GenomeNet

Database: RefSeq
Entry: NP_004159
LinkDB: NP_004159
Original site: NP_004159 
LOCUS       NP_004159                664 aa            linear   PRI 22-NOV-2018
DEFINITION  succinate dehydrogenase [ubiquinone] flavoprotein subunit,
            mitochondrial isoform 1 [Homo sapiens].
ACCESSION   NP_004159
VERSION     NP_004159.2
DBSOURCE    REFSEQ: accession NM_004168.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 664)
  AUTHORS   Tsujii N, Hayashi T, Hayashi T, Kimura A and Nishikubo T.
  TITLE     Barth syndrome associated with triple mutation
  JOURNAL   Pediatr Int 60 (4), 385-387 (2018)
   PUBMED   29508483
  REMARK    GeneRIF: Report left ventricular non-compaction associated with
            Barth Syndrome due to triple mutations in TAZ, DTNA, and SDHA genes
            in multiple members of one family.
REFERENCE   2  (residues 1 to 664)
  AUTHORS   van der Tuin K, Mensenkamp AR, Tops CMJ, Corssmit EPM, Dinjens WN,
            van de Horst-Schrivers ANA, Jansen JC, de Jong MM, Kunst HPM,
            Kusters B, Leter EM, Morreau H, van Nesselrooij BMP, Oldenburg RA,
            Spruijt L, Hes FJ and Timmers HJLM.
  TITLE     Clinical Aspects of SDHA-Related Pheochromocytoma and
            Paraganglioma: A Nationwide Study
  JOURNAL   J. Clin. Endocrinol. Metab. 103 (2), 438-445 (2018)
   PUBMED   29177515
  REMARK    GeneRIF: Germline SDHA mutations are relatively common (7.6%) in
            patients with genetically unexplained paraganglioma (PGL). Most
            index patients presented with apparently sporadic PGL. In this SDHA
            series, the largest assembled so far, we found the lowest
            penetrance of all major PGL predisposition genes.
            Erratum:[J Clin Endocrinol Metab. 2018 May 1;103(5):2077. PMID:
            29538659]
REFERENCE   3  (residues 1 to 664)
  AUTHORS   Bannon AE, Kent J, Forquer I, Town A, Klug LR, McCann K, Beadling
            C, Harismendy O, Sicklick JK, Corless C, Shinde U and Heinrich MC.
  TITLE     Biochemical, Molecular, and Clinical Characterization of Succinate
            Dehydrogenase Subunit A Variants of Unknown Significance
  JOURNAL   Clin. Cancer Res. 23 (21), 6733-6743 (2017)
   PUBMED   28724664
  REMARK    GeneRIF: We used a yeast model to characterize 22 SDHA VUS. These
            data revealed 16 (73%) of SDHA VUS as loss of function (and
            therefore pathogenic), highlighting the importance of understanding
            such variants to provide better clinical recommendations for
            genetic counselors concerning family screening and early detection
            protocols.
REFERENCE   4  (residues 1 to 664)
  AUTHORS   Tufton N, Ghelani R, Srirangalingam U, Kumar AV, Drake WM,
            Iacovazzo D, Skordilis K, Berney D, Al-Mrayat M, Khoo B and Akker
            SA.
  TITLE     SDHA mutated paragangliomas may be at high risk of metastasis
  JOURNAL   Endocr. Relat. Cancer 24 (7), L43-L49 (2017)
   PUBMED   28500238
  REMARK    GeneRIF: The six index cases described here presented with a
            variety of clinical manifestations extending the known phenotypic
            spectrum in SDHA disease.
REFERENCE   5  (residues 1 to 664)
  AUTHORS   Parfait B, Chretien D, Rotig A, Marsac C, Munnich A and Rustin P.
  TITLE     Compound heterozygous mutations in the flavoprotein gene of the
            respiratory chain complex II in a patient with Leigh syndrome
  JOURNAL   Hum. Genet. 106 (2), 236-243 (2000)
   PUBMED   10746566
REFERENCE   6  (residues 1 to 664)
  AUTHORS   Bourgeron T, Rustin P, Chretien D, Birch-Machin M, Bourgeois M,
            Viegas-Pequignot E, Munnich A and Rotig A.
  TITLE     Mutation of a nuclear succinate dehydrogenase gene results in
            mitochondrial respiratory chain deficiency
  JOURNAL   Nat. Genet. 11 (2), 144-149 (1995)
   PUBMED   7550341
REFERENCE   7  (residues 1 to 664)
  AUTHORS   Hirawake H, Wang H, Kuramochi T, Kojima S and Kita K.
  TITLE     Human complex II (succinate-ubiquinone oxidoreductase): cDNA
            cloning of the flavoprotein (Fp) subunit of liver mitochondria
  JOURNAL   J. Biochem. 116 (1), 221-227 (1994)
   PUBMED   7798181
REFERENCE   8  (residues 1 to 664)
  AUTHORS   Morris AA, Farnsworth L, Ackrell BA, Turnbull DM and Birch-Machin
            MA.
  TITLE     The cDNA sequence of the flavoprotein subunit of human heart
            succinate dehydrogenase
  JOURNAL   Biochim. Biophys. Acta 1185 (1), 125-128 (1994)
   PUBMED   8142412
REFERENCE   9  (residues 1 to 664)
  AUTHORS   Rahman,S. and Thorburn,D.
  TITLE     Nuclear Gene-Encoded Leigh Syndrome Overview
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   26425749
REFERENCE   10 (residues 1 to 664)
  AUTHORS   Else,T., Greenberg,S. and Fishbein,L.
  TITLE     Hereditary Paraganglioma-Pheochromocytoma Syndromes
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301715
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA160919.1, BC001380.2,
            AK291311.1, AC021087.5 and HY265959.1.
            On Aug 24, 2007 this sequence version replaced NP_004159.1.
            
            Summary: This gene encodes a major catalytic subunit of
            succinate-ubiquinone oxidoreductase, a complex of the mitochondrial
            respiratory chain. The complex is composed of four nuclear-encoded
            subunits and is localized in the mitochondrial inner membrane.
            Mutations in this gene have been associated with a form of
            mitochondrial respiratory chain deficiency known as Leigh Syndrome.
            A pseudogene has been identified on chromosome 3q29. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.75315.1,
                                           SRR1803617.168940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     Protein         1..664
                     /product="succinate dehydrogenase [ubiquinone]
                     flavoprotein subunit, mitochondrial isoform 1"
                     /EC_number="1.3.5.1"
                     /note="succinate dehydrogenase [ubiquinone] flavoprotein
                     subunit, mitochondrial; flavoprotein subunit of complex
                     II; succinate dehydrogenase complex, subunit A,
                     flavoprotein (Fp)"
                     /calculated_mol_wt=68084
     transit_peptide 1..42
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Mitochondrion. {ECO:0000250|UniProtKB:Q0QF01};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
                     /calculated_mol_wt=4626
     variation       1
                     /replace="c"
                     /db_xref="dbSNP:1085307796"
     variation       1
                     /replace="k"
                     /db_xref="dbSNP:750380279"
     variation       1
                     /replace="l"
                     /db_xref="dbSNP:1061517"
     variation       2
                     /replace="l"
                     /db_xref="dbSNP:780064103"
     variation       2
                     /replace="p"
                     /db_xref="dbSNP:758327622"
     variation       2
                     /replace="s"
                     /db_xref="dbSNP:751383247"
     variation       3
                     /replace="a"
                     /db_xref="dbSNP:1398198098"
     variation       3
                     /replace="g"
                     /db_xref="dbSNP:1252447154"
     variation       3
                     /replace="r"
                     /db_xref="dbSNP:756415935"
     variation       4
                     /replace="f"
                     /db_xref="dbSNP:778069799"
     variation       4
                     /replace="v"
                     /db_xref="dbSNP:749406988"
     variation       5
                     /replace="g"
                     /db_xref="dbSNP:770866830"
     variation       5
                     /replace="q"
                     /db_xref="dbSNP:779027774"
     variation       5
                     /replace="r"
                     /db_xref="dbSNP:1260744894"
     variation       6
                     /replace="d"
                     /db_xref="dbSNP:187964306"
     variation       6
                     /replace="g"
                     /db_xref="dbSNP:775847689"
     variation       6
                     /replace="s"
                     /db_xref="dbSNP:1352756438"
     variation       7
                     /replace="l"
                     /db_xref="dbSNP:760964443"
     variation       8
                     /replace="p"
                     /db_xref="dbSNP:768328967"
     variation       8
                     /replace="s"
                     /db_xref="dbSNP:1060505007"
     variation       8
                     /replace="w"
                     /db_xref="dbSNP:878854631"
     variation       9
                     /replace="l"
                     /db_xref="dbSNP:761508577"
     variation       9
                     /replace="w"
                     /db_xref="dbSNP:776218604"
     variation       10
                     /replace="l"
                     /db_xref="dbSNP:879099314"
     variation       11
                     /replace="l"
                     /db_xref="dbSNP:1139423"
