GenomeNet

Database: RefSeq
Entry: NP_006647
LinkDB: NP_006647
Original site: NP_006647 
LOCUS       NP_006647                461 aa            linear   PRI 22-NOV-2018
DEFINITION  sialidase-3 [Homo sapiens].
ACCESSION   NP_006647
VERSION     NP_006647.3
DBSOURCE    REFSEQ: accession NM_006656.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 461)
  AUTHORS   Takahashi K, Proshin S, Yamaguchi K, Yamashita Y, Katakura R,
            Yamamoto K, Shima H, Hosono M and Miyagi T.
  TITLE     Sialidase NEU3 defines invasive potential of human glioblastoma
            cells by regulating calpain-mediated proteolysis of focal adhesion
            proteins
  JOURNAL   Biochim Biophys Acta Gen Subj 1861 (11 Pt A), 2778-2788 (2017)
   PUBMED   28760640
  REMARK    GeneRIF: This first demonstration of sialidase involvement in
            invasive potential of gliolastoma cells may point to NEU3 as an
            attractive treatment target of human gliomas
REFERENCE   2  (residues 1 to 461)
  AUTHORS   Forcella M, Oldani M, Epistolio S, Freguia S, Monti E, Fusi P and
            Frattini M.
  TITLE     Non-small cell lung cancer (NSCLC), EGFR downstream pathway
            activation and TKI targeted therapies sensitivity: Effect of the
            plasma membrane-associated NEU3
  JOURNAL   PLoS ONE 12 (10), e0187289 (2017)
   PUBMED   29088281
  REMARK    GeneRIF: effect of overexpression on EGFR downstream pathway
            activation and TKI targeted therapies sensitivity in non-small cell
            lung cancer cell lines
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 461)
  AUTHORS   Jia F, Howlader MA and Cairo CW.
  TITLE     Integrin-mediated cell migration is blocked by inhibitors of human
            neuraminidase
  JOURNAL   Biochim. Biophys. Acta 1861 (9 Pt A), 1170-1179 (2016)
   PUBMED   27344026
  REMARK    GeneRIF: The most potent compound tested targeted the human Neu4
            isoenzyme, and was able to substantially reduce the rate of cell
            migration. We found that the lateral mobility of integrins was
            reduced by treatment of cells with Neu3, suggesting that Neu3
            enzyme activity resulted in changes to integrin-co-receptor or
            integrin-cytoskeleton interactions
REFERENCE   4  (residues 1 to 461)
  AUTHORS   Cirillo F, Ghiroldi A, Fania C, Piccoli M, Torretta E, Tettamanti
            G, Gelfi C and Anastasia L.
  TITLE     NEU3 Sialidase Protein Interactors in the Plasma Membrane and in
            the Endosomes
  JOURNAL   J. Biol. Chem. 291 (20), 10615-10624 (2016)
   PUBMED   26987901
  REMARK    GeneRIF: NEU3 possesses the ability to interact with specific
            proteins, many of which are different in each cell compartment,
            supporting NEU3 involvement in the cell stress response, protein
            folding, and intracellular trafficking.
REFERENCE   5  (residues 1 to 461)
  AUTHORS   Shiga K, Takahashi K, Sato I, Kato K, Saijo S, Moriya S, Hosono M
            and Miyagi T.
  TITLE     Upregulation of sialidase NEU3 in head and neck squamous cell
            carcinoma associated with lymph node metastasis
  JOURNAL   Cancer Sci. 106 (11), 1544-1553 (2015)
   PUBMED   26470851
  REMARK    GeneRIF: findings identify NEU3 as a participant in head and neck
            squamous cell carcinoma progression
REFERENCE   6  (residues 1 to 461)
  AUTHORS   Oehler C, Kopitz J and Cantz M.
  TITLE     Substrate specificity and inhibitor studies of a membrane-bound
            ganglioside sialidase isolated from human brain tissue
  JOURNAL   Biol. Chem. 383 (11), 1735-1742 (2002)
   PUBMED   12530538
REFERENCE   7  (residues 1 to 461)
  AUTHORS   Kakugawa Y, Wada T, Yamaguchi K, Yamanami H, Ouchi K, Sato I and
            Miyagi T.
  TITLE     Up-regulation of plasma membrane-associated ganglioside sialidase
            (Neu3) in human colon cancer and its involvement in apoptosis
            suppression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (16), 10718-10723 (2002)
   PUBMED   12149448
  REMARK    GeneRIF: up-regulation of plasma membrane-associated ganglioside
            sialidase (Neu3) in human colon cancer and its involvement in
            apoptosis suppression
REFERENCE   8  (residues 1 to 461)
  AUTHORS   Wang Y, Yamaguchi K, Wada T, Hata K, Zhao X, Fujimoto T and Miyagi
            T.
  TITLE     A close association of the ganglioside-specific sialidase Neu3 with
            caveolin in membrane microdomains
  JOURNAL   J. Biol. Chem. 277 (29), 26252-26259 (2002)
   PUBMED   12011038
  REMARK    GeneRIF: Neu3 functions as a caveolin-related signaling molecule
            within caveolin-rich microdomains
REFERENCE   9  (residues 1 to 461)
  AUTHORS   Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B,
            Croci G, Preti A, Ballabio A, Tettamanti G and Borsani G.
  TITLE     Identification and expression of NEU3, a novel human sialidase
            associated to the plasma membrane
  JOURNAL   Biochem. J. 349 (Pt 1), 343-351 (2000)
   PUBMED   10861246
REFERENCE   10 (residues 1 to 461)
  AUTHORS   Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H and Miyagi T.
  TITLE     Cloning, expression, and chromosomal mapping of a human ganglioside
            sialidase
  JOURNAL   Biochem. Biophys. Res. Commun. 261 (1), 21-27 (1999)
   PUBMED   10405317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB240271.1, CN429425.1 and
            AP001992.4.
            On Nov 1, 2006 this sequence version replaced NP_006647.2.
