LOCUS NP_035476 372 aa linear ROD 28-NOV-2023
DEFINITION L-selectin isoform 1 precursor [Mus musculus].
ACCESSION NP_035476
VERSION NP_035476.1
DBSOURCE REFSEQ: accession NM_011346.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 372)
AUTHORS Merkenschlager J, Berz RM, Ramos V, Uhlig M, MacLean AJ, Nowosad
CR, Oliveira TY and Nussenzweig MC.
TITLE Continually recruited naive T cells contribute to the follicular
helper and regulatory T cell pools in germinal centers
JOURNAL Nat Commun 14 (1), 6944 (2023)
PUBMED 37907454
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 372)
AUTHORS Wang S, Pang X, Tong L, Fan H, Jiang J, Zhao M, Yu X, Li M, Liang
J, Fan Y, Zhang X, Tang Y, Sun Y and Liang X.
TITLE LncRNA SELL/L-selectin promotes HPV-positive HNSCC progression and
drives fucoidan-mediated therapeutic strategies
JOURNAL Acta Biomater 167, 436-448 (2023)
PUBMED 37330030
REMARK GeneRIF: LncRNA SELL/L-selectin promotes HPV-positive HNSCC
progression and drives fucoidan-mediated therapeutic strategies.
REFERENCE 3 (residues 1 to 372)
AUTHORS Ito Y, Nakahara F, Kagoya Y and Kurokawa M.
TITLE CD62L expression level determines the cell fate of myeloid
progenitors
JOURNAL Stem Cell Reports 16 (12), 2871-2886 (2021)
PUBMED 34798065
REMARK GeneRIF: CD62L expression level determines the cell fate of myeloid
progenitors.
REFERENCE 4 (residues 1 to 372)
AUTHORS Eswaran S, Babbar A, Drescher HK, Hitch TCA, Clavel T, Muschaweck
M, Ritz T, Kroy DC, Trautwein C, Wagner N and Schippers A.
TITLE Upregulation of Anti-Oxidative Stress Response Improves Metabolic
Changes in L-Selectin-Deficient Mice but Does Not Prevent NAFLD
Progression or Fecal Microbiota Shifts
JOURNAL Int J Mol Sci 22 (14), 7314 (2021)
PUBMED 34298930
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 372)
AUTHORS Merkenschlager J, Finkin S, Ramos V, Kraft J, Cipolla M, Nowosad
CR, Hartweger H, Zhang W, Olinares PDB, Gazumyan A, Oliveira TY,
Chait BT and Nussenzweig MC.
TITLE Dynamic regulation of TFH selection during the germinal centre
reaction
JOURNAL Nature 591 (7850), 458-463 (2021)
PUBMED 33536617
REFERENCE 6 (residues 1 to 372)
AUTHORS Morse HC 3rd.
TITLE Genetic nomenclature for loci controlling surface antigens of mouse
hemopoietic cells
JOURNAL J Immunol 149 (10), 3129-3134 (1992)
PUBMED 1431091
REMARK Review article
Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE 7 (residues 1 to 372)
AUTHORS Oakey RJ, Watson ML and Seldin MF.
TITLE Construction of a physical map on mouse and human chromosome 1:
comparison of 13 Mb of mouse and 11 Mb of human DNA
JOURNAL Hum Mol Genet 1 (8), 613-620 (1992)
PUBMED 1301170
REFERENCE 8 (residues 1 to 372)
AUTHORS Capeless CG, Whitney G and Azen EA.
TITLE Chromosome mapping of Soa, a gene influencing gustatory sensitivity
to sucrose octaacetate in mice
JOURNAL Behav Genet 22 (6), 655-663 (1992)
PUBMED 1290451
REFERENCE 9 (residues 1 to 372)
AUTHORS Birkenmeier EH, Schneider U and Thurston SJ.
TITLE Fingerprinting genomes by use of PCR with primers that encode
protein motifs or contain sequences that regulate gene expression
JOURNAL Mamm Genome 3 (10), 537-545 (1992)
PUBMED 1421760
REMARK Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE 10 (residues 1 to 372)
AUTHORS Douville PJ and Carbonetto S.
TITLE Genetic linkage analysis in recombinant inbred mice of P40, a
putative clone for the high-affinity laminin receptor
JOURNAL Mamm Genome 3 (8), 438-446 (1992)
PUBMED 1353694
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY210690.1, AK137509.1 and AA182222.1.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK157273.1, AK137509.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849380
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..372
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="1"
/map="1 71.37 cM"
Protein 1..372
/product="L-selectin isoform 1 precursor"
/note="lymphocyte antigen 22; lymph node homing receptor;
leukocyte adhesion molecule 1; CD62 antigen-like family
member L; lymphocyte surface MEL-14 antigen;
leukocyte-endothelial cell adhesion molecule 1"
/calculated_mol_wt=38844
sig_peptide 1..28
/note="propagated from UniProtKB/Swiss-Prot (P18337.1)"
/calculated_mol_wt=3462
mat_peptide 39..372
/product="L-selectin. /id=PRO_0000017480"
/note="propagated from UniProtKB/Swiss-Prot (P18337.1)"
/calculated_mol_wt=37683
Region 39..157
/region_name="CLECT"
/note="C-type lectin (CTL)/C-type lectin-like (CTLD)
domain; cl02432"
/db_xref="CDD:445781"
Site 60
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 104
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site order(126,130,132,141,143..146,149..151)
/site_type="other"
/note="ligand binding surface [chemical binding]"
/db_xref="CDD:153057"
Region 160..192
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site 177
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Region 197..255
/region_name="CCP"
/note="Complement control protein (CCP) modules (aka short
consensus repeats SCRs or SUSHI repeats) have been
identified in several proteins of the complement system;
cd00033"
/db_xref="CDD:153056"
Site order(207,228)
/site_type="active"
/note="receptor-ligand interactions [active]"
/db_xref="CDD:153056"
Site 216
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 226
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 246
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Region 259..317
/region_name="CCP"
/note="Complement control protein (CCP) modules (aka short
consensus repeats SCRs or SUSHI repeats) have been
identified in several proteins of the complement system;
cd00033"
/db_xref="CDD:153056"
Site order(269,290)
/site_type="active"
/note="receptor-ligand interactions [active]"
/db_xref="CDD:153056"
Site 278
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 288
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 308
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 320
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18337.1)"
Site 333..355
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P18337.1)"
CDS 1..372
/gene="Sell"
/gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
/coded_by="NM_011346.2:114..1232"
/note="isoform 1 precursor is encoded by transcript
variant 1"
/db_xref="CCDS:CCDS35753.1"
/db_xref="GeneID:20343"
/db_xref="MGI:MGI:98279"
ORIGIN
1 mvfpwrcegt ywgsrnilkl wvwtllccdf lihhgthcwt yhysekpmnw enarkfckqn
61 ytdlvaiqnk reieylentl pkspyyywig irkigkmwtw vgtnktltke aenwgagepn
121 nkkskedcve iyikrerdsg kwnddachkr kaalcytasc qpgscngrge cvetinnhtc
181 icdagyygpq cqyvvqcepl eapelgtmdc ihplgnfsfq skcafncseg rellgtaetq
241 cgasgnwssp epicqvvqce pleapelgtm dcihplgnfs fqskcafncs egrellgtae
301 tqcgasgnws spepicqetn rsfskikegd ynplfipvav mvtafsglaf liwlarrlkk
361 gkksqermdd py
//
