LOCUS NP_014413 2233 aa linear PLN 15-SEP-2023
DEFINITION acetyl-CoA carboxylase ACC1 [Saccharomyces cerevisiae S288C].
ACCESSION NP_014413
VERSION NP_014413.1
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001183193.1
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 2233)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 2233)
AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K.,
Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R.,
Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P.,
Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F.,
Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A.,
Hani,J. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications
JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997)
PUBMED 9169873
REFERENCE 3 (residues 1 to 2233)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 2233)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (14-SEP-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 2233)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 2233)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (residues 1 to 2233)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (residues 1 to 2233)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA10557.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..2233
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XIV"
Protein 1..2233
/product="acetyl-CoA carboxylase ACC1"
/EC_number="6.3.4.14"
/EC_number="6.4.1.2"
/calculated_mol_wt=250223
Region 59..570
/region_name="AccC"
/note="Biotin carboxylase [Lipid transport and
metabolism]; COG0439"
/db_xref="CDD:223516"
Region 622..769
/region_name="AccB"
/note="Biotin carboxyl carrier protein [Coenzyme transport
and metabolism, Lipid transport and metabolism]; COG0511"
/db_xref="CDD:223585"
Region 768..1479
/region_name="ACC_central"
/note="Acetyl-CoA carboxylase, central region; pfam08326"
/db_xref="CDD:429920"
Region 1574..2118
/region_name="Carboxyl_trans"
/note="Carboxyl transferase domain; pfam01039"
/db_xref="CDD:426008"
CDS 1..2233
/gene="ACC1"
/locus_tag="YNR016C"
/gene_synonym="ABP2; FAS3; MTR7"
/coded_by="NM_001183193.1:1..6702"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:9438137]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0003989
acetyl-CoA carboxylase activity [PMID:8098706]"
/experiment="EXISTENCE:mutant phenotype:GO:0004075 biotin
carboxylase activity [PMID:6108218]"
/experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
import into nucleus [PMID:12730220]"
/experiment="EXISTENCE:mutant phenotype:GO:0042759
long-chain fatty acid biosynthetic process [PMID:6103540]"
/note="Acetyl-CoA carboxylase, biotin containing enzyme;
catalyzes carboxylation of cytosolic acetyl-CoA to form
malonyl-CoA and regulates histone acetylation by
regulating the availability of acetyl-CoA; rate-limiting
step for de novo biosynthesis of long-chain fatty acids;
translational regulation in response to nutrients and cell
cycle stage depends on its upstream ORF; ACC1 has a
paralog, HFA1, that arose from the whole genome
duplication"
/db_xref="GeneID:855750"
/db_xref="SGD:S000005299"
ORIGIN
1 mseeslfess pqkmeyeitn yserhtelpg hfiglntvdk leesplrdfv kshgghtvis
61 kilianngia avkeirsvrk wayetfgddr tvqfvamatp edleanaeyi rmadqyievp
121 ggtnnnnyan vdlivdiaer advdavwagw ghasenpllp eklsqskrkv ifigppgnam
181 rslgdkisst ivaqsakvpc ipwsgtgvdt vhvdektglv svdddiyqkg cctspedglq
241 kakrigfpvm ikaseggggk girqvereed fialyhqaan eipgspifim klagrarhle
301 vqlladqygt nislfgrdcs vqrrhqkiie eapvtiakae tfhemekaav rlgklvgyvs
361 agtveylysh ddgkfyflel nprlqvehpt temvsgvnlp aaqlqiamgi pmhrisdirt
421 lygmnphsas eidfefktqd atkkqrrpip kghctacrit sedpndgfkp sggtlhelnf
481 rsssnvwgyf svgnngnihs fsdsqfghif afgenrqasr khmvvalkel sirgdfrttv
541 eylikllete dfedntittg wlddlithkm taekpdptla vicgaatkaf laseearhky
601 ieslqkgqvl skdllqtmfp vdfihegkry kftvaksgnd rytlfingsk cdiilrqlsd
661 gglliaiggk shtiywkeev aatrlsvdsm ttllevendp tqlrtpspgk lvkflvenge
721 hiikgqpyae ievmkmqmpl vsqengivql lkqpgstiva gdimaimtld dpskvkhalp
781 fegmlpdfgs pviegtkpay kfkslvstle nilkgydnqv imnaslqqli evlrnpklpy
841 sewklhisal hsrlpaklde qmeelvarsl rrgavfparq lsklidmavk npeynpdkll
901 gavvepladi ahkysnglea hehsifvhfl eeyyeveklf ngpnvreeni ilklrdenpk
961 dldkvaltvl shskvsaknn lilailkhyq plcklsskvs aifstplqhi veleskatak
1021 valqareili qgalpsvker teqiehilks svvkvaygss npkrsepdln ilkdlidsny
1081 vvfdvllqfl thqdpvvtaa aaqvyirray raytigdirv hegvtvpive wkfqlpsaaf
1141 stfptvkskm gmnravsvsd lsyvansqss plregilmav dhlddvdeil sqsleviprh
1201 qsssngpapd rsgssaslsn vanvcvaste gfeseeeilv rlreildlnk qelinasirr
1261 itfmfgfkdg sypkyytfng pnynenetir hiepalafql elgrlsnfni kpiftdnrni
1321 hvyeavskts pldkrfftrg iirtghirdd isiqeyltse anrlmsdild nlevtdtsns
1381 dlnhifinfi avfdispedv eaafggfler fgkrllrlrv ssaeiriiik dpqtgapvpl
1441 ralinnvsgy viktemytev knakgewvfk slgkpgsmhl rpiatpypvk ewlqpkryka
1501 hlmgttyvyd fpelfrqass sqwknfsadv kltddffisn eliedengel teverepgan
1561 aigmvafkit vktpeyprgr qfvvvandit fkigsfgpqe deffnkvtey arkrgipriy
1621 laansgarig maeeivplfq vawndaanpd kgfqylylts egmetlkkfd kensvltert
1681 vingeerfvi ktiigsedgl gveclrgsgl iagatsrayh diftitlvtc rsvgigaylv
1741 rlgqraiqve gqpiiltgap ainkmlgrev ytsnlqlggt qimynngvsh ltavddlagv
1801 ekivewmsyv pakrnmpvpi letkdtwdrp vdftptndet ydvrwmiegr etesgfeygl
1861 fdkgsffetl sgwakgvvvg rarlggiplg vigvetrtve nlipadpanp nsaetliqep
1921 gqvwhpnsaf ktaqaindfn ngeqlpmmil anwrgfsggq rdmfnevlky gsfivdalvd
1981 ykqpiiiyip ptgelrggsw vvvdptinad qmemyadvna ragvlepqgm vgikfrrekl
2041 ldtmnrlddk yrelrsqlsn kslapevhqq iskqladrer ellpiygqis lqfadlhdrs
2101 srmvakgvis kelewtearr fffwrlrrrl neeylikrls hqvgeasrle kiarirswyp
2161 asvdheddrq vatwieenyk tlddklkglk lesfaqdlak kirsdhdnai dglsevikml
2221 stddkekllk tlk
//
