GenomeNet

Database: RefSeq
Entry: NP_054878
LinkDB: NP_054878
Original site: NP_054878 
LOCUS       NP_054878               2564 aa            linear   PRI 25-DEC-2018
DEFINITION  histone-lysine N-methyltransferase SETD2 isoform 1 [Homo sapiens].
ACCESSION   NP_054878
VERSION     NP_054878.5
DBSOURCE    REFSEQ: accession NM_014159.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 2564)
  AUTHORS   Fang J, Huang Y, Mao G, Yang S, Rennert G, Gu L, Li H and Li GM.
  TITLE     Cancer-driving H3G34V/R/D mutations block H3K36 methylation and
            H3K36me3-MutSalpha interaction
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 115 (38), 9598-9603 (2018)
   PUBMED   30181289
  REMARK    GeneRIF: H3G34/R/V/D mutations impair the catalytic activity of
            SETD2 due to steric clashes that impede optimal SETD2-H3K36
            interaction promoting genome instability and tumorigenesis by
            inhibiting mismatch repair activity.
REFERENCE   2  (residues 1 to 2564)
  AUTHORS   Jiang C, He C, Wu Z, Li F and Xiao J.
  TITLE     Histone methyltransferase SETD2 regulates osteosarcoma cell growth
            and chemosensitivity by suppressing Wnt/beta-catenin signaling
  JOURNAL   Biochem. Biophys. Res. Commun. 502 (3), 382-388 (2018)
   PUBMED   29842882
  REMARK    GeneRIF: SETD2 regulates tumor growth and chemosensitivity of
            osteosarcoma. Overexpression of SETD2 significantly inhibited
            osteosarcoma cell growth in vitro and in vivo. Moreover, SETD2
            significantly enhanced cisplatin-induced apoptosis in osteosarcoma
            cells and inhibited cancer stem cell properties in OS cells.
            Erratum:[Biochem Biophys Res Commun. 2018 Sep 5;503(2):1178. PMID:
            29954602]
REFERENCE   3  (residues 1 to 2564)
  AUTHORS   Skucha A, Ebner J, Schmollerl J, Roth M, Eder T, Cesar-Razquin A,
            Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Muller
            AC, Gyorffy B, Vakoc CR, Valent P, Bennett KL, Zuber J,
            Superti-Furga G and Grebien F.
  TITLE     MLL-fusion-driven leukemia requires SETD2 to safeguard genomic
            integrity
  JOURNAL   Nat Commun 9 (1), 1983 (2018)
   PUBMED   29777171
  REMARK    GeneRIF: SETD2 is required to maintain high H3K79 di-methylation
            and MLL-AF9-binding to critical target genes, such as Hoxa9.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2564)
  AUTHORS   Chen Z, Raghoonundun C, Chen W, Zhang Y, Tang W, Fan X and Shi X.
  TITLE     SETD2 indicates favourable prognosis in gastric cancer and
            suppresses cancer cell proliferation, migration, and invasion
  JOURNAL   Biochem. Biophys. Res. Commun. 498 (3), 579-585 (2018)
   PUBMED   29522714
  REMARK    GeneRIF: SETD2 expression was decreased in gastric cancer.
            Low-level expression of SETD2 in patients was significantly
            correlated with poor prognosis. Overexpression of SETD2 inhibited
            proliferation, migration, and invasion significantly in Gastric
            Cancer cell lines.
REFERENCE   5  (residues 1 to 2564)
  AUTHORS   Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M,
            Pan Q, Han Y, Wang X, Li Q and Qin J.
  TITLE     Histone methyltransferase SETD2 modulates alternative splicing to
            inhibit intestinal tumorigenesis
  JOURNAL   J. Clin. Invest. 127 (9), 3375-3391 (2017)
   PUBMED   28825595
  REMARK    GeneRIF: SETD2 downregulation affects the alternative splicing of a
            subset of genes implicated in intestinal tumorigenesis
REFERENCE   6  (residues 1 to 2564)
  AUTHORS   Li M, Phatnani HP, Guan Z, Sage H, Greenleaf AL and Zhou P.
  TITLE     Solution structure of the Set2-Rpb1 interacting domain of human
            Set2 and its interaction with the hyperphosphorylated C-terminal
            domain of Rpb1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (49), 17636-17641 (2005)
   PUBMED   16314571
  REMARK    GeneRIF: solution structure of the Set2-Rpb1 interacting domain in
            human Set2 (hSRI domain).
REFERENCE   7  (residues 1 to 2564)
  AUTHORS   Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ,
            Huang QH and Chen Z.
  TITLE     Identification and characterization of a novel human histone H3
            lysine 36-specific methyltransferase
  JOURNAL   J. Biol. Chem. 280 (42), 35261-35271 (2005)
   PUBMED   16118227
  REMARK    GeneRIF: HYPB HMTase may coordinate histone methylation and
            transcriptional regulation in mammals
            GeneRIF: HYPB protein is a histone H3 lysine 36-specific
            methyltransferase that associates with hyperphosphorylated RNA
            polymerase II.
REFERENCE   8  (residues 1 to 2564)
  AUTHORS   Rega S, Stiewe T, Chang DI, Pollmeier B, Esche H, Bardenheuer W,
            Marquitan G and Putzer BM.
  TITLE     Identification of the full-length huntingtin- interacting protein
            p231HBP/HYPB as a DNA-binding factor
  JOURNAL   Mol. Cell. Neurosci. 18 (1), 68-79 (2001)
   PUBMED   11461154
REFERENCE   9  (residues 1 to 2564)
  AUTHORS   Passani LA, Bedford MT, Faber PW, McGinnis KM, Sharp AH, Gusella
            JF, Vonsattel JP and MacDonald ME.
  TITLE     Huntingtin's WW domain partners in Huntington's disease post-mortem
            brain fulfill genetic criteria for direct involvement in
            Huntington's disease pathogenesis
  JOURNAL   Hum. Mol. Genet. 9 (14), 2175-2182 (2000)
   PUBMED   10958656
REFERENCE   10 (residues 1 to 2564)
  AUTHORS   Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF and MacDonald
            ME.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum. Mol. Genet. 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA800082.1, BX649110.1,
            AK127782.1, BC117162.1, AY576987.1 and AI671342.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Aug 28, 2008 this sequence version replaced NP_054878.4.
            
            Summary: Huntington's disease (HD), a neurodegenerative disorder
            characterized by loss of striatal neurons, is caused by an
            expansion of a polyglutamine tract in the HD protein huntingtin.
            This gene encodes a protein belonging to a class of huntingtin
            interacting proteins characterized by WW motifs. This protein is a
            histone methyltransferase that is specific for lysine-36 of histone
            H3, and methylation of this residue is associated with active
            chromatin. This protein also contains a novel transcriptional
            activation domain and has been found associated with
            hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.128468.1,
                                           SRR1803612.178163.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     Protein         1..2564
                     /product="histone-lysine N-methyltransferase SETD2 isoform
                     1"
                     /EC_number="2.1.1.43"
                     /note="huntingtin interacting protein 1; SET domain
                     containing 2; histone-lysine N-methyltransferase SETD2;
                     huntingtin yeast partner B; lysine N-methyltransferase 3A;
                     huntingtin-interacting protein B; protein-lysine
                     N-methyltransferase SETD2"
                     /calculated_mol_wt=287467
     variation       1
                     /replace="l"
                     /db_xref="dbSNP:1003848255"
     variation       1
                     /replace="t"
                     /db_xref="dbSNP:1221828308"
     variation       3
                     /replace="e"
                     /db_xref="dbSNP:1410684482"
     variation       5
                     /replace="lq"
                     /db_xref="dbSNP:768486976"
     variation       6
                     /replace="l"
                     /db_xref="dbSNP:773983305"
     variation       7
                     /replace="*"
                     /db_xref="dbSNP:541943893"
     variation       7
                     /replace="-"
                     /db_xref="dbSNP:1281854919"
     variation       7
                     /replace="lqpq"
                     /db_xref="dbSNP:1316310273"
     variation       8
                     /replace="l"
                     /db_xref="dbSNP:1382765308"
     variation       8
                     /replace="p"
                     /db_xref="dbSNP:574613844"
     variation       8
                     /replace="qp"
                     /db_xref="dbSNP:779757186"
     variation       9
                     /replace="s"
                     /db_xref="dbSNP:1244597073"
     variation       10
                     /replace="l"
                     /db_xref="dbSNP:773221585"
     variation       11
                     /replace="t"
                     /db_xref="dbSNP:868177166"
     variation       13
                     /replace="g"
                     /db_xref="dbSNP:995684824"
     variation       14
                     /replace="i"
                     /db_xref="dbSNP:1435969797"
     variation       16
                     /replace="f"
                     /db_xref="dbSNP:1265402763"
     variation       17
                     /replace="d"
                     /db_xref="dbSNP:1435832395"
     variation       18
                     /replace="p"
                     /db_xref="dbSNP:1205378979"
     variation       22
                     /replace="n"
                     /db_xref="dbSNP:769869483"
     variation       22
                     /replace="t"
                     /db_xref="dbSNP:1325828910"
     variation       23
                     /replace="l"
                     /db_xref="dbSNP:892374525"
     variation       24
                     /replace="g"
                     /db_xref="dbSNP:1181685588"
     variation       27
                     /replace="-"
                     /db_xref="dbSNP:1169474201"
     variation       31
                     /replace="e"
                     /db_xref="dbSNP:919876748"
     variation       32
                     /replace="i"
                     /db_xref="dbSNP:1478318675"
     variation       32
                     /replace="v"
                     /db_xref="dbSNP:1170321784"
     variation       34
                     /replace="h"
                     /db_xref="dbSNP:1244194839"
     variation       35
                     /replace="m"
                     /db_xref="dbSNP:868820087"
     variation       36
                     /replace="r"
                     /db_xref="dbSNP:1442368577"
     variation       39
                     /replace="d"
                     /db_xref="dbSNP:1452927592"
     variation       44
                     /replace="l"
                     /db_xref="dbSNP:1311481935"
     variation       44
                     /replace="p"
                     /db_xref="dbSNP:1305989558"
     variation       44
                     /replace="s"
                     /db_xref="dbSNP:1257544813"
     variation       45
                     /replace="k"
                     /db_xref="dbSNP:753767436"
     variation       45
                     /replace="v"
                     /db_xref="dbSNP:568718208"
     variation       46
                     /replace="*"
                     /db_xref="dbSNP:754023019"
     variation       46
                     /replace="i"
                     /db_xref="dbSNP:763941922"
     variation       46
                     /replace="l"
                     /db_xref="dbSNP:1251864755"
     variation       47
                     /replace="r"
                     /db_xref="dbSNP:1317192082"
     variation       48
                     /replace="d"
                     /db_xref="dbSNP:760120112"
     variation       50
                     /replace="t"
                     /db_xref="dbSNP:191985301"
     variation       53
                     /replace="*"
                     /db_xref="dbSNP:1461772708"
     variation       53
                     /replace="q"
                     /db_xref="dbSNP:745499104"
     variation       60
                     /replace="r"
                     /db_xref="dbSNP:1340972697"
     variation       61
                     /replace="t"
                     /db_xref="dbSNP:1338671014"
     variation       62
                     /replace="e"
                     /db_xref="dbSNP:1454647589"
     variation       63
                     /replace="i"
                     /db_xref="dbSNP:1398215878"
     variation       68
                     /replace="q"
                     /db_xref="dbSNP:373562439"
     variation       68
                     /replace="r"
                     /db_xref="dbSNP:534514808"
     variation       70
                     /replace="*"
                     /db_xref="dbSNP:775039657"
     variation       71
                     /replace="*"
                     /db_xref="dbSNP:1422028846"
     variation       71
                     /replace="r"
                     /db_xref="dbSNP:1295276006"
     variation       72
                     /replace="k"
                     /db_xref="dbSNP:369799172"
     variation       72
                     /replace="r"
                     /db_xref="dbSNP:1161803180"
     variation       73
                     /replace="l"
                     /db_xref="dbSNP:778611476"
     variation       76
                     /replace="i"
                     /db_xref="dbSNP:587778670"
     variation       77
                     /replace="f"
                     /db_xref="dbSNP:955155710"
     variation       79
                     /replace="v"
                     /db_xref="dbSNP:1464543698"
     variation       81
                     /replace="r"
                     /db_xref="dbSNP:1437217362"
     variation       84
                     /replace="l"
                     /db_xref="dbSNP:774673756"
     variation       84
                     /replace="w"
                     /db_xref="dbSNP:1045286391"
     variation       87
                     /replace="k"
                     /db_xref="dbSNP:948019386"
     variation       88
                     /replace="y"
                     /db_xref="dbSNP:770312954"
     variation       89
                     /replace="f"
                     /db_xref="dbSNP:374799616"
     variation       90
                     /replace="t"
                     /db_xref="dbSNP:1399578353"
     variation       91
                     /replace="a"
                     /db_xref="dbSNP:1208991169"
     variation       91
                     /replace="v"
                     /db_xref="dbSNP:552025497"
     variation       94
                     /replace="s"
                     /db_xref="dbSNP:749621716"
     variation       96
                     /replace="-"
                     /db_xref="dbSNP:1339536204"
     variation       100
                     /replace="i"
                     /db_xref="dbSNP:781171183"
     variation       101
                     /replace="l"
                     /db_xref="dbSNP:1479757135"
     variation       101
                     /replace="s"
                     /db_xref="dbSNP:967692998"
     variation       103
                     /replace="s"
                     /db_xref="dbSNP:1285112235"
     variation       104
                     /replace="t"
                     /db_xref="dbSNP:539506462"
     variation       106
                     /replace="i"
                     /db_xref="dbSNP:918252164"
     variation       108
                     /replace="f"
                     /db_xref="dbSNP:1012522280"
     variation       110
                     /replace="i"
                     /db_xref="dbSNP:1374704193"
     variation       110
                     /replace="v"
                     /db_xref="dbSNP:1308648005"
     variation       112
                     /replace="l"
                     /db_xref="dbSNP:187767340"
     variation       112
                     /replace="s"
                     /db_xref="dbSNP:965088151"
     variation       119
                     /replace="q"
                     /db_xref="dbSNP:1356464887"
     variation       120
                     /replace="m"
                     /db_xref="dbSNP:1188177969"
     variation       121
                     /replace="d"
                     /db_xref="dbSNP:1321902987"
     variation       121
                     /replace="g"
                     /db_xref="dbSNP:770266108"
     variation       121
                     /replace="s"
                     /db_xref="dbSNP:912089138"
     variation       126
                     /replace="a"
                     /db_xref="dbSNP:1366595264"
     variation       126
                     /replace="i"
                     /db_xref="dbSNP:1474691499"
     variation       130
                     /replace="y"
                     /db_xref="dbSNP:550723354"
     variation       131
                     /replace="f"
                     /db_xref="dbSNP:1165951113"
     variation       131
                     /replace="s"
                     /db_xref="dbSNP:556549304"
     Site            131
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       132
                     /replace="l"
                     /db_xref="dbSNP:953669232"
     variation       132
                     /replace="p"
                     /db_xref="dbSNP:1035201331"
     variation       133
                     /replace="p"
                     /db_xref="dbSNP:1178691216"
     variation       133
                     /replace="s"
                     /db_xref="dbSNP:1379102709"
     variation       134
                     /replace="k"
                     /db_xref="dbSNP:748238773"
     variation       135
                     /replace="a"
                     /db_xref="dbSNP:1004079942"
     variation       137
                     /replace="g"
                     /db_xref="dbSNP:1268579419"
     variation       137
                     /replace="m"
                     /db_xref="dbSNP:886565042"
     variation       138
                     /replace="e"
                     /db_xref="dbSNP:1174705737"
     variation       139
                     /replace="l"
                     /db_xref="dbSNP:1197801795"
     variation       145
                     /replace="n"
                     /db_xref="dbSNP:749274416"
     variation       146
                     /replace="e"
                     /db_xref="dbSNP:1451896896"
     variation       150
                     /replace="h"
                     /db_xref="dbSNP:781462525"
     variation       150
                     /replace="r"
                     /db_xref="dbSNP:1293708012"
     variation       154
                     /replace="g"
                     /db_xref="dbSNP:1289020291"
     variation       157
                     /replace="v"
                     /db_xref="dbSNP:1352862970"
     variation       158
                     /replace="v"
                     /db_xref="dbSNP:994824638"
     variation       159
                     /replace="a"
                     /db_xref="dbSNP:369333306"
     variation       161
                     /replace="r"
                     /db_xref="dbSNP:1224403595"
     variation       162
                     /replace="t"
                     /db_xref="dbSNP:1375690681"
     variation       162
                     /replace="v"
                     /db_xref="dbSNP:1273240614"
     variation       164
                     /replace="t"
                     /db_xref="dbSNP:1436035298"
     variation       167
                     /replace="l"
                     /db_xref="dbSNP:78682369"
     variation       169
                     /replace="l"
                     /db_xref="dbSNP:1213559776"
     variation       170
                     /replace="a"
                     /db_xref="dbSNP:1346039676"
     variation       172
                     /replace="p"
                     /db_xref="dbSNP:1323241774"
     variation       173
                     /replace="s"
                     /db_xref="dbSNP:1038985708"
     variation       175
                     /replace="s"
                     /db_xref="dbSNP:561734692"
     variation       176
                     /replace="a"
                     /db_xref="dbSNP:1418308102"
     variation       179
                     /replace="e"
                     /db_xref="dbSNP:1299316630"
     variation       179
                     /replace="g"
                     /db_xref="dbSNP:1360418212"
     variation       180
                     /replace="a"
                     /db_xref="dbSNP:1318754770"
     variation       182
                     /replace="a"
                     /db_xref="dbSNP:1234107061"
     variation       183
                     /replace="a"
                     /db_xref="dbSNP:942631934"
     variation       184
                     /replace="n"
                     /db_xref="dbSNP:1024933229"
     variation       185
                     /replace="l"
                     /db_xref="dbSNP:757008196"
     variation       185
                     /replace="s"
                     /db_xref="dbSNP:1240029783"
     variation       186
                     /replace="a"
                     /db_xref="dbSNP:1401928631"
     variation       186
                     /replace="l"
                     /db_xref="dbSNP:78759480"
     variation       186
                     /replace="p"
                     /db_xref="dbSNP:183095591"
     variation       187
                     /replace="l"
                     /db_xref="dbSNP:906591354"
     variation       189
                     /replace="f"
                     /db_xref="dbSNP:1192272615"
     variation       190
                     /replace="l"
                     /db_xref="dbSNP:563907746"
     variation       190
                     /replace="p"
                     /db_xref="dbSNP:752167577"
     variation       190
                     /replace="s"
                     /db_xref="dbSNP:1270653793"
     variation       191
                     /replace="l"
                     /db_xref="dbSNP:1263797208"
     variation       191
                     /replace="p"
                     /db_xref="dbSNP:200665623"
     variation       192
                     /replace="s"
                     /db_xref="dbSNP:1217878686"
     variation       193
                     /replace="l"
                     /db_xref="dbSNP:77310684"
     variation       193
                     /replace="p"
                     /db_xref="dbSNP:113644970"
     variation       194
                     /replace="-"
                     /db_xref="dbSNP:764288610"
     variation       195
                     /replace="q"
                     /db_xref="dbSNP:1340365193"
     variation       197
                     /replace="v"
                     /db_xref="dbSNP:374950143"
     variation       198
                     /replace="k"
                     /db_xref="dbSNP:765963206"
     variation       199
                     /replace="v"
                     /db_xref="dbSNP:1398542713"
     variation       200
                     /replace="a"
                     /db_xref="dbSNP:1417679576"
     variation       200
                     /replace="i"
                     /db_xref="dbSNP:868796097"
     variation       201
                     /replace="a"
                     /db_xref="dbSNP:1460567034"
     variation       202
                     /replace="f"
                     /db_xref="dbSNP:763365671"
     variation       202
                     /replace="l"
                     /db_xref="dbSNP:773519273"
     variation       203
                     /replace="s"
                     /db_xref="dbSNP:1356881725"
     variation       204
                     /replace="s"
                     /db_xref="dbSNP:1279032648"
     variation       206
                     /replace="v"
                     /db_xref="dbSNP:1448903100"
     variation       208
                     /replace="v"
                     /db_xref="dbSNP:1174715079"
     variation       210
                     /replace="q"
                     /db_xref="dbSNP:888376502"
     variation       211
                     /replace="a"
                     /db_xref="dbSNP:1430967942"
     variation       212
                     /replace="m"
                     /db_xref="dbSNP:368670205"
     variation       213
                     /replace="g"
                     /db_xref="dbSNP:1292986984"
     variation       215
                     /replace="s"
                     /db_xref="dbSNP:748715138"
     variation       216
                     /replace="d"
                     /db_xref="dbSNP:777301899"
     variation       217
                     /replace="a"
                     /db_xref="dbSNP:752425225"
     variation       217
                     /replace="k"
                     /db_xref="dbSNP:1482249689"
     variation       217
                     /replace="t"
                     /db_xref="dbSNP:1172384580"
     variation       219
                     /replace="v"
                     /db_xref="dbSNP:1236885387"
     variation       222
                     /replace="i"
                     /db_xref="dbSNP:192262279"
     variation       222
                     /replace="p"
                     /db_xref="dbSNP:1235089560"
     variation       223
                     /replace="k"
                     /db_xref="dbSNP:1265222731"
     variation       223
                     /replace="v"
                     /db_xref="dbSNP:1461887229"
     variation       224
                     /replace="t"
                     /db_xref="dbSNP:1217051214"
     variation       225
                     /replace="v"
                     /db_xref="dbSNP:747088254"
     variation       226
                     /replace="p"
                     /db_xref="dbSNP:758679306"
     variation       226
                     /replace="s"
                     /db_xref="dbSNP:780963440"
     variation       227
                     /replace="l"
                     /db_xref="dbSNP:1377575776"
     variation       228
                     /replace="r"
                     /db_xref="dbSNP:780263835"
     variation       231
                     /replace="v"
                     /db_xref="dbSNP:1236994470"
     variation       232
                     /replace="a"
                     /db_xref="dbSNP:1452709845"
     variation       232
                     /replace="e"
                     /db_xref="dbSNP:918283160"
     variation       234
                     /replace="t"
                     /db_xref="dbSNP:758605231"
     variation       234
                     /replace="v"
                     /db_xref="dbSNP:1328781978"
     variation       235
                     /replace="a"
                     /db_xref="dbSNP:1464806533"
     variation       238
                     /replace="r"
                     /db_xref="dbSNP:1354852343"
     variation       239
                     /replace="k"
                     /db_xref="dbSNP:1212907318"
     variation       241
                     /replace="a"
                     /db_xref="dbSNP:1172245080"
     variation       242
                     /replace="p"
                     /db_xref="dbSNP:1412973640"
     variation       242
                     /replace="r"
                     /db_xref="dbSNP:1421879182"
     variation       244
                     /replace="v"
                     /db_xref="dbSNP:1184200918"
     variation       248
                     /replace="q"
                     /db_xref="dbSNP:990452788"
     variation       249
                     /replace="f"
                     /db_xref="dbSNP:1162661952"
     variation       249
                     /replace="p"
                     /db_xref="dbSNP:1404541560"
     variation       252
                     /replace="g"
                     /db_xref="dbSNP:1040670872"
     variation       252
                     /replace="t"
                     /db_xref="dbSNP:1445256311"
     variation       253
                     /replace="d"
                     /db_xref="dbSNP:1245051295"
     variation       255
                     /replace="k"
                     /db_xref="dbSNP:1330801240"
     variation       256
                     /replace="q"
                     /db_xref="dbSNP:1454793446"
     variation       256
                     /replace="r"
                     /db_xref="dbSNP:1229892824"
     variation       258
                     /replace="a"
                     /db_xref="dbSNP:1308113254"
     variation       258
                     /replace="i"
                     /db_xref="dbSNP:1378977369"
     variation       259
                     /replace="v"
                     /db_xref="dbSNP:750623264"
     variation       260
                     /replace="f"
                     /db_xref="dbSNP:1480415679"
     variation       261
                     /replace="d"
                     /db_xref="dbSNP:943821633"
     variation       262
                     /replace="n"
                     /db_xref="dbSNP:1035678045"
     variation       262
                     /replace="r"
                     /db_xref="dbSNP:544730198"
     variation       263
                     /replace="s"
                     /db_xref="dbSNP:982335553"
     variation       266
                     /replace="d"
                     /db_xref="dbSNP:1320353083"
     variation       266
                     /replace="h"
                     /db_xref="dbSNP:375614739"
     variation       267
                     /replace="i"
                     /db_xref="dbSNP:186148199"
     variation       268
                     /replace="i"
                     /db_xref="dbSNP:1384312268"
     variation       269
                     /replace="q"
                     /db_xref="dbSNP:986324149"
     variation       270
                     /replace="m"
                     /db_xref="dbSNP:777464814"
     variation       271
                     /replace="w"
                     /db_xref="dbSNP:1373568830"
     variation       273
                     /replace="k"
                     /db_xref="dbSNP:1299595121"
     variation       274
                     /replace="*"
                     /db_xref="dbSNP:869025571"
     variation       276
                     /replace="g"
                     /db_xref="dbSNP:1456190392"