     variation       11
                     /replace="p"
                     /db_xref="dbSNP:1139422"
     variation       14
                     /replace="r"
                     /db_xref="dbSNP:1192077362"
     variation       15
                     /replace="p"
                     /db_xref="dbSNP:1060503707"
     variation       15
                     /replace="r"
                     /db_xref="dbSNP:1060505002"
     variation       17
                     /replace="a"
                     /db_xref="dbSNP:764698195"
     variation       18
                     /replace="l"
                     /db_xref="dbSNP:1268905760"
     variation       19
                     /replace="a"
                     /db_xref="dbSNP:749948037"
     variation       21
                     /replace="a"
                     /db_xref="dbSNP:587781942"
     variation       23
                     /replace="l"
                     /db_xref="dbSNP:376207983"
     variation       24
                     /replace="i"
                     /db_xref="dbSNP:1196667387"
     variation       25
                     /replace="v"
                     /db_xref="dbSNP:774378936"
     variation       27
                     /replace="q"
                     /db_xref="dbSNP:759523671"
     variation       28
                     /replace="i"
                     /db_xref="dbSNP:1171584124"
     variation       29
                     /replace="e"
                     /db_xref="dbSNP:1436200566"
     variation       31
                     /replace="*"
                     /db_xref="dbSNP:142441643"
     variation       31
                     /replace="q"
                     /db_xref="dbSNP:752532780"
     variation       32
                     /replace="v"
                     /db_xref="dbSNP:1173329629"
     variation       33
                     /replace="v"
                     /db_xref="dbSNP:1061518"
     variation       34
                     /replace="r"
                     /db_xref="dbSNP:757478250"
     variation       34
                     /replace="y"
                     /db_xref="dbSNP:1395903862"
     variation       35
                     /replace="l"
                     /db_xref="dbSNP:765434536"
     variation       36
                     /replace="a"
                     /db_xref="dbSNP:750500173"
     variation       36
                     /replace="i"
                     /db_xref="dbSNP:1440814662"
     variation       36
                     /replace="t"
                     /db_xref="dbSNP:1301747916"
     variation       37
                     /replace="i"
                     /db_xref="dbSNP:758426529"
     variation       38
                     /replace="e"
                     /db_xref="dbSNP:1061519"
     variation       38
                     /replace="v"
                     /db_xref="dbSNP:34635677"
     Region          40..664
                     /region_name="PTZ00139"
                     /note="Succinate dehydrogenase [ubiquinone] flavoprotein
                     subunit; Provisional"
                     /db_xref="CDD:240286"
     variation       41
                     /replace="q"
                     /db_xref="dbSNP:1061520"
     variation       42
                     /replace="k"
                     /db_xref="dbSNP:747557411"
     mat_peptide     43..664
                     /product="Succinate dehydrogenase [ubiquinone]
                     flavoprotein subunit, mitochondrial"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31040.2)"
                     /calculated_mol_wt=68084
     variation       43
                     /replace="g"
                     /db_xref="dbSNP:1385076821"
     variation       45
                     /replace="t"
                     /db_xref="dbSNP:140736646"
     variation       46
                     /replace="e"
                     /db_xref="dbSNP:144599870"
     variation       47
                     /replace="v"
                     /db_xref="dbSNP:748490907"
     variation       48
                     /replace="s"
                     /db_xref="dbSNP:757353358"
     variation       49
                     /replace="g"
                     /db_xref="dbSNP:80207011"
     variation       50
                     /replace="f"
                     /db_xref="dbSNP:369321221"
     variation       50
                     /replace="s"
                     /db_xref="dbSNP:140264486"
     variation       52
                     /replace="f"
                     /db_xref="dbSNP:377470390"
     variation       52
                     /replace="t"
                     /db_xref="dbSNP:150326789"
     variation       54
                     /replace="q"
                     /db_xref="dbSNP:1468436658"
     variation       55
                     /replace="h"
                     /db_xref="dbSNP:142926807"
     variation       56
                     /replace="p"
                     /db_xref="dbSNP:745316978"
     variation       57
                     /replace="i"
                     /db_xref="dbSNP:1060503724"
     variation       58
                     /replace="-"
                     /db_xref="dbSNP:1230864771"
     variation       58
                     /replace="v"
                     /db_xref="dbSNP:771935948"
     variation       59
                     /replace="a"
                     /db_xref="dbSNP:775449731"
     variation       64
                     /replace="v"
                     /db_xref="dbSNP:760510019"
     variation       66
                     /replace="v"
                     /db_xref="dbSNP:1429525714"
     variation       67
                     /replace="i"
                     /db_xref="dbSNP:754770189"
     variation       68
                     /replace="g"
                     /db_xref="dbSNP:1055082816"
     variation       69
                     /replace="t"
                     /db_xref="dbSNP:370481102"
     variation       69
                     /replace="v"
                     /db_xref="dbSNP:886043564"
     variation       72
                     /replace="e"
                     /db_xref="dbSNP:1204881025"
     variation       72
                     /replace="t"
                     /db_xref="dbSNP:1486695889"
     variation       73
                     /replace="g"
                     /db_xref="dbSNP:776288745"
     variation       74
                     /replace="w"
                     /db_xref="dbSNP:763220651"
     variation       75
                     /replace="*"
                     /db_xref="dbSNP:781764920"
     variation       75
                     /replace="q"
                     /db_xref="dbSNP:751645963"
     variation       76
                     /replace="a"
                     /db_xref="dbSNP:1416043203"
     variation       78
                     /replace="f"
                     /db_xref="dbSNP:201138324"
     variation       79
                     /replace="d"
                     /db_xref="dbSNP:759568419"
     variation       79
                     /replace="g"
                     /db_xref="dbSNP:767927763"
     variation       80
                     /replace="f"
                     /db_xref="dbSNP:1247426048"
     variation       80
                     /replace="p"
                     /db_xref="dbSNP:200005136"
     variation       83
                     /replace="s"
                     /db_xref="dbSNP:1169341508"
     variation       84
                     /replace="e"
                     /db_xref="dbSNP:199615452"
     variation       84
                     /replace="g"
                     /db_xref="dbSNP:753293451"
     variation       85
                     /replace="l"
                     /db_xref="dbSNP:760710175"
     variation       86
                     /replace="d"
                     /db_xref="dbSNP:200519133"
     variation       87
                     /replace="i"
                     /db_xref="dbSNP:756543943"
     variation       88
                     /replace="a"
                     /db_xref="dbSNP:1421838740"
     variation       89
                     /replace="y"
                     /db_xref="dbSNP:138016874"
     variation       90
                     /replace="a"
                     /db_xref="dbSNP:886060514"
     variation       92
                     /replace="n"
                     /db_xref="dbSNP:375298039"
     variation       92
                     /replace="t"
                     /db_xref="dbSNP:778267118"
     variation       93
                     /replace="p"
                     /db_xref="dbSNP:1326611328"
     variation       96
                     /replace="a"
                     /db_xref="dbSNP:1412534704"
     variation       96
                     /replace="i"
                     /db_xref="dbSNP:377620054"
     variation       97
                     /replace="t"
                     /db_xref="dbSNP:371274523"
     variation       99
                     /replace="h"
                     /db_xref="dbSNP:745395045"
     variation       99
                     /replace="y"
                     /db_xref="dbSNP:786205145"
     Site            99
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Tele-8alpha-FAD histidine.
