GenomeNet

Database: RefSeq
Entry: NP_004823
LinkDB: NP_004823
Original site: NP_004823 
LOCUS       NP_004823                241 aa            linear   PRI 29-DEC-2018
DEFINITION  glutathione S-transferase omega-1 isoform 1 [Homo sapiens].
ACCESSION   NP_004823
VERSION     NP_004823.1
DBSOURCE    REFSEQ: accession NM_004832.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 241)
  AUTHORS   Radic TM, Coric VM, Pljesa-Ercegovac MS, Basta-Jovanovic GM,
            Radojevic-Skodric SM, Dragicevic DP, Matic MG, Bogdanovic LM,
            Dzamic ZM, Simic TP and Savic-Radojevic AR.
  TITLE     Concomitance of Polymorphisms in Glutathione Transferase Omega
            Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma
  JOURNAL   Tohoku J. Exp. Med. 246 (1), 35-44 (2018)
   PUBMED   30224590
  REMARK    GeneRIF: the effect of specific GSTO1 and GSTO2 gene variants,
            independently and in interaction with established risk factors
            (smoking, obesity and hypertension) on the risk for the most
            aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC,
            is reported.
REFERENCE   2  (residues 1 to 241)
  AUTHORS   Luo L, Li Y, Gao Y, Zhao L, Feng H, Wei W, Qiu C, He Q, Zhang Y, Fu
            S and Sun D.
  TITLE     Association between arsenic metabolism gene polymorphisms and
            arsenic-induced skin lesions in individuals exposed to high-dose
            inorganic arsenic in northwest China
  JOURNAL   Sci Rep 8 (1), 413 (2018)
   PUBMED   29323258
  REMARK    GeneRIF: Results showed that the variants rs11191979, rs2164624 and
            rs4925 of GSTO1 provide the susceptibility toward developing
            arsenic-induced skin lesions in individuals exposed to high-dose
            inorganic arsenic in northwest China.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 241)
  AUTHORS   Majumder M, Dasgupta UB, Guha Mazumder DN and Das N.
  TITLE     Skin score correlates with global DNA methylation and GSTO1 A140D
            polymorphism in arsenic-affected population of Eastern India
  JOURNAL   Toxicol. Mech. Methods 27 (6), 467-475 (2017)
   PUBMED   28436716
  REMARK    GeneRIF: Significant correlation between severities of skin
            manifestations with GSTO1 polymorphism status in arsenic-exposed
            population of India.
REFERENCE   4  (residues 1 to 241)
  AUTHORS   Almaguer-Mederos LE, Almaguer-Gotay D, Aguilera-Rodriguez R,
            Gonzalez-Zaldivar Y, Cuello-Almarales D, Laffita-Mesa J,
            Vazquez-Mojena Y, Zayas-Feria P, Rodriguez-Labrada R,
            Velazquez-Perez L and MacLeod P.
  TITLE     Association of glutathione S-transferase omega polymorphism and
            spinocerebellar ataxia type 2
  JOURNAL   J. Neurol. Sci. 372, 324-328 (2017)
   PUBMED   28017238
  REMARK    GeneRIF: This study demonstrated that Distribution of the GSTO1
            alleles and genotypes was nearly equal between the control group
            and SCA2 patients. GSTO1 genotypes were not associated to clinical
            markers in SCA2 patients.
REFERENCE   5  (residues 1 to 241)
  AUTHORS   Umlauf E, Rappold E, Schiller B, Fuchs P, Rainer M, Wolf B and
            Zellner M.
  TITLE     Careful neuropsychological testing reveals a novel genetic marker,
            GSTO1*C, linked to the pre-stage of Alzheimer's disease
  JOURNAL   Oncotarget 7 (26), 39108-39117 (2016)
   PUBMED   27259244
  REMARK    GeneRIF: GSTO1*C is linked to the pre-stage of Alzheimer's disease;
            rs4925 could be a genetic marker for cognitive impairment
REFERENCE   6  (residues 1 to 241)
  AUTHORS   Dulhunty A, Gage P, Curtis S, Chelvanayagam G and Board P.
