h"
                     /db_xref="dbSNP:1280868219"
     variation       57
                     /replace="r"
                     /db_xref="dbSNP:35962811"
     variation       58
                     /replace="v"
                     /db_xref="dbSNP:1201188410"
     variation       59
                     /replace="h"
                     /db_xref="dbSNP:1277374324"
     variation       60
                     /replace="a"
                     /db_xref="dbSNP:34599281"
     variation       60
                     /replace="i"
                     /db_xref="dbSNP:1210793630"
     variation       61
                     /replace="c"
                     /db_xref="dbSNP:768171765"
     variation       61
                     /replace="y"
                     /db_xref="dbSNP:760169139"
     variation       62
                     /replace="e"
                     /db_xref="dbSNP:876658473"
     variation       62
                     /replace="k"
                     /db_xref="dbSNP:1231783823"
     variation       63
                     /replace="a"
                     /db_xref="dbSNP:1230335211"
     variation       64
                     /replace="a"
                     /db_xref="dbSNP:200131173"
     variation       65
                     /replace="f"
                     /db_xref="dbSNP:786202185"
     variation       65
                     /replace="h"
                     /db_xref="dbSNP:876659329"
     variation       67
                     /replace="k"
                     /db_xref="dbSNP:1436421650"
     variation       68
                     /replace="y"
                     /db_xref="dbSNP:587782904"
     variation       69
                     /replace="s"
                     /db_xref="dbSNP:1131691048"
     variation       70
                     /replace="t"
                     /db_xref="dbSNP:200890320"
     variation       71
                     /replace="h"
                     /db_xref="dbSNP:794728947"
     variation       72
                     /replace="i"
                     /db_xref="dbSNP:1060503766"
     variation       73
                     /replace="l"
                     /db_xref="dbSNP:763734164"
     variation       73
                     /replace="s"
                     /db_xref="dbSNP:908633978"
     variation       74
                     /replace="a"
                     /db_xref="dbSNP:876658713"
     variation       74
                     /replace="e"
                     /db_xref="dbSNP:199678117"
     variation       75
                     /replace="a"
                     /db_xref="dbSNP:201762207"
     variation       75
                     /replace="g"
                     /db_xref="dbSNP:1232289801"
     variation       76
                     /replace="*"
                     /db_xref="dbSNP:864321638"
     variation       76
                     /replace="f"
                     /db_xref="dbSNP:1322261855"
     variation       78
                     /replace="k"
                     /db_xref="dbSNP:776971836"
     variation       78
                     /replace="r"
                     /db_xref="dbSNP:774960237"
     variation       79
                     /replace="f"
                     /db_xref="dbSNP:771524558"
     variation       79
                     /replace="t"
                     /db_xref="dbSNP:572028124"
     variation       80
                     /replace="e"
                     /db_xref="dbSNP:1131691051"
     variation       81
                     /replace="y"
                     /db_xref="dbSNP:1315623287"
     variation       82
                     /replace="d"
                     /db_xref="dbSNP:984091169"
     variation       83
                     /replace="g"
                     /db_xref="dbSNP:763547482"
     variation       84
                     /replace="a"
                     /db_xref="dbSNP:864321637"
     variation       84
                     /replace="e"
                     /db_xref="dbSNP:1427902008"
     variation       85
                     /replace="f"
                     /db_xref="dbSNP:1454196953"
     variation       85
                     /replace="p"
                     /db_xref="dbSNP:1173727795"
     variation       87
                     /replace="l"
                     /db_xref="dbSNP:1351229825"
     variation       87
                     /replace="s"
                     /db_xref="dbSNP:727504457"
     variation       88
                     /replace="i"
                     /db_xref="dbSNP:915794675"
     variation       88
                     /replace="t"
                     /db_xref="dbSNP:41310416"
     variation       90
                     /replace="*"
                     /db_xref="dbSNP:74315366"
     variation       90
                     /replace="q"
                     /db_xref="dbSNP:570278423"
     variation       91
