LOCUS NP_034492 240 aa linear ROD 16-DEC-2018
DEFINITION glutathione S-transferase omega-1 [Mus musculus].
ACCESSION NP_034492
VERSION NP_034492.1
DBSOURCE REFSEQ: accession NM_010362.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 240)
AUTHORS Fernando N, Wooff Y, Aggio-Bruce R, Chu-Tan JA, Jiao H, Dietrich C,
Rutar M, Rooke M, Menon D, Eells JT, Valter K, Board PG, Provis J
and Natoli R.
TITLE Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating
Retina
JOURNAL Invest. Ophthalmol. Vis. Sci. 59 (11), 4362-4374 (2018)
PUBMED 30193308
REFERENCE 2 (residues 1 to 240)
AUTHORS Menon D, Coll R, O'Neill LA and Board PG.
TITLE GSTO1-1 modulates metabolism in macrophages activated through the
LPS and TLR4 pathway
JOURNAL J. Cell. Sci. 128 (10), 1982-1990 (2015)
PUBMED 25908843
REMARK GeneRIF: Data indicate that GSTO1-1 is required for LPS-mediated
signalling in macrophages and that it acts early in the LPS-TLR4
pro-inflammatory pathway.
REFERENCE 3 (residues 1 to 240)
AUTHORS Menon D, Coll R, O'Neill LA and Board PG.
TITLE Glutathione transferase omega 1 is required for the
lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the
production of reactive oxygen species in macrophages
JOURNAL Free Radic. Biol. Med. 73, 318-327 (2014)
PUBMED 24873723
REMARK GeneRIF: shRNA knockdown of GSTO1-1 in macrophage-like J774.1A
cells blocks the expression of NADPH oxidase 1 and the generation
of reactive oxygen species after Bacterial lipopolysaccharide
stimulation.
REFERENCE 4 (residues 1 to 240)
AUTHORS Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D,
He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB and
Evans RM.
TITLE Thyroid hormone receptor repression is linked to type I
pneumocyte-associated respiratory distress syndrome
JOURNAL Nat. Med. 17 (11), 1466-1472 (2011)
PUBMED 22001906
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 240)
AUTHORS Dittrich AM, Meyer HA, Krokowski M, Quarcoo D, Ahrens B, Kube SM,
Witzenrath M, Esworthy RS, Chu FF and Hamelmann E.
TITLE Glutathione peroxidase-2 protects from allergen-induced airway
inflammation in mice
JOURNAL Eur. Respir. J. 35 (5), 1148-1154 (2010)
PUBMED 19897562
REMARK GeneRIF: Genes encoding the antioxidants GPX2 and GSTO 1-1 are
common inflammatory genes expressed upon induction of allergic
airway inflammation, and independently of allergic susceptibility.
REFERENCE 6 (residues 1 to 240)
AUTHORS Tanaka K, Tamura H, Tanaka H, Katoh M, Futamata Y, Seki N,
Nishimune Y and Hara T.
TITLE Spermatogonia-dependent expression of testicular genes in mice
JOURNAL Dev. Biol. 246 (2), 466-479 (2002)
PUBMED 12051830
REFERENCE 7 (residues 1 to 240)
AUTHORS Rouimi P, Anglade P, Benzekri A, Costet P, Debrauwer L, Pineau T
and Tulliez J.
TITLE Purification and characterization of a glutathione S-transferase
Omega in pig: evidence for two distinct organ-specific transcripts
JOURNAL Biochem. J. 358 (Pt 1), 257-262 (2001)
PUBMED 11485575
REFERENCE 8 (residues 1 to 240)
AUTHORS Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte
GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk
BA, Perregaux DE, Gabel CA, Geoghegan KF and Pandit J.
TITLE Identification, characterization, and crystal structure of the
Omega class glutathione transferases
JOURNAL J. Biol. Chem. 275 (32), 24798-24806 (2000)
PUBMED 10783391
REFERENCE 9 (residues 1 to 240)
AUTHORS Retief JD, Lynch KR and Pearson WR.
TITLE Panning for genes--A visual strategy for identifying novel gene
orthologs and paralogs
JOURNAL Genome Res. 9 (4), 373-382 (1999)
PUBMED 10207159
REFERENCE 10 (residues 1 to 240)
AUTHORS Kodym R, Calkins P and Story M.
TITLE The cloning and characterization of a new stress response protein.