  TITLE     The glutathione transferase structural family includes a nuclear
            chloride channel and a ryanodine receptor calcium release channel
            modulator
  JOURNAL   J. Biol. Chem. 276 (5), 3319-3323 (2001)
   PUBMED   11035031
REFERENCE   7  (residues 1 to 241)
  AUTHORS   Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte
            GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk
            BA, Perregaux DE, Gabel CA, Geoghegan KF and Pandit J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J. Biol. Chem. 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   8  (residues 1 to 241)
  AUTHORS   Kodym R, Calkins P and Story M.
  TITLE     The cloning and characterization of a new stress response protein.
            A mammalian member of a family of theta class glutathione
            s-transferase-like proteins
  JOURNAL   J. Biol. Chem. 274 (8), 5131-5137 (1999)
   PUBMED   9988762
REFERENCE   9  (residues 1 to 241)
  AUTHORS   Ishikawa T, Casini AF and Nishikimi M.
  TITLE     Molecular cloning and functional expression of rat liver
            glutathione-dependent dehydroascorbate reductase
  JOURNAL   J. Biol. Chem. 273 (44), 28708-28712 (1998)
   PUBMED   9786866
REFERENCE   10 (residues 1 to 241)
  AUTHORS   Matoba R, Okubo K, Hori N, Fukushima A and Matsubara K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537431.1.
            
            Summary: The protein encoded by this gene is an omega class
            glutathione S-transferase (GST) with glutathione-dependent thiol
            transferase and dehydroascorbate reductase activities. GSTs are
            involved in the metabolism of xenobiotics and carcinogens. The
            encoded protein acts as a homodimer and is found in the cytoplasm.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.190562.1,
                                           SRR1163658.459091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     Protein         1..241
                     /product="glutathione S-transferase omega-1 isoform 1"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="glutathione-S-transferase like; glutathione
                     S-transferase omega 1-1; MMA(V) reductase;
                     monomethylarsonic acid reductase; S-(Phenacyl)glutathione
                     reductase; glutathione-dependent dehydroascorbate
                     reductase; epididymis secretory protein Li 21"
                     /calculated_mol_wt=27435
     variation       1
                     /replace="r"
                     /db_xref="dbSNP:768426683"
     variation       1
                     /replace="v"
                     /db_xref="dbSNP:1369565112"
     variation       2
                     /replace="c"
                     /db_xref="dbSNP:1003018292"
     variation       2
                     /replace="s"
                     /db_xref="dbSNP:747892529"
     Site            2
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylserine. {ECO:0000244|PubMed:19413330};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       3
                     /replace="g"
                     /db_xref="dbSNP:760881698"
     variation       3
                     /replace="r"
                     /db_xref="dbSNP:772396594"
     variation       4
                     /replace="p"
                     /db_xref="dbSNP:1387528981"
     Region          5..94
                     /region_name="GST_N_Omega"
                     /note="GST_N family, Class Omega subfamily; GSTs are
                     cytosolic dimeric proteins involved in cellular
                     detoxification by catalyzing the conjugation of
                     glutathione (GSH) with a wide range of endogenous and
                     xenobiotic alkylating agents, including carcinogens;
                     cd03055"
                     /db_xref="CDD:239353"
     variation       6
                     /replace="v"
                     /db_xref="dbSNP:1474909556"
     Site            order(7..8,29..31,33,36..37,39..41,43..44,55,57)
                     /site_type="other"
                     /note="C-terminal domain interface [polypeptide binding]"
                     /db_xref="CDD:239353"
     variation       7
                     /replace="m"
                     /db_xref="dbSNP:72559704"
     variation       8
                     /replace="t"
                     /db_xref="dbSNP:1251385813"
     variation       9
                     /replace="l"
                     /db_xref="dbSNP:776806870"
     variation       10
                     /replace="e"
                     /db_xref="dbSNP:760104472"
     variation       11
                     /replace="k"
                     /db_xref="dbSNP:765593231"
     variation       11
                     /replace="r"
                     /db_xref="dbSNP:915721379"
     variation       12
                     /replace="e"
                     /db_xref="dbSNP:1258278989"
     variation       13
                     /replace="r"
                     /db_xref="dbSNP:752612056"
     variation       14
                     /replace="a"
                     /db_xref="dbSNP:45488299"
     variation       15
                     /replace="l"
                     /db_xref="dbSNP:777727184"
     variation       15
                     /replace="p"
                     /db_xref="dbSNP:746736564"
     variation       15