                     /replace="*"
                     /db_xref="dbSNP:878854575"
     variation       93
                     /replace="f"
                     /db_xref="dbSNP:1131691054"
     variation       93
                     /replace="r"
                     /db_xref="dbSNP:727503415"
     variation       96
                     /replace="d"
                     /db_xref="dbSNP:778952116"
     variation       96
                     /replace="g"
                     /db_xref="dbSNP:757123577"
     variation       96
                     /replace="s"
                     /db_xref="dbSNP:587782243"
     variation       99
                     /replace="d"
                     /db_xref="dbSNP:878854576"
     variation       99
                     /replace="s"
                     /db_xref="dbSNP:948603037"
     variation       100
                     /replace="c"
                     /db_xref="dbSNP:121917755"
     variation       100
                     /replace="s"
                     /db_xref="dbSNP:11541235"
     variation       101
                     /replace="y"
                     /db_xref="dbSNP:74315371"
     variation       102
                     /replace="t"
                     /db_xref="dbSNP:777578399"
     variation       103
                     /replace="v"
                     /db_xref="dbSNP:140178341"
     variation       104
                     /replace="k"
                     /db_xref="dbSNP:1389798038"
     variation       104
                     /replace="n"
                     /db_xref="dbSNP:876660346"
     variation       104
                     /replace="r"
                     /db_xref="dbSNP:786201316"
     variation       104
                     /replace="s"
                     /db_xref="dbSNP:1310341038"
     variation       105
                     /replace="l"
                     /db_xref="dbSNP:1356656612"
     variation       106
                     /replace="s"
                     /db_xref="dbSNP:934514080"
     variation       107
                     /replace="r"
                     /db_xref="dbSNP:752361543"
     variation       108
                     /replace="d"
                     /db_xref="dbSNP:767062764"
     variation       109
                     /replace="h"
                     /db_xref="dbSNP:1168768454"
     variation       110
                     /replace="s"
                     /db_xref="dbSNP:1407350591"
     variation       111
                     /replace="s"
                     /db_xref="dbSNP:1060503751"
     variation       112
                     /replace="s"
                     /db_xref="dbSNP:794728948"
     variation       113
                     /replace="c"
                     /db_xref="dbSNP:754582722"
     variation       113
                     /replace="s"
                     /db_xref="dbSNP:864321636"
     variation       114
                     /replace="t"
                     /db_xref="dbSNP:528599830"
     variation       115
                     /replace="*"
                     /db_xref="dbSNP:751000085"
     variation       115
                     /replace="l"
                     /db_xref="dbSNP:200973284"
     variation       116
                     /replace="s"
                     /db_xref="dbSNP:1460143256"
     variation       116
                     /replace="t"
                     /db_xref="dbSNP:777234785"
     variation       117
                     /replace="h"
                     /db_xref="dbSNP:1480267715"
     variation       118
                     /replace="n"
                     /db_xref="dbSNP:200021702"
     variation       119
                     /replace="n"
                     /db_xref="dbSNP:11541234"
     variation       121
                     /replace="f"
                     /db_xref="dbSNP:1194401420"
     variation       121
                     /replace="l"
                     /db_xref="dbSNP:924467627"
     variation       121
                     /replace="p"
                     /db_xref="dbSNP:775925040"
     variation       122
                     /replace="k"
                     /db_xref="dbSNP:1321958068"
     variation       124
                     /replace="f"
                     /db_xref="dbSNP:978525560"
     variation       125
                     /replace="*"
                     /db_xref="dbSNP:786203506"
     variation       126
                     /replace="e"
                     /db_xref="dbSNP:202095022"
     variation       127
                     /replace="l"
                     /db_xref="dbSNP:201372280"
     variation       127
                     /replace="s"
                     /db_xref="dbSNP:786201095"
     variation       128
                     /replace="c"
                     /db_xref="dbSNP:772158627"
     variation       129
                     /replace="r"
                     /db_xref="dbSNP:587781735"
