LOCUS NP_038734 74 aa linear ROD 12-NOV-2023
DEFINITION CAMPATH-1 antigen precursor [Mus musculus].
ACCESSION NP_038734
VERSION NP_038734.1
DBSOURCE REFSEQ: accession NM_013706.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 74)
AUTHORS Mao R, Yang F, Zhang Y, Liu H, Guo P, Liu Y and Zhang T.
TITLE High expression of CD52 in adipocytes: a potential therapeutic
target for obesity with type 2 diabetes
JOURNAL Aging (Albany NY) 13 (8), 11043-11060 (2021)
PUBMED 33705353
REMARK GeneRIF: High expression of CD52 in adipocytes: a potential
therapeutic target for obesity with type 2 diabetes.
REFERENCE 2 (residues 1 to 74)
AUTHORS Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM,
Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE and
Harrison LC.
TITLE CD52 inhibits Toll-like receptor activation of NF-kappaB and
triggers apoptosis to suppress inflammation
JOURNAL Cell Death Differ 25 (2), 392-405 (2018)
PUBMED 29244050
REFERENCE 3 (residues 1 to 74)
AUTHORS Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE,
Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR,
Schreiber RD and Borowsky AD.
TITLE Abnormal Mammary Development in 129:STAT1-Null Mice is
Stroma-Dependent
JOURNAL PLoS One 10 (6), e0129895 (2015)
PUBMED 26075897
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 74)
AUTHORS Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE and
Oliver PL.
TITLE Neuron-specific antioxidant OXR1 extends survival of a mouse model
of amyotrophic lateral sclerosis
JOURNAL Brain 138 (Pt 5), 1167-1181 (2015)
PUBMED 25753484
REFERENCE 5 (residues 1 to 74)
AUTHORS Bandala-Sanchez E, Zhang Y, Reinwald S, Dromey JA, Lee BH, Qian J,
Bohmer RM and Harrison LC.
TITLE T cell regulation mediated by interaction of soluble CD52 with the
inhibitory receptor Siglec-10
JOURNAL Nat Immunol 14 (7), 741-748 (2013)
PUBMED 23685786
REMARK GeneRIF: Soluble CD52 is used by certain CD4-positive cells to
suppress target celss via the inhibitory receptor Siglec-10.
REFERENCE 6 (residues 1 to 74)
AUTHORS Egashira M, Kitamura D, Watanabe T and Niikawa N.
TITLE The human HCLS1 gene maps to chromosome 3q13 by fluorescence in
situ hybridization
JOURNAL Cytogenet Cell Genet 72 (2-3), 175-176 (1996)
PUBMED 8978766
REFERENCE 7 (residues 1 to 74)
AUTHORS Chen C and Nabavi N.
TITLE In vitro induction of T cell anergy by blocking B7 and early T cell
costimulatory molecule ETC-1/B7-2
JOURNAL Immunity 1 (2), 147-154 (1994)
PUBMED 7534198
REFERENCE 8 (residues 1 to 74)
AUTHORS Kirchhoff C.
TITLE A major messenger ribonucleic acid of the rodent epididymis encodes
a small glycosylphosphatidylinositol-anchored lymphocyte surface
antigen
JOURNAL Biol Reprod 50 (4), 896-902 (1994)
PUBMED 7515288
REFERENCE 9 (residues 1 to 74)
AUTHORS Hemmerich P, von Mikecz A, Neumann F, Sozeri O, Wolff-Vorbeck G,
Zoebelein R and Krawinkel U.
TITLE Structural and functional properties of ribosomal protein L7 from
humans and rodents
JOURNAL Nucleic Acids Res 21 (2), 223-231 (1993)
PUBMED 8441630
REFERENCE 10 (residues 1 to 74)
AUTHORS Kubota H, Okazaki H, Onuma M, Kano S, Hattori M and Minato N.
TITLE Identification and gene cloning of a new
phosphatidylinositol-linked antigen expressed on mature
lymphocytes. Down-regulation by lymphocyte activation
JOURNAL J Immunol 145 (11), 3924-3931 (1990)
PUBMED 2147207
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK155728.1 and BC027495.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AI021439.1, AK155728.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN00849383
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..74
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="4"
/map="4 66.5 cM"
Protein 1..74
/product="CAMPATH-1 antigen precursor"
/note="CAMPATH-1 antigen; lymphocyte differentiation
antigen B7"
/calculated_mol_wt=5225
sig_peptide 1..23
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q64389.1)"
/calculated_mol_wt=2591
mat_peptide 24..47
/product="CAMPATH-1 antigen. /id=PRO_0000020908"
/note="propagated from UniProtKB/Swiss-Prot (Q64389.1)"
/calculated_mol_wt=2380
Region 26..47
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q64389.1)"
Site 36
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q64389.1)"
Region 37..74
/region_name="CD52"
/note="CAMPATH-1 antigen; pfam15116"
/db_xref="CDD:434472"
CDS 1..74
/gene="Cd52"
/gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
/coded_by="NM_013706.2:90..314"
/db_xref="CCDS:CCDS38909.1"
/db_xref="GeneID:23833"
/db_xref="MGI:MGI:1346088"
ORIGIN
1 mksfllflti illvviqiqt gslgqattaa sgtnknstst kktplksgas siidagacsf
61 lffantlmcl fyls
//