                     /replace="s"
                     /db_xref="dbSNP:1376725101"
     variation       16
                     /replace="l"
                     /db_xref="dbSNP:771344081"
     variation       16
                     /replace="p"
                     /db_xref="dbSNP:113750935"
     variation       16
                     /replace="t"
                     /db_xref="dbSNP:370320075"
     variation       18
                     /replace="p"
                     /db_xref="dbSNP:370296132"
     variation       18
                     /replace="s"
                     /db_xref="dbSNP:1288941028"
     variation       19
                     /replace="g"
                     /db_xref="dbSNP:1300332345"
     variation       19
                     /replace="i"
                     /db_xref="dbSNP:746005024"
     variation       19
                     /replace="v"
                     /db_xref="dbSNP:1365114261"
     variation       20
                     /replace="a"
                     /db_xref="dbSNP:1181667116"
     variation       20
                     /replace="r"
                     /db_xref="dbSNP:769727460"
     variation       22
                     /replace="d"
                     /db_xref="dbSNP:149222313"
     variation       22
                     /replace="g"
                     /db_xref="dbSNP:1179780007"
     variation       23
                     /replace="s"
                     /db_xref="dbSNP:146640406"
     variation       25
                     /replace="h"
                     /db_xref="dbSNP:1470661480"
     variation       26
                     /replace="v"
                     /db_xref="dbSNP:564705573"
     variation       29
                     /replace="i"
                     /db_xref="dbSNP:1364917793"
     variation       29
                     /replace="t"
                     /db_xref="dbSNP:146896093"
     variation       29
                     /replace="v"
                     /db_xref="dbSNP:762154396"
     variation       30
                     /replace="r"
                     /db_xref="dbSNP:1463349133"
     Site            order(32,34,59,71..73,85..86)
                     /site_type="other"
                     /note="GSH binding site (G-site) [chemical binding]"
                     /db_xref="CDD:239353"
     variation       32
                     /replace="y"
                     /db_xref="dbSNP:45529437"
     Site            32
                     /site_type="active"
                     /note="active site cysteine [active]"
                     /db_xref="CDD:239353"
     variation       33
                     /replace="l"
                     /db_xref="dbSNP:752197685"
     variation       33
                     /replace="p"
                     /db_xref="dbSNP:1304284184"
     variation       33
                     /replace="s"
                     /db_xref="dbSNP:764679950"
     variation       34
                     /replace="c"
                     /db_xref="dbSNP:1336993429"
     variation       34
                     /replace="f"
                     /db_xref="dbSNP:72559705"
     variation       35
                     /replace="a"
                     /db_xref="dbSNP:968485928"
     variation       36
                     /replace="k"
                     /db_xref="dbSNP:1448603478"
     variation       37
                     /replace="k"
                     /db_xref="dbSNP:1388272778"
     variation       38
                     /replace="m"
                     /db_xref="dbSNP:764125468"
     variation       38
                     /replace="t"
                     /db_xref="dbSNP:1394865725"
     variation       39
                     /replace="c"
                     /db_xref="dbSNP:751456497"
     variation       39
                     /replace="l"
                     /db_xref="dbSNP:978522988"
     variation       40
                     /replace="l"
                     /db_xref="dbSNP:563925334"
     variation       41
                     /replace="a"
                     /db_xref="dbSNP:781512367"
     variation       41
                     /replace="i"
                     /db_xref="dbSNP:924378265"
     variation       42
                     /replace="l"
                     /db_xref="dbSNP:543468807"
     variation       42
                     /replace="l"
                     /db_xref="dbSNP:756310087"
     variation       44
                     /replace="a"
                     /db_xref="dbSNP:1040732810"
     variation       45
                     /replace="e"
                     /db_xref="dbSNP:780009826"
     variation       45
                     /replace="n"
                     /db_xref="dbSNP:1415972337"
     variation       45
                     /replace="r"
                     /db_xref="dbSNP:1186845498"
     variation       48
                     /replace="k"
                     /db_xref="dbSNP:1295829625"
     variation       48
                     /replace="s"
                     /db_xref="dbSNP:770704605"
     variation       49
                     /replace="q"
                     /db_xref="dbSNP:747397917"
     variation       49
                     /replace="r"
                     /db_xref="dbSNP:1380325561"
     variation       52
                     /replace="i"
                     /db_xref="dbSNP:953541334"
     variation       52
                     /replace="t"
                     /db_xref="dbSNP:1297390928"
