GenomeNet

Database: RefSeq
Entry: NP_057322
LinkDB: NP_057322
Original site: NP_057322 
LOCUS       NP_057322                565 aa            linear   PRI 29-APR-2025
DEFINITION  anaphase-promoting complex subunit 7 isoform a [Homo sapiens].
ACCESSION   NP_057322
VERSION     NP_057322.3
DBSOURCE    REFSEQ: accession NM_016238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 565)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
  REMARK    GeneRIF: APC7 mediates ubiquitin signaling in constitutive
            heterochromatin in the developing mammalian brain.
REFERENCE   2  (residues 1 to 565)
  AUTHORS   Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
            Barisic,M., Stemmann,O. and Choudhary,C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   3  (residues 1 to 565)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (residues 1 to 565)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 565)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   6  (residues 1 to 565)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   7  (residues 1 to 565)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (residues 1 to 565)
  AUTHORS   Chan,G.K., Jablonski,S.A., Sudakin,V., Hittle,J.C. and Yen,T.J.
  TITLE     Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
            functions at kinetochores and binds the cyclosome/APC
  JOURNAL   J Cell Biol 146 (5), 941-954 (1999)
   PUBMED   10477750
REFERENCE   9  (residues 1 to 565)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (residues 1 to 565)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC144548.8 and BC098362.1.
            
            On Jul 10, 2020 this sequence version replaced NP_057322.2.
            
            Summary: This gene encodes a tetratricopeptide repeat containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for proper protein ubiquitination
            function of APC/C and for the interaction of APC/C with certain
            transcription coactivators. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141848.1, SRR1660809.138278.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455511.9/ ENSP00000394394.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     Protein         1..565
                     /product="anaphase-promoting complex subunit 7 isoform a"
                     /note="cyclosome subunit 7"
                     /calculated_mol_wt=63002
     Region          <99..392
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          101..134
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          169..202
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          203..236
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Site            229
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9WVM3; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          237..270
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          305..>517
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(313..314,316,340,343..344,347..348,350..351,374,
                     377..378,381..382,385)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          338..368
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          339..372
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          373..406
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          407..441
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          442..474
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          442..470
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          475..508
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          475..503
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          509..531
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     Region          513..565
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.5)"
     CDS             1..565
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /coded_by="NM_016238.3:82..1779"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9145.3"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
ORIGIN      
        1 mnvidhvrdm aaaglhsnvr llssllltms nnnpelfspp qkyqllvyha dslfhdkeyr
       61 navskytmal qqkkalskts kvrpstgnsa stpqsqclps eievkykmae cytmlkqdkd
      121 aiaildgips rqrtpkinmm lanlykkagq erpsvtsyke vlrqcplald ailgllslsv
      181 kgaevasmtm nviqtvpnld wlsvwikaya fvhtgdnsra isticslekk sllrdnvdll
      241 gsladlyfra gdnknsvlkf eqaqmldpyl ikgmdvygyl laregrledv enlgcrlfni
      301 sdqhaepwvv sgchsfyskr ysralylgak aiqlnsnsvq alllkgaalr nmgrvqeaii
      361 hfreairlap crldcyegli ecylasnsir eamvmannvy ktlganaqtl tllatvcled
      421 pvtqekaktl ldkaltqrpd yikavvkkae llsreqkyed giallrnala nqsdcvlhri
      481 lgdflvavne yqeamdqysi alsldpndqk slegmqkmek eesptdatqe edvddmegsg
      541 eegdlegsds eaaqwadqeq wfgmq
//
DBGET integrated database retrieval system