LOCUS NP_037142 330 aa linear ROD 19-JUN-2020
DEFINITION 5'-AMP-activated protein kinase subunit gamma-1 [Rattus
norvegicus].
ACCESSION NP_037142
VERSION NP_037142.1
DBSOURCE REFSEQ: accession NM_013010.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 330)
AUTHORS Dopie J, Rajakyla EK, Joensuu MS, Huet G, Ferrantelli E, Xie T,
Jaalinoja H, Jokitalo E and Vartiainen MK.
TITLE Genome-wide RNAi screen for nuclear actin reveals a network of
cofilin regulators
JOURNAL J. Cell. Sci. 128 (13), 2388-2400 (2015)
PUBMED 26021350
REFERENCE 2 (residues 1 to 330)
AUTHORS Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing
C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R,
Martin SR, Carling D and Gamblin SJ.
TITLE Structure of mammalian AMPK and its regulation by ADP
JOURNAL Nature 472 (7342), 230-233 (2011)
PUBMED 21399626
REFERENCE 3 (residues 1 to 330)
AUTHORS Zhu L, Chen L, Zhou XM, Zhang YY, Zhang YJ, Zhao J, Ji SR, Wu JW
and Wu Y.
TITLE Structural insights into the architecture and allostery of
full-length AMP-activated protein kinase
JOURNAL Structure 19 (4), 515-522 (2011)
PUBMED 21481774
REMARK GeneRIF: Studies determine the three-dimensional reconstruction and
subunit organization of the full-length rat AMPK
(alpha1beta1gamma1) through single-particle electron
REFERENCE 4 (residues 1 to 330)
AUTHORS Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 5 (residues 1 to 330)
AUTHORS Jiang W, Zhu Z and Thompson HJ.
TITLE Dietary energy restriction modulates the activity of AMP-activated
protein kinase, Akt, and mammalian target of rapamycin in mammary
carcinomas, mammary gland, and liver
JOURNAL Cancer Res. 68 (13), 5492-5499 (2008)
PUBMED 18593953
REMARK GeneRIF: Dietary energy restriction modulates the activity of
AMP-activated protein kinase in mammary carcinomas, mammary gland,
and liver.
REFERENCE 6 (residues 1 to 330)
AUTHORS Cheung PC, Salt IP, Davies SP, Hardie DG and Carling D.
TITLE Characterization of AMP-activated protein kinase gamma-subunit
isoforms and their role in AMP binding
JOURNAL Biochem. J. 346 Pt 3, 659-669 (2000)
PUBMED 10698692
REFERENCE 7 (residues 1 to 330)
AUTHORS Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE and Bartlett
PF.
TITLE Cellular distribution and developmental expression of AMP-activated
protein kinase isoforms in mouse central nervous system
JOURNAL J. Neurochem. 72 (4), 1707-1716 (1999)
PUBMED 10098881
REFERENCE 8 (residues 1 to 330)
AUTHORS Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK and
Carling D.
TITLE Characterization of AMP-activated protein kinase beta and gamma
subunits. Assembly of the heterotrimeric complex in vitro
JOURNAL J. Biol. Chem. 271 (17), 10282-10290 (1996)
PUBMED 8626596
REFERENCE 9 (residues 1 to 330)
AUTHORS Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR,
Kemp BE and Witters LA.
TITLE Non-catalytic beta- and gamma-subunit isoforms of the
5'-AMP-activated protein kinase
JOURNAL J. Biol. Chem. 271 (15), 8675-8681 (1996)
PUBMED 8621499
REFERENCE 10 (residues 1 to 330)
AUTHORS Stapleton D, Gao G, Michell BJ, Widmer J, Mitchelhill K, Teh T,
House CM, Witters LA and Kemp BE.
TITLE Mammalian 5'-AMP-activated protein kinase non-catalytic subunits
are homologs of proteins that interact with yeast Snf1 protein
kinase
JOURNAL J. Biol. Chem. 269 (47), 29343-29346 (1994)
PUBMED 7961907
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC097940.1.
Summary: non-catalytic component of the heterotrimeric
AMP-activated protein kinase; may phosphorylate and inactivate
enzymes involved in lipid metabolism; may play a role in response
to metabolic stress [RGD, Feb 2006].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC097940.1, X95578.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01906349 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..330
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q36"
Protein 1..330
/product="5'-AMP-activated protein kinase subunit gamma-1"
/note="AMP-activated protein kinase, noncatalytic gamma-1
subunit; protein kinase, AMP-activated, gamma 1
non-catalytic subunit; AMPKg; AMPK gamma-1 chain; AMPK
gamma1; AMPK subunit gamma-1; Protein kinase AMP-activated
gamma"
/calculated_mol_wt=37255
Region 45..174
/region_name="CBS_pair_5"
/note="The CBS domain, named after human CBS, is a small
domain originally identified in cystathionine
beta-synthase and is subsequently found in a wide range of
different proteins. CBS domains usually occur in tandem
repeats. They associate to form a so-called...; cd04618"
/db_xref="CDD:239990"
Region 137..158
/region_name="AMPK pseudosubstrate"
/note="propagated from UniProtKB/Swiss-Prot (P80385.3)"
Region 201..320
/region_name="CBS_pair_28"
/note="The CBS domain, named after human CBS, is a small
domain originally identified in cystathionine
beta-synthase and is subsequently found in a wide range of
different proteins. CBS domains usually occur in tandem
repeats. They associate to form a so-called...; cd04641"
/db_xref="CDD:240012"
Site 260
/site_type="phosphorylation"
/note="Phosphoserine, by ULK1.
/evidence=ECO:0000305|PubMed:21460634; propagated from
UniProtKB/Swiss-Prot (P80385.3)"
Site 262
/site_type="phosphorylation"
/note="Phosphothreonine, by ULK1.
/evidence=ECO:0000305|PubMed:21460634; propagated from
UniProtKB/Swiss-Prot (P80385.3)"
Site 269
/site_type="phosphorylation"
/note="Phosphoserine, by ULK1.
/evidence=ECO:0000269|PubMed:21460634; propagated from
UniProtKB/Swiss-Prot (P80385.3)"
CDS 1..330
/gene="Prkag1"
/gene_synonym="Prkaac; Prkga1"
/coded_by="NM_013010.2:17..1009"
/db_xref="GeneID:25520"
/db_xref="RGD:3388"
ORIGIN
1 mesvaaesap apenehsqet pesnssvytt fmkshrcydl iptssklvvf dtslqvkkaf
61 falvtngvra aplwdskkqs fvgmltitdf inilhryyks alvqiyelee hkietwrevy
121 lqdsfkplvc ispnaslfda vsslirnkih rlpvidpesg ntlyilthkr ilkflklfit
181 efpkpefmsk sleelqigty aniamvrttt pvyvalgifv qhrvsalpvv dekgrvvdiy
241 skfdvinlaa ektynnldvs vtkalqhrsh yfegvlkcyl hetleaiinr lveaevhrlv
301 vvdehdvvkg ivslsdilqa lvltggekkp
//
