LOCUS NP_034619 473 aa linear ROD 28-MAY-2023
DEFINITION hyaluronidase-2 precursor [Mus musculus].
ACCESSION NP_034619
VERSION NP_034619.2
DBSOURCE REFSEQ: accession NM_010489.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 473)
AUTHORS Petrey AC, Obery DR, Kessler SP, Zawerton A, Flamion B and de la
Motte CA.
TITLE Platelet hyaluronidase-2 regulates the early stages of inflammatory
disease in colitis
JOURNAL Blood 134 (9), 765-775 (2019)
PUBMED 31262781
REMARK GeneRIF: Mice deficient in HYAL2 are more susceptible to an acute
model of colitis, and this increased susceptibility is abrogated by
transfusion of HYAL2-competent platelets.
REFERENCE 2 (residues 1 to 473)
AUTHORS Sandireddy R, Cibi DM, Gupta P, Singh A, Tee N, Uemura A, Epstein
JA and Singh MK.
TITLE Semaphorin 3E/PlexinD1 signaling is required for cardiac
ventricular compaction
JOURNAL JCI Insight 4 (16), 125908 (2019)
PUBMED 31434798
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 473)
AUTHORS Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva
G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams
RH, Harten SK, Tzahor E, Zhou B and Harvey RP.
TITLE Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the
building plan for trabeculation
JOURNAL Nature 557 (7705), 439-445 (2018)
PUBMED 29743679
REFERENCE 4 (residues 1 to 473)
AUTHORS Higuchi Y, Nishida Y, Kozawa E, Zhuo L, Arai E, Hamada S, Morita D,
Ikuta K, Kimata K, Ushida T and Ishiguro N.
TITLE Conditional knockdown of hyaluronidase 2 in articular cartilage
stimulates osteoarthritic progression in a mice model
JOURNAL Sci Rep 7 (1), 7028 (2017)
PUBMED 28765635
REMARK GeneRIF: Knockdown of Hyal2 in articular cartilage induced
osteoarthritis development and progression possibly mediated by an
imbalance of hyaluronan metabolism.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 473)
AUTHORS Chowdhury B, Xiang B, Liu M, Hemming R, Dolinsky VW and
Triggs-Raine B.
TITLE Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells,
Congenital Heart Defects, and Heart Failure
JOURNAL Circ Cardiovasc Genet 10 (1), e001598 (2017)
PUBMED 28196902
REMARK GeneRIF: Hyal2(-/-) mice have increased hyaluronan, which may
promote endothelial-to-mesenchymal transition and proliferation of
mesenchymal cells leading to congenital heart defects and heart
failure.
REFERENCE 6 (residues 1 to 473)
AUTHORS Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA and Triggs-Raine
BL.
TITLE Characterization of the murine hyaluronidase gene region reveals
complex organization and cotranscription of Hyal1 with downstream
genes, Fus2 and Hyal3
JOURNAL J Biol Chem 277 (25), 23008-23018 (2002)
PUBMED 11929860
REFERENCE 7 (residues 1 to 473)
AUTHORS Chang NS.
TITLE Transforming growth factor-beta1 blocks the enhancement of tumor
necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929
fibroblasts
JOURNAL BMC Cell Biol 3, 8 (2002)
PUBMED 11960552
REMARK GeneRIF: Hyal-2 enhancement of tumor necrosis
factor-alpha-stimulated cytotoxicity in fibroblasts is blocked by
Transforming growth factor-beta1.
Publication Status: Online-Only
REFERENCE 8 (residues 1 to 473)
AUTHORS Lepperdinger G, Mullegger J and Kreil G.
TITLE Hyal2--less active, but more versatile?
JOURNAL Matrix Biol 20 (8), 509-514 (2001)
PUBMED 11731268
REMARK Review article
REFERENCE 9 (residues 1 to 473)
AUTHORS Rai SK, Duh FM, Vigdorovich V, Danilkovitch-Miagkova A, Lerman MI
and Miller AD.
TITLE Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
(GPI)-anchored cell-surface receptor for jaagsiekte sheep
retrovirus, the envelope protein of which mediates oncogenic
transformation
JOURNAL Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
PUBMED 11296287
REFERENCE 10 (residues 1 to 473)
AUTHORS Strobl B, Wechselberger C, Beier DR and Lepperdinger G.
TITLE Structural organization and chromosomal localization of Hyal2, a
gene encoding a lysosomal hyaluronidase
JOURNAL Genomics 53 (2), 214-219 (1998)
PUBMED 9790770
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL672219.7.
On Mar 10, 2004 this sequence version replaced NP_034619.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK088806.1, AK133886.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..473
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="9"
/map="9 58.12 cM"
Protein 1..473
/product="hyaluronidase-2 precursor"
/EC_number="3.2.1.35"
/note="hyaluronidase-2; hyal-2"
/calculated_mol_wt=51541
sig_peptide 1..20
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2095
mat_peptide 21..448
/product="Hyaluronidase-2. /id=PRO_0000012101"
/note="propagated from UniProtKB/Swiss-Prot (O35632.2)"
/calculated_mol_wt=48964
Region 30..357
/region_name="Glyco_hydro_56"
/note="Hyaluronidase; pfam01630"
/db_xref="CDD:426355"
Site 74
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:19349973; propagated from
UniProtKB/Swiss-Prot (O35632.2)"
Site 103
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35632.2)"
Site 357
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35632.2)"
Site 390
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:19349973; propagated from
UniProtKB/Swiss-Prot (O35632.2)"
Site 448
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine, alternate.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35632.2)"
CDS 1..473
/gene="Hyal2"
/coded_by="NM_010489.3:155..1576"
/db_xref="CCDS:CCDS23496.1"
/db_xref="GeneID:15587"
/db_xref="MGI:MGI:1196334"
ORIGIN
1 mraglgpiit lalvlevawa gelkptappi ftgrpfvvaw nvptqecapr hkvpldlraf
61 dvkatpnegf fnqnittfyy drlglyprfd aagtsvhggv pqngslcahl pmlkesvery
121 iqtqepggla vidweewrpv wvrnwqekdv yrqssrqlva srhpdwpsdr vmkqaqyefe
181 faarqfmlnt lryvkavrpq hlwgfylfpd cynhdyvqnw esytgrcpdv evarndqlaw
241 lwaestalfp svyldetlas svhsrnfvsf rvrealrvah thhanhalpv yvftrptytr
301 gltglsqvdl istigesaal gsagvifwgd sedassmetc qylknyltql lvpyivnvsw
361 atqycswtqc hghgrcvrrn psantflhln assfrlvpgh tpsepqlrpe gqlseadlny
421 lqkhfrcqcy lgwggeqcqr nykgaagnas rawagshlts llglvavalt wtl
//