     variation       277
                     /replace="t"
                     /db_xref="dbSNP:1349108254"
     variation       280
                     /replace="k"
                     /db_xref="dbSNP:932103061"
     variation       280
                     /replace="q"
                     /db_xref="dbSNP:994898155"
     variation       282
                     /replace="-"
                     /db_xref="dbSNP:749545814"
     variation       282
                     /replace="e"
                     /db_xref="dbSNP:1237678583"
     variation       282
                     /replace="g"
                     /db_xref="dbSNP:1205246100"
     variation       286
                     /replace="v"
                     /db_xref="dbSNP:1176819692"
     variation       287
                     /replace="r"
                     /db_xref="dbSNP:899226018"
     variation       290
                     /replace="k"
                     /db_xref="dbSNP:1251495125"
     variation       293
                     /replace="l"
                     /db_xref="dbSNP:1179868843"
     variation       294
                     /replace="v"
                     /db_xref="dbSNP:915409808"
     variation       295
                     /replace="g"
                     /db_xref="dbSNP:1179183570"
     variation       296
                     /replace="p"
                     /db_xref="dbSNP:1487671763"
     variation       297
                     /replace="n"
                     /db_xref="dbSNP:1223812732"
     variation       297
                     /replace="q"
                     /db_xref="dbSNP:761758668"
     variation       298
                     /replace="m"
                     /db_xref="dbSNP:1362195525"
     variation       300
                     /replace="m"
                     /db_xref="dbSNP:1169800340"
     variation       300
                     /replace="p"
                     /db_xref="dbSNP:1284559156"
     variation       303
                     /replace="e"
                     /db_xref="dbSNP:555732883"
     variation       303
                     /replace="k"
                     /db_xref="dbSNP:756020729"
     variation       304
                     /replace="n"
                     /db_xref="dbSNP:1384724360"
     variation       304
                     /replace="t"
                     /db_xref="dbSNP:534195879"
     variation       305
                     /replace="a"
                     /db_xref="dbSNP:1366599019"
     variation       305
                     /replace="t"
                     /db_xref="dbSNP:989764457"
     variation       306
                     /replace="s"
                     /db_xref="dbSNP:956929386"
     variation       307
                     /replace="y"
                     /db_xref="dbSNP:1303561180"
     variation       309
                     /replace="e"
                     /db_xref="dbSNP:1406585106"
     variation       309
                     /replace="t"
                     /db_xref="dbSNP:1358540257"
     variation       311
                     /replace="a"
                     /db_xref="dbSNP:573594314"
     variation       314
                     /replace="a"
                     /db_xref="dbSNP:1446042073"
     variation       316
                     /replace="d"
                     /db_xref="dbSNP:1158030524"
     variation       316
                     /replace="g"
                     /db_xref="dbSNP:1453073655"
     variation       317
                     /replace="v"
                     /db_xref="dbSNP:1363028179"
     variation       319
                     /replace="l"
                     /db_xref="dbSNP:1364463237"
     variation       319
                     /replace="v"
                     /db_xref="dbSNP:1007514570"
     variation       320
                     /replace="d"
                     /db_xref="dbSNP:1326993979"
     variation       320
                     /replace="g"
                     /db_xref="dbSNP:767471789"
     Site            321
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Site            323
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       324
                     /replace="n"
                     /db_xref="dbSNP:754382637"
     variation       329
                     /replace="q"
                     /db_xref="dbSNP:540015912"
     variation       329
                     /replace="r"
                     /db_xref="dbSNP:372869995"
     variation       330
                     /replace="t"
                     /db_xref="dbSNP:1278940315"
     variation       331
                     /replace="s"
                     /db_xref="dbSNP:1200564837"
     variation       332
                     /replace="s"
                     /db_xref="dbSNP:762557594"
     variation       333
                     /replace="r"
                     /db_xref="dbSNP:765649664"
     variation       336
                     /replace="s"
                     /db_xref="dbSNP:764441172"
     variation       337
                     /replace="h"
                     /db_xref="dbSNP:769297861"
     variation       337
                     /replace="r"
                     /db_xref="dbSNP:777214141"
     variation       338
                     /replace="n"
                     /db_xref="dbSNP:1230555956"
     variation       341
                     /replace="i"
                     /db_xref="dbSNP:1481483810"
     variation       344
                     /replace="n"
                     /db_xref="dbSNP:760794263"
     Site            344
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       347
                     /replace="k"
                     /db_xref="dbSNP:902363390"
     variation       348
                     /replace="g"
                     /db_xref="dbSNP:1024103793"
     variation       348
                     /replace="g"
                     /db_xref="dbSNP:1371974950"
     variation       349
                     /replace="k"
                     /db_xref="dbSNP:1412997569"
     variation       350
                     /replace="e"
                     /db_xref="dbSNP:1283598835"
     variation       350
                     /replace="v"
                     /db_xref="dbSNP:1320463023"
     variation       354
                     /replace="s"
                     /db_xref="dbSNP:1225099104"
     variation       355
                     /replace="p"
                     /db_xref="dbSNP:1399765540"
     variation       356
                     /replace="g"
                     /db_xref="dbSNP:112268377"
     variation       357
                     /replace="s"
                     /db_xref="dbSNP:775499197"
     variation       361
                     /replace="g"
                     /db_xref="dbSNP:1297433738"
     variation       362
                     /replace="h"
                     /db_xref="dbSNP:1296937706"
     variation       363
                     /replace="l"
                     /db_xref="dbSNP:1042216833"
     variation       366
                     /replace="t"
                     /db_xref="dbSNP:1382740465"
     variation       368
                     /replace="q"
                     /db_xref="dbSNP:1385695873"
     variation       369
                     /replace="s"
                     /db_xref="dbSNP:1290684917"
     variation       372
                     /replace="e"
                     /db_xref="dbSNP:752743762"
     variation       374
                     /replace="v"
                     /db_xref="dbSNP:1428858409"
     variation       376
                     /replace="i"
                     /db_xref="dbSNP:1177496814"
     variation       376
                     /replace="n"
                     /db_xref="dbSNP:1274949240"
     variation       379
                     /replace="g"
                     /db_xref="dbSNP:761258214"
     variation       379
                     /replace="r"
                     /db_xref="dbSNP:772306607"
     variation       380
                     /replace="c"
                     /db_xref="dbSNP:1193056929"
     variation       381
                     /replace="a"
                     /db_xref="dbSNP:1285909011"
     variation       381
                     /replace="l"
                     /db_xref="dbSNP:746121346"
     variation       382
                     /replace="i"
                     /db_xref="dbSNP:1064796875"
     variation       383
                     /replace="l"
                     /db_xref="dbSNP:776053769"
     variation       383
                     /replace="r"
                     /db_xref="dbSNP:1264545105"
     variation       383
                     /replace="v"
                     /db_xref="dbSNP:1354211496"
     variation       384
                     /replace="e"
                     /db_xref="dbSNP:1263311477"
     variation       384
                     /replace="g"
                     /db_xref="dbSNP:1460529347"
     variation       384
                     /replace="k"
                     /db_xref="dbSNP:1260717819"
     variation       385
                     /replace="*"
                     /db_xref="dbSNP:1224970719"
     variation       385
                     /replace="t"
                     /db_xref="dbSNP:1012081309"
     variation       386
                     /replace="e"
                     /db_xref="dbSNP:1269401183"
     variation       386
                     /replace="g"
                     /db_xref="dbSNP:1315789205"
     variation       387
                     /replace="a"
                     /db_xref="dbSNP:1227947168"
     variation       387
                     /replace="i"
                     /db_xref="dbSNP:1328098829"
     variation       388
                     /replace="q"
                     /db_xref="dbSNP:1450528900"
     variation       388
                     /replace="w"
                     /db_xref="dbSNP:779126757"
     variation       389
                     /replace="y"
                     /db_xref="dbSNP:1405459683"
     variation       392
                     /replace="f"
                     /db_xref="dbSNP:769535379"
     variation       393
                     /replace="q"
                     /db_xref="dbSNP:888313435"
     variation       393
                     /replace="r"
                     /db_xref="dbSNP:914953594"
     variation       394
                     /replace="r"
                     /db_xref="dbSNP:368465960"
     variation       395
                     /replace="k"
                     /db_xref="dbSNP:937652837"
     variation       395
                     /replace="r"
                     /db_xref="dbSNP:994070888"
     variation       396
                     /replace="l"
                     /db_xref="dbSNP:1475982196"
     variation       396
                     /replace="s"
                     /db_xref="dbSNP:781096420"
     variation       398
                     /replace="r"
                     /db_xref="dbSNP:1387872740"
     variation       400
                     /replace="q"
                     /db_xref="dbSNP:1186063799"
     variation       400
                     /replace="r"
                     /db_xref="dbSNP:201148347"
     variation       401
                     /replace="q"
                     /db_xref="dbSNP:374918549"
     variation       402
                     /replace="q"
                     /db_xref="dbSNP:182736967"
     variation       402
                     /replace="w"
                     /db_xref="dbSNP:779483918"
     variation       403
                     /replace="n"
                     /db_xref="dbSNP:1196156010"
     variation       407
                     /replace="a"
                     /db_xref="dbSNP:1350669578"
     variation       407
                     /replace="c"
                     /db_xref="dbSNP:1341284759"
     variation       407
                     /replace="s"
                     /db_xref="dbSNP:1304718519"
     variation       412
                     /replace="v"
                     /db_xref="dbSNP:535540244"
     variation       413
                     /replace="c"
                     /db_xref="dbSNP:889546801"
     variation       413
                     /replace="p"
                     /db_xref="dbSNP:1234240400"
     variation       413
                     /replace="s"
                     /db_xref="dbSNP:1369169200"
     variation       414
                     /replace="g"
                     /db_xref="dbSNP:567935202"
     variation       414
                     /replace="k"
                     /db_xref="dbSNP:1382078518"
     variation       415
                     /replace="s"
                     /db_xref="dbSNP:1358117331"
     variation       416
                     /replace="d"
                     /db_xref="dbSNP:1315851590"
     variation       416
                     /replace="n"
                     /db_xref="dbSNP:1026910604"
     variation       416
                     /replace="s"
                     /db_xref="dbSNP:1049982695"
     variation       417
                     /replace="f"
                     /db_xref="dbSNP:1454697715"
     variation       418
                     /replace="c"
                     /db_xref="dbSNP:867368102"
     variation       419
                     /replace="c"
                     /db_xref="dbSNP:546591954"
     variation       419
                     /replace="y"
                     /db_xref="dbSNP:1410821571"
     variation       421
                     /replace="r"
                     /db_xref="dbSNP:915441021"
     variation       421
                     /replace="w"
                     /db_xref="dbSNP:1399084180"
     Site            422
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       424
                     /replace="*"
                     /db_xref="dbSNP:1278528667"
     variation       424
                     /replace="q"
                     /db_xref="dbSNP:1424607930"
     variation       425
                     /replace="f"
                     /db_xref="dbSNP:973506863"
     variation       426
                     /replace="y"
                     /db_xref="dbSNP:1184046423"
     variation       427
                     /replace="n"
                     /db_xref="dbSNP:1386461954"
     variation       428
                     /replace="f"
                     /db_xref="dbSNP:963471471"
     variation       429
                     /replace="d"
                     /db_xref="dbSNP:989628930"
     variation       430
                     /replace="f"
                     /db_xref="dbSNP:1435980110"
     variation       432
                     /replace="c"
                     /db_xref="dbSNP:1017636782"
     variation       432
                     /replace="h"
                     /db_xref="dbSNP:762208680"
     variation       433
                     /replace="c"
                     /db_xref="dbSNP:528110877"
     variation       433
                     /replace="h"
                     /db_xref="dbSNP:764693453"
     variation       437
                     /replace="g"
                     /db_xref="dbSNP:1452527873"
     variation       437
                     /replace="r"
                     /db_xref="dbSNP:1221591455"
     variation       439
                     /replace="p"
                     /db_xref="dbSNP:1360046226"
     variation       441
                     /replace="g"
                     /db_xref="dbSNP:1293916143"
     variation       441
                     /replace="q"
                     /db_xref="dbSNP:1365305042"
     variation       442
                     /replace="e"
                     /db_xref="dbSNP:1248242508"
     variation       442
                     /replace="q"
                     /db_xref="dbSNP:1376917645"
     variation       443
                     /replace="r"
                     /db_xref="dbSNP:890436153"
     variation       444
                     /replace="a"
                     /db_xref="dbSNP:1348641495"
     variation       444
                     /replace="m"
                     /db_xref="dbSNP:1030309071"
     variation       444
                     /replace="t"
                     /db_xref="dbSNP:1443239882"
     variation       445
                     /replace="c"
                     /db_xref="dbSNP:1306620044"
     variation       445
                     /replace="l"
                     /db_xref="dbSNP:935586454"
     variation       447
                     /replace="f"
                     /db_xref="dbSNP:998524208"
     variation       448
                     /replace="q"
                     /db_xref="dbSNP:564020755"
     variation       448
                     /replace="r"
                     /db_xref="dbSNP:775613201"
     variation       448
                     /replace="w"
                     /db_xref="dbSNP:1245212934"
     variation       449
                     /replace="l"
                     /db_xref="dbSNP:747297425"
     variation       449
                     /replace="p"
                     /db_xref="dbSNP:1166081979"
     variation       449
                     /replace="t"
                     /db_xref="dbSNP:902395542"
     variation       451
                     /replace="a"
                     /db_xref="dbSNP:1042247978"
     variation       451
                     /replace="r"
                     /db_xref="dbSNP:202016239"
     variation       452
                     /replace="d"
                     /db_xref="dbSNP:1200406493"
     variation       456
                     /replace="g"
                     /db_xref="dbSNP:924158634"
     variation       456
                     /replace="q"
                     /db_xref="dbSNP:777476264"
     variation       459
                     /replace="a"
                     /db_xref="dbSNP:1406617602"
     variation       462
                     /replace="g"
                     /db_xref="dbSNP:1197061112"
     variation       464
                     /replace="-"
                     /db_xref="dbSNP:767615152"
     variation       464
                     /replace="e"
                     /db_xref="dbSNP:946528401"
     variation       465
                     /replace="f"
                     /db_xref="dbSNP:1470973719"
     variation       468
                     /replace="t"
                     /db_xref="dbSNP:368082274"
     variation       469
                     /replace="y"
                     /db_xref="dbSNP:770493452"
     variation       471
                     /replace="g"
                     /db_xref="dbSNP:759689866"
     variation       471
                     /replace="k"
                     /db_xref="dbSNP:191313431"
     variation       472
                     /replace="c"
                     /db_xref="dbSNP:771203643"
     variation       472
                     /replace="h"
                     /db_xref="dbSNP:201984344"
     variation       473
                     /replace="t"
                     /db_xref="dbSNP:781008481"
     variation       474
                     /replace="p"
                     /db_xref="dbSNP:1283676464"
     variation       475
                     /replace="s"
                     /db_xref="dbSNP:768620219"
     variation       476
                     /replace="d"
                     /db_xref="dbSNP:563150022"
     variation       476
                     /replace="l"
                     /db_xref="dbSNP:1328928245"
     variation       477
                     /replace="s"
                     /db_xref="dbSNP:746872915"
     variation       478
                     /replace="f"
                     /db_xref="dbSNP:780072755"
     variation       479
                     /replace="-"
                     /db_xref="dbSNP:762902757"
     variation       480
                     /replace="c"
                     /db_xref="dbSNP:1403870429"
     variation       482
                     /replace="d"
                     /db_xref="dbSNP:919469632"
     variation       483
                     /replace="l"
                     /db_xref="dbSNP:758201372"
     variation       483
                     /replace="v"
                     /db_xref="dbSNP:1346555298"
     variation       485
                     /replace="a"
                     /db_xref="dbSNP:1305422724"
     variation       485
                     /replace="t"
                     /db_xref="dbSNP:1429279896"
     variation       488
                     /replace="c"
                     /db_xref="dbSNP:757781388"
     variation       491
                     /replace="p"
                     /db_xref="dbSNP:749964774"
     variation       493
                     /replace="q"
                     /db_xref="dbSNP:757035494"
     variation       493
                     /replace="w"
                     /db_xref="dbSNP:778693117"
     variation       495
                     /replace="s"
                     /db_xref="dbSNP:1432654253"
     variation       495
                     /replace="y"
                     /db_xref="dbSNP:973577177"
     variation       498
                     /replace="e"
                     /db_xref="dbSNP:544331072"
     variation       498
                     /replace="v"
                     /db_xref="dbSNP:1220399210"
     variation       499
                     /replace="t"
                     /db_xref="dbSNP:764601835"
     variation       500
                     /replace="s"
                     /db_xref="dbSNP:963502617"
     variation       501
                     /replace="y"
                     /db_xref="dbSNP:910661629"
     variation       502
                     /replace="v"
                     /db_xref="dbSNP:756518934"
     variation       504
                     /replace="t"
                     /db_xref="dbSNP:986199418"
     variation       504
                     /replace="v"
                     /db_xref="dbSNP:753100818"
     variation       508
                     /replace="v"
                     /db_xref="dbSNP:768072239"
     variation       509
                     /replace="e"
                     /db_xref="dbSNP:1216851775"
     variation       511
                     /replace="s"
                     /db_xref="dbSNP:1448872145"
     variation       514
                     /replace="i"
                     /db_xref="dbSNP:574099059"
     variation       514
                     /replace="l"
                     /db_xref="dbSNP:774483658"
     variation       515
                     /replace="k"
                     /db_xref="dbSNP:1019451348"
     variation       517
                     /replace="e"
                     /db_xref="dbSNP:766558271"
     variation       519
                     /replace="k"
                     /db_xref="dbSNP:1361834704"
     variation       519
                     /replace="r"
                     /db_xref="dbSNP:763211343"
     variation       520
                     /replace="k"
                     /db_xref="dbSNP:377393336"
     variation       521
                     /replace="i"
                     /db_xref="dbSNP:1432277979"
     variation       525
                     /replace="a"
                     /db_xref="dbSNP:768299814"
     variation       526
                     /replace="t"
                     /db_xref="dbSNP:1335620465"
     variation       527
                     /replace="t"
                     /db_xref="dbSNP:769791652"
     variation       527
                     /replace="v"
                     /db_xref="dbSNP:373069098"
     variation       528
                     /replace="e"
                     /db_xref="dbSNP:1168018388"
     variation       529
                     /replace="k"
                     /db_xref="dbSNP:1427769897"
     variation       529
                     /replace="r"
                     /db_xref="dbSNP:772102331"
     variation       530
                     /replace="s"
                     /db_xref="dbSNP:527381545"
     variation       530
                     /replace="w"
                     /db_xref="dbSNP:998829034"
     variation       531
                     /replace="-"
                     /db_xref="dbSNP:773040363"
     variation       531
                     /replace="f"
                     /db_xref="dbSNP:374775442"
     Site            532
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       533
                     /replace="s"
                     /db_xref="dbSNP:1301833521"
     variation       534
                     /replace="a"
                     /db_xref="dbSNP:1241396966"
     variation       534
                     /replace="l"
                     /db_xref="dbSNP:1399887416"
     variation       534
                     /replace="p"
                     /db_xref="dbSNP:1183173051"
     variation       535
                     /replace="d"
                     /db_xref="dbSNP:778603109"
     variation       535
                     /replace="k"
                     /db_xref="dbSNP:777512115"
     variation       535
                     /replace="s"
                     /db_xref="dbSNP:756943490"
     variation       537
                     /replace="l"
                     /db_xref="dbSNP:756365871"
     variation       537
                     /replace="r"
                     /db_xref="dbSNP:753117350"
     variation       538
                     /replace="r"
                     /db_xref="dbSNP:1216856053"
     variation       539
                     /replace="s"
                     /db_xref="dbSNP:755551165"
     variation       539
                     /replace="v"
                     /db_xref="dbSNP:767907420"
     variation       540
                     /replace="*"
                     /db_xref="dbSNP:201756643"
     variation       540
                     /replace="q"
                     /db_xref="dbSNP:371758386"
     variation       541
                     /replace="q"
                     /db_xref="dbSNP:144677816"
     variation       543
                     /replace="s"
                     /db_xref="dbSNP:1240279359"
     variation       543
                     /replace="t"
                     /db_xref="dbSNP:1461245661"
     variation       544
                     /replace="s"
                     /db_xref="dbSNP:773360536"
     variation       545
                     /replace="c"
                     /db_xref="dbSNP:765512793"
     variation       548
                     /replace="r"
                     /db_xref="dbSNP:1422694442"
     variation       549
                     /replace="d"
                     /db_xref="dbSNP:1384588005"
     variation       550
                     /replace="g"
                     /db_xref="dbSNP:1183033223"
     variation       550
                     /replace="n"
                     /db_xref="dbSNP:1445389349"
     variation       552
                     /replace="t"
                     /db_xref="dbSNP:1258519174"
     variation       553
                     /replace="f"
                     /db_xref="dbSNP:1175719412"
     variation       554
                     /replace="c"
                     /db_xref="dbSNP:1010773470"
     variation       554
                     /replace="h"
                     /db_xref="dbSNP:375514539"
     variation       555
                     /replace="s"
                     /db_xref="dbSNP:573301881"
     variation       555
                     /replace="y"
                     /db_xref="dbSNP:775419238"
     variation       556
                     /replace="k"
                     /db_xref="dbSNP:1356347937"
     variation       557
                     /replace="f"
                     /db_xref="dbSNP:774448516"
     variation       557
                     /replace="p"
                     /db_xref="dbSNP:745846357"
     variation       559
                     /replace="p"
                     /db_xref="dbSNP:1246054299"
     variation       561
                     /replace="r"
                     /db_xref="dbSNP:770524703"
     variation       563
                     /replace="m"
                     /db_xref="dbSNP:777231957"
     variation       563
                     /replace="t"
                     /db_xref="dbSNP:202178837"
     variation       563
                     /replace="v"
                     /db_xref="dbSNP:587778668"
     variation       564
                     /replace="l"
                     /db_xref="dbSNP:748432550"
     variation       564
                     /replace="t"
                     /db_xref="dbSNP:755852190"
     variation       565
                     /replace="t"
                     /db_xref="dbSNP:1046489375"
     variation       568
                     /replace="k"
                     /db_xref="dbSNP:1364886050"
     variation       569
                     /replace="c"
                     /db_xref="dbSNP:781658728"
     variation       572
                     /replace="f"
                     /db_xref="dbSNP:1425320029"
     variation       572
                     /replace="p"
                     /db_xref="dbSNP:919540168"
     variation       573
                     /replace="s"
                     /db_xref="dbSNP:1037901055"
     variation       575
                     /replace="f"
                     /db_xref="dbSNP:755358803"
     variation       576
                     /replace="a"
                     /db_xref="dbSNP:1157124836"
     variation       576
                     /replace="i"
                     /db_xref="dbSNP:752022280"
     variation       576
                     /replace="t"
                     /db_xref="dbSNP:142972567"
     variation       577
                     /replace="d"
                     /db_xref="dbSNP:1184775247"
     variation       578
                     /replace="l"
                     /db_xref="dbSNP:138401612"
     variation       578
                     /replace="l"
                     /db_xref="dbSNP:942266422"
     variation       579
                     /replace="i"
                     /db_xref="dbSNP:558486080"
     variation       582
                     /replace="i"
                     /db_xref="dbSNP:1359595763"
     variation       583
                     /replace="e"
                     /db_xref="dbSNP:1417791379"
     variation       583
                     /replace="k"
                     /db_xref="dbSNP:765371082"
     variation       585
                     /replace="s"
