GenomeNet

Database: RefSeq
Entry: NP_034731
LinkDB: NP_034731
Original site: NP_034731 
LOCUS       NP_034731               1095 aa            linear   ROD 29-APR-2025
DEFINITION  voltage-gated inwardly rectifying potassium channel KCNH3 [Mus
            musculus].
ACCESSION   NP_034731
VERSION     NP_034731.3
DBSOURCE    REFSEQ: accession NM_010601.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1095)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1095)
  AUTHORS   Hermanstyne,T.O., Yang,N.D., Granados-Fuentes,D., Li,X.,
            Mellor,R.L., Jegla,T., Herzog,E.D. and Nerbonne,J.M.
  TITLE     Kv12-encoded K+ channels drive the day-night switch in the
            repetitive firing rates of SCN neurons
  JOURNAL   J Gen Physiol 155 (9) (2023)
   PUBMED   37516908
  REMARK    GeneRIF: Kv12-encoded K+ channels drive the day-night switch in the
            repetitive firing rates of SCN neurons.
REFERENCE   3  (residues 1 to 1095)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1095)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (residues 1 to 1095)
  AUTHORS   Vezzali,R., Weise,S.C., Hellbach,N., Machado,V., Heidrich,S. and
            Vogel,T.
  TITLE     The FOXG1/FOXO/SMAD network balances proliferation and
            differentiation of cortical progenitors and activates Kcnh3
            expression in mature neurons
  JOURNAL   Oncotarget 7 (25), 37436-37455 (2016)
   PUBMED   27224923
  REMARK    GeneRIF: Authors identified ligands of the TGFbeta- and IGF-family,
            Foxo1, Foxo3 and Kcnh3 as novel FOXG1-target genes during
            telencephalic development and showed that FOXG1 interferes with
            Foxo1 and Tgfbeta transcription.
REFERENCE   6  (residues 1 to 1095)
  AUTHORS   Noma,K., Kimura,K., Minatohara,K., Nakashima,H., Nagao,Y.,
            Mizoguchi,A. and Fujiyoshi,Y.
  TITLE     Triple N-glycosylation in the long S5-P loop regulates the
            activation and trafficking of the Kv12.2 potassium channel
  JOURNAL   J Biol Chem 284 (48), 33139-33150 (2009)
   PUBMED   19808681
  REMARK    GeneRIF: Data suggest that only glycosylated Kv12.2 channels
            (Kcnh3) show proper voltage dependence and are utilized in vivo.
REFERENCE   7  (residues 1 to 1095)
  AUTHORS   Miyake,A., Takahashi,S., Nakamura,Y., Inamura,K., Matsumoto,S.,
            Mochizuki,S. and Katou,M.
  TITLE     Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances
            cognitive function
  JOURNAL   J Neurosci 29 (46), 14637-14645 (2009)
   PUBMED   19923296
REFERENCE   8  (residues 1 to 1095)
  AUTHORS   Clancy,S.M., Chen,B., Bertaso,F., Mamet,J. and Jegla,T.
  TITLE     KCNE1 and KCNE3 beta-subunits regulate membrane surface expression
            of Kv12.2 K(+) channels in vitro and form a tripartite complex in
            vivo
  JOURNAL   PLoS One 4 (7), e6330 (2009)
   PUBMED   19623261
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 1095)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   10 (residues 1 to 1095)
  AUTHORS   Trudeau,M.C., Titus,S.A., Branchaw,J.L., Ganetzky,B. and
            Robertson,G.A.
  TITLE     Functional analysis of a mouse brain Elk-type K+ channel
  JOURNAL   J Neurosci 19 (8), 2906-2918 (1999)
   PUBMED   10191308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161198.5.
            
            On Feb 23, 2008 this sequence version replaced NP_034731.2.
            
