LOCUS NP_036528 127 aa linear PRI 11-JUN-2023
DEFINITION pleckstrin homology-like domain family A member 3 [Homo sapiens].
ACCESSION NP_036528
VERSION NP_036528.1
DBSOURCE REFSEQ: accession NM_012396.5
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 127)
AUTHORS Saito M, Sada A, Fukuyo M, Aoki K, Okumura K, Tabata Y, Chen Y,
Kaneda A, Wakabayashi Y and Ohki R.
TITLE PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell
Carcinogenesis
JOURNAL J Invest Dermatol 142 (4), 1040-1049 (2022)
PUBMED 34592332
REMARK GeneRIF: PHLDA3 Is an Important Downstream Mediator of p53 in
Squamous Cell Carcinogenesis.
REFERENCE 2 (residues 1 to 127)
AUTHORS Ma S, Quan P, Yu C, Fan X, Yang S, Jia W, Zhang L, Wang F, Liu F,
Yang L, Qin W and Yang X.
TITLE PHLDA3 exerts an antitumor function in prostate cancer by
down-regulating Wnt/beta-catenin pathway via inhibition of Akt
JOURNAL Biochem Biophys Res Commun 571, 66-73 (2021)
PUBMED 34303965
REMARK GeneRIF: PHLDA3 exerts an antitumor function in prostate cancer by
down-regulating Wnt/beta-catenin pathway via inhibition of Akt.
REFERENCE 3 (residues 1 to 127)
AUTHORS R Mangone F, Av Valoyes M, G do Nascimento R, Pf Conceicao M, R
Bastos D, C Pavanelli A, C Soares I, S de Mello E, Nonogaki S, Ab
de T Osorio C and A Nagai M.
TITLE Prognostic and predictive value of Pleckstrin homology-like domain,
family A family members in breast cancer
JOURNAL Biomark Med 14 (16), 1537-1552 (2020)
PUBMED 33179538
REMARK GeneRIF: Prognostic and predictive value of Pleckstrin
homology-like domain, family A family members in breast cancer.
REFERENCE 4 (residues 1 to 127)
AUTHORS Bensellam M, Chan JY, Lee K, Joglekar MV, Hardikar AA, Loudovaris
T, Thomas HE, Jonas JC and Laybutt DR.
TITLE Phlda3 regulates beta cell survival during stress
JOURNAL Sci Rep 9 (1), 12827 (2019)
PUBMED 31492921
REMARK GeneRIF: Phlda3 regulates beta cell survival during stress.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 127)
AUTHORS Liu J, Liu X, Hui X, Cai L, Li X, Yang Y, Shu S, Wang F, Xia H and
Li S.
TITLE Novel Role for Pleckstrin Homology-Like Domain Family A, Member 3
in the Regulation of Pathological Cardiac Hypertrophy
JOURNAL J Am Heart Assoc 8 (16), e011830 (2019)
PUBMED 31426686
REMARK GeneRIF: Novel Role for Pleckstrin Homology-Like Domain Family A,
Member 3 in the Regulation of Pathological Cardiac Hypertrophy.
REFERENCE 6 (residues 1 to 127)
AUTHORS Muroi H, Nakajima M, Satomura H, Takahashi M, Yamaguchi S, Sasaki
K, Yokobori T, Miyazaki T, Kuwano H and Kato H.
TITLE Low PHLDA3 expression in oesophageal squamous cell carcinomas is
associated with poor prognosis
JOURNAL Anticancer Res 35 (2), 949-954 (2015)
PUBMED 25667479
REMARK GeneRIF: Low PHLDA3 expression in ESCC may be predictive of tumor
recurrence suggesting that Akt activation may be a therapeutic
target in ESCCs
REFERENCE 7 (residues 1 to 127)
AUTHORS Ohki R, Saito K, Chen Y, Kawase T, Hiraoka N, Saigawa R, Minegishi
M, Aita Y, Yanai G, Shimizu H, Yachida S, Sakata N, Doi R, Kosuge
T, Shimada K, Tycko B, Tsukada T, Kanai Y, Sumi S, Namiki H, Taya
Y, Shibata T and Nakagama H.
TITLE PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine
tumors
JOURNAL Proc Natl Acad Sci U S A 111 (23), E2404-E2413 (2014)
PUBMED 24912192
REMARK GeneRIF: Results indicate that tumor suppressor PHLDA3-mediated
pathway is important in the development of pancreatic
neuroendocrine tumors (PanNETs).
REFERENCE 8 (residues 1 to 127)
AUTHORS Yoo,N.J., Kim,Y.R. and Lee,S.H.
TITLE Expressional and mutational analysis of PHLDA3 gene in common human
cancers
JOURNAL Pathology 43 (5), 510-511 (2011)
PUBMED 21753719
REMARK GeneRIF: findings indicate somatic mutation of PHLDA3 is rare in
common cancer types; PHLDA3 expression was lost in 22% of prostate
cancers; these results indicate that PHLDA3 are altered in prostate
cancers by loss of expression
REFERENCE 9 (residues 1 to 127)
AUTHORS Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J,
Ohta T, Ichikawa H, Aburatani H, Tashiro F and Taya Y.
TITLE PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt
JOURNAL Cell 136 (3), 535-550 (2009)
PUBMED 19203586
REMARK GeneRIF: Study identifies PHLDA3 as a p53 target gene that encodes
a PH domain-only protein and finds that PHLDA3 competes with the PH
domain of Akt for binding of membrane lipids, inhibiting Akt
translocation to the cellular membrane and activation.
REFERENCE 10 (residues 1 to 127)
AUTHORS Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R and Tycko
B.
TITLE A novel pleckstrin homology-related gene family defined by
Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression,
chromosomal location, and parental imprinting
JOURNAL Mamm Genome 10 (12), 1150-1159 (1999)
PUBMED 10594239
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC096677.2, BC068273.1, BC014390.1, AF151100.1, BE778799.1,
BX090314.1, BE892338.1, BQ000725.1, AI624156.1 and BC033874.1.
Transcript Variant: This variant (1) encodes the functional
protein.
CCDS Note: This CCDS ID represents the protein described in PMID:
19203586 and is supported by BC014390.1. It should be noted this
transcript is predicted to undergo nonsense-mediated mRNA decay
(NMD). However, the protein is represented because it was detected
endogenously in PMID: 19203586. It is likely that the majority of
transcripts representing this variant will undergo NMD, while some
low level of NMD escape may allow for the expression of this
protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803611.126849.1,
SRR1803616.230560.1 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000367311.5/ ENSP00000356280.3
NMD candidate :: PMID: 19203586
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..127
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32.1"
Protein 1..127
/product="pleckstrin homology-like domain family A member
3"
/note="pleckstrin homology-like domain, family A, member
2; TDAG51/Ipl homolog 1"
/calculated_mol_wt=13760
Region 9..88
/region_name="PH"
/note="Pleckstrin homology domain; smart00233"
/db_xref="CDD:214574"
CDS 1..127
/gene="PHLDA3"
/gene_synonym="TIH1"
/coded_by="NM_012396.5:403..786"
/db_xref="CCDS:CCDS1412.1"
/db_xref="GeneID:23612"
/db_xref="HGNC:HGNC:8934"
/db_xref="MIM:607054"
ORIGIN
1 mtaaatatvl kegvlekrsg gllqlwkrkr cvlterglql feakgtggrp kelsfarika
61 vecvestgrh iyftlvtegg geidfrcple dpgwnaqitl glvkfknqqa iqtvrarqsl
121 gtgtlvs
//