GenomeNet

Database: RefSeq
Entry: NP_005229
LinkDB: NP_005229
Original site: NP_005229 
LOCUS       NP_005229                441 aa            linear   PRI 29-APR-2025
DEFINITION  protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION   NP_005229
VERSION     NP_005229.1
DBSOURCE    REFSEQ: accession NM_005238.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 441)
  AUTHORS   Chatterjee,P., Ghosh,D., Chowdhury,S.R. and Roy,S.S.
  TITLE     ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119805 (2024)
   PUBMED   39159682
  REMARK    GeneRIF: ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells.
REFERENCE   2  (residues 1 to 441)
  AUTHORS   Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
            Cao,Q., Zhou,G.P. and Jin,R.
  TITLE     ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
            TGF-beta1-induced epithelial-mesenchymal transition in human
            bronchial epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
   PUBMED   39002703
  REMARK    GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
            suppress TGF-beta1-induced epithelial-mesenchymal transition in
            human bronchial epithelial cells.
REFERENCE   3  (residues 1 to 441)
  AUTHORS   Guo,Y., Pan,J., Gao,X. and Zheng,Y.
  TITLE     Circ-PITX1 promotes non-small-cell lung cancer progression through
            regulating ETS1 expression via miR-615-5p
  JOURNAL   Thorac Cancer 15 (27), 1946-1957 (2024)
   PUBMED   39138880
  REMARK    GeneRIF: Circ-PITX1 promotes non-small-cell lung cancer progression
            through regulating ETS1 expression via miR-615-5p.
REFERENCE   4  (residues 1 to 441)
  AUTHORS   Sreelakshmi,B.J., Karthika,C.L., Ahalya,S., Kalpana,S.R.,
            Kartha,C.C. and Sumi,S.
  TITLE     Mechanoresponsive ETS1 causes endothelial dysfunction and
            arterialization in varicose veins via NOTCH4/DLL4 signaling
  JOURNAL   Eur J Cell Biol 103 (2), 151420 (2024)
   PUBMED   38759515
  REMARK    GeneRIF: Mechanoresponsive ETS1 causes endothelial dysfunction and
            arterialization in varicose veins via NOTCH4/DLL4 signaling.
REFERENCE   5  (residues 1 to 441)
  AUTHORS   Guo,J.R., He,K.Y., Yuan,J.L., An,W., Yin,W.T., Li,Q.T., Lu,L.Y.,
            Yang,J.Y., Liu,M.J., Li,Y.J., Zhao,Y., Yang,Q., Lei,X.Y., Gao,F.,
            Zhang,L., Wu,D.H., Li,J.Q., Zhao,Z.L., Liu,H., Zhu,L.J.,
            Xiang,X.Y., Sun,Q.H., Jian,Y.P. and Xu,Z.X.
  TITLE     HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR
            inhibitors through the ETS1-FKBP12 axis
  JOURNAL   Int J Biol Sci 20 (7), 2640-2657 (2024)
   PUBMED   38725843
  REMARK    GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to
            mTOR inhibitors through the ETS1-FKBP12 axis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 441)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   7  (residues 1 to 441)
  AUTHORS   Majerus,M.A., Bibollet-Ruche,F., Telliez,J.B., Wasylyk,B. and
            Bailleul,B.
  TITLE     Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
  JOURNAL   Nucleic Acids Res 20 (11), 2699-2703 (1992)
   PUBMED   1614856
REFERENCE   8  (residues 1 to 441)
  AUTHORS   Nye,J.A., Petersen,J.M., Gunther,C.V., Jonsen,M.D. and Graves,B.J.
  TITLE     Interaction of murine ets-1 with GGA-binding sites establishes the
            ETS domain as a new DNA-binding motif
  JOURNAL   Genes Dev 6 (6), 975-990 (1992)
   PUBMED   1592264
REFERENCE   9  (residues 1 to 441)
  AUTHORS   Cocquerelle,C., Daubersies,P., Majerus,M.A., Kerckaert,J.P. and
            Bailleul,B.
  TITLE     Splicing with inverted order of exons occurs proximal to large
            introns
  JOURNAL   EMBO J 11 (3), 1095-1098 (1992)
   PUBMED   1339341
REFERENCE   10 (residues 1 to 441)
  AUTHORS   Bhat,N.K., Thompson,C.B., Lindsten,T., June,C.H., Fujiwara,S.,
            Koizumi,S., Fisher,R.J. and Papas,T.S.
  TITLE     Reciprocal expression of human ETS1 and ETS2 genes during T-cell
            activation: regulatory role for the protooncogene ETS1
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3723-3727 (1990)
   PUBMED   2187191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301405.1, BP365215.1,
            J04101.1, AP003397.2 and AK001630.1.
            
            Summary: This gene encodes a member of the ETS family of
            transcription factors, which are defined by the presence of a
            conserved ETS DNA-binding domain that recognizes the core consensus
            DNA sequence GGAA/T in target genes. These proteins function either
            as transcriptional activators or repressors of numerous genes, and
            are involved in stem cell development, cell senescence and death,
            and tumorigenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (2) uses an alternate promoter,
            and differs in the 5' UTR and 5' coding region compared to variant
            1. The resulting isoform (2, also known as Ets-1 p51) is shorter
            with a distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.152042.1,
                                           SRR1803613.252720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     Protein         1..441
                     /product="protein C-ets-1 isoform 2"
                     /note="Avian erythroblastosis virus E26 (v-ets) oncogene
                     homolog-1; protein C-ets-1; v-ets avian erythroblastosis
                     virus E26 oncogene homolog 1; v-ets avian erythroblastosis
                     virus E2 oncogene homolog 1"
                     /calculated_mol_wt=50277
     Site            8
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            15
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          51..138
                     /region_name="SAM_PNT-ETS-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
                     cd08542"
                     /db_xref="CDD:176092"
     Site            order(114,116,120)
                     /site_type="other"
                     /note="ERK2 MAP kinase docking site [polypeptide binding]"
                     /db_xref="CDD:176092"
     Region          130..243
                     /region_name="Activation domain, required for
                     transcription activation.
                     /evidence=ECO:0000269|PubMed:11909962"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Region          147..334
                     /region_name="Ets1_N_flank"
                     /note="Ets1 N-terminal flanking region of Ets domain;
                     pfam19525"
                     /db_xref="CDD:466113"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:15592455; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            265
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            267
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            270
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            285
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          304..312
                     /region_name="Helix HI-1.
                     /evidence=ECO:0000250|UniProtKB:P27577"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            305
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          323..330
                     /region_name="Helix HI-2.
                     /evidence=ECO:0000250|UniProtKB:P27577"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Region          334..418
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     Region          418..422
                     /region_name="Helix H4.
                     /evidence=ECO:0000250|UniProtKB:P27577"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Region          426..432
                     /region_name="Helix H5.
                     /evidence=ECO:0000250|UniProtKB:P27577"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     CDS             1..441
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /coded_by="NM_005238.4:317..1642"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8475.1"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
ORIGIN      
        1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
       61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
      121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
      181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
      241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
      301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
      361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
      421 llgytpeelh amldvkpdad e
//
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