                     {ECO:0000250|UniProtKB:Q0QF01}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       100
                     /replace="a"
                     /db_xref="dbSNP:1304729997"
     variation       100
                     /replace="t"
                     /db_xref="dbSNP:771662494"
     variation       102
                     /replace="v"
                     /db_xref="dbSNP:1240528592"
     variation       103
                     /replace="a"
                     /db_xref="dbSNP:1139424"
     variation       104
                     /replace="*"
                     /db_xref="dbSNP:1423978863"
     variation       104
                     /replace="h"
                     /db_xref="dbSNP:876658637"
     variation       107
                     /replace="v"
                     /db_xref="dbSNP:1060503720"
     variation       108
                     /replace="d"
                     /db_xref="dbSNP:1401224564"
     variation       108
                     /replace="s"
                     /db_xref="dbSNP:758086385"
     variation       110
                     /replace="p"
                     /db_xref="dbSNP:786205209"
     variation       111
                     /replace="l"
                     /db_xref="dbSNP:1477038715"
     variation       111
                     /replace="l"
                     /db_xref="dbSNP:765884036"
     variation       112
                     /replace="g"
                     /db_xref="dbSNP:375645919"
     variation       112
                     /replace="r"
                     /db_xref="dbSNP:751114575"
     variation       113
                     /replace="h"
                     /db_xref="dbSNP:1450249875"
     variation       114
                     /replace="t"
                     /db_xref="dbSNP:199805178"
     variation       114
                     /replace="v"
                     /db_xref="dbSNP:933414586"
     variation       115
                     /replace="e"
                     /db_xref="dbSNP:368286780"
     variation       115
                     /replace="g"
                     /db_xref="dbSNP:1224313150"
     variation       118
                     /replace="n"
                     /db_xref="dbSNP:923803277"
     variation       118
                     /replace="s"
                     /db_xref="dbSNP:987288514"
     variation       124
                     /replace="c"
                     /db_xref="dbSNP:935241830"
     variation       124
                     /replace="y"
                     /db_xref="dbSNP:754393360"
     variation       125
                     /replace="n"
                     /db_xref="dbSNP:780654623"
     variation       126
                     /replace="s"
                     /db_xref="dbSNP:748121363"
     variation       126
                     /replace="t"
                     /db_xref="dbSNP:756039268"
     variation       127
                     /replace="m"
                     /db_xref="dbSNP:777600956"
     variation       128
                     /replace="n"
                     /db_xref="dbSNP:11557099"
     variation       128
                     /replace="t"
                     /db_xref="dbSNP:1392275932"
     variation       130
                     /replace="s"
                     /db_xref="dbSNP:748976493"
     variation       131
                     /replace="n"
                     /db_xref="dbSNP:1324014370"
     variation       133
                     /replace="g"
                     /db_xref="dbSNP:764993861"
     variation       134
                     /replace="g"
                     /db_xref="dbSNP:1218455728"
     variation       135
                     /replace="g"
                     /db_xref="dbSNP:772343171"
     variation       136
                     /replace="e"
                     /db_xref="dbSNP:1365359024"
     variation       136
                     /replace="l"
                     /db_xref="dbSNP:876660259"
     variation       136
                     /replace="q"
                     /db_xref="dbSNP:190477316"
     variation       137
                     /replace="d"
                     /db_xref="dbSNP:1444399160"
     variation       138
                     /replace="a"
                     /db_xref="dbSNP:1219265195"
     variation       138
                     /replace="v"
                     /db_xref="dbSNP:1342456775"
     variation       140
                     /replace="q"
                     /db_xref="dbSNP:747232441"
     variation       140
                     /replace="r"
                     /db_xref="dbSNP:759266253"
     variation       141
                     /replace="c"
                     /db_xref="dbSNP:1377816261"
     variation       141
                     /replace="y"
                     /db_xref="dbSNP:768897373"
     variation       142
                     /replace="v"
                     /db_xref="dbSNP:776848209"
     variation       143
                     /replace="r"
                     /db_xref="dbSNP:200675907"
     variation       143
                     /replace="t"
                     /db_xref="dbSNP:906281170"
     variation       145
                     /replace="e"
                     /db_xref="dbSNP:765784494"
     variation       146
                     /replace="t"
                     /db_xref="dbSNP:773634017"
     variation       146
                     /replace="v"
                     /db_xref="dbSNP:1060503714"
     variation       147
                     /replace="h"
                     /db_xref="dbSNP:763191656"
     variation       147
                     /replace="p"
                     /db_xref="dbSNP:201453889"
     variation       148
                     /replace="a"
                     /db_xref="dbSNP:367618662"
     variation       148
                     /replace="t"
                     /db_xref="dbSNP:375576259"
     variation       149
                     /replace="a"
                     /db_xref="dbSNP:752187837"
     variation       149
                     /replace="t"
                     /db_xref="dbSNP:575617625"
     variation       149
                     /replace="v"
                     /db_xref="dbSNP:1060503709"
     variation       150
                     /replace="m"
                     /db_xref="dbSNP:542980860"
     variation       151
                     /replace="d"
                     /db_xref="dbSNP:1407021164"
     variation       151
                     /replace="i"
                     /db_xref="dbSNP:143148642"
     variation       151
                     /replace="v"
                     /db_xref="dbSNP:138917116"
     variation       152
                     /replace="*"
                     /db_xref="dbSNP:778737664"
     variation       153
                     /replace="l"
                     /db_xref="dbSNP:1200591418"
     variation       154
                     /replace="g"
                     /db_xref="dbSNP:777873911"
     variation       155
                     /replace="s"
                     /db_xref="dbSNP:749824479"
     variation       156
                     /replace="d"
                     /db_xref="dbSNP:569384870"
     variation       156
                     /replace="f"
                     /db_xref="dbSNP:774589410"
     variation       156
                     /replace="m"
                     /db_xref="dbSNP:1190622143"
     variation       156
                     /replace="y"
                     /db_xref="dbSNP:989318548"
     variation       159
                     /replace="l"
                     /db_xref="dbSNP:759827541"
     variation       159
                     /replace="p"
                     /db_xref="dbSNP:771741537"
     variation       160
                     /replace="f"
                     /db_xref="dbSNP:1060503711"
     variation       160
                     /replace="l"
                     /db_xref="dbSNP:775074528"
     variation       162
                     /replace="s"
                     /db_xref="dbSNP:1479127918"
     variation       163
                     /replace="i"
                     /db_xref="dbSNP:375067326"
     variation       166
                     /replace="r"
                     /db_xref="dbSNP:1060503712"
     variation       167
                     /replace="q"
                     /db_xref="dbSNP:763578369"
     Site            167
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       169
                     /replace="c"
                     /db_xref="dbSNP:1464540890"
     variation       171
                     /replace="c"
                     /db_xref="dbSNP:776193478"
     variation       171
                     /replace="h"
                     /db_xref="dbSNP:587782076"
     variation       171
                     /replace="r"
                     /db_xref="dbSNP:765157205"
     variation       172
                     /replace="a"
                     /db_xref="dbSNP:181278759"
     variation       174
                     /replace="c"
                     /db_xref="dbSNP:766258363"
     variation       175
                     /replace="r"
                     /db_xref="dbSNP:753004001"
     variation       176
                     /replace="h"
                     /db_xref="dbSNP:769454045"
     variation       176
                     /replace="r"
                     /db_xref="dbSNP:1269124718"
     variation       177
                     /replace="s"
                     /db_xref="dbSNP:756351128"
     variation       178
                     /replace="l"
                     /db_xref="dbSNP:749329370"
     variation       178
                     /replace="p"
                     /db_xref="dbSNP:777770952"
     variation       179
                     /replace="k"
                     /db_xref="dbSNP:1207914111"
     variation       179
                     /replace="s"
                     /db_xref="dbSNP:753165149"
     Site            179
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            179
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       181
                     /replace="r"
                     /db_xref="dbSNP:1305547879"
     variation       182
                     /replace="k"
                     /db_xref="dbSNP:757707693"
     variation       182
                     /replace="r"
                     /db_xref="dbSNP:1269170598"
     Site            182
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       183
                     /replace="g"
                     /db_xref="dbSNP:61733344"
     variation       184
                     /replace="g"
                     /db_xref="dbSNP:147444427"
     variation       184
                     /replace="r"
                     /db_xref="dbSNP:148246073"
     variation       185
                     /replace="*"
                     /db_xref="dbSNP:775827529"
     variation       185
                     /replace="p"
                     /db_xref="dbSNP:1179470589"
     variation       186
                     /replace="a"
                     /db_xref="dbSNP:199618059"
     variation       186
                     /replace="g"
                     /db_xref="dbSNP:1173940446"
     variation       187
                     /replace="r"
                     /db_xref="dbSNP:1236616384"
     variation       188
                     /replace="q"
                     /db_xref="dbSNP:139881415"
     variation       188
                     /replace="w"
                     /db_xref="dbSNP:553257776"
     variation       190
                     /replace="c"
                     /db_xref="dbSNP:1060505008"
     variation       190
                     /replace="r"
                     /db_xref="dbSNP:908267345"
     variation       191
                     /replace="c"
                     /db_xref="dbSNP:765111856"
     variation       191
                     /replace="y"
                     /db_xref="dbSNP:1393298155"
     variation       192
                     /replace="g"
                     /db_xref="dbSNP:1231756170"
     variation       192
                     /replace="m"
                     /db_xref="dbSNP:773334818"
     variation       195
                     /replace="q"
                     /db_xref="dbSNP:762956849"
     variation       195
                     /replace="r"
                     /db_xref="dbSNP:766339992"
     variation       195
                     /replace="w"
                     /db_xref="dbSNP:1337777456"
     variation       196
                     /replace="t"
                     /db_xref="dbSNP:1278276778"
     variation       199
                     /replace="l"
                     /db_xref="dbSNP:878854633"
     variation       199
                     /replace="s"
                     /db_xref="dbSNP:141874250"
     variation       199
                     /replace="t"
                     /db_xref="dbSNP:770407681"
     variation       200
                     /replace="l"
                     /db_xref="dbSNP:201967413"
     variation       200
                     /replace="l"
                     /db_xref="dbSNP:764307917"
     variation       201
                     /replace="s"
                     /db_xref="dbSNP:150646390"
     variation       202
                     /replace="h"
                     /db_xref="dbSNP:1487422271"
     variation       202
                     /replace="p"
                     /db_xref="dbSNP:899368013"
     variation       203
                     /replace="a"
                     /db_xref="dbSNP:373340696"
     variation       205
                     /replace="*"
                     /db_xref="dbSNP:876658486"
     variation       205
                     /replace="h"
                     /db_xref="dbSNP:61754481"
     variation       207
                     /replace="k"
                     /db_xref="dbSNP:780411478"
     variation       207
                     /replace="r"
                     /db_xref="dbSNP:6555055"
     variation       207
                     /replace="s"
                     /db_xref="dbSNP:1159289835"
     variation       209
                     /replace="l"
                     /db_xref="dbSNP:149821224"
     variation       210
                     /replace="*"
                     /db_xref="dbSNP:775143272"
     variation       210
                     /replace="q"
                     /db_xref="dbSNP:762108779"
     variation       211
                     /replace="c"
                     /db_xref="dbSNP:1235961098"
     variation       211
                     /replace="y"
                     /db_xref="dbSNP:1307665893"
     variation       212
                     /replace="a"
                     /db_xref="dbSNP:750531440"
     variation       212
                     /replace="d"
                     /db_xref="dbSNP:762969594"
     variation       212
                     /replace="n"
                     /db_xref="dbSNP:765376662"
     variation       213
                     /replace="i"
                     /db_xref="dbSNP:766421069"
     variation       214
                     /replace="g"
                     /db_xref="dbSNP:752144637"
     variation       214
                     /replace="n"
                     /db_xref="dbSNP:755432673"
     variation       215
                     /replace="c"
                     /db_xref="dbSNP:781660628"
     variation       215
                     /replace="y"
                     /db_xref="dbSNP:752951211"
     Site            215
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by SRC.