                     /db_xref="dbSNP:1368468789"
     variation       586
                     /replace="r"
                     /db_xref="dbSNP:1386257292"
     variation       587
                     /replace="y"
                     /db_xref="dbSNP:1299511576"
     variation       589
                     /replace="g"
                     /db_xref="dbSNP:762131763"
     variation       589
                     /replace="s"
                     /db_xref="dbSNP:1489152740"
     variation       590
                     /replace="s"
                     /db_xref="dbSNP:1258459428"
     variation       592
                     /replace="k"
                     /db_xref="dbSNP:115569620"
     variation       593
                     /replace="r"
                     /db_xref="dbSNP:1317109866"
     variation       595
                     /replace="s"
                     /db_xref="dbSNP:1308785276"
     variation       597
                     /replace="a"
                     /db_xref="dbSNP:774362891"
     variation       597
                     /replace="s"
                     /db_xref="dbSNP:759435874"
     variation       599
                     /replace="k"
                     /db_xref="dbSNP:1303623813"
     variation       600
                     /replace="v"
                     /db_xref="dbSNP:372547666"
     variation       602
                     /replace="r"
                     /db_xref="dbSNP:949650635"
     variation       605
                     /replace="t"
                     /db_xref="dbSNP:1382756465"
     variation       606
                     /replace="d"
                     /db_xref="dbSNP:1287155457"
     variation       606
                     /replace="n"
                     /db_xref="dbSNP:762537562"
     variation       607
                     /replace="a"
                     /db_xref="dbSNP:1345996475"
     variation       611
                     /replace="k"
                     /db_xref="dbSNP:575862721"
     variation       612
                     /replace="a"
                     /db_xref="dbSNP:1479622345"
     variation       614
                     /replace="f"
                     /db_xref="dbSNP:768946699"
     variation       614
                     /replace="p"
                     /db_xref="dbSNP:780739486"
     Site            614
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       615
                     /replace="l"
                     /db_xref="dbSNP:1435404664"
     variation       616
                     /replace="a"
                     /db_xref="dbSNP:1178792751"
     variation       616
                     /replace="p"
                     /db_xref="dbSNP:747391146"
     variation       617
                     /replace="l"
                     /db_xref="dbSNP:758973573"
     variation       617
                     /replace="s"
                     /db_xref="dbSNP:372521251"
     variation       618
                     /replace="*"
                     /db_xref="dbSNP:750437096"
     variation       619
                     /replace="d"
                     /db_xref="dbSNP:1398723100"
     variation       620
                     /replace="l"
                     /db_xref="dbSNP:1322499901"
     variation       620
                     /replace="r"
                     /db_xref="dbSNP:148810823"
     variation       622
                     /replace="n"
                     /db_xref="dbSNP:116736613"
     variation       623
                     /replace="e"
                     /db_xref="dbSNP:1235190689"
     variation       624
                     /replace="t"
                     /db_xref="dbSNP:1324611364"
     Site            624
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       625
                     /replace="h"
                     /db_xref="dbSNP:923379270"
     variation       626
                     /replace="p"
                     /db_xref="dbSNP:1291887355"
     variation       626
                     /replace="s"
                     /db_xref="dbSNP:1294840523"
     Site            626
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       628
                     /replace="k"
                     /db_xref="dbSNP:764415786"
     variation       629
                     /replace="e"
                     /db_xref="dbSNP:145650484"
     variation       630
                     /replace="v"
                     /db_xref="dbSNP:967358278"
     variation       631
                     /replace="d"
                     /db_xref="dbSNP:763035822"
     variation       631
                     /replace="g"
                     /db_xref="dbSNP:751456809"
     variation       633
                     /replace="-"
                     /db_xref="dbSNP:1467963430"
     variation       634
                     /replace="s"
                     /db_xref="dbSNP:773046699"
     variation       635
                     /replace="i"
                     /db_xref="dbSNP:1020906898"
     variation       635
                     /replace="v"
                     /db_xref="dbSNP:147609782"
     variation       637
                     /replace="e"
                     /db_xref="dbSNP:1375222452"
     variation       638
                     /replace="s"
                     /db_xref="dbSNP:1371836213"
     variation       639
                     /replace="k"
                     /db_xref="dbSNP:761234986"
     variation       640
                     /replace="s"
                     /db_xref="dbSNP:952813382"
     variation       641
                     /replace="t"
                     /db_xref="dbSNP:1428527882"
     variation       643
                     /replace="h"
                     /db_xref="dbSNP:1181265083"
     variation       643
                     /replace="r"
                     /db_xref="dbSNP:776293901"
     variation       646
                     /replace="h"
                     /db_xref="dbSNP:369288116"
     variation       646
                     /replace="y"
                     /db_xref="dbSNP:768359461"
     variation       647
                     /replace="g"
                     /db_xref="dbSNP:780434002"
     variation       652
                     /replace="v"
                     /db_xref="dbSNP:1458709475"
     variation       654
                     /replace="p"
                     /db_xref="dbSNP:778937897"
     variation       656
                     /replace="s"
                     /db_xref="dbSNP:772543414"
     variation       657
                     /replace="e"
                     /db_xref="dbSNP:972544011"
     variation       660
                     /replace="s"
                     /db_xref="dbSNP:746332658"
     variation       662
                     /replace="q"
                     /db_xref="dbSNP:146562413"
     variation       663
                     /replace="v"
                     /db_xref="dbSNP:1183408470"
     variation       664
                     /replace="s"
                     /db_xref="dbSNP:757294853"
     variation       667
                     /replace="f"
                     /db_xref="dbSNP:749340235"
     variation       668
                     /replace="a"
                     /db_xref="dbSNP:1423191971"
     variation       668
                     /replace="h"
                     /db_xref="dbSNP:1019436227"
     variation       668
                     /replace="p"
                     /db_xref="dbSNP:778126699"
     variation       669
                     /replace="t"
                     /db_xref="dbSNP:1008589604"
     variation       670
                     /replace="g"
                     /db_xref="dbSNP:1394795747"
     variation       670
                     /replace="k"
                     /db_xref="dbSNP:374976472"
     variation       675
                     /replace="e"
                     /db_xref="dbSNP:568134733"
     variation       675
                     /replace="g"
                     /db_xref="dbSNP:1462921281"
     variation       677
                     /replace="l"
                     /db_xref="dbSNP:766229574"
     variation       677
                     /replace="l"
                     /db_xref="dbSNP:869025572"
     variation       677
                     /replace="p"
                     /db_xref="dbSNP:906313269"
     variation       677
                     /replace="s"
                     /db_xref="dbSNP:764219907"
     variation       678
                     /replace="r"
                     /db_xref="dbSNP:145499611"
     variation       679
                     /replace="v"
                     /db_xref="dbSNP:750308104"
     variation       680
                     /replace="e"
                     /db_xref="dbSNP:374447180"
     variation       680
                     /replace="g"
                     /db_xref="dbSNP:1189208237"
     variation       683
                     /replace="l"
                     /db_xref="dbSNP:1196200001"
     variation       683
                     /replace="v"
                     /db_xref="dbSNP:1249594991"
     variation       684
                     /replace="t"
                     /db_xref="dbSNP:1234726555"
     variation       686
                     /replace="l"
                     /db_xref="dbSNP:1303815832"
     variation       688
                     /replace="s"
                     /db_xref="dbSNP:761377537"
     variation       690
                     /replace="r"
                     /db_xref="dbSNP:1289576507"
     variation       691
                     /replace="i"
                     /db_xref="dbSNP:371953347"
     variation       693
                     /replace="g"
                     /db_xref="dbSNP:1358821524"
     variation       696
                     /replace="v"
                     /db_xref="dbSNP:1284939260"
     variation       698
                     /replace="f"
                     /db_xref="dbSNP:760367394"
     variation       698
                     /replace="p"
                     /db_xref="dbSNP:763707504"
     variation       698
                     /replace="y"
                     /db_xref="dbSNP:765018349"
     Site            698
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       699
                     /replace="g"
                     /db_xref="dbSNP:368132877"
     variation       700
                     /replace="a"
                     /db_xref="dbSNP:1328580846"
     variation       700
                     /replace="d"
                     /db_xref="dbSNP:775142324"
     variation       702
                     /replace="m"
                     /db_xref="dbSNP:1372945920"
     variation       702
                     /replace="v"
                     /db_xref="dbSNP:1292129571"
     variation       704
                     /replace="e"
                     /db_xref="dbSNP:1301843971"
     variation       704
                     /replace="g"
                     /db_xref="dbSNP:377002134"
     variation       705
                     /replace="a"
                     /db_xref="dbSNP:746219041"
     variation       705
                     /replace="l"
                     /db_xref="dbSNP:552010664"
     variation       705
                     /replace="s"
                     /db_xref="dbSNP:771398677"
     variation       707
                     /replace="f"
                     /db_xref="dbSNP:1362910690"
     variation       708
                     /replace="f"
                     /db_xref="dbSNP:200185785"
     Site            708
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       710
                     /replace="s"
                     /db_xref="dbSNP:1046543806"
     variation       711
                     /replace="v"
                     /db_xref="dbSNP:749379736"
     variation       712
                     /replace="e"
                     /db_xref="dbSNP:1425661679"
     variation       713
                     /replace="a"
                     /db_xref="dbSNP:753222651"
     variation       713
                     /replace="t"
                     /db_xref="dbSNP:1478213869"
     variation       715
                     /replace="t"
                     /db_xref="dbSNP:748343070"
     variation       716
                     /replace="p"
                     /db_xref="dbSNP:781569078"
     variation       717
                     /replace="s"
                     /db_xref="dbSNP:758155750"
     variation       719
                     /replace="d"
                     /db_xref="dbSNP:115859828"
     variation       719
                     /replace="s"
                     /db_xref="dbSNP:376303182"
     variation       722
                     /replace="p"
                     /db_xref="dbSNP:1348798660"
     variation       726
                     /replace="g"
                     /db_xref="dbSNP:757184844"
     variation       728
                     /replace="e"
                     /db_xref="dbSNP:1229325454"
     variation       730
                     /replace="e"
                     /db_xref="dbSNP:759927194"
     variation       731
                     /replace="d"
                     /db_xref="dbSNP:763544216"
     variation       731
                     /replace="y"
                     /db_xref="dbSNP:933495344"
     variation       732
                     /replace="l"
                     /db_xref="dbSNP:760205909"
     variation       734
                     /replace="a"
                     /db_xref="dbSNP:923377367"
     variation       735
                     /replace="a"
                     /db_xref="dbSNP:775054001"
     variation       735
                     /replace="i"
                     /db_xref="dbSNP:1324928449"
     variation       735
                     /replace="t"
                     /db_xref="dbSNP:1398507583"
     variation       737
                     /replace="t"
                     /db_xref="dbSNP:767089221"
     variation       738
                     /replace="l"
                     /db_xref="dbSNP:548377659"
     variation       739
                     /replace="r"
                     /db_xref="dbSNP:539008365"
     variation       742
                     /replace="a"
                     /db_xref="dbSNP:774644234"
     Site            744
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       746
                     /replace="l"
                     /db_xref="dbSNP:1341711015"
     variation       747
                     /replace="r"
                     /db_xref="dbSNP:771436044"
     variation       749
                     /replace="s"
                     /db_xref="dbSNP:749711127"
     variation       750
                     /replace="e"
                     /db_xref="dbSNP:114309972"
     variation       750
                     /replace="g"
                     /db_xref="dbSNP:1248447305"
     variation       750
                     /replace="k"
                     /db_xref="dbSNP:547767170"
     variation       751
                     /replace="r"
                     /db_xref="dbSNP:1283760445"
     variation       751
                     /replace="t"
                     /db_xref="dbSNP:115788094"
     variation       754
                     /replace="s"
                     /db_xref="dbSNP:745647650"
     Site            754
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       755
                     /replace="-"
                     /db_xref="dbSNP:1278879740"
     variation       755
                     /replace="r"
                     /db_xref="dbSNP:931275594"
     variation       755
                     /replace="s"
                     /db_xref="dbSNP:1336807817"
     variation       756
                     /replace="l"
                     /db_xref="dbSNP:1471812761"
     variation       758
                     /replace="n"
                     /db_xref="dbSNP:778626356"
     variation       759
                     /replace="e"
                     /db_xref="dbSNP:200479097"
     variation       760
                     /replace="i"
                     /db_xref="dbSNP:1311443196"
     variation       760
                     /replace="p"
                     /db_xref="dbSNP:115476851"
     variation       761
                     /replace="i"
                     /db_xref="dbSNP:188887061"
     variation       761
                     /replace="t"
                     /db_xref="dbSNP:1368899673"
     variation       763
                     /replace="l"
                     /db_xref="dbSNP:1427956806"
     variation       765
                     /replace="g"
                     /db_xref="dbSNP:1325359308"
     variation       766
                     /replace="t"
                     /db_xref="dbSNP:587778675"
     variation       766
                     /replace="v"
                     /db_xref="dbSNP:755560393"
     variation       767
                     /replace="a"
                     /db_xref="dbSNP:564476604"
     variation       768
                     /replace="m"
                     /db_xref="dbSNP:9311404"
     variation       769
                     /replace="g"
                     /db_xref="dbSNP:751928495"
     variation       771
                     /replace="c"
                     /db_xref="dbSNP:1427099928"
     variation       772
                     /replace="e"
                     /db_xref="dbSNP:142099709"
     variation       773
                     /replace="a"
                     /db_xref="dbSNP:116251336"
     variation       773
                     /replace="t"
                     /db_xref="dbSNP:773798410"
     variation       775
                     /replace="i"
                     /db_xref="dbSNP:770481865"
     variation       776
                     /replace="k"
                     /db_xref="dbSNP:1261564390"
     variation       776
                     /replace="t"
                     /db_xref="dbSNP:371122735"
     variation       777
                     /replace="d"
                     /db_xref="dbSNP:1433046877"
     variation       779
                     /replace="l"
                     /db_xref="dbSNP:754908370"
     variation       780
                     /replace="g"
                     /db_xref="dbSNP:1203428501"
     variation       781
                     /replace="r"
                     /db_xref="dbSNP:1313153861"
     variation       781
                     /replace="t"
                     /db_xref="dbSNP:776618418"
     variation       782
                     /replace="r"
                     /db_xref="dbSNP:747153225"
     variation       783
                     /replace="i"
                     /db_xref="dbSNP:1272088356"
     variation       786
                     /replace="r"
                     /db_xref="dbSNP:780351699"
     variation       787
                     /replace="t"
                     /db_xref="dbSNP:770560635"
     variation       788
                     /replace="t"
                     /db_xref="dbSNP:749091347"
     variation       789
                     /replace="e"
                     /db_xref="dbSNP:986626620"
     variation       791
                     /replace="a"
                     /db_xref="dbSNP:372386788"
     variation       792
                     /replace="d"
                     /db_xref="dbSNP:756110862"
     variation       793
                     /replace="v"
                     /db_xref="dbSNP:1448411812"
     variation       794
                     /replace="y"
                     /db_xref="dbSNP:762665011"
     variation       795
                     /replace="f"
                     /db_xref="dbSNP:1168186509"
     variation       795
                     /replace="r"
                     /db_xref="dbSNP:1360708174"
     variation       796
                     /replace="i"
                     /db_xref="dbSNP:1025206273"
     variation       797
                     /replace="l"
                     /db_xref="dbSNP:1028206043"
     variation       798
                     /replace="n"
                     /db_xref="dbSNP:115016437"
     variation       799
                     /replace="n"
                     /db_xref="dbSNP:367547253"
     variation       800
                     /replace="n"
                     /db_xref="dbSNP:1169288572"
     variation       801
                     /replace="n"
                     /db_xref="dbSNP:200127446"
     variation       801
                     /replace="s"
                     /db_xref="dbSNP:1241448462"
     variation       801
                     /replace="y"
                     /db_xref="dbSNP:1451479186"
     variation       802
                     /replace="r"
                     /db_xref="dbSNP:769273671"
     variation       804
                     /replace="l"
                     /db_xref="dbSNP:115937605"
     variation       805
                     /replace="y"
                     /db_xref="dbSNP:1226560181"
     variation       808
                     /replace="e"
                     /db_xref="dbSNP:1246149226"
     variation       811
                     /replace="d"
                     /db_xref="dbSNP:1015887716"
     variation       812
                     /replace="m"
                     /db_xref="dbSNP:750888033"
     variation       812
                     /replace="t"
                     /db_xref="dbSNP:537620848"
     variation       813
                     /replace="k"
                     /db_xref="dbSNP:765813019"
     variation       814
                     /replace="l"
                     /db_xref="dbSNP:370885797"
     variation       814
                     /replace="p"
                     /db_xref="dbSNP:1381395601"
     variation       814
                     /replace="t"
                     /db_xref="dbSNP:1229889888"
     variation       815
                     /replace="s"
                     /db_xref="dbSNP:777220690"
     variation       816
                     /replace="d"
                     /db_xref="dbSNP:375501235"
     variation       816
                     /replace="v"
                     /db_xref="dbSNP:1380944558"
     variation       817
                     /replace="r"
                     /db_xref="dbSNP:115023083"
     variation       817
                     /replace="v"
                     /db_xref="dbSNP:1296217973"
     variation       818
                     /replace="q"
                     /db_xref="dbSNP:772334379"
     variation       819
                     /replace="v"
                     /db_xref="dbSNP:182050321"
     variation       822
                     /replace="d"
                     /db_xref="dbSNP:749077434"
     variation       824
                     /replace="v"
                     /db_xref="dbSNP:1406422286"
     variation       826
                     /replace="s"
                     /db_xref="dbSNP:773031107"
     variation       828
                     /replace="r"
                     /db_xref="dbSNP:1383483450"
     variation       829
                     /replace="l"
                     /db_xref="dbSNP:769695762"
     variation       836
                     /replace="r"
                     /db_xref="dbSNP:747985166"
     variation       836
                     /replace="w"
                     /db_xref="dbSNP:142668029"
     variation       838
                     /replace="-"
                     /db_xref="dbSNP:1438269880"
     variation       839
                     /replace="g"
                     /db_xref="dbSNP:1441287639"
     variation       840
                     /replace="s"
                     /db_xref="dbSNP:570065365"
     variation       843
                     /replace="g"
                     /db_xref="dbSNP:746587896"
     variation       845
                     /replace="*"
                     /db_xref="dbSNP:201639149"
     variation       846
                     /replace="e"
                     /db_xref="dbSNP:1253096918"
     variation       846
                     /replace="i"
                     /db_xref="dbSNP:779569922"
     variation       847
                     /replace="f"
                     /db_xref="dbSNP:750799970"
     variation       847
                     /replace="s"
                     /db_xref="dbSNP:758169057"
     variation       848
                     /replace="v"
                     /db_xref="dbSNP:75248784"
     variation       849
                     /replace="f"
                     /db_xref="dbSNP:776511280"
     variation       849
                     /replace="r"
                     /db_xref="dbSNP:376422656"
     variation       850
                     /replace="a"
                     /db_xref="dbSNP:1222926375"
     variation       850
                     /replace="d"
                     /db_xref="dbSNP:1350898375"
     variation       851
                     /replace="q"
                     /db_xref="dbSNP:946121334"
     variation       852
                     /replace="f"
                     /db_xref="dbSNP:373313188"
     variation       854
                     /replace="-"
                     /db_xref="dbSNP:895390359"
     variation       855
                     /replace="r"
                     /db_xref="dbSNP:1272627601"
     variation       856
                     /replace="i"
                     /db_xref="dbSNP:775705122"
     variation       857
                     /replace="a"
                     /db_xref="dbSNP:1341456599"
     variation       857
                     /replace="s"
                     /db_xref="dbSNP:767694898"
     variation       859
                     /replace="s"
                     /db_xref="dbSNP:587778669"
     variation       860
                     /replace="i"
                     /db_xref="dbSNP:1292988403"
     variation       862
                     /replace="v"
                     /db_xref="dbSNP:914619858"
     variation       863
                     /replace="f"
                     /db_xref="dbSNP:768463720"
     variation       863
                     /replace="s"
                     /db_xref="dbSNP:759801297"
     variation       866
                     /replace="-"
                     /db_xref="dbSNP:1459391594"
     variation       866
                     /replace="r"
                     /db_xref="dbSNP:774577710"
     variation       866
                     /replace="y"
                     /db_xref="dbSNP:1180147063"
     variation       867
                     /replace="s"
                     /db_xref="dbSNP:1472442239"
     variation       867
                     /replace="v"
                     /db_xref="dbSNP:1157218647"
     variation       868
                     /replace="g"
                     /db_xref="dbSNP:201752182"
     variation       870
                     /replace="l"
                     /db_xref="dbSNP:1184838235"
     variation       871
                     /replace="c"
                     /db_xref="dbSNP:1479731149"
     variation       872
                     /replace="h"
                     /db_xref="dbSNP:747990258"
     variation       873
                     /replace="l"
                     /db_xref="dbSNP:937315949"
     variation       873
                     /replace="p"
                     /db_xref="dbSNP:776420348"
     variation       874
                     /replace="t"
                     /db_xref="dbSNP:779894694"
     variation       874
                     /replace="v"
                     /db_xref="dbSNP:1191265072"
     variation       875
                     /replace="e"
                     /db_xref="dbSNP:746474322"
     variation       878
                     /replace="g"
                     /db_xref="dbSNP:779763630"
     variation       878
                     /replace="r"
                     /db_xref="dbSNP:587778671"
     variation       879
                     /replace="t"
                     /db_xref="dbSNP:145246350"
     variation       880
                     /replace="a"
                     /db_xref="dbSNP:1252783917"
     variation       881
                     /replace="s"
                     /db_xref="dbSNP:1218894136"
     variation       883
                     /replace="f"
                     /db_xref="dbSNP:1269748231"
     variation       884
                     /replace="h"
                     /db_xref="dbSNP:369914066"
     variation       886
                     /replace="f"
                     /db_xref="dbSNP:1344783832"
     variation       886
                     /replace="p"
                     /db_xref="dbSNP:745481079"
     variation       887
                     /replace="p"
                     /db_xref="dbSNP:778709463"
     variation       888
                     /replace="s"
                     /db_xref="dbSNP:1273088485"
     variation       890
                     /replace="v"
                     /db_xref="dbSNP:1194789958"
     variation       892
                     /replace="l"
                     /db_xref="dbSNP:757635668"
     variation       894
                     /replace="i"
                     /db_xref="dbSNP:1292587456"
     variation       895
                     /replace="l"
                     /db_xref="dbSNP:1456888374"
     variation       895
                     /replace="v"
                     /db_xref="dbSNP:1287296292"
     variation       896
                     /replace="s"
                     /db_xref="dbSNP:1339462307"
     variation       897
                     /replace="f"
                     /db_xref="dbSNP:754282648"
     variation       897
                     /replace="l"
                     /db_xref="dbSNP:1468631729"
     variation       897
                     /replace="p"
                     /db_xref="dbSNP:1161810683"
     variation       899
                     /replace="k"
                     /db_xref="dbSNP:1377496437"
     variation       900
                     /replace="c"
                     /db_xref="dbSNP:370480746"
     variation       901
                     /replace="e"
                     /db_xref="dbSNP:1194240525"
     variation       901
                     /replace="r"
                     /db_xref="dbSNP:757476376"
     variation       902
                     /replace="e"
                     /db_xref="dbSNP:767535546"
     variation       902
                     /replace="q"
                     /db_xref="dbSNP:58906143"
     variation       904
