GenomeNet

Database: RefSeq
Entry: NP_005229
LinkDB: NP_005229
Original site: NP_005229 
LOCUS       NP_005229                441 aa            linear   PRI 25-AUG-2020
DEFINITION  protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION   NP_005229
VERSION     NP_005229.1
DBSOURCE    REFSEQ: accession NM_005238.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 441)
  AUTHORS   Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H,
            Kayamori K, Yamaguchi A and Sakamoto K.
  TITLE     AIRE is induced in oral squamous cell carcinoma and promotes cancer
            gene expression
  JOURNAL   PLoS ONE 15 (2), e0222689 (2020)
   PUBMED   32012175
  REMARK    GeneRIF: AIRE is induced in oral squamous cell carcinoma and
            supports cancer-related gene expression in cooperation with ETS1
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 441)
  AUTHORS   Yang S, Liu T, Sun Y and Liang X.
  TITLE     The long noncoding RNA LINC00483 promotes lung adenocarcinoma
            progression by sponging miR-204-3p
  JOURNAL   Cell. Mol. Biol. Lett. 24, 70 (2019)
   PUBMED   31889958
  REMARK    GeneRIF: The study demonstrated that LINC00483 facilitates the
            proliferation, migration and invasion of lung adenocarcinoma cells
            by acting as a sponge for miR-204-3p, which in turn regulates ETS1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 441)
  AUTHORS   Xu H, Zhao G, Zhang Y, Jiang H, Wang W, Zhao D, Yu H and Qi L.
  TITLE     Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and
            angiogenesis of glioma by recruiting transcription factor ETS1 to
            upregulate KIF14 expression
  JOURNAL   J. Exp. Clin. Cancer Res. 38 (1), 486 (2019)
   PUBMED   31823805
  REMARK    GeneRIF: LncRNA PAXIP1-AS1 could upregulate the KIF14 promoter
            activity by recruiting transcription factor ETS1. Results confirmed
            that the interactions between lncRNA PAXIP1-AS1, ETS1 and KIF14
            participated in the growth and angiogenesis of xenograft glioma
            tumors.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 441)
  AUTHORS   Ruan H, Liao Y, Ren Z, Mao L, Yao F, Yu P, Ye Y, Zhang Z, Li S, Xu
            H, Liu J, Diao L, Zhou B, Han L and Wang L.
  TITLE     Single-cell reconstruction of differentiation trajectory reveals a
            critical role of ETS1 in human cardiac lineage commitment
  JOURNAL   BMC Biol. 17 (1), 89 (2019)
   PUBMED   31722692
  REMARK    GeneRIF: This study not only characterized the molecular features
            of different cell types and identified ETS1 as a crucial factor
            induced by cell-cell crosstalk contributing to cardiac lineage
            commitment from a pluripotent state, but may also have important
            implications for understanding human heart development at early
            embryonic stage, as well as directed manipulation of cardiac
            differentiation in regenerative medicine.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 441)
  AUTHORS   Gu C, Cai J, Xu Z, Zhou S, Ye L, Yan Q, Zhang Y, Fang Y, Liu Y, Tu
            C, Wang X, He J, Li Q, Han L, Lin X, Li A and Liu S.
  TITLE     MiR-532-3p suppresses colorectal cancer progression by disrupting
            the ETS1/TGM2 axis-mediated Wnt/beta-catenin signaling
  JOURNAL   Cell Death Dis 10 (10), 739 (2019)
   PUBMED   31570702
  REMARK    GeneRIF: MiR-532-3p suppresses colorectal cancer progression by
            disrupting the ETS1/TGM2 axis-mediated Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 441)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   7  (residues 1 to 441)
  AUTHORS   Majerus MA, Bibollet-Ruche F, Telliez JB, Wasylyk B and Bailleul B.
  TITLE     Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
  JOURNAL   Nucleic Acids Res. 20 (11), 2699-2703 (1992)
   PUBMED   1614856
REFERENCE   8  (residues 1 to 441)
  AUTHORS   Nye JA, Petersen JM, Gunther CV, Jonsen MD and Graves BJ.
  TITLE     Interaction of murine ets-1 with GGA-binding sites establishes the
            ETS domain as a new DNA-binding motif
  JOURNAL   Genes Dev. 6 (6), 975-990 (1992)
   PUBMED   1592264
REFERENCE   9  (residues 1 to 441)
  AUTHORS   Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP and Bailleul
            B.
  TITLE     Splicing with inverted order of exons occurs proximal to large
            introns
  JOURNAL   EMBO J. 11 (3), 1095-1098 (1992)
   PUBMED   1339341
REFERENCE   10 (residues 1 to 441)
  AUTHORS   Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S,
            Fisher RJ and Papas TS.
  TITLE     Reciprocal expression of human ETS1 and ETS2 genes during T-cell
            activation: regulatory role for the protooncogene ETS1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (10), 3723-3727 (1990)
   PUBMED   2187191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301405.1, BP365215.1,
            J04101.1, AP003397.2 and AK001630.1.
            
            Summary: This gene encodes a member of the ETS family of
            transcription factors, which are defined by the presence of a
            conserved ETS DNA-binding domain that recognizes the core consensus
            DNA sequence GGAA/T in target genes. These proteins function either
            as transcriptional activators or repressors of numerous genes, and
            are involved in stem cell development, cell senescence and death,
            and tumorigenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (2) uses an alternate promoter,
            and differs in the 5' UTR and 5' coding region compared to variant
            1. The resulting isoform (2, also known as Ets-1 p51) is shorter
            with a distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.152042.1,
                                           SRR1803613.252720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     Protein         1..441
                     /product="protein C-ets-1 isoform 2"
                     /note="Avian erythroblastosis virus E26 (v-ets) oncogene
                     homolog-1; protein C-ets-1; v-ets avian erythroblastosis
                     virus E26 oncogene homolog 1; v-ets avian erythroblastosis
                     virus E2 oncogene homolog 1"
                     /calculated_mol_wt=50277
     Site            8
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000244|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            15
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000244|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          51..138
                     /region_name="SAM_PNT-ETS-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
                     cd08542"
                     /db_xref="CDD:176092"
     Site            order(114,116,120)
                     /site_type="other"
                     /note="ERK2 MAP kinase docking site [polypeptide binding]"
                     /db_xref="CDD:176092"
     Region          130..243
                     /region_name="Activation domain, required for
                     transcription activation"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000244|PubMed:15592455; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            265
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000244|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            267
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            270
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P27577; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            285
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            305
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000244|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          334..418
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..441
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /coded_by="NM_005238.4:317..1642"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8475.1"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
ORIGIN      
        1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
       61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
      121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
      181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
      241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
      301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
      361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
      421 llgytpeelh amldvkpdad e
//
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