            
            Summary: This gene product belongs to a family of glycohydrolytic
            enzymes which remove sialic acid residues from glycoproteins and
            glycolipids. It is localized in the plasma membrane, and its
            activity is specific for gangliosides. It may play a role in
            modulating the ganglioside content of the lipid bilayer. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y18563.1, ERR279857.766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     Protein         1..461
                     /product="sialidase-3"
                     /EC_number="3.2.1.18"
                     /note="ganglioside sialidase; N-acetyl-alpha-neuraminidase
                     3; membrane sialidase; sialidase 3 (membrane sialidase)"
                     /calculated_mol_wt=51544
     variation       1
                     /replace="i"
                     /db_xref="dbSNP:891339121"
     variation       2
                     /replace="t"
                     /db_xref="dbSNP:1424100251"
     variation       3
                     /replace="l"
                     /db_xref="dbSNP:1391836529"
     variation       3
                     /replace="p"
                     /db_xref="dbSNP:527973476"
     variation       4
                     /replace="a"
                     /db_xref="dbSNP:1158088047"
     variation       5
                     /replace="y"
                     /db_xref="dbSNP:1378188959"
     variation       6
                     /replace="-"
                     /db_xref="dbSNP:1300322995"
     variation       6
                     /replace="l"
                     /db_xref="dbSNP:900266128"
     variation       7
                     /replace="s"
                     /db_xref="dbSNP:1374826078"
     variation       8
                     /replace="a"
                     /db_xref="dbSNP:1445872140"
     variation       8
                     /replace="p"
                     /db_xref="dbSNP:756480483"
     variation       8
                     /replace="r"
                     /db_xref="dbSNP:1421294383"
     variation       9
                     /replace="a"
                     /db_xref="dbSNP:945546694"
     variation       9
                     /replace="h"
                     /db_xref="dbSNP:1380142552"
     variation       9
                     /replace="r"
                     /db_xref="dbSNP:780578598"
     variation       10
                     /replace="p"
                     /db_xref="dbSNP:1307348373"
     variation       11
                     /replace="v"
                     /db_xref="dbSNP:1487737613"
     variation       13
                     /replace="q"
                     /db_xref="dbSNP:1356243695"
     variation       14
                     /replace="t"
                     /db_xref="dbSNP:749790789"
     variation       15
                     /replace="l"
                     /db_xref="dbSNP:997226118"
     variation       15
                     /replace="t"
                     /db_xref="dbSNP:1280221036"
     variation       16
                     /replace="v"
                     /db_xref="dbSNP:1207410587"
     variation       17
                     /replace="f"
                     /db_xref="dbSNP:1247877165"
     variation       18
                     /replace="r"
                     /db_xref="dbSNP:1238763138"
     variation       18
                     /replace="t"
                     /db_xref="dbSNP:1030008872"
     variation       19
                     /replace="f"
                     /db_xref="dbSNP:755035083"
     variation       19
                     /replace="p"
                     /db_xref="dbSNP:1483299524"
     variation       20
                     /replace="v"
                     /db_xref="dbSNP:1236013626"
     variation       21
                     /replace="l"
                     /db_xref="dbSNP:1227990600"
     variation       21
                     /replace="t"
                     /db_xref="dbSNP:1293736171"
     variation       22
                     /replace="r"
                     /db_xref="dbSNP:778975789"
     variation       25
                     /replace="k"
                     /db_xref="dbSNP:778514160"
     variation       26
                     /replace="g"
                     /db_xref="dbSNP:1042554725"
     variation       27
                     /replace="l"
                     /db_xref="dbSNP:1305411483"
     variation       27
                     /replace="p"
                     /db_xref="dbSNP:1412745393"
     variation       28
                     /replace="g"
                     /db_xref="dbSNP:772279045"
     variation       29
                     /replace="v"
                     /db_xref="dbSNP:1394397833"
     variation       31
                     /replace="t"
                     /db_xref="dbSNP:1339497416"
     variation       32
                     /replace="d"
                     /db_xref="dbSNP:1353873970"
     variation       32
                     /replace="k"
                     /db_xref="dbSNP:1413455602"
     variation       33
                     /replace="v"
                     /db_xref="dbSNP:1229821032"
     variation       35
                     /replace="d"
                     /db_xref="dbSNP:1487849007"
     variation       35
                     /replace="g"
                     /db_xref="dbSNP:777944698"
     variation       38
                     /replace="k"
                     /db_xref="dbSNP:200652527"
     variation       42
                     /replace="f"
                     /db_xref="dbSNP:1265288864"
     Region          44..436
                     /region_name="Sialidase_non-viral"
                     /note="Non-viral sialidases; cd15482"
                     /db_xref="CDD:271234"
     variation       44
                     /replace="i"
                     /db_xref="dbSNP:780866349"
     variation       44
                     /replace="s"
                     /db_xref="dbSNP:1186995007"
     variation       46
                     /replace="l"
                     /db_xref="dbSNP:745739557"
     variation       48
                     /replace="q"
                     /db_xref="dbSNP:7115499"
     variation       48
                     /replace="r"
                     /db_xref="dbSNP:762517554"
     variation       48
                     /replace="w"
                     /db_xref="dbSNP:769837017"
     variation       49
                     /replace="p"
                     /db_xref="dbSNP:909174610"
     variation       49
                     /replace="q"
                     /db_xref="dbSNP:768312825"
     variation       51
                     /replace="d"
                     /db_xref="dbSNP:1382270308"
     variation       51
                     /replace="g"
                     /db_xref="dbSNP:1361787061"
     variation       52
                     /replace="e"
                     /db_xref="dbSNP:377669540"
     variation       52
                     /replace="g"
                     /db_xref="dbSNP:1333008676"
     variation       54
                     /replace="d"
                     /db_xref="dbSNP:1212229760"
     variation       54
                     /replace="g"
                     /db_xref="dbSNP:766698480"
     variation       54
                     /replace="r"
                     /db_xref="dbSNP:370929932"
     variation       55
                     /replace="f"
                     /db_xref="dbSNP:375402171"
     variation       56
                     /replace="t"
                     /db_xref="dbSNP:1205424872"
     Region          57..110
                     /region_name="Sialidase propeller 1"
