GenomeNet

Database: RefSeq
Entry: NP_036676
LinkDB: NP_036676
Original site: NP_036676 
LOCUS       NP_036676               1313 aa            linear   ROD 27-APR-2025
DEFINITION  angiotensin-converting enzyme precursor [Rattus norvegicus].
ACCESSION   NP_036676
VERSION     NP_036676.1
DBSOURCE    REFSEQ: accession NM_012544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1313)
  AUTHORS   Ferreira-Duarte,M., Oliveira,L.C.G., Quintas,C.,
            Esteves-Monteiro,M., Duarte-Araujo,M., Sousa,T., Casarini,D.E. and
            Morato,M.
  TITLE     ACE and ACE2 catalytic activity in the fecal content along the gut
  JOURNAL   Neurogastroenterol Motil 35 (9), e14598 (2023)
   PUBMED   37052403
  REMARK    GeneRIF: ACE and ACE2 catalytic activity in the fecal content along
            the gut.
REFERENCE   2  (residues 1 to 1313)
  AUTHORS   Lin,Y., Li,Y.Q., Wang,H., Wu,H.J., Bai,B.L., Ma,L.J., Zou,J.Z.,
            Zhang,Q. and Shi,L.
  TITLE     Increasing angiotensin-converting enzyme 1 regulated by histone 3
            lysine 27 hyperacetylation in high-fat diet-induced hypertensive
            rat kidney
  JOURNAL   J Hypertens 40 (10), 1969-1978 (2022)
   PUBMED   35969203
  REMARK    GeneRIF: Increasing angiotensin-converting enzyme 1 regulated by
            histone 3 lysine 27 hyperacetylation in high-fat diet-induced
            hypertensive rat kidney.
REFERENCE   3  (residues 1 to 1313)
  AUTHORS   Saadat,M.
  TITLE     No significant correlation between ACE Ins/Del genetic polymorphism
            and COVID-19 infection
  JOURNAL   Clin Chem Lab Med 58 (7), 1127-1128 (2020)
   PUBMED   32386188
REFERENCE   4  (residues 1 to 1313)
  AUTHORS   Delanghe,J.R., Speeckaert,M.M. and De Buyzere,M.L.
  TITLE     COVID-19 infections are also affected by human ACE1 D/I
            polymorphism
  JOURNAL   Clin Chem Lab Med 58 (7), 1125-1126 (2020)
   PUBMED   32286246
REFERENCE   5  (residues 1 to 1313)
  AUTHORS   Shu,Y., Cao,X.Y. and Chen,J.
  TITLE     Preparation and antagonistic effect of ACE inhibitory peptide from
            cashew
  JOURNAL   J Sci Food Agric 99 (15), 6822-6832 (2019)
   PUBMED   31385307
REFERENCE   6  (residues 1 to 1313)
  AUTHORS   Weinreb,R.N., O'Donnell,J.J., Sandman,R., Char,D.H. and Kimura,S.J.
  TITLE     Angiotensin-converting enzyme in sarcoid uveitis
  JOURNAL   Invest Ophthalmol Vis Sci 18 (12), 1285-1287 (1979)
   PUBMED   229083
REFERENCE   7  (residues 1 to 1313)
  AUTHORS   Sedov,V.A.
  TITLE     [To sanitize liv stock raising of helminthiases]
  JOURNAL   Veterinariia (12), 10-12 (1978)
   PUBMED   734899
REFERENCE   8  (residues 1 to 1313)
  AUTHORS   Zderkiewicz,E.
  TITLE     [Autoregulation of cerebral blood flow]
  JOURNAL   Pol Tyg Lek 33 (29), 1157-1159 (1978)
   PUBMED   704419
REFERENCE   9  (residues 1 to 1313)
  AUTHORS   Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
  TITLE     The role of the renin-angiotensin-aldosterone system in
            cardiovascular homeostasis in normal human subjects
  JOURNAL   Circulation 53 (3), 400-405 (1976)
   PUBMED   174834
REFERENCE   10 (residues 1 to 1313)
  AUTHORS   Silverstein,E., Friedland,J., Lyons,H.A. and Gourin,A.
