LOCUS NP_057322 599 aa linear PRI 20-JUN-2020
DEFINITION anaphase-promoting complex subunit 7 isoform a [Homo sapiens].
ACCESSION NP_057322
VERSION NP_057322.2
DBSOURCE REFSEQ: accession NM_016238.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 599)
AUTHORS Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M,
Stemmann O and Choudhary C.
TITLE Deletion of APC7 or APC16 Allows Proliferation of Human Cells
without the Spindle Assembly Checkpoint
JOURNAL Cell Rep 25 (9), 2317-2328 (2018)
PUBMED 30485802
REMARK GeneRIF: the contribution of the anaphase-promoting
complex/cyclosome subunits APC7 and APC16 to APC/C composition and
function in human cells.
REFERENCE 2 (residues 1 to 599)
AUTHORS Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y,
van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ,
Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ,
Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B,
Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM,
Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E,
Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ,
Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U,
Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB and
Roepman R.
CONSRTM UK10K Rare Diseases Group
TITLE An organelle-specific protein landscape identifies novel diseases
and molecular mechanisms
JOURNAL Nat Commun 7, 11491 (2016)
PUBMED 27173435
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 599)
AUTHORS Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA,
Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M.
TITLE A human interactome in three quantitative dimensions organized by
stoichiometries and abundances
JOURNAL Cell 163 (3), 712-723 (2015)
PUBMED 26496610
REFERENCE 4 (residues 1 to 599)
AUTHORS Rahimi H, Ahmadzadeh A, Yousef-amoli S, Kokabee L, Shokrgozar MA,
Mahdian R and Karimipoor M.
TITLE The expression pattern of APC2 and APC7 in various cancer cell
lines and AML patients
JOURNAL Adv Med Sci 60 (2), 259-263 (2015)
PUBMED 26046517
REMARK GeneRIF: The results showed that APC2 and APC7 subunits were both
over expressed in cancer cell lines
REFERENCE 5 (residues 1 to 599)
AUTHORS Zhang Z, Yang J, Kong EH, Chao WC, Morris EP, da Fonseca PC and
Barford D.
TITLE Recombinant expression, reconstitution and structure of human
anaphase-promoting complex (APC/C)
JOURNAL Biochem. J. 449 (2), 365-371 (2013)
PUBMED 23078409
REMARK GeneRIF: Data indicate that additional density present in the
anaphase-promoting complex (APC/C) structure, proximal to
Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to
the TPR subunit Apc7, a subunit specific to vertebrate APC/C.
REFERENCE 6 (residues 1 to 599)
AUTHORS Sudakin V, Chan GK and Yen TJ.
TITLE Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
complex of BUBR1, BUB3, CDC20, and MAD2
JOURNAL J. Cell Biol. 154 (5), 925-936 (2001)
PUBMED 11535616
REFERENCE 7 (residues 1 to 599)
AUTHORS Gieffers C, Peters BH, Kramer ER, Dotti CG and Peters JM.
TITLE Expression of the CDH1-associated form of the anaphase-promoting
complex in postmitotic neurons
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (20), 11317-11322 (1999)
PUBMED 10500174
REFERENCE 8 (residues 1 to 599)
AUTHORS Chan GK, Jablonski SA, Sudakin V, Hittle JC and Yen TJ.
TITLE Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
functions at kinetochores and binds the cyclosome/APC
JOURNAL J. Cell Biol. 146 (5), 941-954 (1999)
PUBMED 10477750
REFERENCE 9 (residues 1 to 599)
AUTHORS Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
Schleiffer A, Nasmyth K, Mann M and Peters JM.
TITLE Characterization of the DOC1/APC10 subunit of the yeast and the
human anaphase-promoting complex
JOURNAL J. Biol. Chem. 274 (20), 14500-14507 (1999)
PUBMED 10318877
REFERENCE 10 (residues 1 to 599)
AUTHORS Yu H, Peters JM, King RW, Page AM, Hieter P and Kirschner MW.
TITLE Identification of a cullin homology region in a subunit of the
anaphase-promoting complex
JOURNAL Science 279 (5354), 1219-1222 (1998)
PUBMED 9469815
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB003237.1, BC098362.1 and
AL157481.1.
On Nov 13, 2008 this sequence version replaced NP_057322.1.
Summary: This gene encodes a tetratricopeptide repeat containing
component of the anaphase promoting complex/cyclosome (APC/C), a
large E3 ubiquitin ligase that controls cell cycle progression by
targeting a number of cell cycle regulators such as B-type cyclins
for 26S proteasome-mediated degradation through ubiquitination. The
encoded protein is required for proper protein ubiquitination
function of APC/C and for the interaction of APC/C with certain
transcription coactivators. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Nov 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.231986.1,
SRR1660803.8148.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..599
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.11"
Protein 1..599
/product="anaphase-promoting complex subunit 7 isoform a"
/note="cyclosome subunit 7"
/calculated_mol_wt=66725
Region 135..168
/region_name="TPR 1"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 203..236
/region_name="TPR 2"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 237..270
/region_name="TPR 3"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Site 263
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q9WVM3; propagated from
UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 271..304
/region_name="TPR 4"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 346..404
/region_name="TPR_11"
/note="TPR repeat; pfam13414"
/db_xref="CDD:290150"
Site order(347..348,350,374,377..378,381..382,384..385,408,
411..412,415..416,419)
/site_type="other"
/note="putative protein binding surface [polypeptide
binding]"
/db_xref="CDD:276809"
Region 372..402
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 373..406
/region_name="TPR 5"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 373..404
/region_name="TPR"
/note="Tetratricopeptide repeats; smart00028"
/db_xref="CDD:197478"
Region 407..440
/region_name="TPR 6"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 441..475
/region_name="TPR 7"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 476..508
/region_name="TPR 8"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 476..504
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 481..542
/region_name="TPR_16"
/note="Tetratricopeptide repeat; pfam13432"
/db_xref="CDD:290168"
Region 509..542
/region_name="TPR 9"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
Region 509..537
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 543..565
/region_name="TPR 10"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
CDS 1..599
/gene="ANAPC7"
/gene_synonym="APC7"
/coded_by="NM_016238.2:2..1801"
/note="isoform a is encoded by transcript variant 1"
/db_xref="CCDS:CCDS9145.2"
/db_xref="GeneID:51434"
/db_xref="HGNC:HGNC:17380"
/db_xref="MIM:606949"
ORIGIN
1 mdpgdaaile sslrilyrlf esvlpplpaa lqsrmnvidh vrdmaaaglh snvrllssll
61 ltmsnnnpel fsppqkyqll vyhadslfhd keyrnavsky tmalqqkkal sktskvrpst
121 gnsastpqsq clpseievky kmaecytmlk qdkdaiaild gipsrqrtpk inmmlanlyk
181 kagqerpsvt sykevlrqcp laldailgll slsvkgaeva smtmnviqtv pnldwlsvwi
241 kayafvhtgd nsraistics lekksllrdn vdllgsladl yfragdnkns vlkfeqaqml
301 dpylikgmdv ygyllaregr ledvenlgcr lfnisdqhae pwvvsgchsf yskrysraly
361 lgakaiqlns nsvqalllkg aalrnmgrvq eaiihfreai rlapcrldcy egliecylas
421 nsireamvma nnvyktlgan aqtltllatv cledpvtqek aktlldkalt qrpdyikavv
481 kkaellsreq kyedgiallr nalanqsdcv lhrilgdflv avneyqeamd qysialsldp
541 ndqkslegmq kmekeesptd atqeedvddm egsgeegdle gsdseaaqwa dqeqwfgmq
//