A mammalian member of a family of theta class glutathione
s-transferase-like proteins
JOURNAL J. Biol. Chem. 274 (8), 5131-5137 (1999)
PUBMED 9988762
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC126679.2, BE860946.1,
AK146834.1 and AI846704.1.
Summary: This gene encodes a member of the omega class of
glutathione S-transferase (GST) proteins. GSTs are involved in the
metabolism of xenobiotics and carcinogens. There is evidence that
the encoded protein is involved in the biotransformation of
arsenic. [provided by RefSeq, Dec 2015].
Sequence Note:.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U80819.1, AK146834.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..240
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="19"
/map="19"
Protein 1..240
/product="glutathione S-transferase omega-1"
/EC_number="2.5.1.18"
/EC_number="1.8.5.1"
/EC_number="1.20.4.2"
/note="glutathione-S-transferase like; Glutathione
transferase omega 1 (GSTO 1-1) (p28); MMA(V) reductase;
monomethylarsonic acid reductase; S-(Phenacyl)glutathione
reductase; glutathione S-transferase omega 1-1;
glutathione-dependent dehydroascorbate reductase"
/calculated_mol_wt=27367
Site 2
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine. {ECO:0000250|UniProtKB:P78417};
propagated from UniProtKB/Swiss-Prot (O09131.2)"
Region 5..94
/region_name="GST_N_Omega"
/note="GST_N family, Class Omega subfamily; GSTs are
cytosolic dimeric proteins involved in cellular
detoxification by catalyzing the conjugation of
glutathione (GSH) with a wide range of endogenous and
xenobiotic alkylating agents, including carcinogens;
cd03055"
/db_xref="CDD:239353"
Site order(7..8,29..31,33,36..37,39..41,43..44,55,57)
/site_type="other"
/note="C-terminal domain interface [polypeptide binding]"
/db_xref="CDD:239353"
Region 26..224
/region_name="GstA"
/note="Glutathione S-transferase [Posttranslational
modification, protein turnover, chaperones]; COG0625"
/db_xref="CDD:223698"
Site order(32,34,59,71..73,85..86)
/site_type="other"
/note="GSH binding site (G-site) [chemical binding]"
/db_xref="CDD:239353"
Site 32
/site_type="active"
/note="active site cysteine [active]"
/db_xref="CDD:239353"
Site 57
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P78417};
propagated from UniProtKB/Swiss-Prot (O09131.2)"
Site order(71,84..85,87..88,91)
/site_type="other"
/note="putative dimer interface [polypeptide binding]"
/db_xref="CDD:239353"
Region 85..86
/region_name="Glutathione binding.
{ECO:0000250|UniProtKB:P78417}"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O09131.2)"
Region 108..228
/region_name="GST_C_Omega"
/note="C-terminal, alpha helical domain of Class Omega
Glutathione S-transferases; cd03184"
/db_xref="CDD:198293"
Site order(114..115,118..119,122,148)
/site_type="other"
/note="putative dimer interface [polypeptide binding]"
/db_xref="CDD:198293"
Site order(121,124..125,128..129,179,182,221)
/site_type="other"
/note="substrate binding pocket (H-site) [chemical
binding]"
/db_xref="CDD:198293"
Site 129
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (O09131.2)"
Site 152
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P78417};
propagated from UniProtKB/Swiss-Prot (O09131.2)"
Site order(171,174..175,178,181..182,210,214,224,228)
/site_type="other"
/note="N-terminal domain interface [polypeptide binding]"
/db_xref="CDD:198293"
CDS 1..240
/gene="Gsto1"
/gene_synonym="AA407097; AI194287; AU018802; Gsto-1; Gstx;
p28; Spg-r"
/coded_by="NM_010362.3:117..839"
/db_xref="CCDS:CCDS29893.1"
/db_xref="GeneID:14873"
/db_xref="MGI:MGI:1342273"
ORIGIN
1 msgessrslg kgsappgpvp egqirvysmr fcpfaqrtlm vlkakgirhe vininlknkp
61 ewffeknplg lvpvlensqg hlvtesvitc eyldeaypek klfpddpykk arqkmtlesf
121 skvppliasf vrskrkedsp nlrealenef kkleegmdny ksflggdsps mvdyltwpwf
181 qrlealelke clahtpklkl wmaamqqdpv asshkidakt yreylnlylq dspeacdygl
//