                     /note="Sialidase propeller 1 [structural motif]"
                     /db_xref="CDD:271234"
     Site            order(58,84,258,278,373,403,420)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:271234"
     variation       58
                     /replace="q"
                     /db_xref="dbSNP:377168820"
     variation       58
                     /replace="r"
                     /db_xref="dbSNP:1227584211"
     variation       58
                     /replace="w"
                     /db_xref="dbSNP:754150123"
     variation       59
                     /replace="i"
                     /db_xref="dbSNP:542837204"
     variation       59
                     /replace="l"
                     /db_xref="dbSNP:1484906393"
     variation       59
                     /replace="p"
                     /db_xref="dbSNP:1355813521"
     variation       62
                     /replace="l"
                     /db_xref="dbSNP:370210415"
     variation       62
                     /replace="p"
                     /db_xref="dbSNP:867753731"
     variation       64
                     /replace="c"
                     /db_xref="dbSNP:753244712"
     variation       66
                     /replace="l"
                     /db_xref="dbSNP:559612647"
     variation       66
                     /replace="p"
                     /db_xref="dbSNP:1188455509"
     variation       66
                     /replace="s"
                     /db_xref="dbSNP:758435142"
     variation       67
                     /replace="a"
                     /db_xref="dbSNP:150915961"
     variation       67
                     /replace="l"
                     /db_xref="dbSNP:368708044"
     variation       67
                     /replace="p"
                     /db_xref="dbSNP:769748967"
     variation       68
                     /replace="p"
                     /db_xref="dbSNP:552706985"
     variation       68
                     /replace="t"
                     /db_xref="dbSNP:780097053"
     Region          70..417
                     /region_name="BNR_2"
                     /note="BNR repeat-like domain; pfam13088"
                     /db_xref="CDD:289833"
     variation       70
                     /replace="a"
                     /db_xref="dbSNP:1466032874"
     variation       71
                     /replace="l"
                     /db_xref="dbSNP:749259250"
     variation       72
                     /replace="p"
                     /db_xref="dbSNP:768221197"
     variation       73
                     /replace="t"
                     /db_xref="dbSNP:773737931"
     variation       73
                     /replace="v"
                     /db_xref="dbSNP:747760485"
     variation       75
                     /replace="s"
                     /db_xref="dbSNP:1191101489"
     variation       76
                     /replace="e"
                     /db_xref="dbSNP:771611149"
     variation       78
                     /replace="c"
                     /db_xref="dbSNP:1444271613"
     variation       78
                     /replace="h"
                     /db_xref="dbSNP:772967186"
     variation       79
                     /replace="s"
                     /db_xref="dbSNP:544115"
     variation       80
                     /replace="m"
                     /db_xref="dbSNP:185884919"
     variation       80
                     /replace="t"
                     /db_xref="dbSNP:189950020"
     variation       83
                     /replace="e"
                     /db_xref="dbSNP:763468735"
     variation       83
                     /replace="n"
                     /db_xref="dbSNP:1347150293"
     variation       84
                     /replace="q"
                     /db_xref="dbSNP:374495955"
     variation       85
                     /replace="e"
                     /db_xref="dbSNP:767600414"
     variation       85
                     /replace="h"
                     /db_xref="dbSNP:764171047"
     variation       85
                     /replace="v"
                     /db_xref="dbSNP:1207587009"
     variation       87
                     /replace="i"
                     /db_xref="dbSNP:201747612"
     variation       87
                     /replace="l"
                     /db_xref="dbSNP:780006680"
     variation       88
                     /replace="h"
                     /db_xref="dbSNP:754961062"
     variation       88
                     /replace="p"
                     /db_xref="dbSNP:749169682"
     variation       88
                     /replace="y"
                     /db_xref="dbSNP:951623566"
     variation       90
                     /replace="e"
                     /db_xref="dbSNP:1478712512"
     variation       91
                     /replace="l"
                     /db_xref="dbSNP:368435848"
     variation       93
                     /replace="*"
                     /db_xref="dbSNP:371903396"
     variation       93
                     /replace="q"
                     /db_xref="dbSNP:375051567"
     variation       94
                     /replace="a"
                     /db_xref="dbSNP:369320520"
     variation       94
                     /replace="r"
                     /db_xref="dbSNP:1433121408"
     variation       95
                     /replace="l"
                     /db_xref="dbSNP:1319915842"
     variation       96
                     /replace="r"
                     /db_xref="dbSNP:1396891056"
     variation       97
                     /replace="v"
                     /db_xref="dbSNP:772701570"
     variation       98
                     /replace="e"
                     /db_xref="dbSNP:1290458156"
     variation       98
                     /replace="g"
                     /db_xref="dbSNP:1397241995"
     variation       99
                     /replace="h"
                     /db_xref="dbSNP:1299073653"
     variation       99
                     /replace="k"
                     /db_xref="dbSNP:746688773"
     variation       99
                     /replace="p"
                     /db_xref="dbSNP:770089663"
     variation       100
                     /replace="v"
                     /db_xref="dbSNP:775841599"
     variation       102
                     /replace="l"
                     /db_xref="dbSNP:1224194162"
     variation       104
                     /replace="g"
                     /db_xref="dbSNP:1216965688"
     variation       105
                     /replace="l"
                     /db_xref="dbSNP:1284717091"
     variation       105
                     /replace="p"
                     /db_xref="dbSNP:780779450"
     variation       108
                     /replace="p"
                     /db_xref="dbSNP:745553656"
     variation       109
                     /replace="v"
                     /db_xref="dbSNP:768841662"
     variation       111
                     /replace="a"
                     /db_xref="dbSNP:779337545"
     variation       115
                     /replace="l"
                     /db_xref="dbSNP:533535665"
     variation       115
                     /replace="p"
                     /db_xref="dbSNP:772618610"
     variation       116
                     /replace="a"
                     /db_xref="dbSNP:1461013842"
     variation       116
                     /replace="g"
                     /db_xref="dbSNP:773904835"
     variation       116
                     /replace="r"
                     /db_xref="dbSNP:1023596542"
     variation       117
                     /replace="r"
                     /db_xref="dbSNP:1429992610"
     variation       118