                     /replace="i"
                     /db_xref="dbSNP:1369910266"
     variation       904
                     /replace="t"
                     /db_xref="dbSNP:759642122"
     variation       905
                     /replace="p"
                     /db_xref="dbSNP:587778676"
     variation       906
                     /replace="p"
                     /db_xref="dbSNP:774500085"
     variation       906
                     /replace="s"
                     /db_xref="dbSNP:940126759"
     variation       907
                     /replace="i"
                     /db_xref="dbSNP:556290891"
     variation       908
                     /replace="l"
                     /db_xref="dbSNP:1256470239"
     variation       908
                     /replace="r"
                     /db_xref="dbSNP:148490530"
     variation       910
                     /replace="a"
                     /db_xref="dbSNP:377041426"
     variation       910
                     /replace="t"
                     /db_xref="dbSNP:1305740068"
     variation       911
                     /replace="l"
                     /db_xref="dbSNP:1396372237"
     variation       912
                     /replace="l"
                     /db_xref="dbSNP:776530966"
     variation       914
                     /replace="g"
                     /db_xref="dbSNP:768459098"
     variation       915
                     /replace="e"
                     /db_xref="dbSNP:941629399"
     variation       915
                     /replace="i"
                     /db_xref="dbSNP:1064793453"
     variation       917
                     /replace="r"
                     /db_xref="dbSNP:760615177"
     variation       918
                     /replace="s"
                     /db_xref="dbSNP:775603966"
     variation       919
                     /replace="g"
                     /db_xref="dbSNP:1173628730"
     variation       919
                     /replace="q"
                     /db_xref="dbSNP:1356564703"
     variation       922
                     /replace="k"
                     /db_xref="dbSNP:961811628"
     variation       923
                     /replace="y"
                     /db_xref="dbSNP:1015959894"
     variation       924
                     /replace="s"
                     /db_xref="dbSNP:1468000157"
     variation       924
                     /replace="v"
                     /db_xref="dbSNP:146058926"
     variation       925
                     /replace="g"
                     /db_xref="dbSNP:771644851"
     variation       926
                     /replace="e"
                     /db_xref="dbSNP:1167396235"
     variation       926
                     /replace="r"
                     /db_xref="dbSNP:1449614494"
     variation       928
                     /replace="r"
                     /db_xref="dbSNP:72895708"
     variation       929
                     /replace="l"
                     /db_xref="dbSNP:888768344"
     variation       929
                     /replace="t"
                     /db_xref="dbSNP:1441595298"
     variation       931
                     /replace="g"
                     /db_xref="dbSNP:770681498"
     variation       931
                     /replace="k"
                     /db_xref="dbSNP:368973698"
     variation       932
                     /replace="g"
                     /db_xref="dbSNP:778247125"
     variation       932
                     /replace="i"
                     /db_xref="dbSNP:141532143"
     variation       933
                     /replace="v"
                     /db_xref="dbSNP:202209141"
     variation       934
                     /replace="s"
                     /db_xref="dbSNP:1227675340"
     variation       934
                     /replace="s"
                     /db_xref="dbSNP:1342981365"
     variation       935
                     /replace="h"
                     /db_xref="dbSNP:1173677205"
     variation       936
                     /replace="p"
                     /db_xref="dbSNP:753162692"
     variation       937
                     /replace="s"
                     /db_xref="dbSNP:781674299"
     variation       938
                     /replace="g"
                     /db_xref="dbSNP:755037858"
     variation       938
                     /replace="n"
                     /db_xref="dbSNP:1024019408"
     variation       940
                     /replace="v"
                     /db_xref="dbSNP:751707090"
     variation       941
                     /replace="k"
                     /db_xref="dbSNP:766558333"
     variation       941
                     /replace="r"
                     /db_xref="dbSNP:1398213134"
     variation       942
                     /replace="r"
                     /db_xref="dbSNP:587778672"
     variation       944
                     /replace="a"
                     /db_xref="dbSNP:1429776306"
     variation       944
                     /replace="v"
                     /db_xref="dbSNP:763288798"
     variation       945
                     /replace="p"
                     /db_xref="dbSNP:1189906004"
     variation       947
                     /replace="v"
                     /db_xref="dbSNP:750635158"
     variation       949
                     /replace="m"
                     /db_xref="dbSNP:763914278"
     variation       949
                     /replace="r"
                     /db_xref="dbSNP:760395621"
     variation       950
                     /replace="c"
                     /db_xref="dbSNP:372092336"
     variation       950
                     /replace="h"
                     /db_xref="dbSNP:149265978"
     variation       951
                     /replace="d"
                     /db_xref="dbSNP:116474867"
     variation       952
                     /replace="k"
                     /db_xref="dbSNP:1250914215"
     variation       956
                     /replace="e"
                     /db_xref="dbSNP:774041503"
     variation       956
                     /replace="g"
                     /db_xref="dbSNP:770466394"
     variation       956
                     /replace="r"
                     /db_xref="dbSNP:1378974840"
     variation       957
                     /replace="k"
                     /db_xref="dbSNP:1037005354"
     variation       958
                     /replace="y"
                     /db_xref="dbSNP:748920060"
     variation       959
                     /replace="l"
                     /db_xref="dbSNP:748571014"
     variation       959
                     /replace="s"
                     /db_xref="dbSNP:777321885"
     variation       960
                     /replace="q"
                     /db_xref="dbSNP:1247352821"
     variation       961
                     /replace="d"
                     /db_xref="dbSNP:1349028638"
     variation       962
                     /replace="t"
                     /db_xref="dbSNP:1288231134"
     variation       964
                     /replace="g"
                     /db_xref="dbSNP:946193486"
     variation       965
                     /replace="-"
                     /db_xref="dbSNP:761511186"
     variation       965
                     /replace="g"
                     /db_xref="dbSNP:781662505"
     variation       968
                     /replace="s"
                     /db_xref="dbSNP:190619195"
     variation       971
                     /replace="r"
                     /db_xref="dbSNP:939989327"
     variation       972
                     /replace="q"
                     /db_xref="dbSNP:751617319"
     variation       973
                     /replace="g"
                     /db_xref="dbSNP:1390921555"
     variation       974
                     /replace="s"
                     /db_xref="dbSNP:780135291"
     variation       975
                     /replace="-"
                     /db_xref="dbSNP:776545135"
     variation       975
                     /replace="e"
                     /db_xref="dbSNP:758441915"
     variation       976
                     /replace="g"
                     /db_xref="dbSNP:115097110"
     variation       976
                     /replace="k"
                     /db_xref="dbSNP:1410996770"
     variation       979
                     /replace="i"
                     /db_xref="dbSNP:370019096"
     variation       981
                     /replace="s"
                     /db_xref="dbSNP:200569407"
     variation       983
                     /replace="a"
                     /db_xref="dbSNP:1266756746"
     variation       984
                     /replace="k"
                     /db_xref="dbSNP:765395599"
     variation       985
                     /replace="-"
                     /db_xref="dbSNP:1331923698"
     variation       985
                     /replace="g"
                     /db_xref="dbSNP:752601548"
     variation       985
                     /replace="r"
                     /db_xref="dbSNP:760501131"
     variation       986
                     /replace="-"
                     /db_xref="dbSNP:768398715"
     variation       986
                     /replace="e"
                     /db_xref="dbSNP:767527915"
     variation       986
                     /replace="g"
                     /db_xref="dbSNP:1211878184"
     variation       987
                     /replace="r"
                     /db_xref="dbSNP:759593227"
     variation       988
                     /replace="g"
                     /db_xref="dbSNP:201269290"
     variation       989
                     /replace="h"
                     /db_xref="dbSNP:1218055798"
     variation       990
                     /replace="a"
                     /db_xref="dbSNP:1211480425"
     variation       993
                     /replace="f"
                     /db_xref="dbSNP:1054527589"
     variation       993
                     /replace="s"
                     /db_xref="dbSNP:575258352"
     variation       994
                     /replace="e"
                     /db_xref="dbSNP:371777668"
     variation       995
                     /replace="d"
                     /db_xref="dbSNP:1435057121"
     variation       996
                     /replace="s"
                     /db_xref="dbSNP:772906890"
     variation       998
                     /replace="g"
                     /db_xref="dbSNP:769399537"
     variation       999
                     /replace="i"
                     /db_xref="dbSNP:1455286567"
     variation       999
                     /replace="v"
                     /db_xref="dbSNP:1387514420"
     variation       1001
                     /replace="c"
                     /db_xref="dbSNP:200816574"
     variation       1002
                     /replace="f"
                     /db_xref="dbSNP:184493846"
     variation       1004
                     /replace="e"
                     /db_xref="dbSNP:1458676359"
     variation       1008
                     /replace="nlt"
                     /db_xref="dbSNP:746695772"
     variation       1009
                     /replace="t"
                     /db_xref="dbSNP:114527197"
     variation       1010
                     /replace="d"
                     /db_xref="dbSNP:1171936694"
     variation       1010
                     /replace="g"
                     /db_xref="dbSNP:1422889241"
     variation       1013
                     /replace="g"
                     /db_xref="dbSNP:769034482"
     variation       1015
                     /replace="i"
                     /db_xref="dbSNP:747477368"
     variation       1017
                     /replace="y"
                     /db_xref="dbSNP:977090217"
     variation       1018
                     /replace="a"
                     /db_xref="dbSNP:192593730"
     variation       1018
                     /replace="v"
                     /db_xref="dbSNP:1169355620"
     variation       1020
                     /replace="r"
                     /db_xref="dbSNP:374159100"
     variation       1021
                     /replace="c"
                     /db_xref="dbSNP:780433204"
     variation       1021
                     /replace="y"
                     /db_xref="dbSNP:1046111474"
     variation       1022
                     /replace="d"
                     /db_xref="dbSNP:1331676012"
     variation       1022
                     /replace="v"
                     /db_xref="dbSNP:1209681501"
     variation       1023
                     /replace="c"
                     /db_xref="dbSNP:949335845"
     variation       1026
                     /replace="h"
                     /db_xref="dbSNP:564008173"
     variation       1027
                     /replace="a"
                     /db_xref="dbSNP:745989865"
     variation       1028
                     /replace="s"
                     /db_xref="dbSNP:542200700"
     variation       1029
                     /replace="d"
                     /db_xref="dbSNP:1024384980"
     variation       1029
                     /replace="k"
                     /db_xref="dbSNP:55704515"
     variation       1030
                     /replace="s"
                     /db_xref="dbSNP:991283507"
     variation       1031
                     /replace="a"
                     /db_xref="dbSNP:1440524307"
     variation       1033
                     /replace="a"
                     /db_xref="dbSNP:145759179"
     variation       1035
                     /replace="d"
                     /db_xref="dbSNP:1379635717"
     variation       1038
                     /replace="*"
                     /db_xref="dbSNP:115790187"
     variation       1038
                     /replace="h"
                     /db_xref="dbSNP:1241292221"
     variation       1039
                     /replace="p"
                     /db_xref="dbSNP:752515394"
     variation       1040
                     /replace="d"
                     /db_xref="dbSNP:1306690438"
     variation       1041
                     /replace="p"
                     /db_xref="dbSNP:540694850"
     variation       1042
                     /replace="p"
                     /db_xref="dbSNP:1315689255"
     variation       1044
                     /replace="c"
                     /db_xref="dbSNP:1320811857"
     variation       1044
                     /replace="n"
                     /db_xref="dbSNP:587778673"
     variation       1046
                     /replace="d"
                     /db_xref="dbSNP:199890800"
     variation       1047
                     /replace="g"
                     /db_xref="dbSNP:762521732"
     variation       1047
                     /replace="h"
                     /db_xref="dbSNP:766239670"
     variation       1048
                     /replace="k"
                     /db_xref="dbSNP:587778674"
     variation       1049
                     /replace="g"
                     /db_xref="dbSNP:373744856"
     variation       1049
                     /replace="n"
                     /db_xref="dbSNP:995603520"
     variation       1051
                     /replace="s"
                     /db_xref="dbSNP:1447738499"
     variation       1053
                     /replace="d"
                     /db_xref="dbSNP:1389719873"
     variation       1054
                     /replace="a"
                     /db_xref="dbSNP:772890749"
     variation       1055
                     /replace="g"
                     /db_xref="dbSNP:761407419"
     variation       1056
                     /replace="l"
                     /db_xref="dbSNP:776300341"
     variation       1056
                     /replace="s"
                     /db_xref="dbSNP:768944836"
     variation       1057
                     /replace="g"
                     /db_xref="dbSNP:189671317"
     variation       1058
                     /replace="d"
                     /db_xref="dbSNP:984522347"
     variation       1058
                     /replace="n"
                     /db_xref="dbSNP:764760126"
     variation       1059
                     /replace="n"
                     /db_xref="dbSNP:558262802"
     variation       1060
                     /replace="g"
                     /db_xref="dbSNP:1225457680"
     variation       1060
                     /replace="n"
                     /db_xref="dbSNP:953217480"
     variation       1061
                     /replace="i"
                     /db_xref="dbSNP:1177591994"
     variation       1062
                     /replace="q"
                     /db_xref="dbSNP:1397050140"
     variation       1065
                     /replace="c"
                     /db_xref="dbSNP:765867260"
     variation       1065
                     /replace="h"
                     /db_xref="dbSNP:745925708"
     variation       1066
                     /replace="l"
                     /db_xref="dbSNP:778906590"
     variation       1069
                     /replace="a"
                     /db_xref="dbSNP:1302035546"
     variation       1074
                     /replace="k"
                     /db_xref="dbSNP:757432733"
     variation       1075
                     /replace="q"
                     /db_xref="dbSNP:775096467"
     variation       1077
                     /replace="a"
                     /db_xref="dbSNP:114719990"
     variation       1079
                     /replace="l"
                     /db_xref="dbSNP:778145277"
     variation       1079
                     /replace="p"
                     /db_xref="dbSNP:754761739"
     variation       1080
                     /replace="i"
                     /db_xref="dbSNP:76208147"
     variation       1081
                     /replace="d"
                     /db_xref="dbSNP:766309787"
     variation       1081
                     /replace="k"
                     /db_xref="dbSNP:1447738037"
     variation       1082
                     /replace="e"
                     /db_xref="dbSNP:750397992"
     variation       1082
                     /replace="k"
                     /db_xref="dbSNP:764499297"
     variation       1083
                     /replace="a"
                     /db_xref="dbSNP:764690431"
     variation       1083
                     /replace="t"
                     /db_xref="dbSNP:80241480"
     variation       1084
                     /replace="n"
                     /db_xref="dbSNP:753435281"
     variation       1086
                     /replace="f"
                     /db_xref="dbSNP:1471434383"
     variation       1087
                     /replace="f"
                     /db_xref="dbSNP:1260151759"
     variation       1089
                     /replace="l"
                     /db_xref="dbSNP:536163785"
     variation       1089
                     /replace="w"
                     /db_xref="dbSNP:763434646"
     variation       1090
                     /replace="n"
                     /db_xref="dbSNP:772606528"
     variation       1091
                     /replace="g"
                     /db_xref="dbSNP:1206755591"
     variation       1092
                     /replace="q"
                     /db_xref="dbSNP:114327122"
     variation       1094
                     /replace="c"
                     /db_xref="dbSNP:200216964"
     variation       1094
                     /replace="y"
                     /db_xref="dbSNP:774952312"
     variation       1096
                     /replace="h"
                     /db_xref="dbSNP:1319571533"
     variation       1097
                     /replace="c"
                     /db_xref="dbSNP:146397596"
     variation       1097
                     /replace="h"
                     /db_xref="dbSNP:771066357"
     variation       1097
                     /replace="y"
                     /db_xref="dbSNP:778127046"
     Site            1098
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1100
                     /replace="h"
                     /db_xref="dbSNP:368080733"
     variation       1101
                     /replace="*"
                     /db_xref="dbSNP:547630365"
     variation       1102
                     /replace="k"
                     /db_xref="dbSNP:746798365"
     variation       1103
                     /replace="d"
                     /db_xref="dbSNP:1308698174"
     variation       1105
                     /replace="r"
                     /db_xref="dbSNP:905904627"
     variation       1106
                     /replace="l"
                     /db_xref="dbSNP:779666460"
     variation       1106
                     /replace="s"
                     /db_xref="dbSNP:750263551"
     variation       1107
                     /replace="d"
                     /db_xref="dbSNP:1474818213"
     variation       1107
                     /replace="k"
                     /db_xref="dbSNP:778838574"
     variation       1107
                     /replace="v"
                     /db_xref="dbSNP:756750206"
     variation       1108
                     /replace="p"
                     /db_xref="dbSNP:753416941"
     variation       1108
                     /replace="s"
                     /db_xref="dbSNP:763701176"
     variation       1111
                     /replace="p"
                     /db_xref="dbSNP:1178367705"
     variation       1111
                     /replace="y"
                     /db_xref="dbSNP:760289594"
     variation       1112
                     /replace="l"
                     /db_xref="dbSNP:1410754283"
     variation       1112
                     /replace="l"
                     /db_xref="dbSNP:1487228978"
     variation       1114
                     /replace="k"
                     /db_xref="dbSNP:1170003106"
     variation       1115
                     /replace="d"
                     /db_xref="dbSNP:1264445809"
     variation       1115
                     /replace="g"
                     /db_xref="dbSNP:1353181454"
     variation       1116
                     /replace="e"
                     /db_xref="dbSNP:775822353"
     variation       1120
                     /replace="v"
                     /db_xref="dbSNP:1314067079"
     variation       1121
                     /replace="t"
                     /db_xref="dbSNP:1336548478"
     variation       1122
                     /replace="n"
                     /db_xref="dbSNP:950088283"
     variation       1123
                     /replace="r"
                     /db_xref="dbSNP:899892285"
     variation       1124
                     /replace="p"
                     /db_xref="dbSNP:1317254716"
     variation       1124
                     /replace="v"
                     /db_xref="dbSNP:538871720"
     variation       1125
                     /replace="s"
                     /db_xref="dbSNP:767731111"
     variation       1126
                     /replace="l"
                     /db_xref="dbSNP:774939342"
     variation       1126
                     /replace="s"
                     /db_xref="dbSNP:759947163"
     variation       1128
                     /replace="s"
                     /db_xref="dbSNP:771624180"
     variation       1129
                     /replace="a"
                     /db_xref="dbSNP:570936794"
     variation       1130
                     /replace="k"
                     /db_xref="dbSNP:773475708"
     variation       1130
                     /replace="q"
                     /db_xref="dbSNP:1293115178"
     variation       1134
                     /replace="d"
                     /db_xref="dbSNP:1036217503"
     variation       1136
                     /replace="g"
                     /db_xref="dbSNP:1157394735"
     variation       1136
                     /replace="r"
                     /db_xref="dbSNP:1305587765"
     variation       1141
                     /replace="l"
                     /db_xref="dbSNP:142723093"
     variation       1141
                     /replace="p"
                     /db_xref="dbSNP:748281167"
     variation       1142
                     /replace="e"
                     /db_xref="dbSNP:1161942915"
     variation       1143
                     /replace="i"
                     /db_xref="dbSNP:370889511"
     variation       1144
                     /replace="f"
                     /db_xref="dbSNP:771866928"
     variation       1146
                     /replace="i"
                     /db_xref="dbSNP:1191319440"
     variation       1147
                     /replace="q"
                     /db_xref="dbSNP:201617976"
     variation       1147
                     /replace="r"
                     /db_xref="dbSNP:115323681"
     variation       1148
                     /replace="f"
                     /db_xref="dbSNP:141227139"
     variation       1149
                     /replace="n"
                     /db_xref="dbSNP:757222335"
     variation       1152
                     /replace="q"
                     /db_xref="dbSNP:1265515811"
     variation       1153
                     /replace="m"
                     /db_xref="dbSNP:1417600727"
     variation       1153
                     /replace="r"
                     /db_xref="dbSNP:200491606"
     variation       1154
                     /replace="g"
                     /db_xref="dbSNP:777213195"
     variation       1155
                     /replace="n"
                     /db_xref="dbSNP:6767907"
     variation       1156
                     /replace="c"
                     /db_xref="dbSNP:975806896"
     variation       1156
                     /replace="h"
                     /db_xref="dbSNP:752223546"
     variation       1157
                     /replace="l"
                     /db_xref="dbSNP:767211424"
     variation       1157
                     /replace="l"
                     /db_xref="dbSNP:966084677"
     variation       1159
                     /replace="k"
                     /db_xref="dbSNP:755283712"
     variation       1161
                     /replace="f"
                     /db_xref="dbSNP:752037107"
     variation       1162
                     /replace="-"
                     /db_xref="dbSNP:771730468"
     variation       1162
                     /replace="r"
                     /db_xref="dbSNP:1010506824"
     variation       1162
                     /replace="y"
                     /db_xref="dbSNP:137871492"
     variation       1163
                     /replace="a"
                     /db_xref="dbSNP:1269036911"
     variation       1165
                     /replace="n"
                     /db_xref="dbSNP:1359461709"
     variation       1166
                     /replace="h"
                     /db_xref="dbSNP:763506017"
     variation       1167
                     /replace="e"
                     /db_xref="dbSNP:1389881036"
     variation       1169
                     /replace="g"
                     /db_xref="dbSNP:1291041398"
     variation       1170
                     /replace="s"
                     /db_xref="dbSNP:148902202"
     variation       1171
                     /replace="a"
                     /db_xref="dbSNP:540476365"
     variation       1171
                     /replace="t"
                     /db_xref="dbSNP:756272793"
     variation       1173
                     /replace="h"
                     /db_xref="dbSNP:958493987"
     variation       1173
                     /replace="r"
                     /db_xref="dbSNP:765164967"
     variation       1175
                     /replace="g"
                     /db_xref="dbSNP:748175674"
     variation       1178
                     /replace="y"
                     /db_xref="dbSNP:761968547"
     variation       1182
                     /replace="g"
                     /db_xref="dbSNP:1387873251"
     variation       1182
                     /replace="r"
                     /db_xref="dbSNP:776708071"
     variation       1186
                     /replace="l"
                     /db_xref="dbSNP:1346882059"
     variation       1187
                     /replace="g"
                     /db_xref="dbSNP:1208712406"
     variation       1187
                     /replace="k"
                     /db_xref="dbSNP:1187563928"
     variation       1189
                     /replace="i"
                     /db_xref="dbSNP:768992405"
     variation       1189
                     /replace="t"
                     /db_xref="dbSNP:140803915"
     variation       1190
                     /replace="m"
                     /db_xref="dbSNP:1002109417"
     variation       1190
                     /replace="v"
                     /db_xref="dbSNP:1482877432"
     variation       1194
                     /replace="m"
                     /db_xref="dbSNP:1211620525"
     variation       1194
                     /replace="v"
                     /db_xref="dbSNP:541209644"
     variation       1196
                     /replace="p"
                     /db_xref="dbSNP:770731608"
     variation       1197
                     /replace="r"
                     /db_xref="dbSNP:1295633514"
     variation       1200
                     /replace="g"
                     /db_xref="dbSNP:1447697624"
     variation       1201
                     /replace="q"
                     /db_xref="dbSNP:749181159"
     variation       1202
                     /replace="p"
                     /db_xref="dbSNP:777689107"
     variation       1202
                     /replace="r"
                     /db_xref="dbSNP:746328084"
     variation       1203
                     /replace="p"
                     /db_xref="dbSNP:1298172077"
     variation       1204
                     /replace="m"
                     /db_xref="dbSNP:747750475"
     variation       1204
                     /replace="v"
                     /db_xref="dbSNP:554338477"
     variation       1205
                     /replace="c"
                     /db_xref="dbSNP:780702915"
     variation       1206
                     /replace="s"
                     /db_xref="dbSNP:1479130955"
     variation       1207
                     /replace="s"
                     /db_xref="dbSNP:577048438"
     variation       1208
                     /replace="g"
                     /db_xref="dbSNP:766811216"
     variation       1208
                     /replace="h"
                     /db_xref="dbSNP:755498169"
     variation       1209
