LOCUS NP_033728 732 aa linear ROD 29-APR-2025
DEFINITION angiotensin-converting enzyme isoform 2 precursor [Mus musculus].
ACCESSION NP_033728
VERSION NP_033728.1
DBSOURCE REFSEQ: accession NM_009598.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 732)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (residues 1 to 732)
AUTHORS Shibata,T., Bhat,S.A., Cao,D., Saito,S., Bernstein,E.A., Nishi,E.,
Medenilla,J.D., Wang,E.T., Chan,J.L., Pisarska,M.D.,
Tourtellotte,W.G., Giani,J.F., Bernstein,K.E. and Khan,Z.
TITLE Testicular ACE regulates sperm metabolism and fertilization through
the transcription factor PPARgamma
JOURNAL J Biol Chem 300 (1), 105486 (2024)
PUBMED 37992807
REMARK GeneRIF: Testicular ACE regulates sperm metabolism and
fertilization through the transcription factor PPARgamma.
REFERENCE 3 (residues 1 to 732)
AUTHORS Cao,D., Saito,S., Xu,L., Fan,W., Li,X., Ahmed,F., Jovanovic,P.,
Shibata,T., Che,M., Bernstein,E.A., Gianni,J., Divakaruni,A.S.,
Okwan-Duodu,D., Khan,Z., Riera,C.E., Chen,F. and Bernstein,K.E.
TITLE Myeloid cell ACE shapes cellular metabolism and function in PCSK-9
induced atherosclerosis
JOURNAL Front Immunol 14, 1278383 (2023)
PUBMED 37928535
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 732)
AUTHORS Juretzko,A., Steinbach,A., Witte,J., Hannemann,A., Miehe,B.,
Siegerist,F., Wolke,C., Stracke,S. and Rettig,R.
TITLE Renal angiotensin I-converting enzyme-deficient mice are protected
against aristolochic acid nephropathy
JOURNAL Pflugers Arch 475 (3), 391-403 (2023)
PUBMED 36520238
REMARK GeneRIF: Renal angiotensin I-converting enzyme-deficient mice are
protected against aristolochic acid nephropathy.
REFERENCE 5 (residues 1 to 732)
AUTHORS Gao,Y., Sun,Y., Islam,S., Nakamura,T., Tomita,T., Zou,K. and
Michikawa,M.
TITLE Presenilin 1 deficiency impairs Abeta42-to-Abeta40- and
angiotensin-converting activities of ACE
JOURNAL Front Aging Neurosci 15, 1098034 (2023)
PUBMED 36875692
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 732)
AUTHORS Cambien,F., Poirier,O., Lecerf,L., Evans,A., Cambou,J.P.,
Arveiler,D., Luc,G., Bard,J.M., Bara,L., Ricard,S. et al.
TITLE Deletion polymorphism in the gene for angiotensin-converting enzyme
is a potent risk factor for myocardial infarction
JOURNAL Nature 359 (6396), 641-644 (1992)
PUBMED 1328889
REFERENCE 7 (residues 1 to 732)
AUTHORS Langford,K.G., Shai,S.Y., Howard,T.E., Kovac,M.J., Overbeek,P.A.
and Bernstein,K.E.
TITLE Transgenic mice demonstrate a testis-specific promoter for
angiotensin-converting enzyme
JOURNAL J Biol Chem 266 (24), 15559-15562 (1991)
PUBMED 1651914
REFERENCE 8 (residues 1 to 732)
AUTHORS Howard,T.E., Shai,S.Y., Langford,K.G., Martin,B.M. and
Bernstein,K.E.
TITLE Transcription of testicular angiotensin-converting enzyme (ACE) is
initiated within the 12th intron of the somatic ACE gene
JOURNAL Mol Cell Biol 10 (8), 4294-4302 (1990)
PUBMED 2164636
REFERENCE 9 (residues 1 to 732)
AUTHORS Shai,S.Y., Langford,K.G., Martin,B.M. and Bernstein,K.E.
TITLE Genomic DNA 5' to the mouse and human angiotensin-converting enzyme
genes contains two distinct regions of conserved sequence
JOURNAL Biochem Biophys Res Commun 167 (3), 1128-1133 (1990)
PUBMED 2157425
REFERENCE 10 (residues 1 to 732)
AUTHORS Bernstein,K.E., Martin,B.M., Edwards,A.S. and Bernstein,E.A.
TITLE Mouse angiotensin-converting enzyme is a protein composed of two
homologous domains
JOURNAL J Biol Chem 264 (20), 11945-11951 (1989)
PUBMED 2545691
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL596246.10 and AL731865.9.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M55333.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN00849384
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..732
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 68.84 cM"
Protein 1..732
/product="angiotensin-converting enzyme isoform 2
precursor"
/EC_number="3.4.15.1"
/note="dipeptidyl peptidase; kininase II; dipeptidyl
carboxypeptidase I; angiotensin-converting enzyme;
angiotensin I converting enzyme (peptidyl-dipeptidase A)
1"
/calculated_mol_wt=81054
sig_peptide 1..28
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
/calculated_mol_wt=3012
Region 69..646
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:460196"
CDS 1..732
/gene="Ace"
/gene_synonym="CD143"
/coded_by="NM_009598.3:20..2218"
/note="isoform 2 precursor is encoded by transcript
variant 2"
/db_xref="CCDS:CCDS25544.1"
/db_xref="GeneID:11421"
/db_xref="MGI:MGI:87874"
ORIGIN
1 mgqgwatpgl psflflllcc ghhllvlsqv atdhvtanqg itnqattrsq ttthqatidq
61 ttqipnletd eakadrfvee ydrtaqvlln eyaeanwqyn tnitiegski llekstevsn
121 htlkygtrak tfdvsnfqns sikriikklq nldravlppk eleeynqill dmettyslsn
181 icytngtcmp lepdltnmma tsrkyeellw awkswrdkvg railpffpky vefsnkiakl
241 ngytdagdsw rslyesdnle qdleklyqel qplylnlhay vrrslhrhyg seyinldgpi
301 pahllgnmwa qtwsniydlv apfpsapnid ateamikqgw tprrifkead nfftslgllp
361 vppefwnksm lekptdgrev vchpsawdfy ngkdfrikqc tsvnmedlvi ahhemghiqy
421 fmqykdlpvt freganpgfh eaigdimals vstpkhlysl nllstegsgy eydinflmkm
481 aldkiafipf sylidqwrwr vfdgsitken ynqewwslrl kyqglcppvp rsqgdfdpgs
541 kfhvpanvpy vryfvsfiiq fqfhealcra aghtgplhkc diyqskeagk lladamklgy
601 skpwpeamkl itgqpnmsas ammnyfkplt ewlvtenrrh getlgwpeyn wapntaraeg
661 staesnrvnf lglylepqqa rvgqwvllfl gvallvatvg lahrlynirn hhslrrphrg
721 pqfgsevelr hs
//