                     /replace="q"
                     /db_xref="dbSNP:193254571"
     variation       118
                     /replace="w"
                     /db_xref="dbSNP:199990681"
     Region          119..177
                     /region_name="Sialidase propeller 2"
                     /note="Sialidase propeller 2 [structural motif]"
                     /db_xref="CDD:271234"
     variation       119
                     /replace="t"
                     /db_xref="dbSNP:373985198"
     variation       120
                     /replace="v"
                     /db_xref="dbSNP:759820063"
     variation       121
                     /replace="n"
                     /db_xref="dbSNP:764876214"
     variation       121
                     /replace="s"
                     /db_xref="dbSNP:1323392416"
     variation       122
                     /replace="a"
                     /db_xref="dbSNP:201872634"
     variation       122
                     /replace="l"
                     /db_xref="dbSNP:1232910124"
     variation       122
                     /replace="p"
                     /db_xref="dbSNP:199660611"
     variation       125
                     /replace="a"
                     /db_xref="dbSNP:751524929"
     variation       125
                     /replace="v"
                     /db_xref="dbSNP:756705508"
     variation       127
                     /replace="e"
                     /db_xref="dbSNP:539550282"
     variation       130
                     /replace="n"
                     /db_xref="dbSNP:1037640960"
     variation       133
                     /replace="m"
                     /db_xref="dbSNP:756884337"
     variation       134
                     /replace="l"
                     /db_xref="dbSNP:1275878940"
     variation       135
                     /replace="l"
                     /db_xref="dbSNP:1214923955"
     variation       135
                     /replace="l"
                     /db_xref="dbSNP:372662449"
     variation       138
                     /replace="f"
                     /db_xref="dbSNP:79122131"
     variation       138
                     /replace="t"
                     /db_xref="dbSNP:779629376"
     variation       139
                     /replace="y"
                     /db_xref="dbSNP:1319705519"
     variation       140
                     /replace="v"
                     /db_xref="dbSNP:910904505"
     variation       141
                     /replace="q"
                     /db_xref="dbSNP:778712896"
     variation       141
                     /replace="r"
                     /db_xref="dbSNP:377057355"
     variation       141
                     /replace="r"
                     /db_xref="dbSNP:771078641"
     variation       142
                     /replace="a"
                     /db_xref="dbSNP:776858446"
     variation       142
                     /replace="g"
                     /db_xref="dbSNP:1475898546"
     variation       143
                     /replace="r"
                     /db_xref="dbSNP:770046946"
     variation       143
                     /replace="y"
                     /db_xref="dbSNP:746004555"
     variation       146
                     /replace="d"
                     /db_xref="dbSNP:199928356"
     variation       147
                     /replace="g"
                     /db_xref="dbSNP:201212157"
     variation       147
                     /replace="h"
                     /db_xref="dbSNP:374626408"
     variation       147
                     /replace="r"
                     /db_xref="dbSNP:1484899557"
     variation       148
                     /replace="e"
                     /db_xref="dbSNP:368629826"
     variation       149
                     /replace="q"
                     /db_xref="dbSNP:78682547"
     variation       150
                     /replace="i"
                     /db_xref="dbSNP:1045096679"
     variation       151
                     /replace="m"
                     /db_xref="dbSNP:755627162"
     variation       152
                     /replace="t"
                     /db_xref="dbSNP:766023347"
     variation       154
                     /replace="w"
                     /db_xref="dbSNP:1283265380"
     variation       156
                     /replace="a"
                     /db_xref="dbSNP:753464530"
     variation       158
                     /replace="c"
                     /db_xref="dbSNP:758788013"
     variation       158
                     /replace="h"
                     /db_xref="dbSNP:1008581005"
     variation       163
                     /replace="h"
                     /db_xref="dbSNP:375035167"
     variation       164
                     /replace="n"
                     /db_xref="dbSNP:994065051"
     variation       165
                     /replace="*"
                     /db_xref="dbSNP:1206489673"
     variation       165
                     /replace="p"
                     /db_xref="dbSNP:373749925"
     variation       169
                     /replace="y"
                     /db_xref="dbSNP:1214524100"
     variation       170
                     /replace="s"
                     /db_xref="dbSNP:892142722"
     variation       171
                     /replace="*"
                     /db_xref="dbSNP:1255064357"
     variation       171
                     /replace="*"
                     /db_xref="dbSNP:368114679"
     variation       172
                     /replace="t"
                     /db_xref="dbSNP:202090872"
     variation       174
                     /replace="g"
                     /db_xref="dbSNP:1423685028"
     variation       176
                     /replace="h"
                     /db_xref="dbSNP:199646720"
     variation       179
                     /replace="e"
                     /db_xref="dbSNP:1021883153"
     variation       179
                     /replace="k"
                     /db_xref="dbSNP:142331834"
     variation       180
                     /replace="a"
                     /db_xref="dbSNP:969345096"
     variation       182
                     /replace="t"
                     /db_xref="dbSNP:200654650"
     variation       183
                     /replace="g"
                     /db_xref="dbSNP:769791012"
     variation       183
                     /replace="v"
                     /db_xref="dbSNP:1184665875"
     variation       185
                     /replace="*"
                     /db_xref="dbSNP:775729527"
     variation       186
                     /replace="l"
                     /db_xref="dbSNP:1160800310"
     variation       186
                     /replace="l"
                     /db_xref="dbSNP:1222419506"
     variation       187
                     /replace="*"
                     /db_xref="dbSNP:1386437583"
     variation       188
                     /replace="d"
                     /db_xref="dbSNP:201869289"
     variation       188
                     /replace="r"
                     /db_xref="dbSNP:768371599"
     variation       189
                     /replace="r"
                     /db_xref="dbSNP:774126634"
     variation       190
                     /replace="t"
                     /db_xref="dbSNP:1277203464"
     variation       190
                     /replace="v"
                     /db_xref="dbSNP:1454376479"
     Region          191..250
                     /region_name="Sialidase propeller 3"
                     /note="Sialidase propeller 3 [structural motif]"
                     /db_xref="CDD:271234"
     variation       191
                     /replace="q"
                     /db_xref="dbSNP:770386334"