     variation       130
                     /replace="p"
                     /db_xref="dbSNP:746011241"
     variation       132
                     /replace="p"
                     /db_xref="dbSNP:74315372"
     variation       133
                     /replace="i"
                     /db_xref="dbSNP:201403014"
     variation       133
                     /replace="t"
                     /db_xref="dbSNP:553392349"
     variation       133
                     /replace="v"
                     /db_xref="dbSNP:1392546433"
     variation       134
                     /replace="c"
                     /db_xref="dbSNP:200893429"
     variation       134
                     /replace="h"
                     /db_xref="dbSNP:771004483"
     variation       135
                     /replace="m"
                     /db_xref="dbSNP:201585157"
     variation       138
                     /replace="y"
                     /db_xref="dbSNP:786203529"
     variation       139
                     /replace="f"
                     /db_xref="dbSNP:397516834"
     variation       139
                     /replace="r"
                     /db_xref="dbSNP:777629820"
     variation       140
                     /replace="f"
                     /db_xref="dbSNP:267607032"
     variation       141
                     /replace="p"
                     /db_xref="dbSNP:150542357"
     variation       142
                     /replace="v"
                     /db_xref="dbSNP:759709073"
     variation       145
                     /replace="i"
                     /db_xref="dbSNP:866013015"
     variation       147
                     /replace="*"
                     /db_xref="dbSNP:1060503763"
     variation       147
                     /replace="c"
                     /db_xref="dbSNP:774568101"
     variation       148
                     /replace="h"
                     /db_xref="dbSNP:876659491"
     variation       149
                     /replace="*"
                     /db_xref="dbSNP:876658451"
     variation       149
                     /replace="h"
                     /db_xref="dbSNP:200353146"
     variation       152
                     /replace="f"
                     /db_xref="dbSNP:200414835"
     variation       152
                     /replace="p"
                     /db_xref="dbSNP:886045584"
     variation       152
                     /replace="s"
                     /db_xref="dbSNP:1191500669"
     variation       153
                     /replace="t"
                     /db_xref="dbSNP:1396860069"
     variation       153
                     /replace="v"
                     /db_xref="dbSNP:1450956956"
     variation       154
                     /replace="g"
                     /db_xref="dbSNP:545307760"
     variation       155
                     /replace="s"
                     /db_xref="dbSNP:763008243"
     variation       156
                     /replace="y"
                     /db_xref="dbSNP:199718947"
     variation       160
                     /replace="-"
                     /db_xref="dbSNP:1173714647"
     variation       161
                     /replace="g"
                     /db_xref="dbSNP:1049317868"
     variation       161
                     /replace="m"
                     /db_xref="dbSNP:794728949"
     variation       163
                     /replace="f"
                     /db_xref="dbSNP:769687734"
     variation       163
                     /replace="p"
                     /db_xref="dbSNP:33927012"
     variation       164
                     /replace="r"
                     /db_xref="dbSNP:747984404"
     variation       166
                     /replace="d"
                     /db_xref="dbSNP:1060503760"
     variation       167
                     /replace="*"
                     /db_xref="dbSNP:1060503753"
     variation       171
                     /replace="l"
                     /db_xref="dbSNP:780870337"
     variation       172
                     /replace="q"
                     /db_xref="dbSNP:138937650"
     variation       173
                     /replace="f"
                     /db_xref="dbSNP:895331139"
     variation       173
                     /replace="s"
                     /db_xref="dbSNP:768454654"
     variation       174
                     /replace="t"
                     /db_xref="dbSNP:200301019"
     variation       174
                     /replace="v"
                     /db_xref="dbSNP:969943651"
     variation       175
                     /replace="g"
                     /db_xref="dbSNP:746643960"
     variation       175
                     /replace="q"
                     /db_xref="dbSNP:202203339"
     variation       176
                     /replace="g"
                     /db_xref="dbSNP:201082445"
     variation       176