                     {ECO:0000269|PubMed:22823520}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       216
                     /replace="s"
                     /db_xref="dbSNP:567132614"
     variation       217
                     /replace="v"
                     /db_xref="dbSNP:777530810"
     variation       219
                     /replace="c"
                     /db_xref="dbSNP:756877901"
     variation       219
                     /replace="h"
                     /db_xref="dbSNP:748831715"
     variation       222
                     /replace="f"
                     /db_xref="dbSNP:778256616"
     variation       222
                     /replace="s"
                     /db_xref="dbSNP:991140963"
     variation       223
                     /replace="i"
                     /db_xref="dbSNP:1447167887"
     variation       223
                     /replace="i"
                     /db_xref="dbSNP:587782077"
     variation       225
                     /replace="l"
                     /db_xref="dbSNP:1367248054"
     variation       226
                     /replace="i"
                     /db_xref="dbSNP:745884899"
     variation       228
                     /replace="n"
                     /db_xref="dbSNP:2115272"
     variation       229
                     /replace="g"
                     /db_xref="dbSNP:775359678"
     variation       229
                     /replace="r"
                     /db_xref="dbSNP:41495051"
     variation       230
                     /replace="q"
                     /db_xref="dbSNP:1436777353"
     variation       231
                     /replace="f"
                     /db_xref="dbSNP:746766007"
     variation       231
                     /replace="g"
                     /db_xref="dbSNP:1218573966"
     variation       232
                     /replace="c"
                     /db_xref="dbSNP:878854635"
     variation       232
                     /replace="h"
                     /db_xref="dbSNP:1060503708"
     variation       233
                     /replace="v"
                     /db_xref="dbSNP:878854636"
     variation       234
                     /replace="s"
                     /db_xref="dbSNP:1175771583"
     variation       234
                     /replace="v"
                     /db_xref="dbSNP:1205748459"
     variation       235
                     /replace="f"
                     /db_xref="dbSNP:770023910"
     variation       235
                     /replace="i"
                     /db_xref="dbSNP:549892491"
     variation       235
                     /replace="t"
                     /db_xref="dbSNP:144513891"
     variation       236
                     /replace="a"
                     /db_xref="dbSNP:774277601"
     variation       236
                     /replace="t"
                     /db_xref="dbSNP:774160524"
     variation       236
                     /replace="v"
                     /db_xref="dbSNP:1060503703"
     variation       238
                     /replace="f"
                     /db_xref="dbSNP:1168458733"
     variation       239
                     /replace="l"
                     /db_xref="dbSNP:760106352"
     variation       239
                     /replace="m"
                     /db_xref="dbSNP:1322709882"
     variation       239
                     /replace="r"
                     /db_xref="dbSNP:1466069757"
     variation       240
                     /replace="q"
                     /db_xref="dbSNP:1041946"
     variation       241
                     /replace="d"
                     /db_xref="dbSNP:146653693"
     variation       242
                     /replace="r"
                     /db_xref="dbSNP:764534044"
     variation       243
                     /replace="f"
                     /db_xref="dbSNP:756966025"
     variation       243
                     /replace="s"
                     /db_xref="dbSNP:778543446"
     variation       244
                     /replace="m"
                     /db_xref="dbSNP:1276381441"
     variation       244
                     /replace="v"
                     /db_xref="dbSNP:1162393515"
     variation       245
                     /replace="d"
                     /db_xref="dbSNP:1060503716"
     variation       246
                     /replace="h"
                     /db_xref="dbSNP:745309710"
     variation       247
                     /replace="v"
                     /db_xref="dbSNP:571292356"
     variation       250
                     /replace="r"
                     /db_xref="dbSNP:1060503700"
     Site            250
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            250
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       251
                     /replace="n"
                     /db_xref="dbSNP:1126411"
     variation       251
                     /replace="t"
                     /db_xref="dbSNP:1318566276"
     variation       252
                     /replace="a"
                     /db_xref="dbSNP:746925557"
     variation       252
                     /replace="i"
                     /db_xref="dbSNP:1223320182"
     variation       253
                     /replace="i"
                     /db_xref="dbSNP:1126412"
     variation       254
                     /replace="i"
                     /db_xref="dbSNP:776403592"
     variation       256
                     /replace="a"
                     /db_xref="dbSNP:1409070000"
     variation       257
                     /replace="e"
                     /db_xref="dbSNP:749566947"
     variation       259
                     /replace="y"
                     /db_xref="dbSNP:140243793"
     variation       260
                     /replace="r"
                     /db_xref="dbSNP:940845256"
     variation       261
                     /replace="c"
                     /db_xref="dbSNP:143484394"
     variation       261
                     /replace="h"
                     /db_xref="dbSNP:769228279"
     variation       261
                     /replace="r"
                     /db_xref="dbSNP:1037927856"
     variation       262
                     /replace="p"
                     /db_xref="dbSNP:1203721525"
     variation       264
                     /replace="l"
                     /db_xref="dbSNP:1237513803"
     variation       264
                     /replace="q"
                     /db_xref="dbSNP:1264965507"
     variation       265
                     /replace="e"
                     /db_xref="dbSNP:1440581435"
     variation       265
                     /replace="r"
                     /db_xref="dbSNP:1186598841"
     variation       266
                     /replace="y"
                     /db_xref="dbSNP:1242417575"
     variation       267
                     /replace="m"
                     /db_xref="dbSNP:777167108"
     variation       267
                     /replace="t"
                     /db_xref="dbSNP:543630901"
     variation       270
                     /replace="h"
                     /db_xref="dbSNP:1199457341"
     variation       270
                     /replace="l"
                     /db_xref="dbSNP:1381228775"
     variation       271
                     /replace="s"
                     /db_xref="dbSNP:765611464"
     variation       272
                     /replace="g"
                     /db_xref="dbSNP:750081578"
     variation       273
                     /replace="i"
                     /db_xref="dbSNP:587781720"
     variation       273
                     /replace="t"
                     /db_xref="dbSNP:1041947"
     variation       274
                     /replace="g"
                     /db_xref="dbSNP:34771391"
     variation       275
                     /replace="d"
                     /db_xref="dbSNP:1237373391"
     variation       276
                     /replace="g"
                     /db_xref="dbSNP:754910183"
     variation       276
                     /replace="s"
                     /db_xref="dbSNP:751008647"
     variation       276
                     /replace="v"
                     /db_xref="dbSNP:1280177618"
     variation       277
                     /replace="k"
                     /db_xref="dbSNP:367721665"
     variation       277
                     /replace="t"
                     /db_xref="dbSNP:1470632146"
     variation       278
                     /replace="t"
                     /db_xref="dbSNP:1178613645"
     variation       278
                     /replace="v"
                     /db_xref="dbSNP:1057523490"
     variation       279
                     /replace="i"
                     /db_xref="dbSNP:746145822"
     variation       279
                     /replace="t"
                     /db_xref="dbSNP:777595710"
     variation       279
                     /replace="v"
                     /db_xref="dbSNP:755913710"
     variation       281
                     /replace="a"
                     /db_xref="dbSNP:772325115"
     variation       284
                     /replace="g"
                     /db_xref="dbSNP:552108762"
     variation       285
                     /replace="f"
                     /db_xref="dbSNP:747045191"
     variation       287
                     /replace="w"
                     /db_xref="dbSNP:140797184"
     variation       290
                     /replace="p"
                     /db_xref="dbSNP:1333787672"
     variation       291
                     /replace="e"
                     /db_xref="dbSNP:570393010"
     variation       291
                     /replace="v"
                     /db_xref="dbSNP:1336029027"
     variation       292
                     /replace="l"
                     /db_xref="dbSNP:1272598432"
     variation       294
                     /replace="q"
                     /db_xref="dbSNP:371512265"
     variation       295
                     /replace="l"
                     /db_xref="dbSNP:762349978"
     variation       297
                     /replace="p"
                     /db_xref="dbSNP:1126417"
     variation       297
                     /replace="s"
                     /db_xref="dbSNP:1224049075"
     variation       298
                     /replace="t"
                     /db_xref="dbSNP:774584410"
     variation       299
                     /replace="g"
                     /db_xref="dbSNP:1484385016"
     variation       300
                     /replace="t"
                     /db_xref="dbSNP:878854637"
     variation       300
                     /replace="v"
                     /db_xref="dbSNP:1448561231"
     variation       301
                     /replace="c"
                     /db_xref="dbSNP:182055219"
     variation       301
                     /replace="h"
                     /db_xref="dbSNP:1060503713"
     variation       303
                     /replace="a"
                     /db_xref="dbSNP:1288729347"
     variation       304
                     /replace="l"
                     /db_xref="dbSNP:1484904888"
     variation       305
                     /replace="y"
                     /db_xref="dbSNP:878854638"
     variation       306
                     /replace="l"
                     /db_xref="dbSNP:138828792"
     variation       306
                     /replace="p"
                     /db_xref="dbSNP:1477142607"
     variation       307
                     /replace="v"
                     /db_xref="dbSNP:200632016"
     variation       308
                     /replace="m"
                     /db_xref="dbSNP:1457666982"
     variation       308
                     /replace="t"
                     /db_xref="dbSNP:1355760590"
     variation       309
                     /replace="*"
                     /db_xref="dbSNP:1161810099"