     variation       193
                     /replace="a"
                     /db_xref="dbSNP:761653119"
     variation       194
                     /replace="m"
                     /db_xref="dbSNP:767418979"
     variation       196
                     /replace="p"
                     /db_xref="dbSNP:372007557"
     variation       196
                     /replace="s"
                     /db_xref="dbSNP:144642169"
     variation       197
                     /replace="v"
                     /db_xref="dbSNP:1281247452"
     variation       199
                     /replace="g"
                     /db_xref="dbSNP:1404240627"
     variation       200
                     /replace="l"
                     /db_xref="dbSNP:765830428"
     variation       201
                     /replace="h"
                     /db_xref="dbSNP:533213513"
     variation       201
                     /replace="r"
                     /db_xref="dbSNP:1199981836"
     variation       202
                     /replace="l"
                     /db_xref="dbSNP:1462869469"
     variation       205
                     /replace="r"
                     /db_xref="dbSNP:754684155"
     variation       206
                     /replace="*"
                     /db_xref="dbSNP:543513106"
     variation       208
                     /replace="i"
                     /db_xref="dbSNP:1354123075"
     variation       208
                     /replace="v"
                     /db_xref="dbSNP:907924040"
     variation       210
                     /replace="a"
                     /db_xref="dbSNP:562313920"
     variation       210
                     /replace="l"
                     /db_xref="dbSNP:757748319"
     variation       211
                     /replace="a"
                     /db_xref="dbSNP:750912072"
     variation       211
                     /replace="e"
                     /db_xref="dbSNP:781705613"
     variation       214
                     /replace="*"
                     /db_xref="dbSNP:962071453"
     variation       215
                     /replace="y"
                     /db_xref="dbSNP:756157050"
     variation       215
                     /replace="y"
                     /db_xref="dbSNP:773855264"
     variation       216
                     /replace="f"
                     /db_xref="dbSNP:779999622"
     variation       219
                     /replace="c"
                     /db_xref="dbSNP:1198872533"
     variation       219
                     /replace="r"
                     /db_xref="dbSNP:1336987517"
     variation       220
                     /replace="f"
                     /db_xref="dbSNP:375217007"
     variation       222
                     /replace="*"
                     /db_xref="dbSNP:866386936"
     variation       222
                     /replace="g"
                     /db_xref="dbSNP:115325363"
     variation       225
                     /replace="v"
                     /db_xref="dbSNP:1330772870"
     variation       227
                     /replace="s"
                     /db_xref="dbSNP:1336345363"
     variation       229
                     /replace="t"
                     /db_xref="dbSNP:1291698492"
     variation       232
                     /replace="y"
                     /db_xref="dbSNP:747906258"
     variation       233
                     /replace="a"
                     /db_xref="dbSNP:1281391860"
     variation       234
                     /replace="l"
                     /db_xref="dbSNP:1325762214"
     variation       234
                     /replace="l"
                     /db_xref="dbSNP:1480526783"
     variation       235
                     /replace="k"
                     /db_xref="dbSNP:1224310617"
     variation       236
                     /replace="i"
                     /db_xref="dbSNP:548397936"
     variation       236
                     /replace="v"
                     /db_xref="dbSNP:371627063"
     variation       238
                     /replace="g"
                     /db_xref="dbSNP:773153256"
     variation       238
                     /replace="i"
                     /db_xref="dbSNP:760544688"
     variation       239
                     /replace="d"
                     /db_xref="dbSNP:770409657"
     variation       240
                     /replace="d"
                     /db_xref="dbSNP:1451599919"
     variation       241
                     /replace="l"
                     /db_xref="dbSNP:147894902"
     variation       241
                     /replace="p"
                     /db_xref="dbSNP:1325313547"
     variation       241
                     /replace="q"
                     /db_xref="dbSNP:1272446715"
     variation       243
                     /replace="f"
                     /db_xref="dbSNP:915421795"
     variation       243
                     /replace="g"
                     /db_xref="dbSNP:767180765"
     variation       243
                     /replace="s"
                     /db_xref="dbSNP:759130871"
     variation       244
                     /replace="t"
                     /db_xref="dbSNP:1481150258"
     variation       247
                     /replace="h"
                     /db_xref="dbSNP:1176648177"
     variation       248
                     /replace="d"
                     /db_xref="dbSNP:369776172"
     variation       250
                     /replace="h"
                     /db_xref="dbSNP:527628861"
     variation       253
                     /replace="t"
                     /db_xref="dbSNP:762233174"
     variation       254
                     /replace="i"
                     /db_xref="dbSNP:759777638"
     variation       254
                     /replace="k"
                     /db_xref="dbSNP:1045146884"
     variation       254
                     /replace="l"
                     /db_xref="dbSNP:767782339"
     variation       256
                     /replace="t"
                     /db_xref="dbSNP:1386075649"
     Region          257..299
                     /region_name="Sialidase propeller 4"
                     /note="Sialidase propeller 4 [structural motif]"
                     /db_xref="CDD:271234"
     variation       258
                     /replace="*"
                     /db_xref="dbSNP:906621867"
     variation       259
                     /replace="y"
                     /db_xref="dbSNP:1347414913"
     variation       260
                     /replace="e"
                     /db_xref="dbSNP:750872545"
     variation       262
                     /replace="t"
                     /db_xref="dbSNP:200629627"
     variation       262
                     /replace="v"
                     /db_xref="dbSNP:1366017225"
     variation       262
                     /replace="va"
                     /db_xref="dbSNP:1405676011"
     variation       265
                     /replace="t"
                     /db_xref="dbSNP:1306053631"
     variation       266
                     /replace="e"
                     /db_xref="dbSNP:1252196288"
     variation       266
                     /replace="e"
                     /db_xref="dbSNP:867312992"
     variation       266
                     /replace="g"
                     /db_xref="dbSNP:780666537"
     variation       266
                     /replace="w"
                     /db_xref="dbSNP:1230058442"
     variation       268
                     /replace="v"
                     /db_xref="dbSNP:753890800"
     variation       269
                     /replace="s"
                     /db_xref="dbSNP:755089060"
     variation       270
                     /replace="y"
