GenomeNet

Database: RefSeq
Entry: NP_005229
LinkDB: NP_005229
Original site: NP_005229 
LOCUS       NP_005229                441 aa            linear   PRI 03-SEP-2019
DEFINITION  protein C-ets-1 isoform 2 [Homo sapiens].
ACCESSION   NP_005229
VERSION     NP_005229.1
DBSOURCE    REFSEQ: accession NM_005238.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 441)
  AUTHORS   Nazir SU, Kumar R, Singh A, Khan A, Tanwar P, Tripathi R, Mehrotra
            R and Hussain S.
  TITLE     Breast cancer invasion and progression by MMP-9 through Ets-1
            transcription factor
  JOURNAL   Gene 711, 143952 (2019)
   PUBMED   31265880
  REMARK    GeneRIF: Study demonstrates the effect of Ets-1 in the invasion and
            epithelial to mesenchymal transition in the pathway of breast
            cancer progression, and suggests a plausible role of Ets-1
            dependent regulation of MMP-9 gene which may have a significant
            impact on breast carcinogenesis.
            Erratum:[Gene. 2019 Oct 20;716:144013. PMID: 31377019]
REFERENCE   2  (residues 1 to 441)
  AUTHORS   Jin L, Fang X, Dai C, Xiang N, Tao J, Sun X, Azmi F, Cao Q, Li X,
            Wang Y and Li X.
  TITLE     The potential role of Ets-1 and miR-326 in CD19(+)B cells in the
            pathogenesis of patients with systemic lupus erythematosus
  JOURNAL   Clin. Rheumatol. 38 (4), 1031-1038 (2019)
   PUBMED   30456527
  REMARK    GeneRIF: Our results suggest that miR-326 might promote B cells
            differentiation by targeting Ets-1, a negative regulator of B cells
            differentiation and therefore participate in the pathogenesis of
            systemic lupus erythematosus.
REFERENCE   3  (residues 1 to 441)
  AUTHORS   Li S, Yan G, Yue M, Kang Z and Wang L.
  TITLE     MicroRNA766 inhibits the malignant biological behaviours of
            pancreatic ductal adenocarcinoma by directly targeting ETS1
  JOURNAL   Mol Med Rep 19 (2), 1380-1387 (2019)
   PUBMED   30569091
  REMARK    GeneRIF: ETS1 knockdown simulated the inhibitory effects of the
            overexpression of miR766 on PDAC cells.
REFERENCE   4  (residues 1 to 441)
  AUTHORS   Furlan A, Vercamer C, Heliot L, Wernert N, Desbiens X and Pourtier
            A.
  TITLE     Ets-1 drives breast cancer cell angiogenic potential and
            interactions between breast cancer and endothelial cells
  JOURNAL   Int. J. Oncol. 54 (1), 29-40 (2019)
   PUBMED   30365153
  REMARK    GeneRIF: Study demonstrates that Ets-1 overexpression in breast
            cancer cells promotes their adhesion to endothelial cells and
            invasion.
REFERENCE   5  (residues 1 to 441)
  AUTHORS   Shao Z, Li Y, Dai W, Jia H, Zhang Y, Jiang Q, Chai Y, Li X, Sun H,
            Yang R, Cao Y, Feng F and Guo Y.
  TITLE     ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma
            cells via regulating transcription factor activity of PXR
  JOURNAL   Pharmacol. Res. 135, 188-200 (2018)
   PUBMED   30114438
  REMARK    GeneRIF: Overexpression of ETS-1 accelerates the metabolic
            clearance of Sorafenib in hepatocellular carcinoma and leads to the
            better survival and faster migration of those cells. ETS-1 could
            enhance the activation of PXR and be a potential therapeutic target
            for overcoming Sorafenib resistance in hepatocellular carcinoma
            treatment.
REFERENCE   6  (residues 1 to 441)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   7  (residues 1 to 441)
  AUTHORS   Majerus MA, Bibollet-Ruche F, Telliez JB, Wasylyk B and Bailleul B.