     variation       310
                     /replace="e"
                     /db_xref="dbSNP:760542965"
     variation       311
                     /replace="c"
                     /db_xref="dbSNP:764026731"
     variation       312
                     /replace="h"
                     /db_xref="dbSNP:876660932"
     variation       314
                     /replace="k"
                     /db_xref="dbSNP:1337704280"
     variation       317
                     /replace="t"
                     /db_xref="dbSNP:903136919"
     variation       318
                     /replace="l"
                     /db_xref="dbSNP:1412623947"
     variation       319
                     /replace="i"
                     /db_xref="dbSNP:757167466"
     variation       319
                     /replace="l"
                     /db_xref="dbSNP:377509915"
     variation       320
                     /replace="n"
                     /db_xref="dbSNP:1289327970"
     variation       320
                     /replace="s"
                     /db_xref="dbSNP:765092091"
     variation       321
                     /replace="i"
                     /db_xref="dbSNP:751896104"
     variation       321
                     /replace="s"
                     /db_xref="dbSNP:755235011"
     variation       323
                     /replace="g"
                     /db_xref="dbSNP:142849100"
     variation       324
                     /replace="g"
                     /db_xref="dbSNP:1476304866"
     variation       324
                     /replace="k"
                     /db_xref="dbSNP:147014102"
     variation       325
                     /replace="r"
                     /db_xref="dbSNP:1418778005"
     variation       326
                     /replace="*"
                     /db_xref="dbSNP:761158368"
     variation       327
                     /replace="v"
                     /db_xref="dbSNP:1285443776"
     variation       328
                     /replace="k"
                     /db_xref="dbSNP:778297896"
     variation       329
                     /replace="q"
                     /db_xref="dbSNP:138265892"
     variation       329
                     /replace="r"
                     /db_xref="dbSNP:771328239"
     variation       330
                     /replace="*"
                     /db_xref="dbSNP:886041867"
     variation       330
                     /replace="d"
                     /db_xref="dbSNP:764729977"
     variation       330
                     /replace="y"
                     /db_xref="dbSNP:370547766"
     variation       331
                     /replace="a"
                     /db_xref="dbSNP:1424925197"
     variation       331
                     /replace="g"
                     /db_xref="dbSNP:1206201147"
     variation       331
                     /replace="t"
                     /db_xref="dbSNP:200526913"
     variation       332
                     /replace="a"
                     /db_xref="dbSNP:373509391"
     variation       332
                     /replace="p"
                     /db_xref="dbSNP:1062467"
     variation       333
                     /replace="a"
                     /db_xref="dbSNP:1334921669"
     variation       333
                     /replace="i"
                     /db_xref="dbSNP:1062468"
     variation       333
                     /replace="t"
                     /db_xref="dbSNP:1057517540"
     variation       333
                     /replace="v"
                     /db_xref="dbSNP:149556555"
     variation       334
                     /replace="a"
                     /db_xref="dbSNP:144252500"
     variation       334
                     /replace="t"
                     /db_xref="dbSNP:1401459296"
     variation       334
                     /replace="v"
                     /db_xref="dbSNP:765180271"
     variation       335
                     /replace="e"
                     /db_xref="dbSNP:376745214"
     Site            335
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            335
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       338
                     /replace="a"
                     /db_xref="dbSNP:201341132"
     variation       338
                     /replace="r"
                     /db_xref="dbSNP:1295239305"
     variation       339
                     /replace="s"
                     /db_xref="dbSNP:752738784"
     variation       342
                     /replace="v"
                     /db_xref="dbSNP:1060505004"
     variation       343
                     /replace="g"
                     /db_xref="dbSNP:1218116319"
     variation       345
                     /replace="q"
                     /db_xref="dbSNP:1483236652"
     variation       345
                     /replace="w"
                     /db_xref="dbSNP:760598746"
     variation       346
                     /replace="c"
                     /db_xref="dbSNP:1041948"
     variation       346
                     /replace="s"
                     /db_xref="dbSNP:1041949"
     variation       347
                     /replace="v"
                     /db_xref="dbSNP:1245387180"
     variation       348
                     /replace="s"
                     /db_xref="dbSNP:371484111"
     variation       348
                     /replace="s"
                     /db_xref="dbSNP:779264373"
     variation       349
                     /replace="r"
                     /db_xref="dbSNP:754307527"
     variation       351
                     /replace="s"
                     /db_xref="dbSNP:200103530"
     variation       352
                     /replace="q"
                     /db_xref="dbSNP:199844384"
     variation       352
                     /replace="r"
                     /db_xref="dbSNP:746165168"
     variation       352
                     /replace="r"
                     /db_xref="dbSNP:779804839"
     variation       353
                     /replace="q"
                     /db_xref="dbSNP:1328911130"
     variation       354
                     /replace="*"
                     /db_xref="dbSNP:746611221"
     variation       358
                     /replace="g"
                     /db_xref="dbSNP:1421396049"
     variation       359
                     /replace="s"
                     /db_xref="dbSNP:758817818"
     variation       360
                     /replace="k"
                     /db_xref="dbSNP:766779919"
     variation       363
                     /replace="h"
                     /db_xref="dbSNP:368488126"
     variation       364
                     /replace="i"
                     /db_xref="dbSNP:372738835"
     variation       364
                     /replace="v"
                     /db_xref="dbSNP:886060515"
     variation       366
                     /replace="l"
                     /db_xref="dbSNP:1305056679"
     variation       366
                     /replace="l"
                     /db_xref="dbSNP:1346189100"
     variation       367
                     /replace="*"
                     /db_xref="dbSNP:780941330"
     variation       369
                     /replace="h"
                     /db_xref="dbSNP:1268877544"
     variation       370
                     /replace="n"
                     /db_xref="dbSNP:1060503704"
     variation       372
                     /replace="l"
                     /db_xref="dbSNP:141493530"
     variation       372
                     /replace="s"
                     /db_xref="dbSNP:1364686808"
     variation       373
                     /replace="p"
                     /db_xref="dbSNP:1428505412"
     variation       373
                     /replace="s"
                     /db_xref="dbSNP:1289573477"
     variation       374
                     /replace="d"
                     /db_xref="dbSNP:377283167"
     variation       374
                     /replace="q"
                     /db_xref="dbSNP:1387837713"
     variation       376
                     /replace="p"
                     /db_xref="dbSNP:1433477205"
     variation       378
                     /replace="a"
                     /db_xref="dbSNP:1224187912"
     variation       378
                     /replace="m"
                     /db_xref="dbSNP:777420907"
     variation       378
                     /replace="t"
                     /db_xref="dbSNP:370002515"
     variation       379
                     /replace="c"
                     /db_xref="dbSNP:749309213"
     variation       379
                     /replace="h"
                     /db_xref="dbSNP:770719847"
     variation       380
                     /replace="l"
                     /db_xref="dbSNP:146348714"
     variation       382
                     /replace="d"
                     /db_xref="dbSNP:373067620"
     variation       382
                     /replace="g"
                     /db_xref="dbSNP:768947225"
     variation       382
                     /replace="s"
                     /db_xref="dbSNP:1272640628"
     variation       384
                     /replace="*"
                     /db_xref="dbSNP:151170408"
     variation       384
                     /replace="a"
                     /db_xref="dbSNP:776888362"
     variation       385
                     /replace="e"
                     /db_xref="dbSNP:765356526"
     variation       386
                     /replace="i"
                     /db_xref="dbSNP:773218958"
     variation       388
                     /replace="t"
                     /db_xref="dbSNP:1419241279"
     variation       389
                     /replace="t"
                     /db_xref="dbSNP:763519070"
     variation       389
                     /replace="v"
                     /db_xref="dbSNP:1316310818"
     variation       390
                     /replace="f"
                     /db_xref="dbSNP:35277230"
     variation       391
                     /replace="g"
                     /db_xref="dbSNP:755344854"
     variation       391
                     /replace="t"
                     /db_xref="dbSNP:376597185"
     variation       392
                     /replace="g"
                     /db_xref="dbSNP:1041950"
     variation       393
                     /replace="l"
                     /db_xref="dbSNP:372989971"
     variation       394
                     /replace="d"
                     /db_xref="dbSNP:377317558"
     variation       395
                     /replace="f"
                     /db_xref="dbSNP:748683825"
     variation       396
                     /replace="m"
                     /db_xref="dbSNP:757251714"
     variation       396
                     /replace="t"
                     /db_xref="dbSNP:778667374"
     variation       397
                     /replace="n"
                     /db_xref="dbSNP:1035794713"
     variation       397
                     /replace="t"
                     /db_xref="dbSNP:745798689"
     variation       399
                     /replace="p"
                     /db_xref="dbSNP:771919335"
     variation       399
                     /replace="q"
                     /db_xref="dbSNP:878854625"
     variation       400
                     /replace="i"
                     /db_xref="dbSNP:748383004"
     variation       400
                     /replace="n"
                     /db_xref="dbSNP:876660886"
     variation       402
                     /replace="v"
                     /db_xref="dbSNP:1183961449"
     variation       403
                     /replace="f"
                     /db_xref="dbSNP:1386175077"
     variation       404
                     /replace="l"
                     /db_xref="dbSNP:773368621"
     variation       404
                     /replace="s"
                     /db_xref="dbSNP:769936006"