                     /replace="v"
                     /db_xref="dbSNP:1024800098"
     variation       1210
                     /replace="g"
                     /db_xref="dbSNP:1419653252"
     variation       1211
                     /replace="g"
                     /db_xref="dbSNP:1165214835"
     variation       1213
                     /replace="p"
                     /db_xref="dbSNP:1449674315"
     variation       1213
                     /replace="r"
                     /db_xref="dbSNP:758840930"
     variation       1214
                     /replace="y"
                     /db_xref="dbSNP:201177499"
     variation       1217
                     /replace="c"
                     /db_xref="dbSNP:761799105"
     variation       1217
                     /replace="r"
                     /db_xref="dbSNP:765834098"
     variation       1219
                     /replace="h"
                     /db_xref="dbSNP:192144707"
     variation       1220
                     /replace="n"
                     /db_xref="dbSNP:764195998"
     variation       1221
                     /replace="a"
                     /db_xref="dbSNP:760833718"
     variation       1221
                     /replace="i"
                     /db_xref="dbSNP:775717127"
     variation       1222
                     /replace="s"
                     /db_xref="dbSNP:1272549575"
     variation       1223
                     /replace="h"
                     /db_xref="dbSNP:1204601057"
     variation       1223
                     /replace="r"
                     /db_xref="dbSNP:201973823"
     variation       1224
                     /replace="n"
                     /db_xref="dbSNP:1340321180"
     variation       1226
                     /replace="l"
                     /db_xref="dbSNP:776766535"
     variation       1226
                     /replace="t"
                     /db_xref="dbSNP:1253296900"
     variation       1227
                     /replace="e"
                     /db_xref="dbSNP:1340269021"
     variation       1228
                     /replace="g"
                     /db_xref="dbSNP:1294397889"
     Site            1228
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18220336,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1230
                     /replace="l"
                     /db_xref="dbSNP:749093231"
     variation       1231
                     /replace="r"
                     /db_xref="dbSNP:773007833"
     variation       1233
                     /replace="i"
                     /db_xref="dbSNP:769835535"
     variation       1235
                     /replace="l"
                     /db_xref="dbSNP:747580174"
     variation       1236
                     /replace="n"
                     /db_xref="dbSNP:1398117976"
     variation       1237
                     /replace="y"
                     /db_xref="dbSNP:780705204"
     variation       1238
                     /replace="f"
                     /db_xref="dbSNP:1206648592"
     variation       1239
                     /replace="s"
                     /db_xref="dbSNP:1457184637"
     variation       1241
                     /replace="s"
                     /db_xref="dbSNP:1036962729"
     variation       1242
                     /replace="e"
                     /db_xref="dbSNP:1368796686"
     variation       1244
                     /replace="l"
                     /db_xref="dbSNP:768083138"
     variation       1245
                     /replace="r"
                     /db_xref="dbSNP:554290065"
     variation       1246
                     /replace="g"
                     /db_xref="dbSNP:1471563665"
     variation       1248
                     /replace="d"
                     /db_xref="dbSNP:746595387"
     variation       1248
                     /replace="r"
                     /db_xref="dbSNP:955793443"
     variation       1250
                     /replace="r"
                     /db_xref="dbSNP:779867877"
     variation       1251
                     /replace="s"
                     /db_xref="dbSNP:758824937"
     variation       1252
                     /replace="t"
                     /db_xref="dbSNP:146583143"
     variation       1257
                     /replace="y"
                     /db_xref="dbSNP:750887950"
     variation       1259
                     /replace="d"
                     /db_xref="dbSNP:779260778"
     variation       1261
                     /replace="d"
                     /db_xref="dbSNP:764191157"
     variation       1261
                     /replace="g"
                     /db_xref="dbSNP:536512389"
     variation       1261
                     /replace="n"
                     /db_xref="dbSNP:1274173682"
     variation       1262
                     /replace="s"
                     /db_xref="dbSNP:1288288362"
     variation       1263
                     /replace="c"
                     /db_xref="dbSNP:760745679"
     variation       1263
                     /replace="s"
                     /db_xref="dbSNP:1180921502"
     variation       1265
                     /replace="g"
                     /db_xref="dbSNP:371514512"
     variation       1265
                     /replace="k"
                     /db_xref="dbSNP:1337050438"
     variation       1266
                     /replace="e"
                     /db_xref="dbSNP:767782860"
     variation       1266
                     /replace="r"
                     /db_xref="dbSNP:1385858883"
     variation       1267
                     /replace="l"
                     /db_xref="dbSNP:762731738"
     variation       1268
                     /replace="c"
                     /db_xref="dbSNP:773098323"
     variation       1269
                     /replace="s"
                     /db_xref="dbSNP:769596273"
     variation       1269
                     /replace="t"
                     /db_xref="dbSNP:761770347"
     variation       1270
                     /replace="a"
                     /db_xref="dbSNP:776438900"
     variation       1270
                     /replace="m"
                     /db_xref="dbSNP:752087228"
     variation       1270
                     /replace="t"
                     /db_xref="dbSNP:746577377"
     variation       1271
                     /replace="c"
                     /db_xref="dbSNP:779851402"
     variation       1271
                     /replace="h"
                     /db_xref="dbSNP:1196910580"
     variation       1272
                     /replace="*"
                     /db_xref="dbSNP:115542291"
     variation       1273
                     /replace="q"
                     /db_xref="dbSNP:746200523"
     variation       1274
                     /replace="p"
                     /db_xref="dbSNP:757597436"
     variation       1274
                     /replace="s"
                     /db_xref="dbSNP:779292384"
     variation       1276
                     /replace="n"
                     /db_xref="dbSNP:1224797626"
     variation       1276
                     /replace="s"
                     /db_xref="dbSNP:754307289"
     variation       1278
                     /replace="c"
                     /db_xref="dbSNP:778158607"
     variation       1278
                     /replace="h"
                     /db_xref="dbSNP:548734496"
     variation       1279
                     /replace="a"
                     /db_xref="dbSNP:756174508"
     variation       1280
                     /replace="s"
                     /db_xref="dbSNP:1371195167"
     variation       1281
                     /replace="c"
                     /db_xref="dbSNP:375236917"
     variation       1282
                     /replace="d"
                     /db_xref="dbSNP:767696758"
     variation       1284
                     /replace="h"
                     /db_xref="dbSNP:1438202150"
     variation       1284
                     /replace="r"
                     /db_xref="dbSNP:976218064"
     variation       1284
                     /replace="y"
                     /db_xref="dbSNP:1387669118"
     variation       1287
                     /replace="h"
                     /db_xref="dbSNP:542366860"
     variation       1290
                     /replace="a"
                     /db_xref="dbSNP:765015864"
     variation       1290
                     /replace="t"
                     /db_xref="dbSNP:759803434"
     variation       1290
                     /replace="v"
                     /db_xref="dbSNP:140549337"
     variation       1292
                     /replace="q"
                     /db_xref="dbSNP:776616575"
     variation       1292
                     /replace="r"
                     /db_xref="dbSNP:761525463"
     variation       1293
                     /replace="y"
                     /db_xref="dbSNP:368131294"
     variation       1294
                     /replace="r"
                     /db_xref="dbSNP:374230237"
     variation       1296
                     /replace="s"
                     /db_xref="dbSNP:148795337"
     variation       1297
                     /replace="c"
                     /db_xref="dbSNP:1000273506"
     variation       1297
                     /replace="h"
                     /db_xref="dbSNP:370953553"
     variation       1298
                     /replace="d"
                     /db_xref="dbSNP:1277127386"
     variation       1299
                     /replace="y"
                     /db_xref="dbSNP:150036725"
     variation       1302
                     /replace="d"
                     /db_xref="dbSNP:1348000790"
     variation       1303
                     /replace="n"
                     /db_xref="dbSNP:771272240"
     variation       1303
                     /replace="s"
                     /db_xref="dbSNP:574705730"
     variation       1304
                     /replace="d"
                     /db_xref="dbSNP:1270537136"
     variation       1304
                     /replace="s"
                     /db_xref="dbSNP:1364066394"
     variation       1305
                     /replace="y"
                     /db_xref="dbSNP:749674602"
     variation       1308
                     /replace="p"
                     /db_xref="dbSNP:778250055"
     variation       1312
                     /replace="g"
                     /db_xref="dbSNP:879086562"
     variation       1312
                     /replace="r"
                     /db_xref="dbSNP:756654781"
     variation       1314
                     /replace="-"
                     /db_xref="dbSNP:779291222"
     variation       1314
                     /replace="a"
                     /db_xref="dbSNP:377488968"
     variation       1314
                     /replace="l"
                     /db_xref="dbSNP:1429220590"
     variation       1315
                     /replace="v"
                     /db_xref="dbSNP:1239696144"
     variation       1316
                     /replace="t"
                     /db_xref="dbSNP:374444514"
     variation       1317
                     /replace="a"
                     /db_xref="dbSNP:950016449"
     variation       1319
                     /replace="l"
                     /db_xref="dbSNP:200956000"
     variation       1319
                     /replace="v"
                     /db_xref="dbSNP:753613907"
     variation       1322
                     /replace="q"
                     /db_xref="dbSNP:147170912"
     variation       1324
                     /replace="q"
                     /db_xref="dbSNP:970613934"
     variation       1324
                     /replace="r"
                     /db_xref="dbSNP:1476602371"
     variation       1325
                     /replace="e"
                     /db_xref="dbSNP:1187497298"
     variation       1325
                     /replace="g"
                     /db_xref="dbSNP:775604042"
     variation       1325
                     /replace="r"
                     /db_xref="dbSNP:377604174"
     variation       1326
                     /replace="*"
                     /db_xref="dbSNP:767072110"
     variation       1326
                     /replace="q"
                     /db_xref="dbSNP:552666324"
     variation       1327
                     /replace="l"
                     /db_xref="dbSNP:774042042"
     variation       1327
                     /replace="v"
                     /db_xref="dbSNP:1014766623"
     variation       1330
                     /replace="c"
                     /db_xref="dbSNP:897209847"
     variation       1330
                     /replace="s"
                     /db_xref="dbSNP:770558459"
     variation       1335
                     /replace="c"
                     /db_xref="dbSNP:1216047088"
     variation       1335
                     /replace="h"
                     /db_xref="dbSNP:537154191"
     variation       1335
                     /replace="r"
                     /db_xref="dbSNP:570003364"
     variation       1337
                     /replace="e"
                     /db_xref="dbSNP:115927459"
     variation       1339
                     /replace="-"
                     /db_xref="dbSNP:1314839067"
     variation       1339
                     /replace="d"
                     /db_xref="dbSNP:748587569"
     variation       1340
                     /replace="t"
                     /db_xref="dbSNP:141128971"
     variation       1341
                     /replace="r"
                     /db_xref="dbSNP:1005505765"
     variation       1342
                     /replace="n"
                     /db_xref="dbSNP:936963184"
     variation       1343
                     /replace="k"
                     /db_xref="dbSNP:781672875"
     variation       1344
                     /replace="r"
                     /db_xref="dbSNP:755070193"
     variation       1345
                     /replace="g"
                     /db_xref="dbSNP:200416051"
     variation       1345
                     /replace="n"
                     /db_xref="dbSNP:1252087914"
     variation       1346
                     /replace="g"
                     /db_xref="dbSNP:1049438223"
     variation       1346
                     /replace="v"
                     /db_xref="dbSNP:780288575"
     variation       1347
                     /replace="c"
                     /db_xref="dbSNP:1339187034"
     variation       1348
                     /replace="y"
                     /db_xref="dbSNP:758594682"
     variation       1349
                     /replace="f"
                     /db_xref="dbSNP:750691988"
     variation       1349
                     /replace="l"
                     /db_xref="dbSNP:1237865726"
     variation       1350
                     /replace="s"
                     /db_xref="dbSNP:763937438"
     variation       1352
                     /replace="*"
                     /db_xref="dbSNP:752627883"
     variation       1353
                     /replace="s"
                     /db_xref="dbSNP:113560046"
     variation       1354
                     /replace="n"
                     /db_xref="dbSNP:138005965"
     variation       1358
                     /replace="l"
                     /db_xref="dbSNP:908737172"
     variation       1359
                     /replace="c"
                     /db_xref="dbSNP:1194922971"
     variation       1359
                     /replace="t"
                     /db_xref="dbSNP:369469691"
     variation       1362
                     /replace="k"
                     /db_xref="dbSNP:1288863697"
     variation       1365
                     /replace="g"
                     /db_xref="dbSNP:1336778546"
     variation       1365
                     /replace="r"
                     /db_xref="dbSNP:772882978"
     variation       1368
                     /replace="q"
                     /db_xref="dbSNP:1286399547"
     variation       1369
                     /replace="t"
                     /db_xref="dbSNP:1408025883"
     variation       1370
                     /replace="t"
                     /db_xref="dbSNP:1372739848"
     variation       1371
                     /replace="k"
                     /db_xref="dbSNP:770085871"
     variation       1372
                     /replace="i"
                     /db_xref="dbSNP:1168843901"
     variation       1374
                     /replace="n"
                     /db_xref="dbSNP:762222123"
     variation       1375
                     /replace="d"
                     /db_xref="dbSNP:1165951904"
     variation       1375
                     /replace="s"
                     /db_xref="dbSNP:1348411642"
     variation       1376
                     /replace="f"
                     /db_xref="dbSNP:747176449"
     variation       1376
                     /replace="p"
                     /db_xref="dbSNP:1376976454"
     variation       1377
                     /replace="l"
                     /db_xref="dbSNP:777116969"
     variation       1379
                     /replace="d"
                     /db_xref="dbSNP:769080716"
     variation       1380
                     /replace="t"
                     /db_xref="dbSNP:1420577966"
     variation       1381
                     /replace="*"
                     /db_xref="dbSNP:747086942"
     variation       1381
                     /replace="v"
                     /db_xref="dbSNP:1157617339"
     variation       1382
                     /replace="g"
                     /db_xref="dbSNP:772220706"
     variation       1382
                     /replace="s"
                     /db_xref="dbSNP:779944664"
     variation       1385
                     /replace="e"
                     /db_xref="dbSNP:1373761721"
     variation       1385
                     /replace="k"
                     /db_xref="dbSNP:912983850"
     variation       1387
                     /replace="e"
                     /db_xref="dbSNP:879019101"
     variation       1387
                     /replace="t"
                     /db_xref="dbSNP:746024449"
     variation       1388
                     /replace="y"
                     /db_xref="dbSNP:779295786"
     variation       1390
                     /replace="s"
                     /db_xref="dbSNP:1214033238"
     variation       1393
                     /replace="l"
                     /db_xref="dbSNP:778575217"
     variation       1393
                     /replace="v"
                     /db_xref="dbSNP:1469670151"
     variation       1395
                     /replace="e"
                     /db_xref="dbSNP:559594100"
     variation       1396
                     /replace="s"
                     /db_xref="dbSNP:781155076"
     variation       1397
                     /replace="g"
                     /db_xref="dbSNP:754921650"
     variation       1398
                     /replace="i"
                     /db_xref="dbSNP:1349027161"
     variation       1398
                     /replace="n"
                     /db_xref="dbSNP:145732065"
     variation       1399
                     /replace="r"
                     /db_xref="dbSNP:1365673959"
     variation       1400
                     /replace="d"
                     /db_xref="dbSNP:1442033870"
     variation       1400
                     /replace="g"
                     /db_xref="dbSNP:975690753"
     variation       1400
                     /replace="n"
                     /db_xref="dbSNP:1325494277"
     variation       1402
                     /replace="a"
                     /db_xref="dbSNP:1032998460"
     variation       1402
                     /replace="r"
                     /db_xref="dbSNP:376483573"
     variation       1403
                     /replace="l"
                     /db_xref="dbSNP:1487113527"
     variation       1404
                     /replace="i"
                     /db_xref="dbSNP:765767219"
     variation       1404
                     /replace="l"
                     /db_xref="dbSNP:201888134"
     variation       1406
                     /replace="-"
                     /db_xref="dbSNP:1427557263"
     variation       1406
                     /replace="k"
                     /db_xref="dbSNP:1346378722"
     variation       1407
                     /replace="g"
                     /db_xref="dbSNP:1256168074"
     variation       1412
                     /replace="v"
                     /db_xref="dbSNP:771527963"
     variation       1413
                     /replace="g"
                     /db_xref="dbSNP:750062275"
     Site            1413
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1414
                     /replace="h"
                     /db_xref="dbSNP:373340813"
     variation       1415
                     /replace="s"
                     /db_xref="dbSNP:1020129030"
     Site            1415
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1416
                     /replace="g"
                     /db_xref="dbSNP:1014469298"
     variation       1417
                     /replace="n"
                     /db_xref="dbSNP:762132169"
     Site            1417
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Region          1418..1714
                     /region_name="Interaction with TUBA1A.
                     {ECO:0000269|PubMed:27518565}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1418
                     /replace="d"
                     /db_xref="dbSNP:1172978091"
     variation       1421
                     /replace="p"
                     /db_xref="dbSNP:587778677"
     variation       1424
                     /replace="s"
                     /db_xref="dbSNP:370129587"
     variation       1425
                     /replace="k"
                     /db_xref="dbSNP:761043204"
     variation       1426
                     /replace="k"
                     /db_xref="dbSNP:1297428621"
     variation       1429
                     /replace="e"
                     /db_xref="dbSNP:771991446"
     variation       1429
                     /replace="m"
                     /db_xref="dbSNP:776065001"
     variation       1430
                     /replace="e"
                     /db_xref="dbSNP:1217970288"
     variation       1431
                     /replace="a"
                     /db_xref="dbSNP:1226885899"
     variation       1431
                     /replace="v"
                     /db_xref="dbSNP:746006058"
     variation       1432
                     /replace="g"
                     /db_xref="dbSNP:140120528"
     variation       1432
                     /replace="k"
                     /db_xref="dbSNP:779275813"
     variation       1433
                     /replace="e"
                     /db_xref="dbSNP:747936441"
     variation       1434
                     /replace="r"
                     /db_xref="dbSNP:780802861"
     variation       1435
                     /replace="d"
                     /db_xref="dbSNP:970305479"
     variation       1436
                     /replace="t"
                     /db_xref="dbSNP:1372227656"
     variation       1437
                     /replace="p"
                     /db_xref="dbSNP:1382015466"
     variation       1439
                     /replace="p"
                     /db_xref="dbSNP:1386245911"
     variation       1440
                     /replace="p"
                     /db_xref="dbSNP:74485823"
     variation       1441
                     /replace="s"
                     /db_xref="dbSNP:751386762"
     variation       1444
                     /replace="l"
                     /db_xref="dbSNP:1374293713"
     variation       1445
                     /replace="f"
                     /db_xref="dbSNP:757898935"
     variation       1447
                     /replace="l"
                     /db_xref="dbSNP:749975185"
     variation       1448
                     /replace="f"
                     /db_xref="dbSNP:1192116385"
     variation       1448
                     /replace="s"
                     /db_xref="dbSNP:992969331"
     variation       1448
                     /replace="t"
                     /db_xref="dbSNP:764844518"
     variation       1450
                     /replace="i"
                     /db_xref="dbSNP:898862144"
     variation       1450
                     /replace="v"
                     /db_xref="dbSNP:1180075781"
     variation       1451
                     /replace="t"
                     /db_xref="dbSNP:1206489974"
     variation       1451
                     /replace="v"
                     /db_xref="dbSNP:1485326443"
     variation       1456
                     /replace="a"
                     /db_xref="dbSNP:1254458895"
     variation       1456
                     /replace="d"
                     /db_xref="dbSNP:761403196"
     variation       1457
                     /replace="s"
                     /db_xref="dbSNP:761450181"
     variation       1459
                     /replace="q"
                     /db_xref="dbSNP:777992018"
     variation       1459
                     /replace="r"
                     /db_xref="dbSNP:1037309257"
     variation       1464
                     /replace="v"
                     /db_xref="dbSNP:1350242980"
     variation       1465
                     /replace="k"
                     /db_xref="dbSNP:565146489"
     variation       1465
                     /replace="r"
                     /db_xref="dbSNP:1299536482"
     variation       1466
                     /replace="e"
                     /db_xref="dbSNP:775852697"
     variation       1470
                     /replace="p"
                     /db_xref="dbSNP:759660816"
     variation       1471
                     /replace="r"
                     /db_xref="dbSNP:374706873"
     variation       1472
                     /replace="c"
                     /db_xref="dbSNP:1298245513"
     variation       1475
                     /replace="v"
                     /db_xref="dbSNP:774624204"
     variation       1483
                     /replace="a"
                     /db_xref="dbSNP:543066717"
     variation       1484
                     /replace="v"
                     /db_xref="dbSNP:749482493"
     variation       1486
                     /replace="r"
                     /db_xref="dbSNP:770094902"
     variation       1490
                     /replace="f"
                     /db_xref="dbSNP:1157995960"
     variation       1491
                     /replace="h"
                     /db_xref="dbSNP:1470559897"
     variation       1492
                     /replace="r"
                     /db_xref="dbSNP:1365702407"
     variation       1492
                     /replace="r"
                     /db_xref="dbSNP:746756504"
     Region          1495..1549
                     /region_name="AWS"
                     /note="associated with SET domains; smart00570"
                     /db_xref="CDD:197795"
     variation       1498
                     /replace="k"
                     /db_xref="dbSNP:1012111652"
     variation       1498
                     /replace="p"
                     /db_xref="dbSNP:775304721"
     variation       1500
                     /replace="e"
                     /db_xref="dbSNP:1305683949"
     variation       1502
                     /replace="t"
                     /db_xref="dbSNP:946392198"
     variation       1503
                     /replace="s"
                     /db_xref="dbSNP:771882570"
     variation       1507
                     /replace="g"
                     /db_xref="dbSNP:745734582"
     variation       1509
                     /replace="k"
                     /db_xref="dbSNP:528393799"
     variation       1510
                     /replace="g"
                     /db_xref="dbSNP:778832358"
     variation       1511
                     /replace="e"
                     /db_xref="dbSNP:756750287"
     variation       1514
                     /replace="l"
                     /db_xref="dbSNP:199947065"
     variation       1515
                     /replace="a"
                     /db_xref="dbSNP:1352258634"
     variation       1518
                     /replace="v"
                     /db_xref="dbSNP:1278136449"
     variation       1525
                     /replace="v"
                     /db_xref="dbSNP:1277628559"
     variation       1528
                     /replace="e"
                     /db_xref="dbSNP:777262759"
     variation       1531
                     /replace="f"
                     /db_xref="dbSNP:753650631"
     variation       1532
                     /replace="r"
                     /db_xref="dbSNP:769219765"
     variation       1533
                     /replace="r"
                     /db_xref="dbSNP:747771114"
     variation       1535
                     /replace="n"
                     /db_xref="dbSNP:1311140567"
     variation       1536
                     /replace="g"
                     /db_xref="dbSNP:374824848"
     variation       1538
                     /replace="f"
                     /db_xref="dbSNP:781005010"
     variation       1541
                     /replace="h"
                     /db_xref="dbSNP:755382206"
     variation       1543
                     /replace="q"
                     /db_xref="dbSNP:752011468"
     variation       1545
                     /replace="r"
                     /db_xref="dbSNP:1419227458"
     variation       1548
                     /replace="q"
                     /db_xref="dbSNP:1180014862"
     variation       1549
                     /replace="r"
                     /db_xref="dbSNP:1238229155"
     Region          1550..1673
                     /region_name="SET"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain; smart00317"
                     /db_xref="CDD:214614"
     variation       1550
                     /replace="a"
                     /db_xref="dbSNP:1417952849"
     variation       1553
                     /replace="*"
                     /db_xref="dbSNP:1047233447"
     variation       1555
                     /replace="h"
                     /db_xref="dbSNP:1168915791"
     variation       1557
                     /replace="t"
                     /db_xref="dbSNP:1249012798"
     Region          1560..1562
                     /region_name="Inhibitor binding.