  TITLE     Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
  JOURNAL   Nucleic Acids Res. 20 (11), 2699-2703 (1992)
   PUBMED   1614856
REFERENCE   8  (residues 1 to 441)
  AUTHORS   Nye JA, Petersen JM, Gunther CV, Jonsen MD and Graves BJ.
  TITLE     Interaction of murine ets-1 with GGA-binding sites establishes the
            ETS domain as a new DNA-binding motif
  JOURNAL   Genes Dev. 6 (6), 975-990 (1992)
   PUBMED   1592264
REFERENCE   9  (residues 1 to 441)
  AUTHORS   Cocquerelle C, Daubersies P, Majerus MA, Kerckaert JP and Bailleul
            B.
  TITLE     Splicing with inverted order of exons occurs proximal to large
            introns
  JOURNAL   EMBO J. 11 (3), 1095-1098 (1992)
   PUBMED   1339341
REFERENCE   10 (residues 1 to 441)
  AUTHORS   Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S,
            Fisher RJ and Papas TS.
  TITLE     Reciprocal expression of human ETS1 and ETS2 genes during T-cell
            activation: regulatory role for the protooncogene ETS1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (10), 3723-3727 (1990)
   PUBMED   2187191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301405.1, BP365215.1,
            J04101.1, AP003397.2 and AK001630.1.
            
            Summary: This gene encodes a member of the ETS family of
            transcription factors, which are defined by the presence of a
            conserved ETS DNA-binding domain that recognizes the core consensus
            DNA sequence GGAA/T in target genes. These proteins function either
            as transcriptional activators or repressors of numerous genes, and
            are involved in stem cell development, cell senescence and death,
            and tumorigenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (2) uses an alternate promoter,
            and differs in the 5' UTR and 5' coding region compared to variant
            1. The resulting isoform (2, also known as Ets-1 p51) is shorter
            with a distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.152042.1,
                                           SRR1803613.252720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     Protein         1..441
                     /product="protein C-ets-1 isoform 2"
                     /note="Avian erythroblastosis virus E26 (v-ets) oncogene
                     homolog-1; protein C-ets-1; v-ets avian erythroblastosis
                     virus E26 oncogene homolog 1; v-ets avian erythroblastosis
                     virus E2 oncogene homolog 1"
                     /calculated_mol_wt=50277
     Site            8
                     /site_type="acetylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            15
                     /site_type="acetylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Site            38
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAPK.
                     {ECO:0000250|UniProtKB:P27577}; propagated from
                     UniProtKB/Swiss-Prot (P14921.1)"
     Region          51..138
                     /region_name="SAM_PNT-ETS-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of ETS-1;
                     cd08542"
                     /db_xref="CDD:176092"
     Site            order(114,116,120)
                     /site_type="other"
                     /note="ERK2 MAP kinase docking site [polypeptide binding]"
                     /db_xref="CDD:176092"
     Region          130..243
                     /region_name="Activation domain, required for
                     transcription activation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            223
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine. {ECO:0000244|PubMed:15592455};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            251
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            254
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P27577};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            265
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            267
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            270
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            282
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P27577};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            285
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Site            305
                     /site_type="acetylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P14921.1)"
     Region          334..418
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..441
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /coded_by="NM_005238.4:317..1642"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8475.1"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
ORIGIN      
        1 mkaavdlkpt ltiiktekvd lelfpspdme cadvplltps skemmsqalk atfsgftkeq
       61 qrlgipkdpr qwtethvrdw vmwavnefsl kgvdfqkfcm ngaalcalgk dcflelapdf
      121 vgdilwehle ilqkedvkpy qvngvnpayp esrytsdyfi sygiehaqcv ppsefsepsf
      181 itesyqtlhp isseellslk yendypsvil rdplqtdtlq ndyfaikqev vtpdnmcmgr
      241 tsrgklggqd sfesiesyds cdrltqswss qssfnslqrv psydsfdsed ypaalpnhkp
      301 kgtfkdyvrd radlnkdkpv ipaaalagyt gsgpiqlwqf llelltdksc qsfiswtgdg
      361 wefklsdpde varrwgkrkn kpkmnyekls rglryyydkn iihktagkry vyrfvcdlqs
      421 llgytpeelh amldvkpdad e
//
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