                     /db_xref="dbSNP:779067414"
     variation       271
                     /replace="p"
                     /db_xref="dbSNP:771832431"
     variation       271
                     /replace="q"
                     /db_xref="dbSNP:1485891059"
     variation       271
                     /replace="t"
                     /db_xref="dbSNP:748401241"
     variation       273
                     /replace="l"
                     /db_xref="dbSNP:17133599"
     variation       273
                     /replace="v"
                     /db_xref="dbSNP:777441967"
     variation       274
                     /replace="y"
                     /db_xref="dbSNP:770766955"
     variation       275
                     /replace="y"
                     /db_xref="dbSNP:1462362927"
     variation       276
                     /replace="n"
                     /db_xref="dbSNP:897785622"
     variation       277
                     /replace="d"
                     /db_xref="dbSNP:776747427"
     variation       277
                     /replace="s"
                     /db_xref="dbSNP:944512057"
     variation       278
                     /replace="q"
                     /db_xref="dbSNP:769447064"
     variation       278
                     /replace="r"
                     /db_xref="dbSNP:775221082"
     variation       278
                     /replace="w"
                     /db_xref="dbSNP:376361957"
     variation       279
                     /replace="t"
                     /db_xref="dbSNP:369520041"
     variation       280
                     /replace="l"
                     /db_xref="dbSNP:1316338134"
     variation       281
                     /replace="n"
                     /db_xref="dbSNP:763867572"
     variation       283
                     /replace="y"
                     /db_xref="dbSNP:1313119382"
     variation       284
                     /replace="g"
                     /db_xref="dbSNP:539514716"
     variation       284
                     /replace="q"
                     /db_xref="dbSNP:200007739"
     variation       285
                     /replace="v"
                     /db_xref="dbSNP:766775465"
     variation       286
                     /replace="d"
                     /db_xref="dbSNP:1244302323"
     variation       286
                     /replace="g"
                     /db_xref="dbSNP:1043777997"
     variation       287
                     /replace="a"
                     /db_xref="dbSNP:1360862810"
     variation       287
                     /replace="v"
                     /db_xref="dbSNP:201661038"
     variation       289
                     /replace="g"
                     /db_xref="dbSNP:904815986"
     variation       290
                     /replace="i"
                     /db_xref="dbSNP:1001769382"
     variation       290
                     /replace="t"
                     /db_xref="dbSNP:765305268"
     variation       291
                     /replace="n"
                     /db_xref="dbSNP:752858195"
     variation       292
                     /replace="h"
                     /db_xref="dbSNP:758534119"
     variation       292
                     /replace="r"
                     /db_xref="dbSNP:1262052080"
     variation       293
                     /replace="g"
                     /db_xref="dbSNP:1482043666"
     variation       294
                     /replace="v"
                     /db_xref="dbSNP:778122110"
     variation       295
                     /replace="c"
                     /db_xref="dbSNP:373455752"
     variation       296
                     /replace="v"
                     /db_xref="dbSNP:201144132"
     variation       297
                     /replace="r"
                     /db_xref="dbSNP:781223780"
     variation       300
                     /replace="a"
                     /db_xref="dbSNP:1343472750"
     variation       300
                     /replace="t"
                     /db_xref="dbSNP:1165812726"
     variation       300
                     /replace="v"
                     /db_xref="dbSNP:1347165873"
     variation       301
                     /replace="*"
                     /db_xref="dbSNP:752354749"
     variation       301
                     /replace="v"
                     /db_xref="dbSNP:1443204872"
     variation       302
                     /replace="r"
                     /db_xref="dbSNP:745827893"
     variation       303
                     /replace="*"
                     /db_xref="dbSNP:555974493"
     variation       303
                     /replace="l"
                     /db_xref="dbSNP:775129462"
     variation       305
                     /replace="f"
                     /db_xref="dbSNP:370296365"
     variation       306
                     /replace="r"
                     /db_xref="dbSNP:768164845"
     variation       307
                     /replace="q"
                     /db_xref="dbSNP:1263216514"
     variation       308
                     /replace="l"
                     /db_xref="dbSNP:1202898408"
     variation       308
                     /replace="p"
                     /db_xref="dbSNP:960209662"
     variation       309
                     /replace="p"
                     /db_xref="dbSNP:766760875"
     variation       309
                     /replace="r"
                     /db_xref="dbSNP:774103340"
     variation       310
                     /replace="r"
                     /db_xref="dbSNP:760048743"
     variation       310
                     /replace="t"
                     /db_xref="dbSNP:760484523"
     variation       310
                     /replace="y"
                     /db_xref="dbSNP:777055808"
     Region          311..396
                     /region_name="Sialidase propeller 5"
                     /note="Sialidase propeller 5 [structural motif]"
                     /db_xref="CDD:271234"
     variation       311
                     /replace="s"
                     /db_xref="dbSNP:1460642903"
     variation       312
                     /replace="g"
                     /db_xref="dbSNP:572639453"
     variation       313
                     /replace="q"
                     /db_xref="dbSNP:752714058"
     variation       314
                     /replace="g"
                     /db_xref="dbSNP:758542916"
     variation       315
                     /replace="r"
                     /db_xref="dbSNP:764197897"
     variation       316
                     /replace="m"
                     /db_xref="dbSNP:751826112"
     variation       316
                     /replace="v"
                     /db_xref="dbSNP:1229391116"
     variation       317
                     /replace="*"
                     /db_xref="dbSNP:763841765"
     variation       319
                     /replace="l"
                     /db_xref="dbSNP:372394703"
     variation       320
                     /replace="q"
                     /db_xref="dbSNP:781152049"
     variation       320
                     /replace="r"
                     /db_xref="dbSNP:1031104575"
     variation       320
                     /replace="w"
                     /db_xref="dbSNP:185004433"
     variation       321
                     /replace="p"
                     /db_xref="dbSNP:1468364592"
     variation       321
                     /replace="t"
                     /db_xref="dbSNP:1392031737"
     variation       324
                     /replace="i"
                     /db_xref="dbSNP:1407238616"
     variation       325
                     /replace="h"
                     /db_xref="dbSNP:1338976130"
     variation       325
                     /replace="p"