                     {ECO:0000269|PubMed:23043551}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Region          1560..1562
                     /region_name="S-adenosyl-L-methionine binding.
                     {ECO:0000244|PDB:4H12, ECO:0000244|PDB:5JJY,
                     ECO:0000244|PDB:5JLB, ECO:0000244|PDB:5JLE,
                     ECO:0000244|PDB:5V22, ECO:0000269|PubMed:23043551,
                     ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1560
                     /replace="k"
                     /db_xref="dbSNP:780684040"
     variation       1561
                     /replace="g"
                     /db_xref="dbSNP:1036155862"
     variation       1564
                     /replace="l"
                     /db_xref="dbSNP:79012760"
     variation       1566
                     /replace="t"
                     /db_xref="dbSNP:758888329"
     variation       1572
                     /replace="l"
                     /db_xref="dbSNP:750924110"
     variation       1572
                     /replace="s"
                     /db_xref="dbSNP:762671639"
     variation       1573
                     /replace="s"
                     /db_xref="dbSNP:1452241626"
     variation       1574
                     /replace="s"
                     /db_xref="dbSNP:1361858546"
     variation       1574
                     /replace="t"
                     /db_xref="dbSNP:368834830"
     variation       1576
                     /replace="l"
                     /db_xref="dbSNP:765156374"
     variation       1577
                     /replace="l"
                     /db_xref="dbSNP:1194104307"
     variation       1577
                     /replace="l"
                     /db_xref="dbSNP:1269210905"
     variation       1578
                     /replace="e"
                     /db_xref="dbSNP:761384846"
     variation       1579
                     /replace="y"
                     /db_xref="dbSNP:1258908603"
     variation       1584
                     /replace="l"
                     /db_xref="dbSNP:992061474"
     variation       1584
                     /replace="p"
                     /db_xref="dbSNP:916502458"
     variation       1585
                     /replace="n"
                     /db_xref="dbSNP:1359363019"
     variation       1588
                     /replace="e"
                     /db_xref="dbSNP:139567768"
     variation       1589
                     /replace="f"
                     /db_xref="dbSNP:768311118"
     variation       1592
                     /replace="*"
                     /db_xref="dbSNP:1057518410"
     variation       1593
                     /replace="m"
                     /db_xref="dbSNP:1020053763"
     variation       1595
                     /replace="v"
                     /db_xref="dbSNP:1285090688"
     variation       1600
                     /replace="r"
                     /db_xref="dbSNP:746591640"
     variation       1601
                     /replace="n"
                     /db_xref="dbSNP:775014561"
     variation       1602
                     /replace="t"
                     /db_xref="dbSNP:1004675217"
     variation       1602
                     /replace="v"
                     /db_xref="dbSNP:374749926"
     Region          1603..1605
                     /region_name="Inhibitor binding.
                     {ECO:0000269|PubMed:23043551}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Region          1603..1605
                     /region_name="S-adenosyl-L-methionine binding.
                     {ECO:0000244|PDB:4H12, ECO:0000244|PDB:5JJY,
                     ECO:0000244|PDB:5JLB, ECO:0000244|PDB:5JLE,
                     ECO:0000244|PDB:5V22, ECO:0000269|PubMed:23043551,
                     ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1604
                     /replace="y"
                     /db_xref="dbSNP:1288300837"
     variation       1605
                     /replace="*"
                     /db_xref="dbSNP:772465763"
     variation       1607
                     /replace="t"
                     /db_xref="dbSNP:1303122737"
     variation       1609
                     /replace="l"
                     /db_xref="dbSNP:1442104924"
     variation       1609
                     /replace="l"
                     /db_xref="dbSNP:1488655937"
     variation       1611
                     /replace="t"
                     /db_xref="dbSNP:1370286985"
     variation       1615
                     /replace="t"
                     /db_xref="dbSNP:1373021859"
     variation       1616
                     /replace="v"
                     /db_xref="dbSNP:1064794751"
     variation       1619
                     /replace="q"
                     /db_xref="dbSNP:777208502"
     variation       1623
                     /replace="c"
                     /db_xref="dbSNP:1489000911"
     variation       1624
                     /replace="f"
                     /db_xref="dbSNP:768604404"
     variation       1624
                     /replace="s"
                     /db_xref="dbSNP:75763513"
     Region          1628..1629
                     /region_name="Inhibitor binding.
                     {ECO:0000269|PubMed:23043551}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Region          1628..1629
                     /region_name="S-adenosyl-L-methionine binding.
                     {ECO:0000244|PDB:4H12, ECO:0000244|PDB:5JJY,
                     ECO:0000244|PDB:5JLB, ECO:0000244|PDB:5JLE,
                     ECO:0000244|PDB:5V22, ECO:0000269|PubMed:23043551,
                     ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1631
                     /replace="y"
                     /db_xref="dbSNP:780387684"
     variation       1636
                     /replace="a"
                     /db_xref="dbSNP:1387933251"
     variation       1637
                     /replace="t"
                     /db_xref="dbSNP:772469656"
     variation       1639
                     /replace="k"
                     /db_xref="dbSNP:1212594816"
     variation       1640
                     /replace="g"
                     /db_xref="dbSNP:868343300"
     variation       1641
                     /replace="n"
                     /db_xref="dbSNP:970790216"
     variation       1641
                     /replace="t"
                     /db_xref="dbSNP:527469836"
     variation       1643
                     /replace="n"
                     /db_xref="dbSNP:139879059"
     variation       1645
                     /replace="q"
                     /db_xref="dbSNP:1291443411"
     variation       1649
                     /replace="g"
                     /db_xref="dbSNP:775659248"
     variation       1651
                     /replace="l"
                     /db_xref="dbSNP:759274882"
     variation       1654
                     /replace="e"
                     /db_xref="dbSNP:1289786948"
     variation       1657
                     /replace="p"
                     /db_xref="dbSNP:746024051"
     variation       1657
                     /replace="t"
                     /db_xref="dbSNP:141705382"
     variation       1658
                     /replace="*"
                     /db_xref="dbSNP:1376592606"
     variation       1658
                     /replace="a"
                     /db_xref="dbSNP:587778678"
     variation       1663
                     /replace="m"
                     /db_xref="dbSNP:1478147351"
     variation       1663
                     /replace="t"
                     /db_xref="dbSNP:148325978"
     variation       1665
                     /replace="d"
                     /db_xref="dbSNP:777373516"
     variation       1668
                     /replace="f"
                     /db_xref="dbSNP:1014885291"
     variation       1671
                     /replace="y"
                     /db_xref="dbSNP:748043224"
     Region          1674..1690
                     /region_name="PostSET"
                     /note="Cysteine-rich motif following a subset of SET
                     domains; smart00508"
                     /db_xref="CDD:214703"
     variation       1674
                     /replace="k"
                     /db_xref="dbSNP:770497425"
     variation       1675
                     /replace="a"
                     /db_xref="dbSNP:1293494337"
     variation       1677
                     /replace="k"
                     /db_xref="dbSNP:1007260873"
     variation       1680
                     /replace="c"
                     /db_xref="dbSNP:764385874"
     variation       1684
                     /replace="s"
                     /db_xref="dbSNP:928084094"
     variation       1685
                     /replace="c"
                     /db_xref="dbSNP:761221336"
     variation       1686
                     /replace="q"
                     /db_xref="dbSNP:367601805"
     variation       1686
                     /replace="r"
                     /db_xref="dbSNP:145181962"
     variation       1689
                     /replace="l"
                     /db_xref="dbSNP:759751915"
     variation       1690
                     /replace="g"
                     /db_xref="dbSNP:1451077351"
     variation       1694
                     /replace="k"
                     /db_xref="dbSNP:1282194544"
     Site            1696
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1697
                     /replace="i"
                     /db_xref="dbSNP:1160182106"
     variation       1702
                     /replace="r"
                     /db_xref="dbSNP:774710481"
     variation       1705
                     /replace="r"
                     /db_xref="dbSNP:771225429"
     variation       1706
                     /replace="e"
                     /db_xref="dbSNP:867100662"
     variation       1707
                     /replace="r"
                     /db_xref="dbSNP:867856016"
     variation       1708
                     /replace="r"
                     /db_xref="dbSNP:774671060"
     variation       1709
                     /replace="s"
                     /db_xref="dbSNP:776440125"
     variation       1710
                     /replace="l"
                     /db_xref="dbSNP:1224110613"
     variation       1712
                     /replace="t"
                     /db_xref="dbSNP:1344050600"
     variation       1714
                     /replace="a"
                     /db_xref="dbSNP:1248520088"
     variation       1714
                     /replace="l"
                     /db_xref="dbSNP:1214553514"
     variation       1714
                     /replace="s"
                     /db_xref="dbSNP:1306274414"
     variation       1715
                     /replace="g"
                     /db_xref="dbSNP:745824413"
     variation       1717
                     /replace="g"
                     /db_xref="dbSNP:1461598920"
     variation       1719
                     /replace="l"
                     /db_xref="dbSNP:1279603079"
     variation       1721
                     /replace="t"
                     /db_xref="dbSNP:765445882"
     variation       1723
                     /replace="k"
                     /db_xref="dbSNP:1162303086"
     variation       1723
                     /replace="v"
                     /db_xref="dbSNP:778443256"
     variation       1725
                     /replace="d"
                     /db_xref="dbSNP:770349862"
     variation       1728
                     /replace="v"
                     /db_xref="dbSNP:867505169"
     variation       1729
                     /replace="l"
                     /db_xref="dbSNP:748915919"
     variation       1730
                     /replace="a"
                     /db_xref="dbSNP:777351391"
     variation       1733
                     /replace="n"
                     /db_xref="dbSNP:1352654027"
     variation       1734
                     /replace="h"
                     /db_xref="dbSNP:141847082"
     variation       1737
                     /replace="t"
                     /db_xref="dbSNP:1478136130"
     variation       1740
                     /replace="w"
                     /db_xref="dbSNP:1057523157"
     variation       1741
                     /replace="l"
                     /db_xref="dbSNP:753153096"
     variation       1751
                     /replace="k"
                     /db_xref="dbSNP:781759245"
     variation       1753
                     /replace="t"
                     /db_xref="dbSNP:755494787"
     variation       1754
                     /replace="s"
                     /db_xref="dbSNP:1422216096"
     variation       1756
                     /replace="e"
                     /db_xref="dbSNP:752039809"
     variation       1757
                     /replace="l"
                     /db_xref="dbSNP:144825663"
     variation       1760
                     /replace="h"
                     /db_xref="dbSNP:772972461"
     variation       1760
                     /replace="t"
                     /db_xref="dbSNP:769619404"
     variation       1762
                     /replace="h"
                     /db_xref="dbSNP:781656896"
     variation       1762
                     /replace="n"
                     /db_xref="dbSNP:747825765"
     variation       1763
                     /replace="t"
                     /db_xref="dbSNP:755400687"
     variation       1765
                     /replace="s"
                     /db_xref="dbSNP:1469356938"
     variation       1765
                     /replace="y"
                     /db_xref="dbSNP:1207513586"
     variation       1766
                     /replace="y"
                     /db_xref="dbSNP:1355005608"
     variation       1769
                     /replace="y"
                     /db_xref="dbSNP:747536206"
     variation       1772
                     /replace="e"
                     /db_xref="dbSNP:141027201"
     variation       1773
                     /replace="c"
                     /db_xref="dbSNP:758473163"
     variation       1773
                     /replace="h"
                     /db_xref="dbSNP:750518294"
     variation       1774
                     /replace="h"
                     /db_xref="dbSNP:765319535"
     variation       1786
                     /replace="l"
                     /db_xref="dbSNP:757428064"
     variation       1786
                     /replace="s"
                     /db_xref="dbSNP:1378969991"
     variation       1787
                     /replace="g"
                     /db_xref="dbSNP:754061219"
     variation       1788
                     /replace="d"
                     /db_xref="dbSNP:148618471"
     variation       1789
                     /replace="s"
                     /db_xref="dbSNP:759310174"
     variation       1790
                     /replace="q"
                     /db_xref="dbSNP:376246790"
     variation       1790
                     /replace="r"
                     /db_xref="dbSNP:774344041"
     variation       1791
                     /replace="e"
                     /db_xref="dbSNP:1158364422"
     variation       1791
                     /replace="q"
                     /db_xref="dbSNP:1285983711"
     variation       1792
                     /replace="g"
                     /db_xref="dbSNP:1440735409"
     variation       1792
                     /replace="s"
                     /db_xref="dbSNP:767964434"
     variation       1793
                     /replace="k"
                     /db_xref="dbSNP:1032937854"
     variation       1795
                     /replace="k"
                     /db_xref="dbSNP:772800229"
     variation       1800
                     /replace="i"
                     /db_xref="dbSNP:923518814"
     variation       1805
                     /replace="k"
                     /db_xref="dbSNP:1402083087"
     variation       1806
                     /replace="y"
                     /db_xref="dbSNP:976297119"
     variation       1809
                     /replace="i"
                     /db_xref="dbSNP:762759698"
     variation       1814
                     /replace="k"
                     /db_xref="dbSNP:750391486"
     variation       1815
                     /replace="w"
                     /db_xref="dbSNP:869025570"
     variation       1816
                     /replace="e"
                     /db_xref="dbSNP:776685139"
     variation       1823
                     /replace="v"
                     /db_xref="dbSNP:1403488230"
     variation       1825
                     /replace="q"
                     /db_xref="dbSNP:761473538"
     variation       1826
                     /replace="r"
                     /db_xref="dbSNP:557527064"
     variation       1831
                     /replace="k"
                     /db_xref="dbSNP:768238516"
     variation       1832
                     /replace="s"
                     /db_xref="dbSNP:1011940072"
     variation       1834
                     /replace="i"
                     /db_xref="dbSNP:760392790"
     variation       1834
                     /replace="v"
                     /db_xref="dbSNP:1412164409"
     variation       1836
                     /replace="l"
                     /db_xref="dbSNP:144171734"
     variation       1836
                     /replace="p"
                     /db_xref="dbSNP:964982055"
     variation       1836
                     /replace="s"
                     /db_xref="dbSNP:775677070"
     variation       1837
                     /replace="l"
                     /db_xref="dbSNP:146259664"
     variation       1837
                     /replace="s"
                     /db_xref="dbSNP:1196664039"
     variation       1838
                     /replace="s"
                     /db_xref="dbSNP:779451980"
     variation       1839
                     /replace="e"
                     /db_xref="dbSNP:1257429535"
     variation       1840
                     /replace="r"
                     /db_xref="dbSNP:1219340540"
     Site            1844
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     Site            1845
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1848
                     /replace="t"
                     /db_xref="dbSNP:770995434"
     variation       1849
                     /replace="s"
                     /db_xref="dbSNP:750812600"
     variation       1850
                     /replace="c"
                     /db_xref="dbSNP:376063996"
     variation       1850
                     /replace="p"
                     /db_xref="dbSNP:1341433062"
     variation       1853
                     /replace="t"
                     /db_xref="dbSNP:1419431011"
     Site            1853
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1854
                     /replace="p"
                     /db_xref="dbSNP:1339181529"
     variation       1855
                     /replace="l"
                     /db_xref="dbSNP:201901024"
     variation       1856
                     /replace="s"
                     /db_xref="dbSNP:758229404"
     variation       1856
                     /replace="y"
                     /db_xref="dbSNP:779650219"
     variation       1857
                     /replace="i"
                     /db_xref="dbSNP:1411181149"
     variation       1858
                     /replace="l"
                     /db_xref="dbSNP:750379129"
     variation       1858
                     /replace="p"
                     /db_xref="dbSNP:765302842"
     variation       1860
                     /replace="l"
                     /db_xref="dbSNP:1482913329"
     variation       1861
                     /replace="s"
                     /db_xref="dbSNP:761381072"
     variation       1862
                     /replace="s"
                     /db_xref="dbSNP:1262610955"
     variation       1864
                     /replace="l"
                     /db_xref="dbSNP:1235506167"
     variation       1866
                     /replace="a"
                     /db_xref="dbSNP:539289124"
     variation       1866
                     /replace="t"
                     /db_xref="dbSNP:763690645"
     variation       1867
                     /replace="e"
                     /db_xref="dbSNP:760178740"
     variation       1868
                     /replace="a"
                     /db_xref="dbSNP:775220272"
     variation       1868
                     /replace="d"
                     /db_xref="dbSNP:11721074"
     variation       1870
                     /replace="a"
                     /db_xref="dbSNP:772309871"
     Site            1872
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1874
                     /replace="q"
                     /db_xref="dbSNP:34230736"
     variation       1874
                     /replace="r"
                     /db_xref="dbSNP:759962777"
     variation       1876
                     /replace="l"
                     /db_xref="dbSNP:191022158"
     variation       1876
                     /replace="p"
                     /db_xref="dbSNP:1218578909"
     variation       1877
                     /replace="v"
                     /db_xref="dbSNP:771477731"
     variation       1878
                     /replace="l"
                     /db_xref="dbSNP:138568145"
     variation       1878
                     /replace="s"
                     /db_xref="dbSNP:587778665"
     variation       1879
                     /replace="h"
                     /db_xref="dbSNP:1357325164"
     variation       1879
                     /replace="r"
                     /db_xref="dbSNP:1020972095"
     variation       1883
                     /replace="i"
                     /db_xref="dbSNP:141881457"
     variation       1884
                     /replace="i"
                     /db_xref="dbSNP:1376756053"
     variation       1884
                     /replace="v"
                     /db_xref="dbSNP:769925323"
     variation       1888
                     /replace="i"
                     /db_xref="dbSNP:201244112"
     Site            1888
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1889
                     /replace="t"
                     /db_xref="dbSNP:148097513"
     variation       1890
                     /replace="g"
                     /db_xref="dbSNP:116513862"
     variation       1891
                     /replace="g"
                     /db_xref="dbSNP:781536923"
     variation       1892
                     /replace="a"
                     /db_xref="dbSNP:1347599926"
     variation       1893
                     /replace="n"
                     /db_xref="dbSNP:1322385881"
     variation       1896
                     /replace="p"
                     /db_xref="dbSNP:369233898"
     variation       1896
                     /replace="v"
                     /db_xref="dbSNP:750289124"
     variation       1897
                     /replace="i"
                     /db_xref="dbSNP:1438888811"
     variation       1897
                     /replace="p"
                     /db_xref="dbSNP:376263588"
     variation       1898
                     /replace="g"
                     /db_xref="dbSNP:1379166588"
     variation       1899
                     /replace="g"
                     /db_xref="dbSNP:1380727107"
     variation       1900
                     /replace="l"
                     /db_xref="dbSNP:778869034"
     variation       1902
                     /replace="c"
                     /db_xref="dbSNP:1002572433"
     variation       1902
                     /replace="v"
                     /db_xref="dbSNP:757216690"
     variation       1904
                     /replace="d"
                     /db_xref="dbSNP:1220944666"
     variation       1904
                     /replace="n"
                     /db_xref="dbSNP:753817699"
     variation       1905
                     /replace="s"
                     /db_xref="dbSNP:1490559790"
     variation       1910
                     /replace="h"
                     /db_xref="dbSNP:1294255401"
     variation       1914
                     /replace="n"
                     /db_xref="dbSNP:763453937"
     variation       1915
                     /replace="l"
                     /db_xref="dbSNP:755706240"
     variation       1915
                     /replace="v"
                     /db_xref="dbSNP:752285206"
     variation       1916
                     /replace="l"
                     /db_xref="dbSNP:767241855"
     variation       1917
                     /replace="g"
                     /db_xref="dbSNP:774649665"
     variation       1917
                     /replace="i"
                     /db_xref="dbSNP:372085873"
     variation       1920
                     /replace="d"
                     /db_xref="dbSNP:1436601562"
     variation       1921
                     /replace="e"
                     /db_xref="dbSNP:766760867"
     variation       1921
                     /replace="g"
                     /db_xref="dbSNP:1367009265"
     variation       1923
                     /replace="l"
                     /db_xref="dbSNP:567669330"
     variation       1924
                     /replace="h"
                     /db_xref="dbSNP:551260840"
     variation       1925
                     /replace="a"
                     /db_xref="dbSNP:1405812024"
     variation       1925
                     /replace="s"
                     /db_xref="dbSNP:905089474"
     variation       1926
                     /replace="k"
                     /db_xref="dbSNP:1282949429"
     variation       1926
                     /replace="r"
                     /db_xref="dbSNP:182268641"
     variation       1929
                     /replace="-"
                     /db_xref="dbSNP:1225607454"
     variation       1929
                     /replace="i"
                     /db_xref="dbSNP:769752064"
     variation       1929
                     /replace="l"
                     /db_xref="dbSNP:1424401224"
     variation       1930
                     /replace="p"
                     /db_xref="dbSNP:1285540956"
     variation       1933
                     /replace="v"
                     /db_xref="dbSNP:748296881"
     variation       1934
                     /replace="l"
                     /db_xref="dbSNP:1214843980"
     variation       1934
                     /replace="p"
                     /db_xref="dbSNP:776691995"
     variation       1935
                     /replace="q"
                     /db_xref="dbSNP:1271536742"
     variation       1935
                     /replace="v"
                     /db_xref="dbSNP:1490719275"
     variation       1936
                     /replace="c"
                     /db_xref="dbSNP:1271199345"
     variation       1937
                     /replace="r"
                     /db_xref="dbSNP:768946407"
     variation       1938
                     /replace="i"
                     /db_xref="dbSNP:116417406"
     Region          <1940..2123
                     /region_name="Asp-B-Hydro_N"
                     /note="Aspartyl beta-hydroxylase N-terminal region;
                     pfam05279"
                     /db_xref="CDD:191249"