     variation       53
                     /replace="i"
                     /db_xref="dbSNP:769393338"
     variation       55
                     /replace="s"
                     /db_xref="dbSNP:1042620356"
     variation       57
                     /replace="e"
                     /db_xref="dbSNP:1019133448"
     Site            57
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       60
                     /replace="p"
                     /db_xref="dbSNP:1233432638"
     variation       61
                     /replace="k"
                     /db_xref="dbSNP:968020753"
     variation       62
                     /replace="g"
                     /db_xref="dbSNP:1296328958"
     variation       63
                     /replace="f"
                     /db_xref="dbSNP:775258075"
     variation       63
                     /replace="l"
                     /db_xref="dbSNP:977702048"
     variation       64
                     /replace="l"
                     /db_xref="dbSNP:762588581"
     variation       66
                     /replace="k"
                     /db_xref="dbSNP:1285585480"
     variation       67
                     /replace="s"
                     /db_xref="dbSNP:763724479"
     variation       68
                     /replace="l"
                     /db_xref="dbSNP:867668983"
     variation       68
                     /replace="s"
                     /db_xref="dbSNP:1188685675"
     variation       70
                     /replace="a"
                     /db_xref="dbSNP:1008689901"
     Site            order(71,84..85,87..88,91)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:239353"
     variation       71
                     /replace="l"
                     /db_xref="dbSNP:370867402"
     variation       72
                     /replace="v"
                     /db_xref="dbSNP:761670384"
     variation       73
                     /replace="s"
                     /db_xref="dbSNP:374294843"
     variation       76
                     /replace="g"
                     /db_xref="dbSNP:1337492547"
     variation       79
                     /replace="q"
                     /db_xref="dbSNP:532583793"
     variation       81
                     /replace="s"
                     /db_xref="dbSNP:1392790835"
     variation       82
                     /replace="v"
                     /db_xref="dbSNP:1431116964"
     variation       83
                     /replace="m"
                     /db_xref="dbSNP:760498687"
     variation       83
                     /replace="t"
                     /db_xref="dbSNP:1173648582"
     variation       83
                     /replace="v"
                     /db_xref="dbSNP:750251204"
     variation       84
                     /replace="y"
                     /db_xref="dbSNP:747444602"
     Region          85..86
                     /region_name="Glutathione binding.
                     {ECO:0000269|PubMed:10783391,
                     ECO:0000269|PubMed:21106529}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       85
                     /replace="k"
                     /db_xref="dbSNP:754091728"
     variation       86
                     /replace="c"
                     /db_xref="dbSNP:11509436"
     variation       87
                     /replace="a"
                     /db_xref="dbSNP:755145894"
     variation       87
                     /replace="v"
                     /db_xref="dbSNP:1385375315"
     variation       89
                     /replace="i"
                     /db_xref="dbSNP:1018697878"
     variation       89
                     /replace="t"
                     /db_xref="dbSNP:964403466"
     variation       94
                     /replace="a"
                     /db_xref="dbSNP:1215096671"
     variation       97
                     /replace="*"
                     /db_xref="dbSNP:1373009716"
     variation       97
                     /replace="h"
                     /db_xref="dbSNP:1301153852"
     variation       98
                     /replace="l"
                     /db_xref="dbSNP:752711264"
     variation       98
                     /replace="t"
                     /db_xref="dbSNP:146967406"
     variation       99
                     /replace="e"
                     /db_xref="dbSNP:758896615"
     variation       100
                     /replace="k"
                     /db_xref="dbSNP:1468313552"
     variation       100
                     /replace="r"
                     /db_xref="dbSNP:1261738193"
     variation       100
                     /replace="r"
                     /db_xref="dbSNP:764539556"
     variation       101
                     /replace="n"
                     /db_xref="dbSNP:1212133493"
     variation       101
                     /replace="r"
                     /db_xref="dbSNP:1209463110"
     variation       101
                     /replace="r"
                     /db_xref="dbSNP:1310487761"
     variation       103
                     /replace="f"
                     /db_xref="dbSNP:148006054"
     variation       103
                     /replace="l"
                     /db_xref="dbSNP:1255454238"
     variation       104
                     /replace="l"
                     /db_xref="dbSNP:141645977"
     variation       104
                     /replace="p"
                     /db_xref="dbSNP:781651960"
