LOCUS NP_005229 441 aa linear PRI 03-SEP-2019
DEFINITION protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION NP_005229
VERSION NP_005229.1
DBSOURCE REFSEQ: accession NM_005238.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 441)
AUTHORS Nazir SU, Kumar R, Singh A, Khan A, Tanwar P, Tripathi R, Mehrotra
R and Hussain S.
TITLE Breast cancer invasion and progression by MMP-9 through Ets-1
transcription factor
JOURNAL Gene 711, 143952 (2019)
PUBMED 31265880
REMARK GeneRIF: Study demonstrates the effect of Ets-1 in the invasion and
epithelial to mesenchymal transition in the pathway of breast
cancer progression, and suggests a plausible role of Ets-1
dependent regulation of MMP-9 gene which may have a significant
impact on breast carcinogenesis.
Erratum:[Gene. 2019 Oct 20;716:144013. PMID: 31377019]
REFERENCE 2 (residues 1 to 441)
AUTHORS Jin L, Fang X, Dai C, Xiang N, Tao J, Sun X, Azmi F, Cao Q, Li X,
Wang Y and Li X.
TITLE The potential role of Ets-1 and miR-326 in CD19(+)B cells in the
pathogenesis of patients with systemic lupus erythematosus
JOURNAL Clin. Rheumatol. 38 (4), 1031-1038 (2019)
PUBMED 30456527
REMARK GeneRIF: Our results suggest that miR-326 might promote B cells
differentiation by targeting Ets-1, a negative regulator of B cells
differentiation and therefore participate in the pathogenesis of
systemic lupus erythematosus.
REFERENCE 3 (residues 1 to 441)
AUTHORS Li S, Yan G, Yue M, Kang Z and Wang L.
TITLE MicroRNA766 inhibits the malignant biological behaviours of
pancreatic ductal adenocarcinoma by directly targeting ETS1
JOURNAL Mol Med Rep 19 (2), 1380-1387 (2019)
PUBMED 30569091
REMARK GeneRIF: ETS1 knockdown simulated the inhibitory effects of the
overexpression of miR766 on PDAC cells.
REFERENCE 4 (residues 1 to 441)
AUTHORS Furlan A, Vercamer C, Heliot L, Wernert N, Desbiens X and Pourtier
A.
TITLE Ets-1 drives breast cancer cell angiogenic potential and
interactions between breast cancer and endothelial cells
JOURNAL Int. J. Oncol. 54 (1), 29-40 (2019)
PUBMED 30365153
REMARK GeneRIF: Study demonstrates that Ets-1 overexpression in breast
cancer cells promotes their adhesion to endothelial cells and
invasion.
REFERENCE 5 (residues 1 to 441)
AUTHORS Shao Z, Li Y, Dai W, Jia H, Zhang Y, Jiang Q, Chai Y, Li X, Sun H,
Yang R, Cao Y, Feng F and Guo Y.
TITLE ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma
cells via regulating transcription factor activity of PXR
JOURNAL Pharmacol. Res. 135, 188-200 (2018)
PUBMED 30114438
REMARK GeneRIF: Overexpression of ETS-1 accelerates the metabolic
clearance of Sorafenib in hepatocellular carcinoma and leads to the
better survival and faster migration of those cells. ETS-1 could
enhance the activation of PXR and be a potential therapeutic target
for overcoming Sorafenib resistance in hepatocellular carcinoma
treatment.
REFERENCE 6 (residues 1 to 441)
AUTHORS Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
Kovar H, Joubert I, de Jong P, Rouleau G et al.
TITLE Gene fusion with an ETS DNA-binding domain caused by chromosome
translocation in human tumours
JOURNAL Nature 359 (6391), 162-165 (1992)
PUBMED 1522903
REFERENCE 7 (residues 1 to 441)
AUTHORS Majerus MA, Bibollet-Ruche F, Telliez JB, Wasylyk B and Bailleul B.
TITLE Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
JOURNAL Nucleic Acids Res. 20 (11), 2699-2703 (1992)
PUBMED 1614856
REFERENCE 8 (residues 1 to 441)
AUTHORS Nye JA, Petersen JM, Gunther CV, Jonsen MD and Graves BJ.
TITLE Interaction of murine ets-1 with GGA-binding sites establishes the
ETS domain as a new DNA-binding motif
JOURNAL Genes Dev. 6 (6), 975-990 (1992)
PUBMED 1592264
REFERENCE 9 (residues 1 to 441)
AUTHORS Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP and Bailleul
B.
TITLE Splicing with inverted order of exons occurs proximal to large
introns
JOURNAL EMBO J. 11 (3), 1095-1098 (1992)
PUBMED 1339341
REFERENCE 10 (residues 1 to 441)
AUTHORS Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S,
Fisher RJ and Papas TS.
TITLE Reciprocal expression of human ETS1 and ETS2 genes during T-cell
activation: regulatory role for the protooncogene ETS1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (10), 3723-3727 (1990)
PUBMED 2187191
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK301405.1, BP365215.1,
J04101.1, AP003397.2 and AK001630.1.
Summary: This gene encodes a member of the ETS family of
transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus
DNA sequence GGAA/T in target genes. These proteins function either
as transcriptional activators or repressors of numerous genes, and
are involved in stem cell development, cell senescence and death,
and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this
gene.[provided by RefSeq, Jul 2011].
Transcript Variant: This variant (2) uses an alternate promoter,
and differs in the 5' UTR and 5' coding region compared to variant
1. The resulting isoform (2, also known as Ets-1 p51) is shorter
with a distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.152042.1,
SRR1803613.252720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2467146 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..441
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.3"
Protein 1..441
/product="protein C-ets-1 isoform 2"
/note="Avian erythroblastosis virus E26 (v-ets) oncogene
homolog-1; protein C-ets-1; v-ets avian erythroblastosis
virus E26 oncogene homolog 1; v-ets avian erythroblastosis
virus E2 oncogene homolog 1"
/calculated_mol_wt=50277
Site 8
/site_type="acetylation"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000244|PubMed:19608861}; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 15
/site_type="acetylation"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000244|PubMed:19608861}; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Site 38
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK.
{ECO:0000250|UniProtKB:P27577}; propagated from
UniProtKB/Swiss-Prot (P14921.1)"
Region 51..138
/region_name="SAM_PNT-ETS-1"
/note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
cd08542"
/db_xref="CDD:176092"
Site order(114,116,120)
/site_type="other"
/note="ERK2 MAP kinase docking site [polypeptide binding]"
/db_xref="CDD:176092"
Region 130..243
/region_name="Activation domain, required for
transcription activation"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 223
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine. {ECO:0000244|PubMed:15592455};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 251
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 254
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P27577};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 265
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 267
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 270
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:19690332};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 282
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P27577};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 285
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:19690332};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Site 305
/site_type="acetylation"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
propagated from UniProtKB/Swiss-Prot (P14921.1)"
Region 334..418
/region_name="ETS"
/note="erythroblast transformation specific domain;
smart00413"
/db_xref="CDD:197710"
CDS 1..441
/gene="ETS1"
/gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
/coded_by="NM_005238.4:317..1642"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS8475.1"
/db_xref="GeneID:2113"
/db_xref="HGNC:HGNC:3488"
/db_xref="MIM:164720"
ORIGIN
1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
421 llgytpeelh amldvkpdad e
//