                     /replace="q"
                     /db_xref="dbSNP:794728946"
     variation       177
                     /replace="c"
                     /db_xref="dbSNP:149091125"
     variation       177
                     /replace="h"
                     /db_xref="dbSNP:150437793"
     variation       180
                     /replace="l"
                     /db_xref="dbSNP:528442805"
     variation       180
                     /replace="p"
                     /db_xref="dbSNP:1210181271"
     variation       181
                     /replace="d"
                     /db_xref="dbSNP:199809975"
     variation       181
                     /replace="n"
                     /db_xref="dbSNP:201385062"
     variation       181
                     /replace="v"
                     /db_xref="dbSNP:905999296"
     variation       182
                     /replace="r"
                     /db_xref="dbSNP:201928318"
     variation       183
                     /replace="l"
                     /db_xref="dbSNP:1411654404"
     variation       184
                     /replace="y"
                     /db_xref="dbSNP:202098600"
     variation       185
                     /replace="e"
                     /db_xref="dbSNP:761890806"
     variation       185
                     /replace="g"
                     /db_xref="dbSNP:786203899"
     variation       185
                     /replace="k"
                     /db_xref="dbSNP:1045881797"
     variation       188
                     /replace="f"
                     /db_xref="dbSNP:1392463987"
     variation       188
                     /replace="l"
                     /db_xref="dbSNP:776487215"
     variation       189
                     /replace="f"
                     /db_xref="dbSNP:876658540"
     variation       190
                     /replace="t"
                     /db_xref="dbSNP:199789177"
     variation       190
                     /replace="v"
                     /db_xref="dbSNP:201900648"
     variation       192
                     /replace="r"
                     /db_xref="dbSNP:786202732"
     variation       192
                     /replace="s"
                     /db_xref="dbSNP:397516835"
     variation       193
                     /replace="g"
                     /db_xref="dbSNP:760438782"
     variation       194
                     /replace="s"
                     /db_xref="dbSNP:200535030"
     variation       194
                     /replace="t"
                     /db_xref="dbSNP:775450654"
     variation       196
                     /replace="c"
                     /db_xref="dbSNP:1060505015"
     variation       196
                     /replace="y"
                     /db_xref="dbSNP:876658367"
     variation       197
                     /replace="r"
                     /db_xref="dbSNP:74315367"
     variation       198
                     /replace="a"
                     /db_xref="dbSNP:1060503757"
     variation       199
                     /replace="g"
                     /db_xref="dbSNP:1131691059"
     variation       200
                     /replace="c"
                     /db_xref="dbSNP:397516836"
     variation       201
                     /replace="*"
                     /db_xref="dbSNP:1060503759"
     variation       202
                     /replace="k"
                     /db_xref="dbSNP:1131691053"
     variation       202
                     /replace="n"
                     /db_xref="dbSNP:199653121"
     variation       203
                     /replace="i"
                     /db_xref="dbSNP:587782617"
     variation       203
                     /replace="r"
                     /db_xref="dbSNP:201517260"
     variation       204
                     /replace="t"
                     /db_xref="dbSNP:1131691050"
     variation       205
                     /replace="r"
                     /db_xref="dbSNP:774090318"
     variation       207
                     /replace="l"
                     /db_xref="dbSNP:1487270391"
     variation       207
                     /replace="r"
                     /db_xref="dbSNP:1060503752"
     variation       208
                     /replace="g"
                     /db_xref="dbSNP:1214592422"
     variation       209
                     /replace="p"
                     /db_xref="dbSNP:1060505016"
     variation       210
                     /replace="v"
                     /db_xref="dbSNP:1252727177"
     variation       212
                     /replace="h"
                     /db_xref="dbSNP:1307247907"
     variation       212
                     /replace="l"
                     /db_xref="dbSNP:778439194"
     variation       212
                     /replace="v"
                     /db_xref="dbSNP:1228560456"
     variation       213
                     /replace="i"
