LOCUS NP_005229 441 aa linear PRI 25-AUG-2020
DEFINITION protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION NP_005229
VERSION NP_005229.1
DBSOURCE REFSEQ: accession NM_005238.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 441)
AUTHORS Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H,
Kayamori K, Yamaguchi A and Sakamoto K.
TITLE AIRE is induced in oral squamous cell carcinoma and promotes cancer
gene expression
JOURNAL PLoS ONE 15 (2), e0222689 (2020)
PUBMED 32012175
REMARK GeneRIF: AIRE is induced in oral squamous cell carcinoma and
supports cancer-related gene expression in cooperation with ETS1
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 441)
AUTHORS Yang S, Liu T, Sun Y and Liang X.
TITLE The long noncoding RNA LINC00483 promotes lung adenocarcinoma
progression by sponging miR-204-3p
JOURNAL Cell. Mol. Biol. Lett. 24, 70 (2019)
PUBMED 31889958
REMARK GeneRIF: The study demonstrated that LINC00483 facilitates the
proliferation, migration and invasion of lung adenocarcinoma cells
by acting as a sponge for miR-204-3p, which in turn regulates ETS1.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 441)
AUTHORS Xu H, Zhao G, Zhang Y, Jiang H, Wang W, Zhao D, Yu H and Qi L.
TITLE Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and
angiogenesis of glioma by recruiting transcription factor ETS1 to
upregulate KIF14 expression
JOURNAL J. Exp. Clin. Cancer Res. 38 (1), 486 (2019)
PUBMED 31823805
REMARK GeneRIF: LncRNA PAXIP1-AS1 could upregulate the KIF14 promoter
activity by recruiting transcription factor ETS1. Results confirmed
that the interactions between lncRNA PAXIP1-AS1, ETS1 and KIF14
participated in the growth and angiogenesis of xenograft glioma
tumors.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 441)
AUTHORS Ruan H, Liao Y, Ren Z, Mao L, Yao F, Yu P, Ye Y, Zhang Z, Li S, Xu
H, Liu J, Diao L, Zhou B, Han L and Wang L.
TITLE Single-cell reconstruction of differentiation trajectory reveals a
critical role of ETS1 in human cardiac lineage commitment
JOURNAL BMC Biol. 17 (1), 89 (2019)
PUBMED 31722692
REMARK GeneRIF: This study not only characterized the molecular features
of different cell types and identified ETS1 as a crucial factor
induced by cell-cell crosstalk contributing to cardiac lineage
commitment from a pluripotent state, but may also have important
implications for understanding human heart development at early
embryonic stage, as well as directed manipulation of cardiac
differentiation in regenerative medicine.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 441)
AUTHORS Gu C, Cai J, Xu Z, Zhou S, Ye L, Yan Q, Zhang Y, Fang Y, Liu Y, Tu
C, Wang X, He J, Li Q, Han L, Lin X, Li A and Liu S.
TITLE MiR-532-3p suppresses colorectal cancer progression by disrupting
the ETS1/TGM2 axis-mediated Wnt/beta-catenin signaling
JOURNAL Cell Death Dis 10 (10), 739 (2019)
PUBMED 31570702
REMARK GeneRIF: MiR-532-3p suppresses colorectal cancer progression by
disrupting the ETS1/TGM2 axis-mediated Wnt/beta-catenin signaling.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 441)
AUTHORS Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
Kovar H, Joubert I, de Jong P, Rouleau G et al.
TITLE Gene fusion with an ETS DNA-binding domain caused by chromosome
translocation in human tumours
JOURNAL Nature 359 (6391), 162-165 (1992)
PUBMED 1522903
REFERENCE 7 (residues 1 to 441)
AUTHORS Majerus MA, Bibollet-Ruche F, Telliez JB, Wasylyk B and Bailleul B.
TITLE Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
JOURNAL Nucleic Acids Res. 20 (11), 2699-2703 (1992)
PUBMED 1614856
REFERENCE 8 (residues 1 to 441)
AUTHORS Nye JA, Petersen JM, Gunther CV, Jonsen MD and Graves BJ.
TITLE Interaction of murine ets-1 with GGA-binding sites establishes the
ETS domain as a new DNA-binding motif
JOURNAL Genes Dev. 6 (6), 975-990 (1992)
PUBMED 1592264
REFERENCE 9 (residues 1 to 441)
AUTHORS Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP and Bailleul
B.
TITLE Splicing with inverted order of exons occurs proximal to large
introns
JOURNAL EMBO J. 11 (3), 1095-1098 (1992)
PUBMED 1339341
REFERENCE 10 (residues 1 to 441)
AUTHORS Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S,
Fisher RJ and Papas TS.
TITLE Reciprocal expression of human ETS1 and ETS2 genes during T-cell
activation: regulatory role for the protooncogene ETS1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (10), 3723-3727 (1990)
PUBMED 2187191
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK301405.1, BP365215.1,
J04101.1, AP003397.2 and AK001630.1.
Summary: This gene encodes a member of the ETS family of
transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus
DNA sequence GGAA/T in target genes. These proteins function either
as transcriptional activators or repressors of numerous genes, and
are involved in stem cell development, cell senescence and death,
and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this
gene.[provided by RefSeq, Jul 2011].
Transcript Variant: This variant (2) uses an alternate promoter,
and differs in the 5' UTR and 5' coding region compared to variant
1. The resulting isoform (2, also known as Ets-1 p51) is shorter
with a distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.152042.1,
SRR1803613.252720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2467146 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..441
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.3"
Protein 1..441
/product="protein C-ets-1 isoform 2"
/note="Avian erythroblastosis virus E26 (v-ets) oncogene
homolog-1; protein C-ets-1; v-ets avian erythroblastosis
virus E26 oncogene homolog 1; v-ets avian erythroblastosis
virus E2 oncogene homolog 1"
/calculated_mol_wt=50277
Site 8
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000244|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 15
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000244|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 38
/site_type="phosphorylation"
/note="Phosphothreonine, by MAPK.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 51..138
/region_name="SAM_PNT-ETS-1"
/note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
cd08542"
/db_xref="CDD:176092"
Site order(114,116,120)
/site_type="other"
/note="ERK2 MAP kinase docking site [polypeptide binding]"
/db_xref="CDD:176092"
Region 130..243
/region_name="Activation domain, required for
transcription activation"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 223
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0000244|PubMed:15592455; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 251
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 254
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 265
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000244|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 267
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 270
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 282
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P27577; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 285
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 305
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000244|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 334..418
/region_name="ETS"
/note="erythroblast transformation specific domain;
smart00413"
/db_xref="CDD:197710"
CDS 1..441
/gene="ETS1"
/gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
/coded_by="NM_005238.4:317..1642"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS8475.1"
/db_xref="GeneID:2113"
/db_xref="HGNC:HGNC:3488"
/db_xref="MIM:164720"
ORIGIN
1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
421 llgytpeelh amldvkpdad e
//