  TITLE     Elevation of angiotensin-converting enzyme in granulomatous lymph
            nodes and serum in sarcoidosis: clinical and possible pathogenic
            significance
  JOURNAL   Ann N Y Acad Sci 278, 498-513 (1976)
   PUBMED   183595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U03734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03734.1, BC085760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..1313
                     /product="angiotensin-converting enzyme precursor"
                     /EC_number="3.4.15.1"
                     /note="kininase II; angiotensin-converting enzyme;
                     dipeptidyl carboxypeptidase I; angiotensin 1 converting
                     enzyme 1; Dipeptidyl carboxypeptidase 1 (Angiotensin
                     I-converting enzyme); angiotensin I-converting enzyme
                     (Dipeptidyl carboxypeptidase 1); angiotensin I converting
                     enzyme 1; angiotensin I converting enzyme
                     (peptidyl-dipeptidase A) 1; angiotensin-converting
                     enzyme-like"
                     /calculated_mol_wt=147263
     sig_peptide     1..35
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3635
     mat_peptide     36..1313
                     /product="Angiotensin-converting enzyme.
                     /id=PRO_0000028557"
                     /note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
                     /calculated_mol_wt=147263
     Site            44
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Region          46..629
                     /region_name="Peptidase_M2"
                     /note="Angiotensin-converting enzyme; pfam01401"
                     /db_xref="CDD:460196"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            80
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            117
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            152
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            324
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            515
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Region          650..1227
                     /region_name="Peptidase_M2"
                     /note="Angiotensin-converting enzyme; pfam01401"
                     /db_xref="CDD:460196"
     Site            683
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            701
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            720
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            766
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            948
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Site            1197
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     Region          1221..1262
                     /region_name="Juxtamembrane stalk.
                     /evidence=ECO:0000250|UniProtKB:P12821"
                     /note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
     Site            1266..1282
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
     Site            1306
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47820.1)"
     CDS             1..1313
                     /gene="Ace"
                     /gene_synonym="CD143; Dcp1; StsRR92"
                     /coded_by="NM_012544.1:24..3965"
                     /db_xref="GeneID:24310"
                     /db_xref="RGD:2493"
ORIGIN      
        1 mgaasgqrgr wplsppllml slllllllpp spapaldpgl qpgnfsadea gaqlfadsyn
       61 ssaevvmfqs taaswahdtn iteenarlqe eaalinqefa evwgkkakel yesiwqnftd
      121 qklrriigsv qtlgpanlpl tqrlqynsll snmsriystg kvcfpnktat cwsldpeltn
      181 ilassrnyak vlfawegwhd avgiplkply qdftalsnea yrqdgfsdtg aywrswyesp
      241 sfeeslehly hqveplylnl hafvrralhr rygdkyinlr gpipahllgd mwaqsweniy
      301 dmvvpfpdkp nldvtstmvq kgwnathmfr vaeefftslg lspmppefwa esmlekpadg
      361 revvchasaw dfynrkdfri kqctrvtmdq lstvhhemgh vqyylqykdl hvslrrganp
      421 gfheaigdvl alsvstpahl hkiglldrva ndiesdinyl lkmalekiaf lpfgylvdqw
      481 rwgvfsgrtp psrynydwwy lrtkyqgicp pvarnethfd agakfhipsv tpyiryfvsf
      541 vlqfqfhqal ckeaghqgpl hqcdiyqstk agaklqqvlq agcsrpwqev lkdlvgsdal
      601 dasalmeyfq pvsqwlqeqn qrngevlgwp eyqwrpplpd nypegidlet deakanrfve
      661 eydrtakvlw neyaeanwhy ntnitiegsk illqknkevs nhtlkygtwa ktfdvsnfqn
      721 stikriikkv qnvdravlpp neleeynqil ldmettysva nvcytngtcl slepdltnim
      781 atsrkyeell wvwkswrdkv grailpffpk yvdfsnkiak lngysdagds wrssyesddl
      841 eqdleklyqe lqplylnlha yvrrslhrhy gseyinldgp ipahllgnmw aqtwsniydl
      901 vapfpsapsi dateamikqg wtprrifkea dnfftslgll pvppefwnks mlekptdgre
      961 vvchasawdf yngkdfrikq ctsvnmeelv iahhemghiq yfmqykdlpv tfreganpgf
     1021 heaigdvlal svstpkhlhs lnllssegsg yehdinflmk maldkiafip fsylidqwrw
     1081 rvfdgsitke nynqewwslr lkyqglcppv prsqgdfdpg skfhvpanvp yiryfisfii
     1141 qfqfhealcr aaghtgplyk cdiyqskeag klladamklg yskqwpeamk iitgqpnmsa
     1201 saimnyfkpl tewlvtenrr hgetlgwpey twtpntarae gslpessrvn flgmylepqq
     1261 arvgqwvllf lgvallvatv glahrlynih nhhslrrphr gpqfgsevel rhs
//
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