     variation       1940
                     /replace="g"
                     /db_xref="dbSNP:115156486"
     variation       1940
                     /replace="n"
                     /db_xref="dbSNP:146956978"
     variation       1940
                     /replace="r"
                     /db_xref="dbSNP:943452157"
     variation       1941
                     /replace="a"
                     /db_xref="dbSNP:1310907958"
     variation       1943
                     /replace="d"
                     /db_xref="dbSNP:1301224390"
     variation       1943
                     /replace="k"
                     /db_xref="dbSNP:369421455"
     variation       1943
                     /replace="s"
                     /db_xref="dbSNP:1455352918"
     variation       1944
                     /replace="m"
                     /db_xref="dbSNP:749168216"
     variation       1945
                     /replace="d"
                     /db_xref="dbSNP:1275828128"
     variation       1946
                     /replace="s"
                     /db_xref="dbSNP:1398931878"
     variation       1947
                     /replace="g"
                     /db_xref="dbSNP:1340757729"
     variation       1947
                     /replace="i"
                     /db_xref="dbSNP:1290362272"
     variation       1951
                     /replace="a"
                     /db_xref="dbSNP:146894026"
     Site            1952
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1953
                     /replace="e"
                     /db_xref="dbSNP:1176670897"
     variation       1953
                     /replace="g"
                     /db_xref="dbSNP:1358400248"
     variation       1955
                     /replace="d"
                     /db_xref="dbSNP:923467940"
     variation       1955
                     /replace="q"
                     /db_xref="dbSNP:761536283"
     variation       1957
                     /replace="d"
                     /db_xref="dbSNP:934648887"
     variation       1958
                     /replace="p"
                     /db_xref="dbSNP:377115716"
     variation       1959
                     /replace="e"
                     /db_xref="dbSNP:1323141237"
     variation       1961
                     /replace="d"
                     /db_xref="dbSNP:1262728301"
     variation       1962
                     /replace="h"
                     /db_xref="dbSNP:4082155"
     variation       1963
                     /replace="e"
                     /db_xref="dbSNP:1482463965"
     variation       1963
                     /replace="k"
                     /db_xref="dbSNP:1255823357"
     variation       1964
                     /replace="q"
                     /db_xref="dbSNP:967881460"
     variation       1965
                     /replace="n"
                     /db_xref="dbSNP:1204853330"
     variation       1965
                     /replace="r"
                     /db_xref="dbSNP:768174639"
     variation       1966
                     /replace="n"
                     /db_xref="dbSNP:766676601"
     variation       1967
                     /replace="d"
                     /db_xref="dbSNP:143991928"
     variation       1967
                     /replace="s"
                     /db_xref="dbSNP:371395770"
     variation       1968
                     /replace="t"
                     /db_xref="dbSNP:773590674"
     variation       1969
                     /replace="r"
                     /db_xref="dbSNP:372610050"
     variation       1970
                     /replace="q"
                     /db_xref="dbSNP:1297230565"
     variation       1973
                     /replace="r"
                     /db_xref="dbSNP:762246808"
     variation       1974
                     /replace="v"
                     /db_xref="dbSNP:867673390"
     variation       1975
                     /replace="n"
                     /db_xref="dbSNP:747170105"
     variation       1975
                     /replace="t"
                     /db_xref="dbSNP:768858060"
     variation       1975
                     /replace="y"
                     /db_xref="dbSNP:776729678"
     variation       1976
                     /replace="e"
                     /db_xref="dbSNP:960778490"
     variation       1976
                     /replace="v"
                     /db_xref="dbSNP:1035150114"
     variation       1977
                     /replace="d"
                     /db_xref="dbSNP:981834946"
     variation       1977
                     /replace="q"
                     /db_xref="dbSNP:1183280787"
     variation       1978
                     /replace="t"
                     /db_xref="dbSNP:1034841407"
     variation       1979
                     /replace="t"
                     /db_xref="dbSNP:1465200347"
     Site            1980
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1981
                     /replace="r"
                     /db_xref="dbSNP:189529024"
     variation       1982
                     /replace="d"
                     /db_xref="dbSNP:1267301409"
     variation       1982
                     /replace="g"
                     /db_xref="dbSNP:587778664"
     variation       1987
                     /replace="v"
                     /db_xref="dbSNP:969721121"
     Site            1988
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1990
                     /replace="a"
                     /db_xref="dbSNP:749146060"
     variation       1991
                     /replace="e"
                     /db_xref="dbSNP:1005632737"
     variation       1993
                     /replace="g"
                     /db_xref="dbSNP:1184603919"
     variation       1993
                     /replace="q"
                     /db_xref="dbSNP:1255826196"
     variation       1994
                     /replace="r"
                     /db_xref="dbSNP:756031689"
     Site            1995
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:E9Q5F9};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       1996
                     /replace="r"
                     /db_xref="dbSNP:748068732"
     variation       1998
                     /replace="q"
                     /db_xref="dbSNP:950433324"
     variation       1999
                     /replace="p"
                     /db_xref="dbSNP:1198615233"
     variation       2000
                     /replace="g"
                     /db_xref="dbSNP:139064872"
     variation       2002
                     /replace="i"
                     /db_xref="dbSNP:373627213"
     variation       2003
                     /replace="v"
                     /db_xref="dbSNP:148671940"
     variation       2004
                     /replace="g"
                     /db_xref="dbSNP:1444726256"
     variation       2005
                     /replace="v"
                     /db_xref="dbSNP:779750876"
     variation       2006
                     /replace="g"
                     /db_xref="dbSNP:1315408533"
     variation       2009
                     /replace="a"
                     /db_xref="dbSNP:758664614"
     variation       2009
                     /replace="d"
                     /db_xref="dbSNP:74566171"
     variation       2013
                     /replace="l"
                     /db_xref="dbSNP:750747918"
     variation       2015
                     /replace="g"
                     /db_xref="dbSNP:1231297521"
     variation       2015
                     /replace="n"
                     /db_xref="dbSNP:1366338930"
     variation       2020
                     /replace="r"
                     /db_xref="dbSNP:573687627"
     variation       2022
                     /replace="v"
                     /db_xref="dbSNP:149499141"
     variation       2029
                     /replace="n"
                     /db_xref="dbSNP:1414315565"
     variation       2029
                     /replace="r"
                     /db_xref="dbSNP:569043668"
     variation       2030
                     /replace="q"
                     /db_xref="dbSNP:758026999"
     variation       2031
                     /replace="i"
                     /db_xref="dbSNP:750045087"
     variation       2036
                     /replace="a"
                     /db_xref="dbSNP:374583536"
     variation       2037
                     /replace="a"
                     /db_xref="dbSNP:113798770"
     variation       2037
                     /replace="r"
                     /db_xref="dbSNP:914740277"
     variation       2038
                     /replace="a"
                     /db_xref="dbSNP:1186595470"
     variation       2039
                     /replace="g"
                     /db_xref="dbSNP:1331804243"
     variation       2040
                     /replace="*"
                     /db_xref="dbSNP:976581260"
     variation       2040
                     /replace="p"
                     /db_xref="dbSNP:1244929991"
     variation       2041
                     /replace="g"
                     /db_xref="dbSNP:1196717599"
     variation       2043
                     /replace="g"
                     /db_xref="dbSNP:1456482272"
     variation       2046
                     /replace="g"
                     /db_xref="dbSNP:1272452422"
     variation       2051
                     /replace="t"
                     /db_xref="dbSNP:751805961"
     variation       2052
                     /replace="h"
                     /db_xref="dbSNP:749666698"
     variation       2052
                     /replace="p"
                     /db_xref="dbSNP:534787801"
     variation       2052
                     /replace="s"
                     /db_xref="dbSNP:766552660"
     variation       2053
                     /replace="a"
                     /db_xref="dbSNP:543870526"
     variation       2053
                     /replace="v"
                     /db_xref="dbSNP:1296278122"
     variation       2054
                     /replace="l"
                     /db_xref="dbSNP:139016283"
     variation       2054
                     /replace="p"
                     /db_xref="dbSNP:760543486"
     variation       2057
                     /replace="s"
                     /db_xref="dbSNP:146911485"
     variation       2058
                     /replace="n"
                     /db_xref="dbSNP:146461266"
     variation       2058
                     /replace="s"
                     /db_xref="dbSNP:116277395"
     variation       2060
                     /replace="l"
                     /db_xref="dbSNP:745410359"
     variation       2060
                     /replace="p"
                     /db_xref="dbSNP:1465373100"
     variation       2060
                     /replace="s"
                     /db_xref="dbSNP:140252916"
     variation       2064
                     /replace="e"
                     /db_xref="dbSNP:748980966"
     variation       2064
                     /replace="e"
                     /db_xref="dbSNP:749901643"
     variation       2064
                     /replace="h"
                     /db_xref="dbSNP:770439891"
     variation       2065
                     /replace="a"
                     /db_xref="dbSNP:1388458918"
     variation       2065
                     /replace="p"
                     /db_xref="dbSNP:778218771"
     variation       2066
                     /replace="h"
                     /db_xref="dbSNP:1033277635"
     variation       2067
                     /replace="k"
                     /db_xref="dbSNP:756561112"
     variation       2069
                     /replace="s"
                     /db_xref="dbSNP:748653635"
     variation       2071
                     /replace="k"
                     /db_xref="dbSNP:781655817"
     variation       2076
                     /replace="k"
                     /db_xref="dbSNP:1232312443"
     variation       2077
                     /replace="q"
                     /db_xref="dbSNP:981018402"
     variation       2077
                     /replace="r"
                     /db_xref="dbSNP:1205330893"
     variation       2078
                     /replace="-"
                     /db_xref="dbSNP:1287950651"
     variation       2079
                     /replace="n"
                     /db_xref="dbSNP:755057984"
     variation       2080
                     /replace="s"
                     /db_xref="dbSNP:577861724"
     Site            2080
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       2081
                     /replace="l"
                     /db_xref="dbSNP:777053122"
     Site            2082
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       2084
                     /replace="h"
                     /db_xref="dbSNP:758547176"
     variation       2085
                     /replace="f"
                     /db_xref="dbSNP:750653362"
     variation       2086
                     /replace="f"
                     /db_xref="dbSNP:763860515"
     variation       2087
                     /replace="-"
                     /db_xref="dbSNP:1443780205"
     variation       2089
                     /replace="k"
                     /db_xref="dbSNP:183768442"
     variation       2090
                     /replace="q"
                     /db_xref="dbSNP:149758106"
     variation       2090
                     /replace="w"
                     /db_xref="dbSNP:760529168"
     variation       2092
                     /replace="i"
                     /db_xref="dbSNP:1022882936"
     variation       2094
                     /replace="k"
                     /db_xref="dbSNP:1349363771"
     variation       2094
                     /replace="k"
                     /db_xref="dbSNP:36092203"
     variation       2096
                     /replace="g"
                     /db_xref="dbSNP:1424966648"
     variation       2098
                     /replace="g"
                     /db_xref="dbSNP:1359343324"
     variation       2099
                     /replace="y"
                     /db_xref="dbSNP:557972733"
     variation       2100
                     /replace="g"
                     /db_xref="dbSNP:1345617918"
     variation       2102
                     /replace="p"
                     /db_xref="dbSNP:539146125"
     variation       2102
                     /replace="q"
                     /db_xref="dbSNP:750635731"
     variation       2103
                     /replace="a"
                     /db_xref="dbSNP:755881799"
     variation       2106
                     /replace="n"
                     /db_xref="dbSNP:752383389"
     variation       2109
                     /replace="q"
                     /db_xref="dbSNP:967982470"
     variation       2113
                     /replace="c"
                     /db_xref="dbSNP:867188953"
     variation       2114
                     /replace="i"
                     /db_xref="dbSNP:869025569"
     variation       2114
                     /replace="s"
                     /db_xref="dbSNP:371523162"
     variation       2116
                     /replace="l"
                     /db_xref="dbSNP:1485734385"
     variation       2118
                     /replace="t"
                     /db_xref="dbSNP:759326574"
     variation       2119
                     /replace="e"
                     /db_xref="dbSNP:751531243"
     variation       2120
                     /replace="e"
                     /db_xref="dbSNP:765974403"
     variation       2121
                     /replace="r"
                     /db_xref="dbSNP:762619229"
     variation       2122
                     /replace="r"
                     /db_xref="dbSNP:1279854337"
     variation       2123
                     /replace="k"
                     /db_xref="dbSNP:772972330"
     variation       2125
                     /replace="s"
                     /db_xref="dbSNP:1325198540"
     variation       2128
                     /replace="e"
                     /db_xref="dbSNP:958559712"
     variation       2132
                     /replace="w"
                     /db_xref="dbSNP:769623377"
     variation       2134
                     /replace="a"
                     /db_xref="dbSNP:761551649"
     Region          2137..2366
                     /region_name="Low charge region.
                     {ECO:0000269|PubMed:16118227}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       2137
                     /replace="l"
                     /db_xref="dbSNP:1290413013"
     variation       2138
                     /replace="q"
                     /db_xref="dbSNP:776824718"
     variation       2139
                     /replace="h"
                     /db_xref="dbSNP:1003072976"
     variation       2143
                     /replace="k"
                     /db_xref="dbSNP:139626026"
     variation       2149
                     /replace="p"
                     /db_xref="dbSNP:747454617"
     variation       2150
                     /replace="l"
                     /db_xref="dbSNP:1470326034"
     variation       2152
                     /replace="c"
                     /db_xref="dbSNP:139628048"
     variation       2153
                     /replace="d"
                     /db_xref="dbSNP:1168585860"
     variation       2153
                     /replace="v"
                     /db_xref="dbSNP:1257298139"
     variation       2154
                     /replace="c"
                     /db_xref="dbSNP:772107314"
     variation       2154
                     /replace="s"
                     /db_xref="dbSNP:993839048"
     variation       2157
                     /replace="s"
                     /db_xref="dbSNP:1420585757"
     variation       2159
                     /replace="a"
                     /db_xref="dbSNP:1188677702"
     variation       2159
                     /replace="t"
                     /db_xref="dbSNP:1474422525"
     variation       2160
                     /replace="l"
                     /db_xref="dbSNP:745996964"
     variation       2160
                     /replace="p"
                     /db_xref="dbSNP:368137896"
     variation       2163
                     /replace="l"
                     /db_xref="dbSNP:1204908942"
     variation       2165
                     /replace="a"
                     /db_xref="dbSNP:1200173976"
     variation       2165
                     /replace="v"
                     /db_xref="dbSNP:1433904494"
     variation       2167
                     /replace="y"
                     /db_xref="dbSNP:556641040"
     variation       2169
                     /replace="p"
                     /db_xref="dbSNP:1038647856"
     variation       2170
                     /replace="v"
                     /db_xref="dbSNP:754096506"
     variation       2173
                     /replace="i"
                     /db_xref="dbSNP:1226151109"
     variation       2174
                     /replace="r"
                     /db_xref="dbSNP:780794651"
     variation       2175
                     /replace="a"
                     /db_xref="dbSNP:1482489476"
     variation       2175
                     /replace="v"
                     /db_xref="dbSNP:754860506"
     variation       2176
                     /replace="y"
                     /db_xref="dbSNP:751448015"
     variation       2179
                     /replace="p"
                     /db_xref="dbSNP:879001663"
     variation       2180
                     /replace="t"
                     /db_xref="dbSNP:766462859"
     variation       2182
                     /replace="p"
                     /db_xref="dbSNP:535446525"
     variation       2187
                     /replace="v"
                     /db_xref="dbSNP:749906734"
     variation       2188
                     /replace="l"
                     /db_xref="dbSNP:764875408"
     variation       2190
                     /replace="l"
                     /db_xref="dbSNP:1408383191"
     variation       2190
                     /replace="p"
                     /db_xref="dbSNP:1296528720"
     variation       2191
                     /replace="t"
                     /db_xref="dbSNP:754300919"
     variation       2193
                     /replace="g"
                     /db_xref="dbSNP:1007136037"
     variation       2193
                     /replace="n"
                     /db_xref="dbSNP:199893441"
     variation       2194
                     /replace="s"
                     /db_xref="dbSNP:775773381"
     variation       2200
                     /replace="-"
                     /db_xref="dbSNP:772400023"
     variation       2200
                     /replace="l"
                     /db_xref="dbSNP:1443135936"
     variation       2200
                     /replace="p"
                     /db_xref="dbSNP:1385061284"
     variation       2200
                     /replace="s"
                     /db_xref="dbSNP:776399134"
     variation       2201
                     /replace="t"
                     /db_xref="dbSNP:764377763"
     variation       2202
                     /replace="a"
                     /db_xref="dbSNP:143083979"
     variation       2202
                     /replace="p"
                     /db_xref="dbSNP:535130915"
     variation       2204
                     /replace="e"
                     /db_xref="dbSNP:528430487"
     variation       2205
                     /replace="n"
                     /db_xref="dbSNP:1051270951"
     variation       2205
                     /replace="r"
                     /db_xref="dbSNP:746404627"
     variation       2206
                     /replace="v"
                     /db_xref="dbSNP:1252670264"
     variation       2208
                     /replace="p"
                     /db_xref="dbSNP:1219857550"
     variation       2214
                     /replace="t"
                     /db_xref="dbSNP:934104750"
     variation       2216
                     /replace="l"
                     /db_xref="dbSNP:752976032"
     variation       2216
                     /replace="t"
                     /db_xref="dbSNP:774347385"
     variation       2219
                     /replace="a"
                     /db_xref="dbSNP:1247999135"
     variation       2222
                     /replace="s"
                     /db_xref="dbSNP:587778666"
     variation       2224
                     /replace="a"
                     /db_xref="dbSNP:1304905045"
     variation       2225
                     /replace="a"
                     /db_xref="dbSNP:941392264"
     variation       2225
                     /replace="v"
                     /db_xref="dbSNP:115177770"
     variation       2229
                     /replace="g"
                     /db_xref="dbSNP:377066147"
     variation       2229
                     /replace="m"
                     /db_xref="dbSNP:1171530720"
     variation       2229
                     /replace="v"
                     /db_xref="dbSNP:778126148"
     variation       2230
                     /replace="e"
                     /db_xref="dbSNP:759870020"
     variation       2233
                     /replace="a"
                     /db_xref="dbSNP:767329614"
     variation       2233
                     /replace="l"
                     /db_xref="dbSNP:1423045377"
     variation       2233
                     /replace="v"
                     /db_xref="dbSNP:1164619683"
     variation       2234
                     /replace="a"
                     /db_xref="dbSNP:1427050464"
     variation       2234
                     /replace="q"
                     /db_xref="dbSNP:754699948"
     variation       2235
                     /replace="i"
                     /db_xref="dbSNP:780019200"
     variation       2236
                     /replace="p"
                     /db_xref="dbSNP:1042427777"
     variation       2238
                     /replace="a"
                     /db_xref="dbSNP:758375586"
     variation       2240
                     /replace="y"
                     /db_xref="dbSNP:934035500"
     variation       2242
                     /replace="a"
                     /db_xref="dbSNP:764822620"
     variation       2242
                     /replace="t"
                     /db_xref="dbSNP:750393537"
     variation       2249
                     /replace="h"
                     /db_xref="dbSNP:1292161591"
     variation       2249
                     /replace="r"
                     /db_xref="dbSNP:756854758"
     variation       2253
                     /replace="r"
                     /db_xref="dbSNP:753398896"
     variation       2253
                     /replace="s"
                     /db_xref="dbSNP:763855153"
     variation       2254
                     /replace="i"
                     /db_xref="dbSNP:746928112"
     variation       2255
                     /replace="g"
                     /db_xref="dbSNP:1239748039"
     variation       2256
                     /replace="v"
                     /db_xref="dbSNP:147243526"
     variation       2257
                     /replace="v"
                     /db_xref="dbSNP:767871315"
     variation       2257
                     /replace="w"
                     /db_xref="dbSNP:1403270185"
     variation       2258
                     /replace="s"
                     /db_xref="dbSNP:867632296"
     variation       2259
                     /replace="l"
                     /db_xref="dbSNP:199618415"
     variation       2260
                     /replace="l"
                     /db_xref="dbSNP:759979231"
     variation       2260
                     /replace="p"
                     /db_xref="dbSNP:774896853"
     variation       2261
                     /replace="p"
                     /db_xref="dbSNP:1388854944"
     variation       2261
                     /replace="v"
                     /db_xref="dbSNP:770913885"
     variation       2262
                     /replace="p"
                     /db_xref="dbSNP:149552397"
     variation       2263
                     /replace="g"
                     /db_xref="dbSNP:1364956563"
     variation       2263
                     /replace="s"
                     /db_xref="dbSNP:1454824814"
     variation       2264
                     /replace="p"
                     /db_xref="dbSNP:757875305"
     variation       2264
                     /replace="t"
                     /db_xref="dbSNP:1173653586"
     variation       2266
                     /replace="r"
                     /db_xref="dbSNP:867342876"
     variation       2267
                     /replace="g"
                     /db_xref="dbSNP:1479878894"
     variation       2269
                     /replace="h"
                     /db_xref="dbSNP:1269196065"
     variation       2270
                     /replace="y"
                     /db_xref="dbSNP:114332101"
     variation       2272
                     /replace="f"
                     /db_xref="dbSNP:1191506417"
     variation       2274
                     /replace="g"
                     /db_xref="dbSNP:373366089"
     variation       2274
                     /replace="n"
                     /db_xref="dbSNP:770011339"