     variation       104
                     /replace="s"
                     /db_xref="dbSNP:747379810"
     variation       106
                     /replace="d"
                     /db_xref="dbSNP:768364262"
     variation       106
                     /replace="n"
                     /db_xref="dbSNP:748966808"
     variation       107
                     /replace="s"
                     /db_xref="dbSNP:150506133"
     Region          108..229
                     /region_name="GST_C_Omega"
                     /note="C-terminal, alpha helical domain of Class Omega
                     Glutathione S-transferases; cd03184"
                     /db_xref="CDD:198293"
     variation       108
                     /replace="c"
                     /db_xref="dbSNP:569087890"
     variation       109
                     /replace="k"
                     /db_xref="dbSNP:773171640"
     variation       110
                     /replace="e"
                     /db_xref="dbSNP:760491652"
     variation       110
                     /replace="k"
                     /db_xref="dbSNP:1397725776"
     variation       111
                     /replace="g"
                     /db_xref="dbSNP:916334054"
     Site            order(114..115,118..119,122,152)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:198293"
     variation       114
                     /replace="-"
                     /db_xref="dbSNP:947854586"
     variation       118
                     /replace="e"
                     /db_xref="dbSNP:766183768"
     variation       118
                     /replace="q"
                     /db_xref="dbSNP:1371252485"
     Site            order(121,124..125,128..129,180,183,222)
                     /site_type="other"
                     /note="substrate binding pocket (H-site) [chemical
                     binding]"
                     /db_xref="CDD:198293"
     variation       122
                     /replace="t"
                     /db_xref="dbSNP:1307980105"
     variation       123
                     /replace="m"
                     /db_xref="dbSNP:1473004441"
     variation       125
                     /replace="t"
                     /db_xref="dbSNP:763042697"
     variation       125
                     /replace="y"
                     /db_xref="dbSNP:557588649"
     variation       126
                     /replace="w"
                     /db_xref="dbSNP:767639530"
     variation       127
                     /replace="i"
                     /db_xref="dbSNP:751531910"
     variation       129
                     /replace="n"
                     /db_xref="dbSNP:1374901912"
     variation       129
                     /replace="s"
                     /db_xref="dbSNP:1031409217"
     Site            129
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       130
                     /replace="f"
                     /db_xref="dbSNP:994146086"
     variation       131
                     /replace="i"
                     /db_xref="dbSNP:768133416"
     variation       131
                     /replace="n"
                     /db_xref="dbSNP:575960084"
     variation       133
                     /replace="n"
                     /db_xref="dbSNP:139445649"
     variation       133
                     /replace="r"
                     /db_xref="dbSNP:756524212"
     variation       137
                     /replace="-"
                     /db_xref="dbSNP:1303647082"
     variation       137
                     /replace="d"
                     /db_xref="dbSNP:1346508228"
     variation       137
                     /replace="q"
                     /db_xref="dbSNP:780242946"
     variation       137
                     /replace="t"
                     /db_xref="dbSNP:750494494"
     variation       139
                     /replace="c"
                     /db_xref="dbSNP:955721136"
     variation       140
                     /replace="a"
                     /db_xref="dbSNP:111637087"
     variation       140
                     /replace="d"
                     /db_xref="dbSNP:4925"
     variation       142
                     /replace="l"
                     /db_xref="dbSNP:1325405813"
     variation       143
                     /replace="e"
                     /db_xref="dbSNP:757930662"
     Site            143
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       144
                     /replace="e"
                     /db_xref="dbSNP:1804834"
     variation       145
                     /replace="-"
                     /db_xref="dbSNP:771562518"
     variation       145
                     /replace="q"
                     /db_xref="dbSNP:777343283"
     variation       146
                     /replace="l"
                     /db_xref="dbSNP:746500935"
     variation       147
                     /replace="c"
                     /db_xref="dbSNP:777056461"
     variation       147
                     /replace="p"
                     /db_xref="dbSNP:141387929"
     variation       147
                     /replace="r"
                     /db_xref="dbSNP:1476378717"
     variation       148
                     /replace="*"
                     /db_xref="dbSNP:775096136"
     Site            148
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       149
                     /replace="*"
                     /db_xref="dbSNP:1394624522"
     variation       149