            Summary: The protein encoded by this gene is a voltage-gated
            potassium channel alpha subunit predominantly expressed in the
            forebrain. An increase in cognitive function was observed when this
            gene was knocked out, while deletion of the gene resulted in
            hippocampal hyperexcitability and epilepsy. [provided by RefSeq,
            Sep 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141013.1, AY380579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.08 cM"
     Protein         1..1095
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH3"
                     /note="potassium voltage-gated channel subfamily H member
                     3; ELK channel 2; ether-a-go-go-like potassium channel 2;
                     voltage-gated potassium channel subunit Kv12.2; ether a
                     go-go like"
                     /calculated_mol_wt=118113
     Region          40..135
                     /region_name="PAS_9"
                     /note="PAS domain; pfam13426"
                     /db_xref="CDD:463873"
     Region          137..161
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          227..>662
                     /region_name="PLN03192"
                     /note="Voltage-dependent potassium channel; Provisional"
                     /db_xref="CDD:215625"
     Site            229..249
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            260..280
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            303..323
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            332..352
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            362..382
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          417..447
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            421
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19808681; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            428
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19808681; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            447
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19808681; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          476..481
                     /region_name="Selectivity filter. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Site            491..511
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          <617..712
                     /region_name="cyc_nuc_ocin"
                     /note="bacteriocin-type transport-associated protein;
                     TIGR03896"
                     /db_xref="CDD:274839"
     Region          740..823
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          854..883
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     Region          965..1069
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVJ0.3)"
     CDS             1..1095
                     /gene="Kcnh3"
                     /gene_synonym="C030044P22Rik; Elk2; Kv12.2; Melk2"
                     /coded_by="NM_010601.4:385..3672"
                     /db_xref="CCDS:CCDS27817.1"
                     /db_xref="GeneID:16512"
                     /db_xref="MGI:MGI:1341723"
ORIGIN      
        1 mpamrgllap qntfldtiat rfdgthsnfv lgnaqvaglf pvvycsdgfc dltgfsraev
       61 mqrgcacsfl ygpdtselvr qqirkaldeh kefkaelily rksglpfwcl ldvipiknek
      121 gevalflvsh kdisetknrg gpdnwkergg grrrygrags kgfnanrrrs ravlyhlsgh
      181 lqkqpkgkhk lnkgvfgekp nlpeykvaai rkspfillhc galratwdgf illatlyvav
      241 tvpysvcvst arepsaargp psvcdlavev lfildivlnf rttfvsksgq vvfapksicl
      301 hyvttwflld viaalpfdll hafkvnvyvg ahllktvrll rllrllprld rysqysavvl
      361 tllmavfall ahwvacvwfy igqqeiesse selpeigwlq elarrletpy ylvsrspdgg
      421 nssgqsencs ssssssgsgg grgseangtg lellggpslr sayitslyfa lssltsvgfg
      481 nvsantdtek ifsictmlig almhavvfgn vtaiiqrmya rrflyhsrtr dlrdyirihr
      541 ipkplkqrml eyfqatwavn ngidttellq slpdelradi amhlhkevlq lplfeaasrg
      601 clralslalr pafctpgeyl ihqgdalqal yfvcsgsmev lkggtvlail gkgdligcel
      661 pqreqvvkan advkgltycv lqclqlaglh eslalypefa prfsrglrge lsynlgaggv
      721 saevdtssls gdntlmstle eketdgeqgh tvspapadep sspllspgct ssssaaklls
      781 prrtaprprl ggrgrpsrag vlkpeagpsa hprsldglql ppmpwnvppd lsprvvdgie
      841 dgcssdqpkf sfrvgqsgpe cssspspgte sglltvplgp searntdtld klrqavmels
      901 eqvlqmregl qslrqavqli lvpqgegqcp rgsgeepcpa tasgllqplr vdtgassycl
      961 qppagsvlsg twphprpgqp pplmapwpwg ppasqsspwp ratalwtsts dseppgsgdl
     1021 csepstpasp ppseegartg tpapvsqaea tstgepppgp ggralpwdph slemvligch
     1081 gpgtvqwtqe egtgv
//
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