     variation       2275
                     /replace="a"
                     /db_xref="dbSNP:1156971620"
     variation       2275
                     /replace="s"
                     /db_xref="dbSNP:748416761"
     variation       2278
                     /replace="q"
                     /db_xref="dbSNP:779931413"
     variation       2278
                     /replace="r"
                     /db_xref="dbSNP:1205573489"
     variation       2279
                     /replace="p"
                     /db_xref="dbSNP:201453289"
     variation       2279
                     /replace="s"
                     /db_xref="dbSNP:758322649"
     variation       2280
                     /replace="c"
                     /db_xref="dbSNP:1322967408"
     variation       2280
                     /replace="l"
                     /db_xref="dbSNP:752287641"
     variation       2280
                     /replace="v"
                     /db_xref="dbSNP:745791498"
     variation       2281
                     /replace="s"
                     /db_xref="dbSNP:778947906"
     variation       2283
                     /replace="q"
                     /db_xref="dbSNP:756696500"
     variation       2285
                     /replace="l"
                     /db_xref="dbSNP:1318081365"
     variation       2288
                     /replace="a"
                     /db_xref="dbSNP:753338268"
     variation       2290
                     /replace="l"
                     /db_xref="dbSNP:763541766"
     variation       2291
                     /replace="s"
                     /db_xref="dbSNP:1025412739"
     variation       2294
                     /replace="s"
                     /db_xref="dbSNP:755724649"
     variation       2294
                     /replace="t"
                     /db_xref="dbSNP:1333759267"
     variation       2295
                     /replace="m"
                     /db_xref="dbSNP:150476239"
     variation       2295
                     /replace="v"
                     /db_xref="dbSNP:759219467"
     variation       2296
                     /replace="c"
                     /db_xref="dbSNP:1173959948"
     variation       2297
                     /replace="y"
                     /db_xref="dbSNP:759960773"
     variation       2298
                     /replace="e"
                     /db_xref="dbSNP:1372228141"
     variation       2299
                     /replace="g"
                     /db_xref="dbSNP:1448619183"
     variation       2299
                     /replace="r"
                     /db_xref="dbSNP:1193656443"
     variation       2301
                     /replace="t"
                     /db_xref="dbSNP:774810866"
     variation       2303
                     /replace="l"
                     /db_xref="dbSNP:1305779424"
     variation       2304
                     /replace="t"
                     /db_xref="dbSNP:766959990"
     variation       2305
                     /replace="v"
                     /db_xref="dbSNP:190589738"
     variation       2306
                     /replace="c"
                     /db_xref="dbSNP:773305513"
     variation       2307
                     /replace="s"
                     /db_xref="dbSNP:1221088802"
     variation       2307
                     /replace="v"
                     /db_xref="dbSNP:769772469"
     variation       2311
                     /replace="p"
                     /db_xref="dbSNP:1334047835"
     variation       2313
                     /replace="s"
                     /db_xref="dbSNP:1188781276"
     variation       2314
                     /replace="k"
                     /db_xref="dbSNP:1269929027"
     variation       2314
                     /replace="q"
                     /db_xref="dbSNP:762073578"
     variation       2315
                     /replace="t"
                     /db_xref="dbSNP:567503863"
     variation       2316
                     /replace="a"
                     /db_xref="dbSNP:771957568"
     variation       2317
                     /replace="l"
                     /db_xref="dbSNP:770500112"
     variation       2318
                     /replace="r"
                     /db_xref="dbSNP:374228543"
     variation       2319
                     /replace="i"
                     /db_xref="dbSNP:778593874"
     variation       2319
                     /replace="s"
                     /db_xref="dbSNP:1281517794"
     variation       2320
                     /replace="v"
                     /db_xref="dbSNP:370881673"
     variation       2321
                     /replace="k"
                     /db_xref="dbSNP:749186852"
     variation       2324
                     /replace="s"
                     /db_xref="dbSNP:1162711197"
     variation       2324
                     /replace="v"
                     /db_xref="dbSNP:1425169903"
     variation       2326
                     /replace="l"
                     /db_xref="dbSNP:867369702"
     variation       2326
                     /replace="p"
                     /db_xref="dbSNP:774127573"
     variation       2326
                     /replace="s"
                     /db_xref="dbSNP:1282148926"
     variation       2327
                     /replace="g"
                     /db_xref="dbSNP:1468649782"
     variation       2327
                     /replace="r"
                     /db_xref="dbSNP:1018953967"
     variation       2328
                     /replace="-"
                     /db_xref="dbSNP:781188306"
     variation       2328
                     /replace="v"
                     /db_xref="dbSNP:1232434419"
     variation       2330
                     /replace="c"
                     /db_xref="dbSNP:977569469"
     variation       2332
                     /replace="q"
                     /db_xref="dbSNP:770644452"
     variation       2332
                     /replace="r"
                     /db_xref="dbSNP:1316070128"
     variation       2333
                     /replace="g"
                     /db_xref="dbSNP:749235253"
     variation       2334
                     /replace="q"
                     /db_xref="dbSNP:777640124"
     variation       2335
                     /replace="h"
                     /db_xref="dbSNP:971681007"
     variation       2336
                     /replace="v"
                     /db_xref="dbSNP:769263465"
     variation       2337
                     /replace="y"
                     /db_xref="dbSNP:747707927"
     variation       2338
                     /replace="a"
                     /db_xref="dbSNP:1349322470"
     variation       2338
                     /replace="i"
                     /db_xref="dbSNP:1198773854"
     variation       2339
                     /replace="g"
                     /db_xref="dbSNP:1364648104"
     variation       2341
                     /replace="p"
                     /db_xref="dbSNP:780703918"
     variation       2344
                     /replace="m"
                     /db_xref="dbSNP:754588966"
     variation       2345
                     /replace="v"
                     /db_xref="dbSNP:751178367"
     variation       2347
                     /replace="e"
                     /db_xref="dbSNP:1024557543"
     variation       2348
                     /replace="p"
                     /db_xref="dbSNP:115148593"
     variation       2349
                     /replace="a"
                     /db_xref="dbSNP:780412960"
     variation       2350
                     /replace="e"
                     /db_xref="dbSNP:765890389"
     variation       2350
                     /replace="t"
                     /db_xref="dbSNP:199739297"
     variation       2354
                     /replace="a"
                     /db_xref="dbSNP:145377213"
     variation       2354
                     /replace="t"
                     /db_xref="dbSNP:903734088"
     variation       2355
                     /replace="i"
                     /db_xref="dbSNP:1407268741"
     variation       2355
                     /replace="v"
                     /db_xref="dbSNP:995303125"
     variation       2356
                     /replace="f"
                     /db_xref="dbSNP:753926826"
     variation       2356
                     /replace="v"
                     /db_xref="dbSNP:200525700"
     variation       2357
                     /replace="a"
                     /db_xref="dbSNP:140288461"
     variation       2358
                     /replace="l"
                     /db_xref="dbSNP:775632004"
     variation       2359
                     /replace="e"
                     /db_xref="dbSNP:766193321"
     variation       2361
                     /replace="l"
                     /db_xref="dbSNP:1221799902"
     variation       2361
                     /replace="p"
                     /db_xref="dbSNP:552916928"
     variation       2363
                     /replace="p"
                     /db_xref="dbSNP:773181646"
     variation       2364
                     /replace="l"
                     /db_xref="dbSNP:534732505"
     variation       2364
                     /replace="l"
                     /db_xref="dbSNP:748117514"
     variation       2364
                     /replace="w"
                     /db_xref="dbSNP:1284290834"
     variation       2365
                     /replace="e"
                     /db_xref="dbSNP:894915057"
     variation       2367
                     /replace="s"
                     /db_xref="dbSNP:149025565"
     variation       2368
                     /replace="k"
                     /db_xref="dbSNP:759827888"
     variation       2369
                     /replace="i"
                     /db_xref="dbSNP:1213736696"
     variation       2369
                     /replace="t"
                     /db_xref="dbSNP:1410167729"
     variation       2371
                     /replace="m"
                     /db_xref="dbSNP:772953443"
     variation       2373
                     /replace="s"
                     /db_xref="dbSNP:114833216"
     variation       2375
                     /replace="p"
                     /db_xref="dbSNP:376889343"
     variation       2376
                     /replace="l"
                     /db_xref="dbSNP:922299511"
     variation       2377
                     /replace="d"
                     /db_xref="dbSNP:761683828"
     variation       2378
                     /replace="l"
                     /db_xref="dbSNP:370566360"
     variation       2379
                     /replace="l"
                     /db_xref="dbSNP:200186997"
     variation       2379
                     /replace="p"
                     /db_xref="dbSNP:768154988"
     variation       2380
                     /replace="p"
                     /db_xref="dbSNP:1361147882"
     variation       2381
                     /replace="p"
                     /db_xref="dbSNP:771580579"
     variation       2383
                     /replace="p"
                     /db_xref="dbSNP:1428267918"
     variation       2384
                     /replace="p"
                     /db_xref="dbSNP:1391231740"
     variation       2385
                     /replace="n"
                     /db_xref="dbSNP:779361258"
     variation       2385
                     /replace="r"
                     /db_xref="dbSNP:745537058"
     variation       2388
                     /replace="n"
                     /db_xref="dbSNP:1323986990"
     variation       2388
                     /replace="t"
                     /db_xref="dbSNP:144752494"
     variation       2389
                     /replace="h"
                     /db_xref="dbSNP:865813555"
     variation       2390
                     /replace="i"
                     /db_xref="dbSNP:1468250923"
     Region          2391..2420
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:278809"
     variation       2392
                     /replace="l"
                     /db_xref="dbSNP:778464270"
     variation       2392
                     /replace="t"
                     /db_xref="dbSNP:749808656"
     variation       2393
                     /replace="a"
                     /db_xref="dbSNP:1249234668"
     variation       2394
                     /replace="d"
                     /db_xref="dbSNP:564576540"
     variation       2394
                     /replace="t"
                     /db_xref="dbSNP:756197752"
     variation       2396
                     /replace="r"
                     /db_xref="dbSNP:1200573511"
     variation       2398
                     /replace="a"
                     /db_xref="dbSNP:111843964"
     variation       2399
                     /replace="q"
                     /db_xref="dbSNP:752671469"
     variation       2399
                     /replace="r"
                     /db_xref="dbSNP:201274969"
     variation       2403
                     /replace="g"
                     /db_xref="dbSNP:751796954"
     variation       2404
                     /replace="k"
                     /db_xref="dbSNP:765007030"
     Site            order(2406,2417)
                     /site_type="binding"
                     /note="binding pocket"
                     /db_xref="CDD:238122"
     variation       2406
                     /replace="y"
                     /db_xref="dbSNP:761667563"
     variation       2409
                     /replace="h"
                     /db_xref="dbSNP:1250307556"
     variation       2410
                     /replace="m"
                     /db_xref="dbSNP:1476371771"
     variation       2411
                     /replace="i"
                     /db_xref="dbSNP:753749527"
     variation       2414
                     /replace="p"
                     /db_xref="dbSNP:1259012873"
     variation       2416
                     /replace="q"
                     /db_xref="dbSNP:780299120"
     variation       2420
                     /replace="l"
                     /db_xref="dbSNP:1329961934"
     variation       2420
                     /replace="p"
                     /db_xref="dbSNP:1265109832"
     variation       2421
                     /replace="a"
                     /db_xref="dbSNP:76132393"
     variation       2424
                     /replace="g"
                     /db_xref="dbSNP:751118723"
     variation       2424
                     /replace="n"
                     /db_xref="dbSNP:147822770"
     variation       2427
                     /replace="h"
                     /db_xref="dbSNP:1330883280"
     variation       2428
                     /replace="-"
                     /db_xref="dbSNP:764649149"
     variation       2428
                     /replace="d"
                     /db_xref="dbSNP:201285612"
     variation       2428
                     /replace="g"
                     /db_xref="dbSNP:1324691280"
     variation       2429
                     /replace="a"
                     /db_xref="dbSNP:1320510851"
     variation       2430
                     /replace="s"
                     /db_xref="dbSNP:760469263"
     variation       2432
                     /replace="d"
                     /db_xref="dbSNP:752737051"
     variation       2433
                     /replace="r"
                     /db_xref="dbSNP:1021696810"
     variation       2435
                     /replace="a"
                     /db_xref="dbSNP:140828600"
     variation       2436
                     /replace="d"
                     /db_xref="dbSNP:766930052"
     variation       2439
                     /replace="l"
                     /db_xref="dbSNP:1435835794"
     variation       2441
                     /replace="t"
                     /db_xref="dbSNP:759157028"
     variation       2442
                     /replace="p"
                     /db_xref="dbSNP:774125145"
     variation       2443
                     /replace="a"
                     /db_xref="dbSNP:770659526"
     variation       2443
                     /replace="k"
                     /db_xref="dbSNP:1209297833"
     variation       2443
                     /replace="t"
                     /db_xref="dbSNP:762727320"
     variation       2444
                     /replace="c"
                     /db_xref="dbSNP:1195379679"
     variation       2444
                     /replace="y"
                     /db_xref="dbSNP:1270169187"
     variation       2446
                     /replace="*"
                     /db_xref="dbSNP:376734320"
     variation       2448
                     /replace="t"
                     /db_xref="dbSNP:773384230"
     variation       2449
                     /replace="i"
                     /db_xref="dbSNP:781782105"
     variation       2449
                     /replace="l"
                     /db_xref="dbSNP:770211227"
     variation       2449
                     /replace="r"
                     /db_xref="dbSNP:559045162"
     variation       2450
                     /replace="k"
                     /db_xref="dbSNP:1167873049"
     variation       2451
                     /replace="v"
                     /db_xref="dbSNP:587778667"
     variation       2452
                     /replace="l"
                     /db_xref="dbSNP:775780402"
     variation       2452
                     /replace="s"
                     /db_xref="dbSNP:368025625"
     variation       2453
                     /replace="r"
                     /db_xref="dbSNP:1169041202"
     variation       2454
                     /replace="n"
                     /db_xref="dbSNP:1192809896"
     variation       2454
                     /replace="r"
                     /db_xref="dbSNP:76973370"
     Region          2457..2564
                     /region_name="Interaction with POLR2A.
                     {ECO:0000269|PubMed:16314571}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYW2.3)"
     variation       2458
                     /replace="a"
                     /db_xref="dbSNP:775487978"
     variation       2462
                     /replace="t"
                     /db_xref="dbSNP:978532524"
     variation       2467
                     /replace="g"
                     /db_xref="dbSNP:374861220"
     variation       2468
                     /replace="k"
                     /db_xref="dbSNP:746071825"
     Region          2469..2548
                     /region_name="SRI"
                     /note="SRI (Set2 Rpb1 interacting) domain; pfam08236"
                     /db_xref="CDD:285448"
     variation       2469
                     /replace="k"
                     /db_xref="dbSNP:759120660"
     variation       2472
                     /replace="d"
                     /db_xref="dbSNP:779235044"
     variation       2473
                     /replace="i"
                     /db_xref="dbSNP:773863597"
     variation       2473
                     /replace="v"
                     /db_xref="dbSNP:1362412741"
     variation       2478
                     /replace="i"
                     /db_xref="dbSNP:1452746194"
     variation       2479
                     /replace="s"
                     /db_xref="dbSNP:764468233"
     variation       2481
                     /replace="l"
                     /db_xref="dbSNP:1393123387"
     variation       2482
                     /replace="i"
                     /db_xref="dbSNP:1221536539"
     variation       2482
                     /replace="v"
                     /db_xref="dbSNP:761150552"
     variation       2483
                     /replace="i"
                     /db_xref="dbSNP:141852778"
     variation       2485
                     /replace="c"
                     /db_xref="dbSNP:1288526031"
     variation       2486
                     /replace="v"
                     /db_xref="dbSNP:1229860454"
     variation       2488
                     /replace="p"
                     /db_xref="dbSNP:895374808"
     variation       2489
                     /replace="f"
                     /db_xref="dbSNP:1343408083"
     variation       2490
                     /replace="w"
                     /db_xref="dbSNP:772135964"
     variation       2492
                     /replace="l"
                     /db_xref="dbSNP:1275303091"
     variation       2496
                     /replace="a"
                     /db_xref="dbSNP:1351585264"
     variation       2496
                     /replace="l"
                     /db_xref="dbSNP:746019134"
     variation       2498
                     /replace="r"
                     /db_xref="dbSNP:774308278"
     variation       2500
                     /replace="a"
                     /db_xref="dbSNP:1468592664"
     variation       2500
                     /replace="t"
                     /db_xref="dbSNP:148499835"
     variation       2503
                     /replace="d"
                     /db_xref="dbSNP:1388010738"
     variation       2504
                     /replace="n"
                     /db_xref="dbSNP:749502690"
     variation       2505
                     /replace="f"
                     /db_xref="dbSNP:1244994348"
     variation       2514
                     /replace="h"
                     /db_xref="dbSNP:767954928"
     variation       2524
                     /replace="y"
                     /db_xref="dbSNP:1415345880"
     variation       2525
                     /replace="e"
                     /db_xref="dbSNP:759966189"
     variation       2530
                     /replace="l"
                     /db_xref="dbSNP:199973330"
     variation       2534
                     /replace="a"
                     /db_xref="dbSNP:1449450654"
     variation       2534
                     /replace="e"
                     /db_xref="dbSNP:1248081279"
     variation       2535
                     /replace="n"
                     /db_xref="dbSNP:770936612"
     variation       2536
                     /replace="v"
                     /db_xref="dbSNP:902794659"
     variation       2537
                     /replace="q"
                     /db_xref="dbSNP:1482006562"
     variation       2542
                     /replace="a"
                     /db_xref="dbSNP:368761115"
     variation       2548
                     /replace="i"
                     /db_xref="dbSNP:1255000290"
     variation       2548
                     /replace="t"
                     /db_xref="dbSNP:1015979303"
     variation       2548
                     /replace="v"
                     /db_xref="dbSNP:1042058100"
     variation       2549
                     /replace="*"
                     /db_xref="dbSNP:1210400257"
     variation       2549
                     /replace="q"
                     /db_xref="dbSNP:763210716"
     variation       2550
                     /replace="t"
                     /db_xref="dbSNP:773606468"
     variation       2551
                     /replace="l"
                     /db_xref="dbSNP:1386662369"
     variation       2552
                     /replace="g"
                     /db_xref="dbSNP:1443231280"
     variation       2554
                     /replace="i"
                     /db_xref="dbSNP:768564000"
     variation       2560
                     /replace="v"
                     /db_xref="dbSNP:374840624"
     variation       2563
                     /replace="f"
                     /db_xref="dbSNP:34246758"
     variation       2564
                     /replace="k"
                     /db_xref="dbSNP:780004717"
     CDS             1..2564
                     /gene="SETD2"
                     /gene_synonym="HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A;
                     LLS; p231HBP; SET2"
                     /coded_by="NM_014159.6:54..7748"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2749.2"
                     /db_xref="GeneID:29072"
                     /db_xref="HGNC:HGNC:18420"
                     /db_xref="MIM:612778"
ORIGIN      
        1 mkqlqpqppp kmgdfydpeh ptpeeeenea kienvqktgf ikgpmfkgva ssrflpkgtk
       61 tkvnleeqgr qkvsfsfslt kktlqnrflt algnekqsdt pnppavplqv dstpkmkmei
      121 gdtlstaees sppksrvelg kihfkkhllh vtsrpllatt tavaspptha aplpaviaes
      181 ttvdsppssp ppppppaqat tlsspapvte pvalphtpit vlmaapvplp vdvavrslke
      241 ppiiivpesl eadtkqdtis nsleehvtqi lneqadissk kedshigkde eipdsskisl
      301 sckktgskkk ssqsegiflg sesdedsvrt sssqrshdlk fsasiekerd fkkssaplks
      361 edlgkpsrsk tdrddkyfsy sklerdtryv ssrcrserer rrsrshsrse rgsrtnlsys
      421 rsershyyds drryhrsspy rertrysrpy tdnraressd seeeykktys rrtsshsssy
      481 rdlrtssysk sdrdcktets ylemerrgky ssklereskr tseneaikrc csppnelgfr
      541 rgssyskhds sasrykstls kpipksdkfk nsfcctelne eikqshsfsl qtpcskgsel
      601 rminknpere kagspapsnr lndsptlkkl delpifksef ithdshdsik eldslskvkn
      661 dqlrsfcpie lningspgae sdlatfctsk tdavlmtsdd svtgselspl vkacmlssng
      721 fqnisrckek dlddtcmlhk ksespfrete plvsphqdkl msmpvmtvdy sktvvkepvd
      781 trvsccktkd sdiyctlnds npslcnseae niepsvmkis snsfmnvhle skpvicdsrn
      841 ltdhskface eykqsigsts sasvnhfddl yqpigssgia sslqslppgi kvdsltllkc
      901 gentspvlda vlkskkssef lkhagketiv evgsdlpdsg kgfasrenrr nnglsgkclq
      961 eaqeegnsil perrgrpeis ldergegghv htsddsevvf sscdlnltme dsdgvtyalk
     1021 cdssghapei vstvhedysg ssessndesd sedtdsddss iprnrlqsvv vvpknstlpm
     1081 eetspcssrs sqsyrhysdh wederlesrr hlyeekfesi askacpqtdk fflhkgtekn
     1141 peisftqssr kqidnrlpel shpqsdgvds tshtdvksdp lghpnseetv kakipsrqqe
     1201 elpiyssdfe dvpnkswqqt tfqnrpdsrl gktelsfsss ceiphvdglh sseelrnlgw
     1261 dfsqekpstt yqqpdssyga cgghkyqqna eqyggtrdyw qgngywdprs grppgtgvvy
     1321 drtqgqvpds ltddreeeen wdqqdgshfs dqsdkfllsl qkdkgsvqap eissnsikdt
     1381 lavnekkdfs knlekndikd rgplkkrrqe iesdsesdge lqdrkkvrve veqgetsvpp
     1441 gsalvgpscv mddfrdpqrw kecakqgkmp cyfdlieenv ylterkknks hrdikrmqce
     1501 ctplskdera qgeiacgedc lnrllmiecs srcpngdycs nrrfqrkqha dveviltekk
     1561 gwglraakdl psntfvleyc gevldhkefk arvkeyarnk nihyyfmalk ndeiidatqk
     1621 gncsrfmnhs cepncetqkw tvngqlrvgf fttklvpsgs eltfdyqfqr ygkeaqkcfc
     1681 gsancrgylg genrvsiraa ggkmkkersr kkdsvdgele almengegls dknqvlslsr
     1741 lmvrietleq kltcleliqn thsqsclksf lerhglsllw iwmaelgdgr esnqklqeei
     1801 iktlehlpip tknmleeskv lpiiqrwsqt ktavpplseg dgyssentsr ahtplntpdp
     1861 stklsteadt dtpkklmfrr lkiisensmd saisdatsel egkdgkedld qlenvpveee
     1921 eelqsqqllp qqlpeckvds etnieasklp tsepeadaei epkesngtkl eepineetps
     1981 qdeeegvsdv esersqeqpd ktvdisdlat klldswkdlk evyripkksq tekenttter
     2041 grdavgfrdq tpapktpnrs rerdpdkqtq nkekrkrrss lsppssayer gtkrpddryd
     2101 tptskkkvri kdrnklstee rrklfeqeva qreaqkqqqq mqnlgmtspl pydslgynap
     2161 hhpfagyppg ypmqayvdps npnagkvllp tpsmdpvcsp apydhaqplv ghsteplsap
     2221 ppvpvvphva apvevsssqy vaqsdgvvhq dssvavlpvp apgpvqgqny svwdsnqqsv
     2281 svqqqyspaq sqatiyyqgq tcptvygvts pysqttppiv qsyaqpslqy iqgqqiftah
     2341 pqgvvvqpaa avttivapgq pqplqpsemv vtnnlldlpp psppkpktiv lppnwktard
     2401 pegkiyyyhv itrqtqwdpp twespgddas leheaemdlg tptydenpmk askkpktaea
     2461 dtsselakks kevfrkemsq fivqclnpyr kpdckvgrit ttedfkhlar klthgvmnke
     2521 lkycknpedl ecnenvkhkt keyikkymqk fgavykpked tele
//
DBGET integrated database retrieval system