                     /db_xref="dbSNP:1131691047"
     variation       213
                     /replace="l"
                     /db_xref="dbSNP:770622939"
     variation       213
                     /replace="t"
                     /db_xref="dbSNP:202014362"
     variation       214
                     /replace="*"
                     /db_xref="dbSNP:876658461"
     variation       214
                     /replace="p"
                     /db_xref="dbSNP:781590955"
     variation       214
                     /replace="q"
                     /db_xref="dbSNP:1278834014"
     variation       215
                     /replace="a"
                     /db_xref="dbSNP:1473312934"
     variation       215
                     /replace="t"
                     /db_xref="dbSNP:772798766"
     variation       215
                     /replace="v"
                     /db_xref="dbSNP:1060503761"
     variation       217
                     /replace="g"
                     /db_xref="dbSNP:200245469"
     variation       217
                     /replace="l"
                     /db_xref="dbSNP:747518441"
     variation       218
                     /replace="*"
                     /db_xref="dbSNP:916516745"
     variation       220
                     /replace="t"
                     /db_xref="dbSNP:878854578"
     variation       220
                     /replace="v"
                     /db_xref="dbSNP:1188548211"
     variation       221
                     /replace="d"
                     /db_xref="dbSNP:1475864409"
     variation       224
                     /replace="n"
                     /db_xref="dbSNP:780477085"
     variation       227
                     /replace="a"
                     /db_xref="dbSNP:1191046308"
     variation       227
                     /replace="i"
                     /db_xref="dbSNP:1486615365"
     variation       228
                     /replace="g"
                     /db_xref="dbSNP:762812025"
     variation       229
                     /replace="a"
                     /db_xref="dbSNP:1209914140"
     variation       229
                     /replace="d"
                     /db_xref="dbSNP:1060503754"
     variation       230
                     /replace="c"
                     /db_xref="dbSNP:138996609"
     variation       230
                     /replace="h"
                     /db_xref="dbSNP:587782604"
     variation       232
                     /replace="a"
                     /db_xref="dbSNP:779143585"
     variation       232
                     /replace="v"
                     /db_xref="dbSNP:746224555"
     variation       234
                     /replace="l"
                     /db_xref="dbSNP:201728852"
     variation       234
                     /replace="l"
                     /db_xref="dbSNP:370397369"
     variation       234
                     /replace="p"
                     /db_xref="dbSNP:786202913"
     variation       237
                     /replace="a"
                     /db_xref="dbSNP:186768244"
     variation       237
                     /replace="r"
                     /db_xref="dbSNP:878854579"
     variation       238
                     /replace="s"
                     /db_xref="dbSNP:876660642"
     variation       239
                     /replace="c"
                     /db_xref="dbSNP:201098090"
     variation       239
                     /replace="y"
                     /db_xref="dbSNP:587781266"
     variation       240
                     /replace="l"
                     /db_xref="dbSNP:759446340"
     variation       240
                     /replace="p"
                     /db_xref="dbSNP:1131691046"
     variation       240
                     /replace="s"
                     /db_xref="dbSNP:1060503764"
     variation       240
                     /replace="t"
                     /db_xref="dbSNP:794728950"
     variation       241
                     /replace="c"
                     /db_xref="dbSNP:878854582"
     variation       241
                     /replace="d"
                     /db_xref="dbSNP:1060503758"
     variation       241
                     /replace="y"
                     /db_xref="dbSNP:878854583"
     variation       242
                     /replace="h"
                     /db_xref="dbSNP:74315368"
     variation       242
                     /replace="s"
                     /db_xref="dbSNP:786203251"
     variation       244
                     /replace="y"
                     /db_xref="dbSNP:766038910"
     variation       246
                     /replace="i"
                     /db_xref="dbSNP:1476198465"
     variation       246
                     /replace="v"
                     /db_xref="dbSNP:146800605"
     variation       247
                     /replace="v"
                     /db_xref="dbSNP:200896502"
     variation       248