                     /replace="a"
                     /db_xref="dbSNP:1005666879"
     variation       149
                     /replace="n"
                     /db_xref="dbSNP:1364904675"
     variation       150
                     /replace="c"
                     /db_xref="dbSNP:1175535889"
     variation       150
                     /replace="l"
                     /db_xref="dbSNP:954444943"
     variation       152
                     /replace="k"
                     /db_xref="dbSNP:1403210320"
     Site            152
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P78417.2)"
     variation       153
                     /replace="r"
                     /db_xref="dbSNP:1318102193"
     variation       155
                     /replace="-"
                     /db_xref="dbSNP:72323784"
     variation       155
                     /replace="-"
                     /db_xref="dbSNP:868194276"
     variation       155
                     /replace="e"
                     /db_xref="dbSNP:964249034"
     variation       156
                     /replace="v"
                     /db_xref="dbSNP:202080684"
     variation       158
                     /replace="s"
                     /db_xref="dbSNP:1171295245"
     variation       159
                     /replace="d"
                     /db_xref="dbSNP:775355821"
     variation       159
                     /replace="s"
                     /db_xref="dbSNP:1237962921"
     variation       160
                     /replace="k"
                     /db_xref="dbSNP:1277414360"
     variation       161
                     /replace="t"
                     /db_xref="dbSNP:200745440"
     variation       162
                     /replace="m"
                     /db_xref="dbSNP:369551343"
     variation       162
                     /replace="t"
                     /db_xref="dbSNP:1272271976"
     variation       163
                     /replace="n"
                     /db_xref="dbSNP:116993524"
     variation       163
                     /replace="t"
                     /db_xref="dbSNP:762022730"
     variation       165
                     /replace="f"
                     /db_xref="dbSNP:199820147"
     variation       166
                     /replace="g"
                     /db_xref="dbSNP:1287205143"
     variation       167
                     /replace="d"
                     /db_xref="dbSNP:1260244599"
     variation       168
                     /replace="k"
                     /db_xref="dbSNP:761270521"
     variation       168
                     /replace="s"
                     /db_xref="dbSNP:148403642"
     variation       169
                     /replace="s"
                     /db_xref="dbSNP:1234833675"
     variation       170
                     /replace="t"
                     /db_xref="dbSNP:1165520884"
     variation       170
                     /replace="v"
                     /db_xref="dbSNP:376039597"
     variation       171
                     /replace="y"
                     /db_xref="dbSNP:754290509"
     Site            order(172,175..176,179,182..183,211,215,225,229)
                     /site_type="other"
                     /note="N-terminal domain interface [polypeptide binding]"
                     /db_xref="CDD:198293"
     variation       172
                     /replace="i"
                     /db_xref="dbSNP:1279898487"
     variation       173
                     /replace="t"
                     /db_xref="dbSNP:369692828"
     variation       174
                     /replace="d"
                     /db_xref="dbSNP:763851200"
     variation       175
                     /replace="c"
                     /db_xref="dbSNP:751246906"
     variation       175
                     /replace="y"
                     /db_xref="dbSNP:756850357"
     variation       176
                     /replace="f"
                     /db_xref="dbSNP:780689474"
     variation       178
                     /replace="*"
                     /db_xref="dbSNP:749866804"
     variation       179
                     /replace="l"
                     /db_xref="dbSNP:201522765"
     variation       179
                     /replace="p"
                     /db_xref="dbSNP:1226395170"
     variation       183
                     /replace="q"
                     /db_xref="dbSNP:1292504288"
     variation       183
                     /replace="w"
                     /db_xref="dbSNP:779840419"
     variation       184
                     /replace="l"
                     /db_xref="dbSNP:749156346"
     variation       186
                     /replace="t"
                     /db_xref="dbSNP:1235136197"
     variation       191
                     /replace="d"
                     /db_xref="dbSNP:1427312417"
     variation       192
                     /replace="c"
                     /db_xref="dbSNP:747954684"
     variation       193
                     /replace="a"
                     /db_xref="dbSNP:772481441"
     variation       195
                     /replace="n"
                     /db_xref="dbSNP:1172415741"
     variation       196
                     /replace="s"
                     /db_xref="dbSNP:748168061"
     variation       197
                     /replace="l"
                     /db_xref="dbSNP:560168668"
     variation       198
                     /replace="q"
