LOCUS       NP_041242                721 aa            linear   VRL 13-AUG-2018
DEFINITION  nonstructural protein [Minute virus of mice].
ACCESSION   NP_041242
VERSION     NP_041242.1
DBLINK      BioProject: PRJNA485481
DBSOURCE    REFSEQ: accession NC_001510.1
KEYWORDS    RefSeq.
SOURCE      Minute virus of mice
  ORGANISM  Minute virus of mice
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Quintoviricetes; Piccovirales; Parvoviridae; Parvovirinae;
            Protoparvovirus; Protoparvovirus rodent1.
REFERENCE   1  (sites)
  AUTHORS   Morgan,W.R. and Ward,D.C.
  TITLE     Three splicing patterns are used to excise the small intron common
            to all minute virus of mice RNAs
  JOURNAL   J. Virol. 60 (3), 1170-1174 (1986)
   PUBMED   3783817
REFERENCE   2  (residues 1 to 721)
  AUTHORS   Astell,C.R., Gardiner,E.M. and Tattersall,P.
  TITLE     DNA sequence of the lymphotropic variant of minute virus of mice,
            MVM(i), and comparison with the DNA sequence of the fibrotropic
            prototype strain
  JOURNAL   J. Virol. 57 (2), 656-669 (1986)
   PUBMED   3502703
REFERENCE   3  (residues 1 to 721)
  AUTHORS   Astell,C.R., Thomson,M., Merchlinsky,M. and Ward,D.C.
  TITLE     The complete DNA sequence of minute virus of mice, an autonomous
            parvovirus
  JOURNAL   Nucleic Acids Res. 11 (4), 999-1018 (1983)
   PUBMED   6298737
REFERENCE   4  (residues 1 to 721)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2000) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAA67108.
            The parvoviridae family cantains two groups that infect mammalian
            hosts: (i) defective (helper-dependent) adeno-associated viruses,
            and (ii) autonomous (helper-independent) parvoviruses. MVM is a
            member of the latter group. Both groups have been demonstrated to
            package both plus and minus strands (in separate particles) of the
            ss-DNA genome, though the minus strand is more typically packaged
            in the latter group.
            The sequence below corresponds to the plus (+) strand, also
            referred to as the C-strand. The minus (-) strand is also referred
            to as the V-strand.
            The 3' and 5' termini both exhibit the potential for forming stable
            'fold-back' hairpins; these sequences appear to play a role in
            replication [1].
            The left and right halves of the genome encode two distinct, but
            overlapping transcriptional units. The transcripts can be
            summarized [1] (1 map unit (mu) = 51 bp):
               R1 (4.8 kb): 4.5 mu - 46 mu; 46+ mu - 95 mu
               R2 (3.3 kb): 4.5 mu - 10.7 mu; 38 mu - 46 mu; 46+ mu - 95 mu
               R3 (3.0 kb): 40 mu - 46 mu; 46+ mu - 95 mu
            R3 is the major transcript.
            There are two major open reading frames, both on the plus (or C)
            strand. The left side ORF (261-2279) probably encodes a non-capsid
            protein of 85 kd; the right side ORF probably encodes the viral
            capsid proteins, VP1 (or A, 83 kd), VP2 (or B, 64 kd), and VP3 (or
            C, 61 kd). But because of uncertainties about the precise splice
            points in the transcripts, the exact starts, stops and (possible)
            intron boundaries are not known.
            revision   4804     4870     a-65bp-a in [2]; aa in [1] [2]
            revises [1].
            [3]  sites; splice sites.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Minute virus of mice"
                     /strain="MVM(p)"
                     /db_xref="taxon:10794"
                     /lab_host="mouse l (variant A-9) cell"
     Protein         1..721
                     /product="nonstructural protein"
                     /calculated_mol_wt=81765
     Region          234..304
                     /region_name="PV_NSP1"
                     /note="Parvovirus non-structural protein 1; pfam12433"
                     /db_xref="CDD:403585"
     Region          326..596
                     /region_name="Parvo_NS1"
                     /note="Parvovirus non-structural protein NS1; pfam01057"
                     /db_xref="CDD:426020"
     Region          601..721
                     /region_name="DUF3580"
                     /note="Protein of unknown function (DUF3580); pfam12117"
                     /db_xref="CDD:288933"
     CDS             1..721
                     /gene="NS1"
                     /locus_tag="MMVgp1"
                     /coded_by="NC_001510.1:114..2279"
                     /note="putative"
                     /db_xref="GeneID:1489590"
ORIGIN      
        1 misgsgslnq gakrkwawfk vykqllksvt ylffhsvsrd aqkesnqltm agnaysdevl
       61 gatnwlkeks nqevfsfvfk nenvqlngkd igwnsykkel qedelkslqr gaettwdqse
      121 dmewettvde mtkkqvfifd slvkkclfev lntknifpgd vnwfvqhewg kdqgwhchvl
      181 iggkdfsqaq gkwwrrqlnv ywsrwlvtac nvqltpaeri klreiaedne wvtlltykhk
      241 qtkkdytkcv lfgnmiayyf ltkkkistsp prdggyflss dsgwktnflk egerhlvskl
      301 ytddmrpetv ettvttaqet krgriqtkke vsikttlkel vhkrvtsped wmmmqpdsyi
      361 emmaqpggen llkntleict ltlartktaf dlilekaets kltnfslpdt rtcrifafhg
      421 wnyvkvchai ccvlnrqggk rntvlfhgpa stgksiiaqa iaqavgnvgc ynaanvnfpf
      481 ndctnknliw veeagnfgqq vnqfkaicsg qtiridqkgk gskqieptpv imttnenitv
      541 vrigceerpe htqpirdrml nihlthtlpg dfglvdknew pmicawlvkn gyqstmasyc
      601 akwgkvpdws enwaepkvpt pinllgsars pfttpkstpl sqnyaltpla sdledlalep
      661 wstpntpvag taetqntgea gskacqdgql sptwseieed lracfgaepl kkdfseplnl
      721 d
//