     variation       405
                     /replace="t"
                     /db_xref="dbSNP:762888704"
     variation       406
                     /replace="m"
                     /db_xref="dbSNP:1258201485"
     variation       407
                     /replace="r"
                     /db_xref="dbSNP:374087393"
     variation       408
                     /replace="c"
                     /db_xref="dbSNP:1345848958"
     variation       408
                     /replace="h"
                     /db_xref="dbSNP:201826964"
     variation       409
                     /replace="h"
                     /db_xref="dbSNP:1404377989"
     variation       410
                     /replace="v"
                     /db_xref="dbSNP:876658852"
     variation       411
                     /replace="g"
                     /db_xref="dbSNP:376530094"
     variation       412
                     /replace="c"
                     /db_xref="dbSNP:768055345"
     variation       412
                     /replace="g"
                     /db_xref="dbSNP:1331649574"
     variation       413
                     /replace="v"
                     /db_xref="dbSNP:1375757287"
     variation       414
                     /replace="p"
                     /db_xref="dbSNP:777306884"
     variation       416
                     /replace="d"
                     /db_xref="dbSNP:1355851620"
     variation       416
                     /replace="n"
                     /db_xref="dbSNP:1280816822"
     variation       416
                     /replace="s"
                     /db_xref="dbSNP:1409603646"
     variation       417
                     /replace="c"
                     /db_xref="dbSNP:528628545"
     variation       417
                     /replace="h"
                     /db_xref="dbSNP:1350684986"
     variation       418
                     /replace="e"
                     /db_xref="dbSNP:1378783078"
     variation       419
                     /replace="g"
                     /db_xref="dbSNP:753410011"
     variation       422
                     /replace="l"
                     /db_xref="dbSNP:1405485459"
     variation       423
                     /replace="k"
                     /db_xref="dbSNP:1294693469"
     variation       423
                     /replace="r"
                     /db_xref="dbSNP:1404639088"
     variation       424
                     /replace="h"
                     /db_xref="dbSNP:754805626"
     variation       425
                     /replace="g"
                     /db_xref="dbSNP:200047573"
     variation       425
                     /replace="m"
                     /db_xref="dbSNP:201822097"
     variation       426
                     /replace="s"
                     /db_xref="dbSNP:1060503725"
     variation       427
                     /replace="g"
                     /db_xref="dbSNP:561918468"
     variation       429
                     /replace="n"
                     /db_xref="dbSNP:988419580"
     variation       430
                     /replace="h"
                     /db_xref="dbSNP:772728779"
     variation       431
                     /replace="t"
                     /db_xref="dbSNP:776188923"
     variation       432
                     /replace="a"
                     /db_xref="dbSNP:1490844767"
     variation       432
                     /replace="v"
                     /db_xref="dbSNP:1223308548"
     variation       433
                     /replace="l"
                     /db_xref="dbSNP:747488969"
     variation       433
                     /replace="p"
                     /db_xref="dbSNP:144473374"
     variation       434
                     /replace="s"
                     /db_xref="dbSNP:529198317"
     variation       435
                     /replace="l"
                     /db_xref="dbSNP:35964044"
     variation       436
                     /replace="h"
                     /db_xref="dbSNP:772729820"
     variation       436
                     /replace="y"
                     /db_xref="dbSNP:762494024"
     variation       437
                     /replace="a"
                     /db_xref="dbSNP:377506772"
     variation       438
                     /replace="f"
                     /db_xref="dbSNP:1424809160"
     variation       439
                     /replace="-"
                     /db_xref="dbSNP:768469627"
     variation       439
                     /replace="e"
                     /db_xref="dbSNP:374086655"
     variation       441
                     /replace="a"
                     /db_xref="dbSNP:751561561"
     variation       442
                     /replace="t"
                     /db_xref="dbSNP:754893758"
     variation       444
                     /replace="a"
                     /db_xref="dbSNP:1060505011"
     variation       445
                     /replace="l"
                     /db_xref="dbSNP:1296066077"
     variation       445
                     /replace="s"
                     /db_xref="dbSNP:200223188"
     variation       446
                     /replace="a"
                     /db_xref="dbSNP:201741295"
     variation       446
                     /replace="v"
                     /db_xref="dbSNP:1313266403"
     variation       447
                     /replace="r"
                     /db_xref="dbSNP:779151375"
     variation       448
                     /replace="g"
                     /db_xref="dbSNP:551497992"
     variation       448
                     /replace="s"
                     /db_xref="dbSNP:1064795863"
     variation       448
                     /replace="v"
                     /db_xref="dbSNP:746065356"
     variation       449
                     /replace="p"
                     /db_xref="dbSNP:1485193902"
     variation       449
                     /replace="v"
                     /db_xref="dbSNP:201139275"
     variation       450
                     /replace="n"
                     /db_xref="dbSNP:533902090"
     variation       451
                     /replace="h"
                     /db_xref="dbSNP:370690436"
     variation       451
                     /replace="r"
                     /db_xref="dbSNP:555342133"
     variation       452
                     /replace="f"
                     /db_xref="dbSNP:1064796477"
     variation       452
                     /replace="l"
                     /db_xref="dbSNP:748496836"
     variation       453
                     /replace="e"
                     /db_xref="dbSNP:1169286790"
     variation       453
                     /replace="r"
                     /db_xref="dbSNP:770028533"
     variation       454
                     /replace="t"
                     /db_xref="dbSNP:1057517550"
     variation       455
                     /replace="h"
                     /db_xref="dbSNP:567820710"
     variation       456
                     /replace="l"
                     /db_xref="dbSNP:76896145"
     variation       456
                     /replace="s"
                     /db_xref="dbSNP:149875171"
     variation       457
                     /replace="l"
                     /db_xref="dbSNP:75091805"
     variation       460
                     /replace="l"
                     /db_xref="dbSNP:760686493"
     variation       461
                     /replace="a"
                     /db_xref="dbSNP:767452676"
     variation       461
                     /replace="f"
                     /db_xref="dbSNP:373021394"
     variation       465
                     /replace="q"
                     /db_xref="dbSNP:138277996"
     variation       465
                     /replace="r"
                     /db_xref="dbSNP:752461029"
     variation       466
                     /replace="a"
                     /db_xref="dbSNP:878854626"
     variation       466
                     /replace="t"
                     /db_xref="dbSNP:111387770"
     variation       467
                     /replace="s"
                     /db_xref="dbSNP:1315131938"
     variation       468
                     /replace="d"
                     /db_xref="dbSNP:1057524636"
     variation       470
                     /replace="n"
                     /db_xref="dbSNP:1241820374"
     variation       470
                     /replace="s"
                     /db_xref="dbSNP:556476038"
     variation       471
                     /replace="i"
                     /db_xref="dbSNP:34779890"
     variation       472
                     /replace="a"
                     /db_xref="dbSNP:200305419"
     variation       472
                     /replace="k"
                     /db_xref="dbSNP:143798161"
     variation       473
                     /replace="e"
                     /db_xref="dbSNP:898003329"
     variation       474
                     /replace="s"
                     /db_xref="dbSNP:201868424"
     variation       475
                     /replace="r"
                     /db_xref="dbSNP:781747137"
     variation       475
                     /replace="s"
                     /db_xref="dbSNP:748567636"
     variation       476
                     /replace="r"
                     /db_xref="dbSNP:377415114"
     variation       477
                     /replace="l"
                     /db_xref="dbSNP:146990772"
     variation       477
                     /replace="s"
                     /db_xref="dbSNP:770506764"
     variation       478
                     /replace="*"
                     /db_xref="dbSNP:759041443"
     Site            480
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       481
                     /replace="v"
                     /db_xref="dbSNP:751871185"
     variation       482
                     /replace="h"
                     /db_xref="dbSNP:759661610"
     variation       482
                     /replace="p"
                     /db_xref="dbSNP:767646499"
     variation       482
                     /replace="s"
                     /db_xref="dbSNP:1205384855"
     variation       484
                     /replace="v"
                     /db_xref="dbSNP:1224049828"
     Site            485
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            485
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       486
                     /replace="t"
                     /db_xref="dbSNP:1060503706"
     variation       487
                     /replace="h"
                     /db_xref="dbSNP:1208182306"
     variation       487
                     /replace="n"
                     /db_xref="dbSNP:187540602"
     variation       488
                     /replace="t"
                     /db_xref="dbSNP:369100772"
     variation       488
                     /replace="v"
                     /db_xref="dbSNP:1421325038"
     variation       489
                     /replace="a"
                     /db_xref="dbSNP:1430552498"
     variation       491
                     /replace="*"
                     /db_xref="dbSNP:778207102"
     variation       491
                     /replace="a"
                     /db_xref="dbSNP:754324916"
     variation       492
                     /replace="s"
                     /db_xref="dbSNP:1376968004"
     variation       495
                     /replace="h"
                     /db_xref="dbSNP:757663708"
     variation       496
                     /replace="i"
                     /db_xref="dbSNP:1305001616"
     variation       498
                     /replace="q"
                     /db_xref="dbSNP:372039270"
     variation       498
                     /replace="r"
                     /db_xref="dbSNP:745592653"
     Site            498
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            498
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       499