                     /db_xref="dbSNP:756119499"
     variation       325
                     /replace="t"
                     /db_xref="dbSNP:745719653"
     variation       326
                     /replace="y"
                     /db_xref="dbSNP:780183112"
     variation       327
                     /replace="*"
                     /db_xref="dbSNP:753763414"
     variation       327
                     /replace="g"
                     /db_xref="dbSNP:376457739"
     variation       327
                     /replace="t"
                     /db_xref="dbSNP:748727030"
     variation       328
                     /replace="y"
                     /db_xref="dbSNP:1322223359"
     variation       330
                     /replace="v"
                     /db_xref="dbSNP:768236036"
     variation       331
                     /replace="c"
                     /db_xref="dbSNP:1384995376"
     variation       331
                     /replace="t"
                     /db_xref="dbSNP:1348557280"
     variation       333
                     /replace="s"
                     /db_xref="dbSNP:773836008"
     variation       335
                     /replace="d"
                     /db_xref="dbSNP:747842277"
     variation       336
                     /replace="a"
                     /db_xref="dbSNP:776965933"
     variation       336
                     /replace="v"
                     /db_xref="dbSNP:771228179"
     variation       337
                     /replace="l"
                     /db_xref="dbSNP:1481540642"
     variation       338
                     /replace="i"
                     /db_xref="dbSNP:557819590"
     variation       339
                     /replace="t"
                     /db_xref="dbSNP:765700356"
     variation       340
                     /replace="h"
                     /db_xref="dbSNP:1178823824"
     variation       340
                     /replace="r"
                     /db_xref="dbSNP:1479508465"
     variation       341
                     /replace="*"
                     /db_xref="dbSNP:1430292589"
     variation       344
                     /replace="l"
                     /db_xref="dbSNP:7936236"
     variation       344
                     /replace="p"
                     /db_xref="dbSNP:1475521318"
     variation       344
                     /replace="s"
                     /db_xref="dbSNP:370933888"
     variation       345
                     /replace="v"
                     /db_xref="dbSNP:1168847002"
     variation       346
                     /replace="n"
                     /db_xref="dbSNP:1374482394"
     variation       347
                     /replace="s"
                     /db_xref="dbSNP:188710231"
     variation       348
                     /replace="l"
                     /db_xref="dbSNP:1443480084"
     variation       350
                     /replace="l"
                     /db_xref="dbSNP:563424082"
     variation       350
                     /replace="p"
                     /db_xref="dbSNP:751661285"
     variation       351
                     /replace="a"
                     /db_xref="dbSNP:750215269"
     variation       351
                     /replace="k"
                     /db_xref="dbSNP:767922424"
     variation       352
                     /replace="d"
                     /db_xref="dbSNP:1243189922"
     variation       355
                     /replace="r"
                     /db_xref="dbSNP:7935409"
     variation       356
                     /replace="i"
                     /db_xref="dbSNP:1213762134"
     variation       356
                     /replace="p"
                     /db_xref="dbSNP:143740329"
     variation       357
                     /replace="l"
                     /db_xref="dbSNP:7936249"
     variation       357
                     /replace="p"
                     /db_xref="dbSNP:374973319"
     variation       360
                     /replace="s"
                     /db_xref="dbSNP:367851903"
     variation       360
                     /replace="t"
                     /db_xref="dbSNP:754379276"
     variation       361
                     /replace="r"
                     /db_xref="dbSNP:1489870951"
     variation       362
                     /replace="f"
                     /db_xref="dbSNP:1341678703"
     variation       362
                     /replace="l"
                     /db_xref="dbSNP:747668366"
     variation       365
                     /replace="l"
                     /db_xref="dbSNP:561931411"
     variation       365
                     /replace="s"
                     /db_xref="dbSNP:1475176055"
     variation       366
                     /replace="y"
                     /db_xref="dbSNP:777439762"
     variation       367
                     /replace="p"
                     /db_xref="dbSNP:527548797"
     variation       368
                     /replace="a"
                     /db_xref="dbSNP:770163312"
     variation       369
                     /replace="g"
                     /db_xref="dbSNP:376424993"
     variation       372
                     /replace="*"
                     /db_xref="dbSNP:763516757"
     variation       373
                     /replace="g"
                     /db_xref="dbSNP:757296217"
     variation       374
                     /replace="d"
                     /db_xref="dbSNP:1364300615"
     variation       377
                     /replace="s"
                     /db_xref="dbSNP:1422213133"
     variation       379
                     /replace="c"
                     /db_xref="dbSNP:769105197"
     variation       379
                     /replace="y"
                     /db_xref="dbSNP:762026856"
     variation       382
                     /replace="p"
                     /db_xref="dbSNP:1429540134"
     variation       383
                     /replace="n"
                     /db_xref="dbSNP:767832775"
     variation       386
                     /replace="e"
                     /db_xref="dbSNP:200560033"
     variation       386
                     /replace="g"
                     /db_xref="dbSNP:779073288"
     variation       388
                     /replace="t"
                     /db_xref="dbSNP:928119252"
     variation       390
                     /replace="l"
                     /db_xref="dbSNP:1214984450"
     variation       391
                     /replace="c"
                     /db_xref="dbSNP:750698043"
     variation       392
                     /replace="c"
                     /db_xref="dbSNP:760507666"
     variation       392
                     /replace="h"
                     /db_xref="dbSNP:749465509"
     variation       393
                     /replace="a"
                     /db_xref="dbSNP:184113548"
     variation       393
                     /replace="p"
                     /db_xref="dbSNP:1292507746"
     variation       394
                     /replace="*"
                     /db_xref="dbSNP:753660330"
     variation       395
                     /replace="i"
                     /db_xref="dbSNP:1429364601"
     variation       400
                     /replace="p"
                     /db_xref="dbSNP:1043424536"
     Region          402..436
                     /region_name="Sialidase propeller 6"
                     /note="Sialidase propeller 6 [structural motif]"
                     /db_xref="CDD:271234"
     variation       403
                     /replace="c"
                     /db_xref="dbSNP:754929121"
     variation       403
                     /replace="y"
                     /db_xref="dbSNP:778781995"
     variation       404
