LOCUS NP_033728 732 aa linear ROD 23-DEC-2018
DEFINITION angiotensin-converting enzyme isoform 2 precursor [Mus musculus].
ACCESSION NP_033728
VERSION NP_033728.1
DBSOURCE REFSEQ: accession NM_009598.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 732)
AUTHORS Moraes OA, Flues K, Scapini KB, Mostarda C, Evangelista FS,
Rodrigues B, Dartora DR, Fiorino P, Angelis K and Irigoyen MC.
TITLE ACE gene dosage determines additional autonomic dysfunction and
increases renal angiotensin II levels in diabetic mice
JOURNAL Clinics (Sao Paulo) 73, e246 (2018)
PUBMED 30088535
REMARK GeneRIF: a small increase in angiotensin-converting enzyme activity
in diabetic animals leads to greater impairment of autonomic
function, as demonstrated by increased sympathetic modulation and
reduced cardiac vagal modulation along with increased renal
expression of Ang II.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 732)
AUTHORS Srivillibhuthur M, Warder BN, Toke NH, Shah PP, Feng Q, Gao N,
Bonder EM and Verzi MP.
TITLE TFAM is required for maturation of the fetal and adult intestinal
epithelium
JOURNAL Dev. Biol. 439 (2), 92-101 (2018)
PUBMED 29684311
REFERENCE 3 (residues 1 to 732)
AUTHORS Kohlstedt K, Trouvain C, Fromel T, Mudersbach T, Henschler R and
Fleming I.
TITLE Role of the angiotensin-converting enzyme in the G-CSF-induced
mobilization of progenitor cells
JOURNAL Basic Res. Cardiol. 113 (3), 18 (2018)
PUBMED 29549541
REMARK GeneRIF: ACE expression/phosphorylation in the bone-marrow niche
interface negatively regulates G-CSF-induced signaling and
hematopoietic progenitor cell mobilization.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 732)
AUTHORS Moran CS, Biros E, Krishna SM, Wang Y, Tikellis C, Morton SK, Moxon
JV, Cooper ME, Norman PE, Burrell LM, Thomas MC and Golledge J.
TITLE Resveratrol Inhibits Growth of Experimental Abdominal Aortic
Aneurysm Associated With Upregulation of Angiotensin-Converting
Enzyme 2
JOURNAL Arterioscler. Thromb. Vasc. Biol. 37 (11), 2195-2203 (2017)
PUBMED 28935757
REMARK GeneRIF: Resveratrol upregulated ACE2 and inhibited abdominal
aortic aneurysm growth in a mouse model.
REFERENCE 5 (residues 1 to 732)
AUTHORS Song R, Lopez MLSS and Yosypiv IV.
TITLE Foxd1 is an upstream regulator of the renin-angiotensin system
during metanephric kidney development
JOURNAL Pediatr. Res. 82 (5), 855-862 (2017)
PUBMED 28665931
REFERENCE 6 (residues 1 to 732)
AUTHORS Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc
G, Bard JM, Bara L, Ricard S et al.
TITLE Deletion polymorphism in the gene for angiotensin-converting enzyme
is a potent risk factor for myocardial infarction
JOURNAL Nature 359 (6396), 641-644 (1992)
PUBMED 1328889
REFERENCE 7 (residues 1 to 732)
AUTHORS Langford KG, Shai SY, Howard TE, Kovac MJ, Overbeek PA and
Bernstein KE.
TITLE Transgenic mice demonstrate a testis-specific promoter for
angiotensin-converting enzyme
JOURNAL J. Biol. Chem. 266 (24), 15559-15562 (1991)
PUBMED 1651914
REFERENCE 8 (residues 1 to 732)
AUTHORS Howard TE, Shai SY, Langford KG, Martin BM and Bernstein KE.
TITLE Transcription of testicular angiotensin-converting enzyme (ACE) is
initiated within the 12th intron of the somatic ACE gene
JOURNAL Mol. Cell. Biol. 10 (8), 4294-4302 (1990)
PUBMED 2164636
REFERENCE 9 (residues 1 to 732)
AUTHORS Shai SY, Langford KG, Martin BM and Bernstein KE.
TITLE Genomic DNA 5' to the mouse and human angiotensin-converting enzyme
genes contains two distinct regions of conserved sequence
JOURNAL Biochem. Biophys. Res. Commun. 167 (3), 1128-1133 (1990)
PUBMED 2157425
REFERENCE 10 (residues 1 to 732)
AUTHORS Bernstein KE, Martin BM, Edwards AS and Bernstein EA.
TITLE Mouse angiotensin-converting enzyme is a protein composed of two
homologous domains
JOURNAL J. Biol. Chem. 264 (20), 11945-11951 (1989)
PUBMED 2545691
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
M55333.1, AK164780.1 and AL731865.9.
Transcript Variant: The variant (2) differs in the 5' UTR and lacks
multiple 5' coding exons, compared to variant 1. It initiates
translation at an alternate start codon. The encoded isoform (2) is
shorter and has a distinct N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M55333.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN00849384
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..732
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 68.84 cM"
Protein 1..732
/product="angiotensin-converting enzyme isoform 2
precursor"
/EC_number="3.4.15.1"
/note="dipeptidyl peptidase; kininase II; dipeptidyl
carboxypeptidase I; angiotensin-converting enzyme"
/calculated_mol_wt=81054
sig_peptide 1..28
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=3012
Region 69..646
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:279709"
Site order(383..385,413..414,417,441,487,541..543,548,550,553)
/site_type="active"
/db_xref="CDD:188999"
Site order(413,417,441)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188999"
CDS 1..732
/gene="Ace"
/gene_synonym="AW208573; CD143"
/coded_by="NM_009598.2:1..2199"
/note="isoform 2 precursor is encoded by transcript
variant 2"
/db_xref="CCDS:CCDS25544.1"
/db_xref="GeneID:11421"
/db_xref="MGI:MGI:87874"
ORIGIN
1 mgqgwatpgl psflflllcc ghhllvlsqv atdhvtanqg itnqattrsq ttthqatidq
61 ttqipnletd eakadrfvee ydrtaqvlln eyaeanwqyn tnitiegski llekstevsn
121 htlkygtrak tfdvsnfqns sikriikklq nldravlppk eleeynqill dmettyslsn
181 icytngtcmp lepdltnmma tsrkyeellw awkswrdkvg railpffpky vefsnkiakl
241 ngytdagdsw rslyesdnle qdleklyqel qplylnlhay vrrslhrhyg seyinldgpi
301 pahllgnmwa qtwsniydlv apfpsapnid ateamikqgw tprrifkead nfftslgllp
361 vppefwnksm lekptdgrev vchpsawdfy ngkdfrikqc tsvnmedlvi ahhemghiqy
421 fmqykdlpvt freganpgfh eaigdimals vstpkhlysl nllstegsgy eydinflmkm
481 aldkiafipf sylidqwrwr vfdgsitken ynqewwslrl kyqglcppvp rsqgdfdpgs
541 kfhvpanvpy vryfvsfiiq fqfhealcra aghtgplhkc diyqskeagk lladamklgy
601 skpwpeamkl itgqpnmsas ammnyfkplt ewlvtenrrh getlgwpeyn wapntaraeg
661 staesnrvnf lglylepqqa rvgqwvllfl gvallvatvg lahrlynirn hhslrrphrg
721 pqfgsevelr hs
//
