LOCUS NP_036676 1313 aa linear ROD 11-NOV-2018
DEFINITION angiotensin-converting enzyme precursor [Rattus norvegicus].
ACCESSION NP_036676
VERSION NP_036676.1
DBSOURCE REFSEQ: accession NM_012544.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 1313)
AUTHORS Faulk KE, Nedungadi TP and Cunningham JT.
TITLE Angiotensin converting enzyme 1 in the median preoptic nucleus
contributes to chronic intermittent hypoxia hypertension
JOURNAL Physiol Rep 5 (10) (2017)
PUBMED 28536140
REMARK GeneRIF: Data suggest that angiotensin converting enzyme 1 within
median preoptic nucleus plays a critical role in the sustained
hypertension seen in chronic intermittent hypoxia.
REFERENCE 2 (residues 1 to 1313)
AUTHORS Faulk K, Shell B, Nedungadi TP and Cunningham JT.
TITLE Role of angiotensin-converting enzyme 1 within the median preoptic
nucleus following chronic intermittent hypoxia
JOURNAL Am. J. Physiol. Regul. Integr. Comp. Physiol. 312 (2), R245-R252
(2017)
PUBMED 28003214
REMARK GeneRIF: Chromatin immunoprecipitation (ChIP) assays demonstrated
an increase in FosB/DeltaFosB association with the ACE1 gene within
the MnPO following CIH. FosB/DeltaFosB may transcriptionally target
ACE1 within the MnPO following CIH to affect the downstream PVN
region, which may influence SNA and blood pressure.
REFERENCE 3 (residues 1 to 1313)
AUTHORS Sanguesa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R
and Alegret M.
TITLE Type of supplemented simple sugar, not merely calorie intake,
determines adverse effects on metabolism and aortic function in
female rats
JOURNAL Am. J. Physiol. Heart Circ. Physiol. 312 (2), H289-H304 (2017)
PUBMED 27923787
REFERENCE 4 (residues 1 to 1313)
AUTHORS Wang J, Yin N, Deng Y, Wei Y, Huang Y, Pu X, Li L, Zheng Y, Guo J,
Yu J, Li X and Yi P.
TITLE Ascorbic Acid Protects against Hypertension through Downregulation
of ACE1 Gene Expression Mediated by Histone Deacetylation in
Prenatal Inflammation-Induced Offspring
JOURNAL Sci Rep 6, 39469 (2016)
PUBMED 27995995
REMARK GeneRIF: ascorbic acid is able to prevent hypertension in offspring
from prenatal inflammation exposure through ACE1 downregulation
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 1313)
AUTHORS Dos Santos RL, Dellacqua LO, Delgado NT, Rouver WN, Podratz PL,
Lima LC, Piccin MP, Meyrelles SS, Mauad H, Graceli JB and Moyses
MR.
TITLE Pomegranate peel extract attenuates oxidative stress by decreasing
coronary angiotensin-converting enzyme (ACE) activity in
hypertensive female rats
JOURNAL J. Toxicol. Environ. Health Part A 79 (21), 998-1007 (2016)
PUBMED 27710705
REMARK GeneRIF: Pomegranate peel extract consumption conferred protection
against hypertension in the spontaneously hypertensive rat model.
This finding was demonstrated by marked reduction in coronary ACE
activity, oxidative stress, and vascular remodelling.
REFERENCE 6 (residues 1 to 1313)
AUTHORS Martinelli I, Mainini E and Mazzi C.
TITLE [Effect of 5-hydroxytryptophan on the secretion of PRL, GH, TSH and
cortisol in obesity]
JOURNAL Minerva Endocrinol. 17 (3), 121-126 (1992)
PUBMED 1298871
REFERENCE 7 (residues 1 to 1313)
AUTHORS Weinreb,R.N., O'Donnell,J.J., Sandman,R., Char,D.H. and Kimura,S.J.
TITLE Angiotensin-converting enzyme in sarcoid uveitis
JOURNAL Invest. Ophthalmol. Vis. Sci. 18 (12), 1285-1287 (1979)
PUBMED 229083
REFERENCE 8 (residues 1 to 1313)
AUTHORS Sedov,V.A.
TITLE [To sanitize liv stock raising of helminthiases]
JOURNAL Veterinariia (12), 10-12 (1978)
PUBMED 734899
REFERENCE 9 (residues 1 to 1313)
AUTHORS Zderkiewicz,E.
TITLE [Autoregulation of cerebral blood flow]
JOURNAL Pol Tyg Lek 33 (29), 1157-1159 (1978)
PUBMED 704419
REFERENCE 10 (residues 1 to 1313)
AUTHORS Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
TITLE The role of the renin-angiotensin-aldosterone system in
cardiovascular homeostasis in normal human subjects
JOURNAL Circulation 53 (3), 400-405 (1976)
PUBMED 174834
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from U03734.1.
