LOCUS NP_057322 565 aa linear PRI 29-APR-2025
DEFINITION anaphase-promoting complex subunit 7 isoform a [Homo sapiens].
ACCESSION NP_057322
VERSION NP_057322.3
DBSOURCE REFSEQ: accession NM_016238.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 565)
AUTHORS Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
Schulman,B.A., Brown,N.G. and Bonni,A.
TITLE APC7 mediates ubiquitin signaling in constitutive heterochromatin
in the developing mammalian brain
JOURNAL Mol Cell 82 (1), 90-105 (2022)
PUBMED 34942119
REMARK GeneRIF: APC7 mediates ubiquitin signaling in constitutive
heterochromatin in the developing mammalian brain.
REFERENCE 2 (residues 1 to 565)
AUTHORS Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
Barisic,M., Stemmann,O. and Choudhary,C.
TITLE Deletion of APC7 or APC16 Allows Proliferation of Human Cells
without the Spindle Assembly Checkpoint
JOURNAL Cell Rep 25 (9), 2317-2328 (2018)
PUBMED 30485802
REMARK GeneRIF: the contribution of the anaphase-promoting
complex/cyclosome subunits APC7 and APC16 to APC/C composition and
function in human cells.
REFERENCE 3 (residues 1 to 565)
AUTHORS Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
and Rape,M.
TITLE Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
and Protein Quality Control
JOURNAL Cell 171 (4), 918-933 (2017)
PUBMED 29033132
REFERENCE 4 (residues 1 to 565)
AUTHORS Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
CONSRTM UK10K Rare Diseases Group
TITLE An organelle-specific protein landscape identifies novel diseases
and molecular mechanisms
JOURNAL Nat Commun 7, 11491 (2016)
PUBMED 27173435
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 565)
AUTHORS Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
Skehel,M. and Barford,D.
TITLE Molecular mechanism of APC/C activation by mitotic phosphorylation
JOURNAL Nature 533 (7602), 260-264 (2016)
PUBMED 27120157
REFERENCE 6 (residues 1 to 565)
AUTHORS Sudakin,V., Chan,G.K. and Yen,T.J.
TITLE Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
complex of BUBR1, BUB3, CDC20, and MAD2
JOURNAL J Cell Biol 154 (5), 925-936 (2001)
PUBMED 11535616
REFERENCE 7 (residues 1 to 565)
AUTHORS Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
TITLE Expression of the CDH1-associated form of the anaphase-promoting
complex in postmitotic neurons
JOURNAL Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
PUBMED 10500174
REFERENCE 8 (residues 1 to 565)
AUTHORS Chan,G.K., Jablonski,S.A., Sudakin,V., Hittle,J.C. and Yen,T.J.
TITLE Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
functions at kinetochores and binds the cyclosome/APC
JOURNAL J Cell Biol 146 (5), 941-954 (1999)
PUBMED 10477750
REFERENCE 9 (residues 1 to 565)
AUTHORS Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
TITLE Characterization of the DOC1/APC10 subunit of the yeast and the
human anaphase-promoting complex
JOURNAL J Biol Chem 274 (20), 14500-14507 (1999)
PUBMED 10318877
REFERENCE 10 (residues 1 to 565)
AUTHORS Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
Kirschner,M.W.
TITLE Identification of a cullin homology region in a subunit of the
anaphase-promoting complex
JOURNAL Science 279 (5354), 1219-1222 (1998)
PUBMED 9469815
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC144548.8 and BC098362.1.
On Jul 10, 2020 this sequence version replaced NP_057322.2.
Summary: This gene encodes a tetratricopeptide repeat containing
component of the anaphase promoting complex/cyclosome (APC/C), a
large E3 ubiquitin ligase that controls cell cycle progression by
targeting a number of cell cycle regulators such as B-type cyclins
for 26S proteasome-mediated degradation through ubiquitination. The
encoded protein is required for proper protein ubiquitination
function of APC/C and for the interaction of APC/C with certain
transcription coactivators. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Nov 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC141848.1, SRR1660809.138278.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000455511.9/ ENSP00000394394.4
RefSeq Select criteria :: based on manual assertion, conservation,
expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..565
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.11"
Protein 1..565
/product="anaphase-promoting complex subunit 7 isoform a"
/note="cyclosome subunit 7"
/calculated_mol_wt=63002
Region <99..392
/region_name="PEP_TPR_lipo"
/note="putative PEP-CTERM system TPR-repeat lipoprotein;
TIGR02917"
/db_xref="CDD:274350"
Region 101..134
/region_name="TPR 1"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 169..202
/region_name="TPR 2"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 203..236
/region_name="TPR 3"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Site 229
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q9WVM3; propagated from
UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 237..270
/region_name="TPR 4"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 305..>517
/region_name="LapB"
/note="Lipopolysaccharide biosynthesis regulator
YciM/LapB, contains six TPR domains and a C-terminal
metal-binding domain [Cell wall/membrane/envelope
biogenesis]; COG2956"
/db_xref="CDD:442196"
Site order(313..314,316,340,343..344,347..348,350..351,374,
377..378,381..382,385)
/site_type="other"
/note="putative protein binding surface [polypeptide
binding]"
/db_xref="CDD:276809"
Region 338..368
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 339..372
/region_name="TPR 5"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 373..406
/region_name="TPR 6"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 407..441
/region_name="TPR 7"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 442..474
/region_name="TPR 8"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 442..470
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 475..508
/region_name="TPR 9"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 475..503
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 509..531
/region_name="TPR 10"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
Region 513..565
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
CDS 1..565
/gene="ANAPC7"
/gene_synonym="APC7; FERBON"
/coded_by="NM_016238.3:82..1779"
/note="isoform a is encoded by transcript variant 1"
/db_xref="CCDS:CCDS9145.3"
/db_xref="GeneID:51434"
/db_xref="HGNC:HGNC:17380"
/db_xref="MIM:606949"
ORIGIN
1 mnvidhvrdm aaaglhsnvr llssllltms nnnpelfspp qkyqllvyha dslfhdkeyr
61 navskytmal qqkkalskts kvrpstgnsa stpqsqclps eievkykmae cytmlkqdkd
121 aiaildgips rqrtpkinmm lanlykkagq erpsvtsyke vlrqcplald ailgllslsv
181 kgaevasmtm nviqtvpnld wlsvwikaya fvhtgdnsra isticslekk sllrdnvdll
241 gsladlyfra gdnknsvlkf eqaqmldpyl ikgmdvygyl laregrledv enlgcrlfni
301 sdqhaepwvv sgchsfyskr ysralylgak aiqlnsnsvq alllkgaalr nmgrvqeaii
361 hfreairlap crldcyegli ecylasnsir eamvmannvy ktlganaqtl tllatvcled
421 pvtqekaktl ldkaltqrpd yikavvkkae llsreqkyed giallrnala nqsdcvlhri
481 lgdflvavne yqeamdqysi alsldpndqk slegmqkmek eesptdatqe edvddmegsg
541 eegdlegsds eaaqwadqeq wfgmq
//
