LOCUS NP_005229 441 aa linear PRI 29-APR-2025
DEFINITION protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION NP_005229
VERSION NP_005229.1
DBSOURCE REFSEQ: accession NM_005238.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 441)
AUTHORS Chatterjee,P., Ghosh,D., Chowdhury,S.R. and Roy,S.S.
TITLE ETS1 drives EGF-induced glycolytic shift and metastasis of
epithelial ovarian cancer cells
JOURNAL Biochim Biophys Acta Mol Cell Res 1871 (8), 119805 (2024)
PUBMED 39159682
REMARK GeneRIF: ETS1 drives EGF-induced glycolytic shift and metastasis of
epithelial ovarian cancer cells.
REFERENCE 2 (residues 1 to 441)
AUTHORS Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
Cao,Q., Zhou,G.P. and Jin,R.
TITLE ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
TGF-beta1-induced epithelial-mesenchymal transition in human
bronchial epithelial cells
JOURNAL Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
PUBMED 39002703
REMARK GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
suppress TGF-beta1-induced epithelial-mesenchymal transition in
human bronchial epithelial cells.
REFERENCE 3 (residues 1 to 441)
AUTHORS Guo,Y., Pan,J., Gao,X. and Zheng,Y.
TITLE Circ-PITX1 promotes non-small-cell lung cancer progression through
regulating ETS1 expression via miR-615-5p
JOURNAL Thorac Cancer 15 (27), 1946-1957 (2024)
PUBMED 39138880
REMARK GeneRIF: Circ-PITX1 promotes non-small-cell lung cancer progression
through regulating ETS1 expression via miR-615-5p.
REFERENCE 4 (residues 1 to 441)
AUTHORS Sreelakshmi,B.J., Karthika,C.L., Ahalya,S., Kalpana,S.R.,
Kartha,C.C. and Sumi,S.
TITLE Mechanoresponsive ETS1 causes endothelial dysfunction and
arterialization in varicose veins via NOTCH4/DLL4 signaling
JOURNAL Eur J Cell Biol 103 (2), 151420 (2024)
PUBMED 38759515
REMARK GeneRIF: Mechanoresponsive ETS1 causes endothelial dysfunction and
arterialization in varicose veins via NOTCH4/DLL4 signaling.
REFERENCE 5 (residues 1 to 441)
AUTHORS Guo,J.R., He,K.Y., Yuan,J.L., An,W., Yin,W.T., Li,Q.T., Lu,L.Y.,
Yang,J.Y., Liu,M.J., Li,Y.J., Zhao,Y., Yang,Q., Lei,X.Y., Gao,F.,
Zhang,L., Wu,D.H., Li,J.Q., Zhao,Z.L., Liu,H., Zhu,L.J.,
Xiang,X.Y., Sun,Q.H., Jian,Y.P. and Xu,Z.X.
TITLE HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR
inhibitors through the ETS1-FKBP12 axis
JOURNAL Int J Biol Sci 20 (7), 2640-2657 (2024)
PUBMED 38725843
REMARK GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to
mTOR inhibitors through the ETS1-FKBP12 axis.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 441)
AUTHORS Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
TITLE Gene fusion with an ETS DNA-binding domain caused by chromosome
translocation in human tumours
JOURNAL Nature 359 (6391), 162-165 (1992)
PUBMED 1522903
REFERENCE 7 (residues 1 to 441)
AUTHORS Majerus,M.A., Bibollet-Ruche,F., Telliez,J.B., Wasylyk,B. and
Bailleul,B.
TITLE Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
JOURNAL Nucleic Acids Res 20 (11), 2699-2703 (1992)
PUBMED 1614856
REFERENCE 8 (residues 1 to 441)
AUTHORS Nye,J.A., Petersen,J.M., Gunther,C.V., Jonsen,M.D. and Graves,B.J.
TITLE Interaction of murine ets-1 with GGA-binding sites establishes the
ETS domain as a new DNA-binding motif
JOURNAL Genes Dev 6 (6), 975-990 (1992)
PUBMED 1592264
REFERENCE 9 (residues 1 to 441)
AUTHORS Cocquerelle,C., Daubersies,P., Majerus,M.A., Kerckaert,J.P. and
Bailleul,B.
TITLE Splicing with inverted order of exons occurs proximal to large
introns
JOURNAL EMBO J 11 (3), 1095-1098 (1992)
PUBMED 1339341
REFERENCE 10 (residues 1 to 441)
AUTHORS Bhat,N.K., Thompson,C.B., Lindsten,T., June,C.H., Fujiwara,S.,
Koizumi,S., Fisher,R.J. and Papas,T.S.
TITLE Reciprocal expression of human ETS1 and ETS2 genes during T-cell
activation: regulatory role for the protooncogene ETS1
JOURNAL Proc Natl Acad Sci U S A 87 (10), 3723-3727 (1990)
PUBMED 2187191
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK301405.1, BP365215.1,
J04101.1, AP003397.2 and AK001630.1.
Summary: This gene encodes a member of the ETS family of
transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus
DNA sequence GGAA/T in target genes. These proteins function either
as transcriptional activators or repressors of numerous genes, and
are involved in stem cell development, cell senescence and death,
and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this
gene.[provided by RefSeq, Jul 2011].
Transcript Variant: This variant (2) uses an alternate promoter,
and differs in the 5' UTR and 5' coding region compared to variant
1. The resulting isoform (2, also known as Ets-1 p51) is shorter
with a distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.152042.1,
SRR1803613.252720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2467146 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..441
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.3"
Protein 1..441
/product="protein C-ets-1 isoform 2"
/note="Avian erythroblastosis virus E26 (v-ets) oncogene
homolog-1; protein C-ets-1; v-ets avian erythroblastosis
virus E26 oncogene homolog 1; v-ets avian erythroblastosis
virus E2 oncogene homolog 1"
/calculated_mol_wt=50277
Site 8
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 15
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 38
/site_type="phosphorylation"
/note="Phosphothreonine, by MAPK.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 51..138
/region_name="SAM_PNT-ETS-1"
/note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
cd08542"
/db_xref="CDD:176092"
Site order(114,116,120)
/site_type="other"
/note="ERK2 MAP kinase docking site [polypeptide binding]"
/db_xref="CDD:176092"
Region 130..243
/region_name="Activation domain, required for
transcription activation.
/evidence=ECO:0000269|PubMed:11909962"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Region 147..334
/region_name="Ets1_N_flank"
/note="Ets1 N-terminal flanking region of Ets domain;
pfam19525"
/db_xref="CDD:466113"
Site 223
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0007744|PubMed:15592455; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 251
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 254
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 265
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 267
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 270
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 282
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 285
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 304..312
/region_name="Helix HI-1.
/evidence=ECO:0000250|UniProtKB:P27577"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 305
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 323..330
/region_name="Helix HI-2.
/evidence=ECO:0000250|UniProtKB:P27577"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Region 334..418
/region_name="ETS"
/note="erythroblast transformation specific domain;
smart00413"
/db_xref="CDD:197710"
Region 418..422
/region_name="Helix H4.
/evidence=ECO:0000250|UniProtKB:P27577"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Region 426..432
/region_name="Helix H5.
/evidence=ECO:0000250|UniProtKB:P27577"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
CDS 1..441
/gene="ETS1"
/gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
/coded_by="NM_005238.4:317..1642"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS8475.1"
/db_xref="GeneID:2113"
/db_xref="HGNC:HGNC:3488"
/db_xref="MIM:164720"
ORIGIN
1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
421 llgytpeelh amldvkpdad e
//
