LOCUS NP_034736 425 aa linear ROD 17-SEP-2023
DEFINITION G protein-activated inward rectifier potassium channel 2 isoform
Girk2A-1 [Mus musculus].
ACCESSION NP_034736 XP_358884 XP_489694
VERSION NP_034736.2
DBSOURCE REFSEQ: accession NM_010606.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 425)
AUTHORS Oh Y, Yoo ES, Ju SH, Kim E, Lee S, Kim S, Wickman K and Sohn JW.
TITLE GIRK2 potassium channels expressed by the AgRP neurons decrease
adiposity and body weight in mice
JOURNAL PLoS Biol 21 (8), e3002252 (2023)
PUBMED 37594983
REMARK GeneRIF: GIRK2 potassium channels expressed by the AgRP neurons
decrease adiposity and body weight in mice.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 425)
AUTHORS Van Heesbeen HJ, Von Oerthel L, De Vries PM, Wagemans CMRJ and
Smidt MP.
TITLE Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor
Associated with Human Brain Aging via H3K79 Hypermethylation
JOURNAL Int J Mol Sci 24 (2), 1387 (2023)
PUBMED 36674903
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 425)
AUTHORS Taylor EL, Weaver SR, Lorang IM, Arnold KM, Bradley EW, Marron
Fernandez de Velasco E, Wickman K and Westendorf JJ.
TITLE GIRK3 deletion facilitates kappa opioid signaling in chondrocytes,
delays vascularization and promotes bone lengthening in mice
JOURNAL Bone 159, 116391 (2022)
PUBMED 35314385
REFERENCE 4 (residues 1 to 425)
AUTHORS Chen IS, Eldstrom J, Fedida D and Kubo Y.
TITLE A novel ion conducting route besides the central pore in an
inherited mutant of G-protein-gated inwardly rectifying K+ channel
JOURNAL J Physiol 600 (3), 603-622 (2022)
PUBMED 34881429
REMARK GeneRIF: A novel ion conducting route besides the central pore in
an inherited mutant of G-protein-gated inwardly rectifying K(+)
channel.
REFERENCE 5 (residues 1 to 425)
AUTHORS Alfaro-Ruiz R, Martin-Belmonte A, Aguado C, Hernandez F,
Moreno-Martinez AE, Avila J and Lujan R.
TITLE The Expression and Localisation of G-Protein-Coupled Inwardly
Rectifying Potassium (GIRK) Channels Is Differentially Altered in
the Hippocampus of Two Mouse Models of Alzheimer's Disease
JOURNAL Int J Mol Sci 22 (20), 11106 (2021)
PUBMED 34681766
REMARK GeneRIF: The Expression and Localisation of G-Protein-Coupled
Inwardly Rectifying Potassium (GIRK) Channels Is Differentially
Altered in the Hippocampus of Two Mouse Models of Alzheimer's
Disease.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 425)
AUTHORS Takeda H, Yoshiki A, Nishikawa S, Nishikawa S, Kunisada T, Sakakura
T, Amanuma H and Kusakabe M.
TITLE Expression of c-kit, a proto-oncogene of the murine W locus, in
cerebella of normal and neurological mutant mice:
immunohistochemical and in situ hybridization analysis
JOURNAL Differentiation 51 (2), 121-127 (1992)
PUBMED 1282111
REFERENCE 7 (residues 1 to 425)
AUTHORS Crepel,F. and Mariani,J.
TITLE Multiple innervation of Purkinje cells by climbing fibers in the
cerebellum of the Weaver Mutant Mouse
JOURNAL J Neurobiol 7 (6), 579-582 (1976)
PUBMED 1003203
REFERENCE 8 (residues 1 to 425)
AUTHORS Mallet,J., Huchet,M., Pougeois,R. and Changeux,J.P.