                     /replace="f"
                     /db_xref="dbSNP:777354093"
     variation       404
                     /replace="p"
                     /db_xref="dbSNP:757950196"
     variation       405
                     /replace="n"
                     /db_xref="dbSNP:369416436"
     variation       407
                     /replace="a"
                     /db_xref="dbSNP:770073579"
     variation       408
                     /replace="a"
                     /db_xref="dbSNP:896035564"
     variation       408
                     /replace="g"
                     /db_xref="dbSNP:749686639"
     variation       408
                     /replace="s"
                     /db_xref="dbSNP:200648775"
     variation       409
                     /replace="v"
                     /db_xref="dbSNP:1399660639"
     variation       410
                     /replace="e"
                     /db_xref="dbSNP:1346664408"
     variation       411
                     /replace="g"
                     /db_xref="dbSNP:769179997"
     variation       412
                     /replace="-"
                     /db_xref="dbSNP:1315751042"
     variation       413
                     /replace="g"
                     /db_xref="dbSNP:774773091"
     variation       415
                     /replace="s"
                     /db_xref="dbSNP:761936903"
     variation       416
                     /replace="g"
                     /db_xref="dbSNP:1248032944"
     variation       420
                     /replace="q"
                     /db_xref="dbSNP:1265052408"
     variation       421
                     /replace="c"
                     /db_xref="dbSNP:772311050"
     variation       422
                     /replace="r"
                     /db_xref="dbSNP:773502260"
     variation       423
                     /replace="n"
                     /db_xref="dbSNP:1014456673"
     variation       423
                     /replace="t"
                     /db_xref="dbSNP:1286610514"
     variation       424
                     /replace="e"
                     /db_xref="dbSNP:1447860958"
     variation       424
                     /replace="m"
                     /db_xref="dbSNP:201796271"
     variation       425
                     /replace="e"
                     /db_xref="dbSNP:1015502396"
     variation       428
                     /replace="k"
                     /db_xref="dbSNP:188848747"
     variation       429
                     /replace="*"
                     /db_xref="dbSNP:201158439"
     variation       430
                     /replace="v"
                     /db_xref="dbSNP:759287846"
     variation       431
                     /replace="v"
                     /db_xref="dbSNP:1328672177"
     variation       433
                     /replace="c"
                     /db_xref="dbSNP:375818814"
     variation       433
                     /replace="l"
                     /db_xref="dbSNP:369919491"
     variation       437
                     /replace="q"
                     /db_xref="dbSNP:763594992"
     variation       438
                     /replace="q"
                     /db_xref="dbSNP:201609223"
     variation       438
                     /replace="w"
                     /db_xref="dbSNP:535584862"
     variation       439
                     /replace="d"
                     /db_xref="dbSNP:780751872"
     variation       440
                     /replace="n"
                     /db_xref="dbSNP:1223954674"
     variation       442
                     /replace="n"
                     /db_xref="dbSNP:373139126"
     variation       444
                     /replace="l"
                     /db_xref="dbSNP:1159088762"
     variation       445
                     /replace="r"
                     /db_xref="dbSNP:1471152334"
     variation       446
                     /replace="g"
                     /db_xref="dbSNP:7113716"
     variation       447
                     /replace="n"
                     /db_xref="dbSNP:779436662"
     variation       447
                     /replace="t"
                     /db_xref="dbSNP:750544672"
     variation       447
                     /replace="v"
                     /db_xref="dbSNP:748672038"
     variation       448
                     /replace="c"
                     /db_xref="dbSNP:1281299396"
     variation       448
                     /replace="r"
                     /db_xref="dbSNP:772221260"
     variation       449
                     /replace="i"
                     /db_xref="dbSNP:1463306284"
     variation       449
                     /replace="s"
                     /db_xref="dbSNP:773412584"
     variation       449
                     /replace="t"
                     /db_xref="dbSNP:747151638"
     variation       450
                     /replace="v"
                     /db_xref="dbSNP:1214998103"
     variation       451
                     /replace="h"
                     /db_xref="dbSNP:771153617"
     variation       451
                     /replace="p"
                     /db_xref="dbSNP:369109760"
     variation       452
                     /replace="d"
                     /db_xref="dbSNP:1464428629"
     variation       452
                     /replace="g"
                     /db_xref="dbSNP:1018826396"
     variation       452
                     /replace="s"
                     /db_xref="dbSNP:372569575"
     variation       453
                     /replace="g"
                     /db_xref="dbSNP:1250416401"
     variation       454
                     /replace="h"
                     /db_xref="dbSNP:1225956665"
     variation       454
                     /replace="t"
                     /db_xref="dbSNP:764970067"
     variation       455
                     /replace="r"
                     /db_xref="dbSNP:759885061"
     variation       456
                     /replace="i"
                     /db_xref="dbSNP:762887602"
     variation       456
                     /replace="r"
                     /db_xref="dbSNP:988031577"
     variation       456
                     /replace="s"
                     /db_xref="dbSNP:764073275"
     variation       457
                     /replace="l"
                     /db_xref="dbSNP:969619346"
     variation       458
                     /replace="i"
                     /db_xref="dbSNP:1175236665"
     variation       458
                     /replace="l"
                     /db_xref="dbSNP:756770214"
     variation       458
                     /replace="s"
                     /db_xref="dbSNP:751042212"
     variation       459
                     /replace="e"
                     /db_xref="dbSNP:1470832851"
     CDS             1..461
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /coded_by="NM_006656.6:129..1514"
                     /db_xref="CCDS:CCDS44682.1"
                     /db_xref="GeneID:10825"
                     /db_xref="HGNC:HGNC:7760"
                     /db_xref="MIM:604617"
ORIGIN      
        1 mrpadlpprp meespasssa pteteepgss aevmeevttc sfnsplfrqe ddrgityrip
       61 allyipptht flafaekrst rrdedalhlv lrrglrigql vqwgplkplm eatlpghrtm
      121 npcpvweqks gcvflfficv rghvterqqi vsgrnaarlc fiysqdagcs wsevrdltee
      181 vigselkhwa tfavgpghgi qlqsgrlvip aytyyipswf fcfqlpcktr phslmiysdd
      241 lgvtwhhgrl irpmvtvece vaevtgragh pvlycsartp nrcraealst dhgegfqrla
      301 lsrqlcepph gcqgsvvsfr pleiphrcqd ssskdaptiq qsspgsslrl eeeagtpses
      361 wllyshptsr kqrvdlgiyl nqtpleaacw srpwilhcgp cgysdlaale eeglfgclfe
      421 cgtkqeceqi afrlfthrei lshlqgdcts pgrnpsqfks n
//
DBGET integrated database retrieval system