LOCUS NP_032447 511 aa linear ROD 22-DEC-2022
DEFINITION potassium voltage-gated channel subfamily C member 1 isoform 2 [Mus
musculus].
ACCESSION NP_032447 NP_796127
VERSION NP_032447.1
DBSOURCE REFSEQ: accession NM_008421.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 511)
AUTHORS Richardson A, Ciampani V, Stancu M, Bondarenko K, Newton S,
Steinert JR, Pilati N, Graham BP, Kopp-Scheinpflug C and Forsythe
ID.
TITLE Kv3.3 subunits control presynaptic action potential waveform and
neurotransmitter release at a central excitatory synapse
JOURNAL Elife 11, e75219 (2022)
PUBMED 35510987
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 511)
AUTHORS Stevens SR, Longley CM, Ogawa Y, Teliska LH, Arumanayagam AS, Nair
S, Oses-Prieto JA, Burlingame AL, Cykowski MD, Xue M and Rasband
MN.
TITLE Ankyrin-R regulates fast-spiking interneuron excitability through
perineuronal nets and Kv3.1b K+ channels
JOURNAL Elife 10, e66491 (2021)
PUBMED 34180393
REMARK GeneRIF: Ankyrin-R regulates fast-spiking interneuron excitability
through perineuronal nets and Kv3.1b K(+) channels.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 511)
AUTHORS Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar
L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA,
Kaczmarek LK and Wu LG.
TITLE Presynaptic Kv3 channels are required for fast and slow endocytosis
of synaptic vesicles
JOURNAL Neuron 109 (6), 938-946 (2021)
PUBMED 33508244
REFERENCE 4 (residues 1 to 511)
AUTHORS Rowan MJM and Christie JM.
TITLE Rapid State-Dependent Alteration in Kv3 Channel Availability Drives
Flexible Synaptic Signaling Dependent on Somatic Subthreshold
Depolarization
JOURNAL Cell Rep 18 (8), 2018-2029 (2017)
PUBMED 28228266
REFERENCE 5 (residues 1 to 511)
AUTHORS Vogt D, Cho KKA, Lee AT, Sohal VS and Rubenstein JLR.
TITLE The parvalbumin/somatostatin ratio is increased in Pten mutant mice
and by human PTEN ASD alleles
JOURNAL Cell Rep 11 (6), 944-956 (2015)
PUBMED 25937288
REFERENCE 6 (residues 1 to 511)
AUTHORS Stubbs L, Rinchik EM, Goldberg E, Rudy B, Handel MA and Johnson D.
TITLE Clustering of six human 11p15 gene homologs within a 500-kb
interval of proximal mouse chromosome 7
JOURNAL Genomics 24 (2), 324-332 (1994)
PUBMED 7698755
REFERENCE 7 (residues 1 to 511)
AUTHORS Sellar GC, Oghene K, Boyle S, Bickmore WA and Whitehead AS.
TITLE Organization of the region encompassing the human serum amyloid A
(SAA) gene family on chromosome 11p15.1
JOURNAL Genomics 23 (2), 492-495 (1994)
PUBMED 7835903
REFERENCE 8 (residues 1 to 511)
AUTHORS Lesage F, Attali B, Lazdunski M and Barhanin J.
TITLE Developmental expression of voltage-sensitive K+ channels in mouse
skeletal muscle and C2C12 cells
JOURNAL FEBS Lett 310 (2), 162-166 (1992)
PUBMED 1383027
REFERENCE 9 (residues 1 to 511)
AUTHORS Perney TM, Marshall J, Martin KA, Hockfield S and Kaczmarek LK.
TITLE Expression of the mRNAs for the Kv3.1 potassium channel gene in the
adult and developing rat brain
JOURNAL J Neurophysiol 68 (3), 756-766 (1992)
PUBMED 1432046
REFERENCE 10 (residues 1 to 511)
AUTHORS Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T and
Numa S.
TITLE Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells.
Primary structure and functional expression from cDNAs
JOURNAL FEBS Lett 259 (1), 37-42 (1989)
PUBMED 2599109
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC020786.20 and AC090652.32.
On Oct 8, 2014 this sequence version replaced NP_796127.1.
Transcript Variant: This variant (2) lacks two exons and its 3'
exon extends past a splice site used in variant 1, resulting in a
distinct 3' coding region and 3' UTR, compared to variant 1. The
encoded isoform (2) has a shorter and distinct C-terminus, compared
to isoform 1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK147476.1, Y07521.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849377
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..511
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="7"
/map="7 30.1 cM"
Protein 1..511
/product="potassium voltage-gated channel subfamily C
member 1 isoform 2"
/note="potassium voltage-gated channel subfamily C member
1; voltage-gated potassium channel subunit Kv4;
voltage-gated potassium channel subunit Kv3.1"
/calculated_mol_wt=57798
Region 6..122
/region_name="BTB_KCNC1_3"
/note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
(poxvirus and zinc finger) domain found in potassium
voltage-gated channel subfamily C members KCNC1 and KCNC3;
cd18414"
/db_xref="CDD:349721"
Site order(13,15..22,25,56,58..59,62,65,69,72,75,77,85..86,89)
/site_type="other"
/note="putative tetramer interface [polypeptide binding]"
/db_xref="CDD:349721"
Site 44
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P25122; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Region 121..147
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 130
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P25122; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 142
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P25122; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 158
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P25122; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 160
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Region 189..447
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Site 191..209
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 220
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 229
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 248..267
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 277..295
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 309..331
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 345..366
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Region 400..405
/region_name="Selectivity filter. /evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 415..436
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P15388.1)"
Site 474
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
Site 483
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P15388.1)"
CDS 1..511
/gene="Kcnc1"
/gene_synonym="C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4;
NGK2; Shaw"
/coded_by="NM_008421.3:1211..2746"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS21278.1"
/db_xref="GeneID:16502"
/db_xref="MGI:MGI:96667"
ORIGIN
1 mgqgdeseri vinvggtrhq tyrstlrtlp gtrlawlaep dahshfdydp radefffdrh
61 pgvfahilny yrtgklhcpa dvcgplyeee lafwgidetd vepccwmtyr qhrdaeeald
121 sfggapldns addadadgpg dsgdgedele mtkrlalsds pdgrpggfwr rwqpriwalf
181 edpyssryar yvafaslffi lvsittfcle therfnpivn kteienvrng tqvryyreae
241 teafltyieg vcvvwftfef lmrvvfcpnk vefiknslni idfvailpfy levglsglss
301 kaakdvlgfl rvvrfvrilr ifkltrhfvg lrvlghtlra stneflllii flalgvlifa
361 tmiyyaerig aqpndpsase hthfknipig fwwavvtmtt lgygdmypqt wsgmlvgalc
421 alagvltiam pvpvivnnfg myyslamakq klpkkkkkhi prppqlgspn ycksvvnsph
481 hstqsdtcpl aqeeileinr agrkplrgms i
//
