Database: RefSeq
Entry: NP_057321
LinkDB: NP_057321
Original site: NP_057321 
LOCUS       NP_057321                755 aa            linear   PRI 07-SEP-2020
DEFINITION  anaphase-promoting complex subunit 5 isoform a [Homo sapiens].
VERSION     NP_057321.2
DBSOURCE    REFSEQ: accession NM_016237.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 755)
  AUTHORS   Xu M, Liu X, Xu Y, Zhu S and Gao Y.
  TITLE     Coexpression of Axin and APC gene fragments inhibits colorectal
            cancer cell growth via regulation of the Wnt signaling pathway
  JOURNAL   Mol Med Rep 16 (4), 3783-3790 (2017)
   PUBMED   28731177
  REMARK    GeneRIF: coexpression of APC5 and Axin genes significantly
            downregulated Wnt signaling in human SW480 CRC cells and inhibited
            cell growth.
REFERENCE   2  (residues 1 to 755)
  AUTHORS   Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M and
            Pandolfi PP.
  TITLE     Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a
            phosphatase-independent manner
  JOURNAL   Cell 144 (2), 187-199 (2011)
   PUBMED   21241890
REFERENCE   3  (residues 1 to 755)
  AUTHORS   Tran K, Kamil JP, Coen DM and Spector DH.
  TITLE     Inactivation and disassembly of the anaphase-promoting complex
            during human cytomegalovirus infection is associated with
            degradation of the APC5 and APC4 subunits and does not require
            UL97-mediated phosphorylation of Cdh1
  JOURNAL   J. Virol. 84 (20), 10832-10843 (2010)
   PUBMED   20686030
  REMARK    GeneRIF: Inactivation and disassembly of the anaphase-promoting
            complex during human cytomegalovirus infection is associated with
            degradation of the APC5 and APC4 subunits and does not require
            UL97-mediated phosphorylation of Cdh1.
REFERENCE   4  (residues 1 to 755)
  AUTHORS   Wasch R, Robbins JA and Cross FR.
  TITLE     The emerging role of APC/CCdh1 in controlling differentiation,
            genomic stability and tumor suppression
  JOURNAL   Oncogene 29 (1), 1-10 (2010)
   PUBMED   19826416
  REMARK    GeneRIF: Studies indicate that APC/C(Cdh1) is required to maintain
            genomic stability.
            Review article
REFERENCE   5  (residues 1 to 755)
  AUTHORS   Jin L, Williamson A, Banerjee S, Philipp I and Rape M.
  TITLE     Mechanism of ubiquitin-chain formation by the human
            anaphase-promoting complex
  JOURNAL   Cell 133 (4), 653-665 (2008)
   PUBMED   18485873
REFERENCE   6  (residues 1 to 755)
  AUTHORS   Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J and
            Peters JM.
  TITLE     Mitotic regulation of the human anaphase-promoting complex by
  JOURNAL   EMBO J. 22 (24), 6598-6609 (2003)
   PUBMED   14657031
REFERENCE   7  (residues 1 to 755)
  AUTHORS   Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F and Peters
  TITLE     TPR subunits of the anaphase-promoting complex mediate binding to
            the activator protein CDH1
  JOURNAL   Curr. Biol. 13 (17), 1459-1468 (2003)
   PUBMED   12956947
REFERENCE   8  (residues 1 to 755)
  AUTHORS   Autieri MV.
  TITLE     Expression of anaphase-promoting complex 5 in balloon
            angioplasty-injured rat carotid arteries and mitogen-stimulated
            human vascular smooth muscle cells
  JOURNAL   Biochem. Biophys. Res. Commun. 282 (3), 723-728 (2001)
   PUBMED   11401522
REFERENCE   9  (residues 1 to 755)
  AUTHORS   Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
            Schleiffer A, Nasmyth K, Mann M and Peters JM.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J. Biol. Chem. 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (residues 1 to 755)
  AUTHORS   Yu H, Peters JM, King RW, Page AM, Hieter P and Kirschner MW.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI879332.1, BC001950.1,
            AA349724.1 and BX381618.2.
            On Apr 10, 2002 this sequence version replaced NP_057321.1.
            Summary: This gene encodes a tetratricopeptide repeat-containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for the proper ubiquitination function
            of APC/C and for the interaction of APC/C with transcription
            coactivators. It also interacts with polyA binding protein and
            represses internal ribosome entry site-mediated translation.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. These differences cause translation initiation
            at a downstream AUG and result in a shorter protein (isoform b),
            compared to isoform a. [provided by RefSeq, Nov 2008].
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            Transcript exon combination :: SRR1803617.250353.1,
                                           SRR1803612.195069.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
            MANE Ensembl match     :: ENST00000261819.8/ ENSP00000261819.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
     Protein         1..755
                     /product="anaphase-promoting complex subunit 5 isoform a"
                     /note="cyclosome subunit 5"
     Region          32..165
                     /note="N-terminal domain of the anaphase-promoting complex
                     subunit Apc5 (or Anapc5); cd16270"
     Site            order(44..45,54,57..58,61..62,64..65,69,124,129..132)
                     /note="Apc4 interaction interface [polypeptide binding]"
     Site            order(104..106,109,113,143,147..150,152..153)
                     /note="CDC23 interaction interface [polypeptide binding]"
     Site            order(134,137..138,141,144..145)
                     /note="APC subunit 15 interaction interface [polypeptide
     Site            195
                     /evidence=ECO:0000269|PubMed:14657031; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          209..249
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Site            232
                     /evidence=ECO:0000244|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          248..282
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
     Region          250..300
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          254..354
                     /note="Anaphase-promoting complex subunit 5; pfam12862"
     Region          300..333
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
     Region          301..337
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          338..378
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          379..418
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          419..466
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          467..500
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          501..540
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          541..580
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          581..620
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          621..660
                     /region_name="TPR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          661..696
                     /region_name="TPR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     Region          697..736
                     /region_name="TPR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX4.2)"
     CDS             1..755
                     /note="isoform a is encoded by transcript variant 1"
        1 masvheslyf npmmtngvvh anvfgikdwv tpykiavlvl lnemsrtgeg avslmerrrl
       61 nqlllpllqg pditlsklyk lieescpqla nsvqiriklm aegelkdmeq ffddlsdsfs
      121 gtepevhkts vvglflrhmi laysklsfsq vfklytalqq yfqngekktv edadmeltsr
      181 degerkmeke eldvsvreee vscsgplsqk qaefflsqqa sllkndetka ltpaslqkel
      241 nnllkfnpdf aeahylsyln nlrvqdvfss thsllhyfdr liltgaesks ngeegygrsl
      301 ryaalnlaal hcrfghyqqa elalqeairi aqesndhvcl qhclswlyvl gqkrsdsyvl
      361 lehsvkkavh fglpylaslg iqslvqqraf agktanklmd alkdsdllhw khslselidi
      421 siaqktaiwr lygrstmalq qaqmllsmns leavnagvqq nntesfaval chlaelhaeq
      481 gcfaaasevl khlkerfppn sqhaqlwmlc dqkiqfdram ndgkyhlads lvtgitalns
      541 iegvyrkavv lqaqnqmsea hkllqkllvh cqklkntemv isvllsvael ywrsssptia
      601 lpmllqalal skeyrlqyla setvlnlafa qlilgipeqa lsllhmaiep iladgaildk
      661 gramflvakc qvasaasydq pkkaealeaa ienlneakny fakvdckeri rdvvyfqarl
      721 yhtlgktqer nrcamlfrql hqelpshgvp linhl
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