                     /replace="k"
                     /db_xref="dbSNP:1131691058"
     variation       249
                     /replace="r"
                     /db_xref="dbSNP:1064794664"
     variation       249
                     /replace="y"
                     /db_xref="dbSNP:1064794269"
     variation       250
                     /replace="i"
                     /db_xref="dbSNP:1057517537"
     variation       251
                     /replace="s"
                     /db_xref="dbSNP:201094649"
     variation       252
                     /replace="i"
                     /db_xref="dbSNP:769359897"
     variation       253
                     /replace="y"
                     /db_xref="dbSNP:786201085"
     variation       254
                     /replace="l"
                     /db_xref="dbSNP:34309090"
     variation       254
                     /replace="l"
                     /db_xref="dbSNP:948484408"
     variation       255
                     /replace="n"
                     /db_xref="dbSNP:761295633"
     variation       256
                     /replace="g"
                     /db_xref="dbSNP:1060505017"
     variation       257
                     /replace="l"
                     /db_xref="dbSNP:199714034"
     variation       257
                     /replace="v"
                     /db_xref="dbSNP:761350633"
     variation       260
                     /replace="r"
                     /db_xref="dbSNP:1187293049"
     variation       261
                     /replace="k"
                     /db_xref="dbSNP:1060505014"
     variation       262
                     /replace="a"
                     /db_xref="dbSNP:768118230"
     variation       262
                     /replace="v"
                     /db_xref="dbSNP:776093267"
     variation       263
                     /replace="i"
                     /db_xref="dbSNP:1395418494"
     variation       263
                     /replace="s"
                     /db_xref="dbSNP:1064795128"
     variation       265
                     /replace="g"
                     /db_xref="dbSNP:1469877501"
     variation       266
                     /replace="i"
                     /db_xref="dbSNP:760042733"
     variation       267
                     /replace="n"
                     /db_xref="dbSNP:771388711"
     variation       267
                     /replace="r"
                     /db_xref="dbSNP:774666954"
     variation       268
                     /replace="*"
                     /db_xref="dbSNP:1060503755"
     variation       269
                     /replace="v"
                     /db_xref="dbSNP:749612417"
     variation       270
                     /replace="v"
                     /db_xref="dbSNP:878854584"
     variation       271
                     /replace="s"
                     /db_xref="dbSNP:1418428253"
     variation       272
                     /replace="a"
                     /db_xref="dbSNP:545681543"
     variation       272
                     /replace="i"
                     /db_xref="dbSNP:1195207024"
     variation       272
                     /replace="t"
                     /db_xref="dbSNP:1454454086"
     variation       273
                     /replace="c"
                     /db_xref="dbSNP:773523792"
     variation       274
                     /replace="e"
                     /db_xref="dbSNP:1273897502"
     variation       274
                     /replace="m"
                     /db_xref="dbSNP:1211308568"
     variation       275
                     /replace="-"
                     /db_xref="dbSNP:1221042239"
     variation       275
                     /replace="k"
                     /db_xref="dbSNP:1486588594"
     variation       276
                     /replace="k"
                     /db_xref="dbSNP:1260768784"
     variation       279
                     /replace="s"
                     /db_xref="dbSNP:770120161"
     variation       279
                     /replace="t"
                     /db_xref="dbSNP:1275426951"
     CDS             1..280
                     /gene="SDHB"
                     /gene_synonym="CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP"
                     /coded_by="NM_003000.2:152..994"
                     /db_xref="CCDS:CCDS176.1"
                     /db_xref="GeneID:6390"
                     /db_xref="HGNC:HGNC:10681"
                     /db_xref="MIM:185470"
ORIGIN      
        1 maavvalslr rrlpattlgg aclqasrgaq taaataprik kfaiyrwdpd kagdkphmqt
       61 yevdlnkcgp mvldalikik nevdstltfr rscregicgs camninggnt lactrridtn
      121 lnkvskiypl phmyvikdlv pdlsnfyaqy ksiepylkkk desqegkqqy lqsieerekl
      181 dglyecilca ccstscpsyw wngdkylgpa vlmqayrwmi dsrddfteer laklqdpfsl
      241 yrchtimnct rtcpkglnpg kaiaeikkmm atykekkasv
//
DBGET integrated database retrieval system