                     /db_xref="dbSNP:747154809"
     variation       202
                     /replace="g"
                     /db_xref="dbSNP:1274976017"
     variation       203
                     /replace="i"
                     /db_xref="dbSNP:1233433012"
     variation       205
                     /replace="p"
                     /db_xref="dbSNP:770951049"
     variation       206
                     /replace="i"
                     /db_xref="dbSNP:532141559"
     variation       206
                     /replace="v"
                     /db_xref="dbSNP:1383952851"
     variation       207
                     /replace="k"
                     /db_xref="dbSNP:1333502273"
     variation       208
                     /replace="k"
                     /db_xref="dbSNP:11509438"
     variation       209
                     /replace="e"
                     /db_xref="dbSNP:369926436"
     variation       210
                     /replace="s"
                     /db_xref="dbSNP:746372013"
     variation       211
                     /replace="p"
                     /db_xref="dbSNP:770264722"
     variation       211
                     /replace="s"
                     /db_xref="dbSNP:758257453"
     variation       212
                     /replace="v"
                     /db_xref="dbSNP:3211015"
     variation       214
                     /replace="a"
                     /db_xref="dbSNP:775896923"
     variation       214
                     /replace="t"
                     /db_xref="dbSNP:1233688548"
     variation       215
                     /replace="p"
                     /db_xref="dbSNP:763287842"
     variation       216
                     /replace="l"
                     /db_xref="dbSNP:200773057"
     variation       217
                     /replace="n"
                     /db_xref="dbSNP:15032"
     variation       220
                     /replace="k"
                     /db_xref="dbSNP:370094147"
     variation       220
                     /replace="r"
                     /db_xref="dbSNP:772817786"
     variation       220
                     /replace="s"
                     /db_xref="dbSNP:777494081"
     variation       221
                     /replace="n"
                     /db_xref="dbSNP:764766650"
     variation       223
                     /replace="e"
                     /db_xref="dbSNP:921626074"
     variation       223
                     /replace="q"
                     /db_xref="dbSNP:760335095"
     variation       224
                     /replace="g"
                     /db_xref="dbSNP:765820640"
     variation       225
                     /replace="i"
                     /db_xref="dbSNP:1263505296"
     variation       226
                     /replace="l"
                     /db_xref="dbSNP:1462077543"
     variation       227
                     /replace="q"
                     /db_xref="dbSNP:753323694"
     variation       228
                     /replace="f"
                     /db_xref="dbSNP:754940007"
     variation       228
                     /replace="l"
                     /db_xref="dbSNP:1161491792"
     variation       229
                     /replace="c"
                     /db_xref="dbSNP:569003679"
     variation       229
                     /replace="l"
                     /db_xref="dbSNP:1413125020"
     variation       231
                     /replace="h"
                     /db_xref="dbSNP:373305518"
     variation       231
                     /replace="p"
                     /db_xref="dbSNP:1176324895"
     variation       232
                     /replace="n"
                     /db_xref="dbSNP:758238780"
     variation       234
                     /replace="p"
                     /db_xref="dbSNP:1254871168"
     variation       234
                     /replace="s"
                     /db_xref="dbSNP:888045519"
     variation       236
                     /replace="v"
                     /db_xref="dbSNP:11509439"
     variation       237
                     /replace="y"
                     /db_xref="dbSNP:986118514"
     variation       238
                     /replace="v"
                     /db_xref="dbSNP:747220782"
     variation       239
                     /replace="c"
                     /db_xref="dbSNP:148530043"
     variation       239
                     /replace="y"
                     /db_xref="dbSNP:1324025414"
     variation       240
                     /replace="g"
                     /db_xref="dbSNP:1424252330"
     variation       241
                     /replace="f"
                     /db_xref="dbSNP:781132094"
     variation       241
                     /replace="l"
                     /db_xref="dbSNP:1045505"
     CDS             1..241
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /coded_by="NM_004832.3:38..763"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7555.1"
                     /db_xref="GeneID:9446"
                     /db_xref="HGNC:HGNC:13312"
                     /db_xref="MIM:605482"
ORIGIN      
        1 msgesarslg kgsappgpvp egsiriysmr fcpfaertrl vlkakgirhe vininlknkp
       61 ewffkknpfg lvpvlensqg qliyesaitc eyldeaypgk kllpddpyek acqkmilelf
      121 skvpslvgsf irsqnkedya glkeefrkef tkleevltnk kttffggnsi smidyliwpw
      181 ferleamkln ecvdhtpklk lwmaamkedp tvsalltsek dwqgflelyl qnspeacdyg
      241 l
//
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