Summary: catalyzes the conversion of angiotensin I to angiotensin
II; plays a role in regulation of blood pressure [RGD, Feb 2006].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC085760.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00052296, SAMD00052297
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1313
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="10"
/map="10q32.1"
Protein 1..1313
/product="angiotensin-converting enzyme precursor"
/EC_number="3.4.15.1"
/note="kininase II; angiotensin-converting enzyme;
dipeptidyl carboxypeptidase I; angiotensin 1 converting
enzyme 1; Dipeptidyl carboxypeptidase 1 (Angiotensin
I-converting enzyme); angiotensin I-converting enzyme
(Dipeptidyl carboxypeptidase 1); angiotensin I converting
enzyme 1; angiotensin I converting enzyme
(peptidyl-dipeptidase A) 1"
/calculated_mol_wt=147263
sig_peptide 1..35
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=3635
mat_peptide 36..1313
/product="Angiotensin-converting enzyme"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
/calculated_mol_wt=147263
Region 36..636
/region_name="Peptidase M2 1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
Region 46..629
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:279709"
Site order(366..368,396..397,400,424,470,524..526,531,533,536)
/site_type="active"
/db_xref="CDD:188999"
Site order(396,400,424)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188999"
Region 637..1238
/region_name="Peptidase M2 2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
Region 650..1227
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:279709"
Site order(964..966,994..995,998,1022,1068,1122..1124,1129,
1131,1134)
/site_type="active"
/db_xref="CDD:188999"
Site order(994,998,1022)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188999"
Site 1266..1282
/site_type="transmembrane region"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P47820.1)"
Site 1306
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:22673903};
propagated from UniProtKB/Swiss-Prot (P47820.1)"
CDS 1..1313
/gene="Ace"
/gene_synonym="CD143; Dcp1; StsRR92"
/coded_by="NM_012544.1:24..3965"
/db_xref="GeneID:24310"
/db_xref="RGD:2493"
ORIGIN
1 mgaasgqrgr wplsppllml slllllllpp spapaldpgl qpgnfsadea gaqlfadsyn
61 ssaevvmfqs taaswahdtn iteenarlqe eaalinqefa evwgkkakel yesiwqnftd
121 qklrriigsv qtlgpanlpl tqrlqynsll snmsriystg kvcfpnktat cwsldpeltn
181 ilassrnyak vlfawegwhd avgiplkply qdftalsnea yrqdgfsdtg aywrswyesp
241 sfeeslehly hqveplylnl hafvrralhr rygdkyinlr gpipahllgd mwaqsweniy
301 dmvvpfpdkp nldvtstmvq kgwnathmfr vaeefftslg lspmppefwa esmlekpadg
361 revvchasaw dfynrkdfri kqctrvtmdq lstvhhemgh vqyylqykdl hvslrrganp
421 gfheaigdvl alsvstpahl hkiglldrva ndiesdinyl lkmalekiaf lpfgylvdqw
481 rwgvfsgrtp psrynydwwy lrtkyqgicp pvarnethfd agakfhipsv tpyiryfvsf
541 vlqfqfhqal ckeaghqgpl hqcdiyqstk agaklqqvlq agcsrpwqev lkdlvgsdal
601 dasalmeyfq pvsqwlqeqn qrngevlgwp eyqwrpplpd nypegidlet deakanrfve
661 eydrtakvlw neyaeanwhy ntnitiegsk illqknkevs nhtlkygtwa ktfdvsnfqn
721 stikriikkv qnvdravlpp neleeynqil ldmettysva nvcytngtcl slepdltnim
781 atsrkyeell wvwkswrdkv grailpffpk yvdfsnkiak lngysdagds wrssyesddl
841 eqdleklyqe lqplylnlha yvrrslhrhy gseyinldgp ipahllgnmw aqtwsniydl
901 vapfpsapsi dateamikqg wtprrifkea dnfftslgll pvppefwnks mlekptdgre
961 vvchasawdf yngkdfrikq ctsvnmeelv iahhemghiq yfmqykdlpv tfreganpgf
1021 heaigdvlal svstpkhlhs lnllssegsg yehdinflmk maldkiafip fsylidqwrw
1081 rvfdgsitke nynqewwslr lkyqglcppv prsqgdfdpg skfhvpanvp yiryfisfii
1141 qfqfhealcr aaghtgplyk cdiyqskeag klladamklg yskqwpeamk iitgqpnmsa
1201 saimnyfkpl tewlvtenrr hgetlgwpey twtpntarae gslpessrvn flgmylepqq
1261 arvgqwvllf lgvallvatv glahrlynih nhhslrrphr gpqfgsevel rhs
//