TITLE Anatomical, physiological and biochemical studies on the cerebellum
from mutant mice. III. Protein differences associated with the
weaver, staggerer and nervous mutations
JOURNAL Brain Res 103 (2), 291-312 (1976)
PUBMED 1252920
REFERENCE 9 (residues 1 to 425)
AUTHORS Sotelo,C.
TITLE Anatomical, physiological and biochemical studies of the cerebellum
from mutant mice. II. Morphological study of cerebellar cortical
neurons and circuits in the weaver mouse
JOURNAL Brain Res 94 (1), 19-44 (1975)
PUBMED 1148865
REFERENCE 10 (residues 1 to 425)
AUTHORS Murad,S. and Kishimoto,Y.
TITLE Alpha hydroxylation of lignoceric acid to cerebronic acid during
brain development. Diminished hydroxylase activity in
myelin-deficient mouse mutants
JOURNAL J Biol Chem 250 (15), 5841-5846 (1975)
PUBMED 1150661
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BB591362.2, AK044218.1, AB029502.1 and AC165271.2.
On Jul 21, 2005 this sequence version replaced NP_034736.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U51124.1, BC120794.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164131, SAMN01164139
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..425
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="16"
/map="16 55.44 cM"
Protein 1..425
/product="G protein-activated inward rectifier potassium
channel 2 isoform Girk2A-1"
/note="potassium inwardly-rectifying channel J6; g
protein-activated inward rectifier potassium channel 2;
GIRK-2; G-protein-coupled inward rectifier K+ channel 2-B;
inward rectifier K(+) channel Kir3.2; potassium channel,
inwardly rectifying subfamily J member 6;
G-protein-coupled inward rectifier K+ channel 2-1;
G-protein-coupled inward rectifier K+ channel 2-A;
G-protein-coupled inward rectifier K+ channel 2-C"
/calculated_mol_wt=48549
Site 18
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P48542.1)"
Site 25
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P48542.1)"
Region 59..198
/region_name="IRK"
/note="Inward rectifier potassium channel; pfam01007"
/db_xref="CDD:425984"
Site 92..116
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P48542.1)"
Region 154..159
/region_name="Selectivity filter. /evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (P48542.1)"
Site 169..190
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P48542.1)"
Site 184
/site_type="other"
/note="Role in the control of polyamine-mediated channel
gating and in the blocking by intracellular magnesium.
/evidence=ECO:0000250; propagated from
UniProtKB/Swiss-Prot (P48542.1)"
Region 205..374
/region_name="IRK_C"
/note="Inward rectifier potassium channel C-terminal
domain; pfam17655"
/db_xref="CDD:435949"
Region 392..425
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P48542.1)"
Region 422..425
/region_name="PDZ-binding"
/note="propagated from UniProtKB/Swiss-Prot (P48542.1)"
CDS 1..425
/gene="Kcnj6"
/gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
wv"
/coded_by="NM_010606.2:529..1806"
/note="isoform Girk2A-1 is encoded by transcript variant
Girk2A-1"
/db_xref="CCDS:CCDS37409.1"
/db_xref="GeneID:16522"
/db_xref="MGI:MGI:104781"
ORIGIN
1 mtmakltesm tnvlegdsmd qdvespvaih qpklpkqard dlprhisrdr tkrkiqryvr
61 kdgkcnvhhg nvretyrylt difttlvdlk wrfnllifvm vytvtwlffg miwwliayir
121 gdmdhiedps wtpcvtnlng fvsaflfsie tettigygyr vitdkcpegi illliqsvlg
181 sivnafmvgc mfvkisqpkk raetlvfsth avismrdgkl clmfrvgdlr nshiveasir
241 aklikskqts egefiplnqt dinvgyytgd drlflvspli isheinqqsp fweiskaqlp
301 keeleivvil egmveatgmt cqarssyits eilwgyrftp vltledgfye vdynsfhety
361 etstpslsak elaelanrae lplswsvssk lnqhaelete eeeknpeelt erngdvanle
421 neskv
//