                     /replace="l"
                     /db_xref="dbSNP:1320988567"
     variation       501
                     /replace="y"
                     /db_xref="dbSNP:757932443"
     variation       502
                     /replace="a"
                     /db_xref="dbSNP:1364448678"
     variation       505
                     /replace="n"
                     /db_xref="dbSNP:1060503722"
     variation       506
                     /replace="m"
                     /db_xref="dbSNP:955444699"
     variation       508
                     /replace="i"
                     /db_xref="dbSNP:151266052"
     variation       508
                     /replace="s"
                     /db_xref="dbSNP:1060503718"
     variation       508
                     /replace="t"
                     /db_xref="dbSNP:1356814435"
     variation       509
                     /replace="*"
                     /db_xref="dbSNP:1064793567"
     variation       509
                     /replace="s"
                     /db_xref="dbSNP:746453879"
     variation       509
                     /replace="w"
                     /db_xref="dbSNP:397514541"
     variation       511
                     /replace="l"
                     /db_xref="dbSNP:876658698"
     variation       511
                     /replace="p"
                     /db_xref="dbSNP:375194444"
     variation       511
                     /replace="v"
                     /db_xref="dbSNP:768257880"
     variation       512
                     /replace="*"
                     /db_xref="dbSNP:748089700"
     variation       512
                     /replace="p"
                     /db_xref="dbSNP:192818312"
     variation       514
                     /replace="r"
                     /db_xref="dbSNP:1301221379"
     variation       514
                     /replace="t"
                     /db_xref="dbSNP:587781729"
     variation       516
                     /replace="e"
                     /db_xref="dbSNP:1251348764"
     variation       516
                     /replace="r"
                     /db_xref="dbSNP:981171929"
     variation       517
                     /replace="e"
                     /db_xref="dbSNP:786205210"
     variation       517
                     /replace="k"
                     /db_xref="dbSNP:772822136"
     Site            517
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       519
                     /replace="t"
                     /db_xref="dbSNP:377706701"
     variation       520
                     /replace="h"
                     /db_xref="dbSNP:1261025402"
     variation       522
                     /replace="-"
                     /db_xref="dbSNP:1325342549"
     variation       523
                     /replace="a"
                     /db_xref="dbSNP:150192376"
     variation       524
                     /replace="a"
                     /db_xref="dbSNP:185679709"
     variation       524
                     /replace="v"
                     /db_xref="dbSNP:137852767"
     variation       525
                     /replace="m"
                     /db_xref="dbSNP:979815942"
     variation       525
                     /replace="v"
                     /db_xref="dbSNP:766757653"
     variation       527
                     /replace="c"
                     /db_xref="dbSNP:138723511"
     variation       527
                     /replace="h"
                     /db_xref="dbSNP:766352407"
     variation       529
                     /replace="r"
                     /db_xref="dbSNP:370291114"
     variation       530
                     /replace="s"
                     /db_xref="dbSNP:1060503701"
     variation       531
                     /replace="m"
                     /db_xref="dbSNP:371056571"
     variation       532
                     /replace="f"
                     /db_xref="dbSNP:1449742263"
     variation       533
                     /replace="e"
                     /db_xref="dbSNP:149367009"
     variation       533
                     /replace="p"
                     /db_xref="dbSNP:1395387473"
     variation       533
                     /replace="q"
                     /db_xref="dbSNP:1407806818"
     variation       535
                     /replace="c"
                     /db_xref="dbSNP:777622021"
     variation       535
                     /replace="g"
                     /db_xref="dbSNP:1219265731"
     variation       537
                     /replace="a"
                     /db_xref="dbSNP:1192321920"
     variation       537
                     /replace="g"
                     /db_xref="dbSNP:1060505009"
     Site            538
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            538
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       539
                     /replace="n"
                     /db_xref="dbSNP:1060503715"
     variation       539
                     /replace="s"
                     /db_xref="dbSNP:749219128"
     variation       540
                     /replace="n"
                     /db_xref="dbSNP:1281362761"
     variation       541
                     /replace="k"
                     /db_xref="dbSNP:35502109"
     Site            541
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       542
                     /replace="l"
                     /db_xref="dbSNP:1269358534"
     variation       542
                     /replace="p"
                     /db_xref="dbSNP:1233761838"
     variation       543
                     /replace="c"
                     /db_xref="dbSNP:778670859"
     variation       543
                     /replace="h"
                     /db_xref="dbSNP:1339009840"
     variation       543
                     /replace="y"
                     /db_xref="dbSNP:747249998"
     variation       544
                     /replace="r"
                     /db_xref="dbSNP:1338347881"
     variation       546
                     /replace="l"
                     /db_xref="dbSNP:1041963"
     variation       546
                     /replace="r"
                     /db_xref="dbSNP:1483390447"
     variation       547
                     /replace="n"
                     /db_xref="dbSNP:1267429398"
     variation       547
                     /replace="q"
                     /db_xref="dbSNP:1221826146"
     Site            547
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     Site            547
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:Q8K2B3}; propagated from
                     UniProtKB/Swiss-Prot (P31040.2)"
     variation       548
                     /replace="h"
                     /db_xref="dbSNP:1126427"
     variation       550
                     /replace="*"
                     /db_xref="dbSNP:1400219619"
     variation       550
                     /replace="k"
                     /db_xref="dbSNP:1359705251"
     Site            550
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       551
                     /replace="a"
                     /db_xref="dbSNP:1200051286"
     variation       551
                     /replace="m"
                     /db_xref="dbSNP:181238392"
     variation       551
                     /replace="t"
                     /db_xref="dbSNP:761927291"
     variation       552
                     /replace="f"
                     /db_xref="dbSNP:1170030451"
     variation       553
                     /replace="a"
                     /db_xref="dbSNP:1060503723"
     variation       553
                     /replace="n"
                     /db_xref="dbSNP:769882609"
     variation       554
                     /replace="q"
                     /db_xref="dbSNP:376391115"
     variation       554
                     /replace="w"
                     /db_xref="dbSNP:9809219"
     variation       555
                     /replace="*"
                     /db_xref="dbSNP:1392860800"
     variation       555
                     /replace="e"
                     /db_xref="dbSNP:137852768"
     variation       556
                     /replace="v"
                     /db_xref="dbSNP:980397872"
     variation       557
                     /replace="v"
                     /db_xref="dbSNP:767963713"
     variation       560
                     /replace="a"
                     /db_xref="dbSNP:1269114291"
     variation       560
                     /replace="m"
                     /db_xref="dbSNP:775350508"
     variation       560
                     /replace="t"
                     /db_xref="dbSNP:1139449"
     variation       564
                     /replace="e"
                     /db_xref="dbSNP:368388954"
     variation       564
                     /replace="v"
                     /db_xref="dbSNP:763529675"
     variation       565
                     /replace="n"
                     /db_xref="dbSNP:757176672"
     variation       565
                     /replace="t"
                     /db_xref="dbSNP:765113103"
     variation       566
                     /replace="v"
                     /db_xref="dbSNP:142936520"
     variation       569
                     /replace="q"
                     /db_xref="dbSNP:959934068"
     variation       569
                     /replace="r"
                     /db_xref="dbSNP:1159670475"
     variation       570
                     /replace="n"
                     /db_xref="dbSNP:1404993199"
     variation       571
                     /replace="l"
                     /db_xref="dbSNP:1377424433"
     variation       573
                     /replace="l"
                     /db_xref="dbSNP:17415917"
     variation       573
                     /replace="v"
                     /db_xref="dbSNP:1445945083"
     variation       575
                     /replace="a"
                     /db_xref="dbSNP:758252610"
     variation       575
                     /replace="t"
                     /db_xref="dbSNP:1301370839"
     variation       575
                     /replace="v"
                     /db_xref="dbSNP:750327309"
     variation       576
                     /replace="l"
                     /db_xref="dbSNP:779807887"
     variation       576
                     /replace="p"
                     /db_xref="dbSNP:1318046349"
     variation       578
                     /replace="i"
                     /db_xref="dbSNP:1349207461"
     variation       578
                     /replace="t"
                     /db_xref="dbSNP:748328205"
     variation       579
                     /replace="i"
                     /db_xref="dbSNP:201454617"
     variation       579
                     /replace="t"
                     /db_xref="dbSNP:1323205068"
     variation       579
                     /replace="v"
                     /db_xref="dbSNP:1042052"
     variation       580
                     /replace="c"
                     /db_xref="dbSNP:372707443"
     variation       580
                     /replace="n"
                     /db_xref="dbSNP:1042056"
     variation       580
                     /replace="y"
                     /db_xref="dbSNP:3181540"
     variation       581
                     /replace="r"
                     /db_xref="dbSNP:771111180"
     variation       584
                     /replace="a"
                     /db_xref="dbSNP:13070"
     variation       584
                     /replace="t"
                     /db_xref="dbSNP:878854629"
     variation       584
                     /replace="v"
                     /db_xref="dbSNP:201068049"
     variation       585
                     /replace="g"
                     /db_xref="dbSNP:200397144"
     variation       585
                     /replace="q"
                     /db_xref="dbSNP:752360961"
