LOCUS NP_032091 454 aa linear ROD 29-MAY-2023
DEFINITION GA-binding protein alpha chain isoform 1 [Mus musculus].
ACCESSION NP_032091
VERSION NP_032091.2
DBSOURCE REFSEQ: accession NM_008065.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 454)
AUTHORS Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S,
Wang Q, Sesaki H, Mitra K, Liu K and Jiao K.
TITLE Drp1 regulates transcription of ribosomal protein genes in
embryonic hearts
JOURNAL J Cell Sci 135 (4) (2022)
PUBMED 35099001
REFERENCE 2 (residues 1 to 454)
AUTHORS AlOgayil N, Bauermeister K, Galvez JH, Venkatesh VS, Zhuang QK,
Chang ML, Davey RA, Zajac JD, Ida K, Kamiya A, Taketo T, Bourque G
and Naumova AK.
TITLE Distinct roles of androgen receptor, estrogen receptor alpha, and
BCL6 in the establishment of sex-biased DNA methylation in mouse
liver
JOURNAL Sci Rep 11 (1), 13766 (2021)
PUBMED 34215813
REMARK Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. PMID: 34811454]
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 454)
AUTHORS Ou-Yang H, Wu SC, Sung LY, Yang SH, Yang SH, Chong KY and Chen CM.
TITLE STAT3 Is an Upstream Regulator of Granzyme G in the
Maternal-To-Zygotic Transition of Mouse Embryos
JOURNAL Int J Mol Sci 22 (1), 460 (2021)
PUBMED 33466434
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 454)
AUTHORS Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim
K, Shinoda K, Sponton CH, Brown Z, Brack A and Kajimura S.
TITLE Thermal stress induces glycolytic beige fat formation via a
myogenic state
JOURNAL Nature 565 (7738), 180-185 (2019)
PUBMED 30568302
REFERENCE 5 (residues 1 to 454)
AUTHORS Luo CT, Osmanbeyoglu HU, Do MH, Bivona MR, Toure A, Kang D, Xie Y,
Leslie CS and Li MO.
TITLE Ets transcription factor GABP controls T cell homeostasis and
immunity
JOURNAL Nat Commun 8 (1), 1062 (2017)
PUBMED 29051483
REMARK GeneRIF: Depletion of GABPalpha impairs T-cell homeostatic
survival, proliferation, and antigen-induced responses in vivo.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 454)
AUTHORS Wei J, Hodes ME, Wang Y, Feng Y, Ghetti B and Dlouhy SR.
TITLE Direct cDNA selection with DNA microdissected from mouse chromosome
16: isolation of novel clones and construction of a partial
transcription map of the C3-C4 region
JOURNAL Genome Res 6 (8), 678-687 (1996)
PUBMED 8858343
REFERENCE 7 (residues 1 to 454)
AUTHORS Chrast R, Chen H, Morris MA and Antonarakis SE.
TITLE Mapping of the human transcription factor GABPA (E4TF1-60) gene to
chromosome 21
JOURNAL Genomics 28 (1), 119-122 (1995)
PUBMED 7590737
REFERENCE 8 (residues 1 to 454)
AUTHORS de la Brousse FC, Birkenmeier EH, King DS, Rowe LB and McKnight SL.
TITLE Molecular and genetic characterization of GABP beta
JOURNAL Genes Dev 8 (15), 1853-1865 (1994)
PUBMED 7958862
REFERENCE 9 (residues 1 to 454)
AUTHORS Brown TA and McKnight SL.
TITLE Specificities of protein-protein and protein-DNA interaction of
GABP alpha and two newly defined ets-related proteins
JOURNAL Genes Dev 6 (12B), 2502-2512 (1992)
PUBMED 1340465
REFERENCE 10 (residues 1 to 454)
AUTHORS LaMarco K, Thompson CC, Byers BP, Walton EM and McKnight SL.
TITLE Identification of Ets- and notch-related subunits in GA binding
protein
JOURNAL Science 253 (5021), 789-792 (1991)
PUBMED 1876836
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC164162.2.
On Aug 28, 2003 this sequence version replaced NP_032091.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC052448.1, AK145838.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849377
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..454
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="16"
/map="16 46.92 cM"
Protein 1..454
/product="GA-binding protein alpha chain isoform 1"
/note="GA-binding protein alpha chain; GA-binding protein
alpha-subunit; GABP subunit alpha"
/calculated_mol_wt=51213
Region 40..119
/region_name="GABP-alpha"
/note="GA-binding protein alpha chain; pfam11620"
/db_xref="CDD:402975"
Region 168..254
/region_name="SAM_PNT-GABP-alpha"
/note="Sterile alpha motif (SAM)/Pointed domain of
GA-binding protein (GABP) alpha chain; cd08534"
/db_xref="CDD:176084"
Region 295..316
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q00422.2)"
Site 303
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q06546; propagated from
UniProtKB/Swiss-Prot (Q00422.2)"
Region 319..403
/region_name="ETS"
/note="erythroblast transformation specific domain;
smart00413"
/db_xref="CDD:197710"
CDS 1..454
/gene="Gabpa"
/gene_synonym="GABPalpha"
/coded_by="NM_008065.3:646..2010"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS28284.1"
/db_xref="GeneID:14390"
/db_xref="MGI:MGI:95610"
ORIGIN
1 mtkreaeeli eieidgteka ecteesiveq tytpaecvsq aidinepign lkklleprlq
61 csldaheicl qdiqldpdrs lfdqgvktdg tvqlsvqvis yqgmepklni leivktaetv
121 evvidpdahh aeaeahlvee aqvitldgtk hittisdets eqvtrwaaal egyrkeqerl
181 gipydpihws tdqvlhwvvw vmkefsmtdi dlttlnisgr elcslnqedf fqrvprgeil
241 wshlellrky vlasqeqqmn eivtidqpvq iipasvppat pttikvinss akaakvqrsp
301 risgedrssp gnrtgnngqi qlwqfllell tdkdardcis wvgdegefkl nqpelvaqkw
361 gqrknkptmn yeklsralry yydgdmickv qgkrfvykfv cdlktligys aaelnrlvie
421 ceqkklarmq lhgiaqpvta valaatslqa dkei
//