     variation       585
                     /replace="r"
                     /db_xref="dbSNP:760254364"
     variation       589
                     /replace="q"
                     /db_xref="dbSNP:763766162"
     variation       589
                     /replace="w"
                     /db_xref="dbSNP:387906780"
     variation       590
                     /replace="g"
                     /db_xref="dbSNP:142457602"
     variation       591
                     /replace="a"
                     /db_xref="dbSNP:555028212"
     variation       591
                     /replace="t"
                     /db_xref="dbSNP:1042170"
     variation       591
                     /replace="v"
                     /db_xref="dbSNP:367621815"
     variation       592
                     /replace="h"
                     /db_xref="dbSNP:1126538"
     variation       594
                     /replace="k"
                     /db_xref="dbSNP:1302547655"
     variation       594
                     /replace="r"
                     /db_xref="dbSNP:751329013"
     variation       595
                     /replace="*"
                     /db_xref="dbSNP:756312616"
     variation       596
                     /replace="g"
                     /db_xref="dbSNP:1126557"
     variation       596
                     /replace="y"
                     /db_xref="dbSNP:371304688"
     variation       597
                     /replace="h"
                     /db_xref="dbSNP:1060503721"
     variation       597
                     /replace="y"
                     /db_xref="dbSNP:1226155499"
     Site            598
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       599
                     /replace="m"
                     /db_xref="dbSNP:574659983"
     variation       599
                     /replace="v"
                     /db_xref="dbSNP:1060505012"
     variation       600
                     /replace="q"
                     /db_xref="dbSNP:1126568"
     variation       600
                     /replace="w"
                     /db_xref="dbSNP:878854630"
     variation       603
                     /replace="k"
                     /db_xref="dbSNP:1332545587"
     variation       604
                     /replace="y"
                     /db_xref="dbSNP:1436919553"
     variation       605
                     /replace="e"
                     /db_xref="dbSNP:1341691681"
     variation       605
                     /replace="n"
                     /db_xref="dbSNP:771593214"
     variation       606
                     /replace="h"
                     /db_xref="dbSNP:17400614"
     variation       606
                     /replace="y"
                     /db_xref="dbSNP:1226342299"
     variation       607
                     /replace="c"
                     /db_xref="dbSNP:775611963"
     variation       607
                     /replace="p"
                     /db_xref="dbSNP:1183122120"
     Site            608
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       609
                     /replace="p"
                     /db_xref="dbSNP:1060505006"
     variation       610
                     /replace="m"
                     /db_xref="dbSNP:1209697697"
     variation       612
                     /replace="e"
                     /db_xref="dbSNP:1057523336"
     variation       615
                     /replace="n"
                     /db_xref="dbSNP:1442827207"
     Site            615
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       616
                     /replace="e"
                     /db_xref="dbSNP:1453752069"
     variation       616
                     /replace="k"
                     /db_xref="dbSNP:1189442479"
     variation       617
                     /replace="l"
                     /db_xref="dbSNP:1485754812"
     variation       617
                     /replace="s"
                     /db_xref="dbSNP:1199988395"
     variation       619
                     /replace="e"
                     /db_xref="dbSNP:1247081812"
     variation       620
                     /replace="e"
                     /db_xref="dbSNP:1447230295"
     variation       623
                     /replace="k"
                     /db_xref="dbSNP:13992"
     Site            624
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       627
                     /replace="l"
                     /db_xref="dbSNP:1169965410"
     variation       627
                     /replace="l"
                     /db_xref="dbSNP:1390181757"
     variation       628
                     /replace="s"
                     /db_xref="dbSNP:1224468457"
     variation       629
                     /replace="c"
                     /db_xref="dbSNP:6960"
     variation       629
                     /replace="l"
                     /db_xref="dbSNP:750865703"
     variation       629
                     /replace="l"
                     /db_xref="dbSNP:765604736"
     variation       629
                     /replace="y"
                     /db_xref="dbSNP:1161452640"
     variation       630
                     /replace="a"
                     /db_xref="dbSNP:1392791825"
     variation       630
                     /replace="v"
                     /db_xref="dbSNP:1405784467"
     variation       631
                     /replace="d"
                     /db_xref="dbSNP:1364764796"
     variation       631
                     /replace="y"
                     /db_xref="dbSNP:776500078"
     variation       632
                     /replace="a"
                     /db_xref="dbSNP:774609159"
     variation       632
                     /replace="f"
                     /db_xref="dbSNP:369639811"
     variation       634
                     /replace="a"
                     /db_xref="dbSNP:1017441235"
     variation       635
                     /replace="g"
                     /db_xref="dbSNP:1327040639"
     variation       636
                     /replace="n"
                     /db_xref="dbSNP:1244151760"
     Site            636
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       637
                     /replace="f"
                     /db_xref="dbSNP:769599373"
     variation       637
                     /replace="v"
                     /db_xref="dbSNP:11557098"
     variation       638
                     /replace="i"
                     /db_xref="dbSNP:370133236"
     variation       639
                     /replace="g"
                     /db_xref="dbSNP:1224000198"
     variation       639
                     /replace="v"
                     /db_xref="dbSNP:1126697"
     variation       640
                     /replace="g"
                     /db_xref="dbSNP:372480044"
     variation       641
                     /replace="c"
                     /db_xref="dbSNP:1385127518"
     variation       641
                     /replace="y"
                     /db_xref="dbSNP:1444319863"
     variation       643
                     /replace="p"
                     /db_xref="dbSNP:761201589"
     variation       643
                     /replace="r"
                     /db_xref="dbSNP:1060503717"
     variation       644
                     /replace="m"
                     /db_xref="dbSNP:3211483"
     variation       644
                     /replace="v"
                     /db_xref="dbSNP:6961"
     variation       645
                     /replace="i"
                     /db_xref="dbSNP:762128553"
     variation       645
                     /replace="t"
                     /db_xref="dbSNP:1282623859"
     variation       646
                     /replace="n"
                     /db_xref="dbSNP:376986935"
     Site            647
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:Q8K2B3};
                     propagated from UniProtKB/Swiss-Prot (P31040.2)"
     variation       648
                     /replace="p"
                     /db_xref="dbSNP:758054627"
     variation       648
                     /replace="s"
                     /db_xref="dbSNP:1420345359"
     variation       649
                     /replace="e"
                     /db_xref="dbSNP:112307877"
     variation       649
                     /replace="f"
                     /db_xref="dbSNP:1257258254"
     variation       649
                     /replace="f"
                     /db_xref="dbSNP:901491121"
     variation       649
                     /replace="s"
                     /db_xref="dbSNP:899598021"
     variation       650
                     /replace="n"
                     /db_xref="dbSNP:1042430"
     variation       650
                     /replace="s"
                     /db_xref="dbSNP:1485747007"
     variation       651
                     /replace="k"
                     /db_xref="dbSNP:375396913"
     variation       653
                     /replace="d"
                     /db_xref="dbSNP:781029975"
     variation       654
                     /replace="g"
                     /db_xref="dbSNP:60587941"
     variation       656
                     /replace="t"
                     /db_xref="dbSNP:3211499"
     variation       657
                     /replace="a"
                     /db_xref="dbSNP:777565341"
     variation       657
                     /replace="i"
                     /db_xref="dbSNP:6962"
     variation       657
                     /replace="v"
                     /db_xref="dbSNP:746083858"
     variation       658
                     /replace="l"
                     /db_xref="dbSNP:377632619"
     variation       658
                     /replace="p"
                     /db_xref="dbSNP:1042446"
     variation       659
                     /replace="p"
                     /db_xref="dbSNP:768693502"
     variation       659
                     /replace="q"
                     /db_xref="dbSNP:1310267623"
     variation       660
                     /replace="v"
                     /db_xref="dbSNP:191412461"
     variation       661
                     /replace="t"
                     /db_xref="dbSNP:111540173"
     variation       661
                     /replace="v"
                     /db_xref="dbSNP:112937607"
     variation       662
                     /replace="h"
                     /db_xref="dbSNP:1042457"
     variation       662
                     /replace="r"
                     /db_xref="dbSNP:762372686"
     variation       663
                     /replace="f"
                     /db_xref="dbSNP:1060503719"
     CDS             1..664
                     /gene="SDHA"
                     /gene_synonym="CMD1GG; FP; PGL5; SDH1; SDH2; SDHF"
                     /coded_by="NM_004168.4:37..2031"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3853.1"
                     /db_xref="GeneID:6389"
                     /db_xref="HGNC:HGNC:10680"
                     /db_xref="MIM:600857"
ORIGIN      
        1 msgvrglsrl lsarrlalak awptvlqtgt rgfhftvdgn krasakvsds isaqypvvdh
       61 efdavvvgag gaglraafgl seagfntacv tklfptrsht vaaqgginaa lgnmeednwr
      121 whfydtvkgs dwlgdqdaih ymteqapaav velenygmpf srtedgkiyq rafggqslkf
      181 gkggqahrcc cvadrtghsl lhtlygrslr ydtsyfveyf aldllmenge crgvialcie
      241 dgsihrirak ntvvatggyg rtyfsctsah tstgdgtami traglpcqdl efvqfhptgi
      301 ygagcliteg crgeggilin sqgerfmery apvakdlasr dvvsrsmtle iregrgcgpe
      361 kdhvylqlhh lppeqlatrl pgisetamif agvdvtkepi pvlptvhynm ggiptnykgq
      421 vlrhvngqdq ivpglyacge aacasvhgan rlganslldl vvfgracals ieescrpgdk
      481 vppikpnage esvmnldklr fadgsirtse lrlsmqksmq nhaavfrvgs vlqegcgkis
      541 klygdlkhlk tfdrgmvwnt dlvetlelqn lmlcalqtiy gaearkesrg aharedykvr
      601 ideydyskpi qgqqkkpfee hwrkhtlsyv dvgtgkvtle yrpvidktln eadcatvppa
      661 irsy
//
DBGET integrated database retrieval system