Database: RefSeq
Entry: NP_057322
LinkDB: NP_057322
Original site: NP_057322 
LOCUS       NP_057322                599 aa            linear   PRI 20-JUN-2020
DEFINITION  anaphase-promoting complex subunit 7 isoform a [Homo sapiens].
VERSION     NP_057322.2
DBSOURCE    REFSEQ: accession NM_016238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M,
            Stemmann O and Choudhary C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y,
            van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ,
            Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ,
            Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B,
            Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM,
            Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E,
            Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ,
            Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U,
            Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB and
            Roepman R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA,
            Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Rahimi H, Ahmadzadeh A, Yousef-amoli S, Kokabee L, Shokrgozar MA,
            Mahdian R and Karimipoor M.
  TITLE     The expression pattern of APC2 and APC7 in various cancer cell
            lines and AML patients
  JOURNAL   Adv Med Sci 60 (2), 259-263 (2015)
   PUBMED   26046517
  REMARK    GeneRIF: The results showed that APC2 and APC7 subunits were both
            over expressed in cancer cell lines
REFERENCE   5  (residues 1 to 599)
  AUTHORS   Zhang Z, Yang J, Kong EH, Chao WC, Morris EP, da Fonseca PC and
            Barford D.
  TITLE     Recombinant expression, reconstitution and structure of human
            anaphase-promoting complex (APC/C)
  JOURNAL   Biochem. J. 449 (2), 365-371 (2013)
   PUBMED   23078409
  REMARK    GeneRIF: Data indicate that additional density present in the
            anaphase-promoting complex (APC/C) structure, proximal to
            Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to
            the TPR subunit Apc7, a subunit specific to vertebrate APC/C.
REFERENCE   6  (residues 1 to 599)
  AUTHORS   Sudakin V, Chan GK and Yen TJ.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J. Cell Biol. 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   7  (residues 1 to 599)
  AUTHORS   Gieffers C, Peters BH, Kramer ER, Dotti CG and Peters JM.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (residues 1 to 599)
  AUTHORS   Chan GK, Jablonski SA, Sudakin V, Hittle JC and Yen TJ.
  TITLE     Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
            functions at kinetochores and binds the cyclosome/APC
  JOURNAL   J. Cell Biol. 146 (5), 941-954 (1999)
   PUBMED   10477750
REFERENCE   9  (residues 1 to 599)
  AUTHORS   Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
            Schleiffer A, Nasmyth K, Mann M and Peters JM.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J. Biol. Chem. 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (residues 1 to 599)
  AUTHORS   Yu H, Peters JM, King RW, Page AM, Hieter P and Kirschner MW.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB003237.1, BC098362.1 and
            On Nov 13, 2008 this sequence version replaced NP_057322.1.
            Summary: This gene encodes a tetratricopeptide repeat containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for proper protein ubiquitination
            function of APC/C and for the interaction of APC/C with certain
            transcription coactivators. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            Transcript exon combination :: SRR1803616.231986.1,
                                           SRR1660803.8148.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
     Protein         1..599
                     /product="anaphase-promoting complex subunit 7 isoform a"
                     /note="cyclosome subunit 7"
     Region          135..168
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          203..236
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          237..270
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Site            263
                     /evidence=ECO:0000250|UniProtKB:Q9WVM3; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          271..304
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          346..404
                     /note="TPR repeat; pfam13414"
     Site            order(347..348,350,374,377..378,381..382,384..385,408,
                     /note="putative protein binding surface [polypeptide
     Region          372..402
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
     Region          373..406
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          373..404
                     /note="Tetratricopeptide repeats; smart00028"
     Region          407..440
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          441..475
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          476..508
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          476..504
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
     Region          481..542
                     /note="Tetratricopeptide repeat; pfam13432"
     Region          509..542
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     Region          509..537
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
     Region          543..565
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX3.4)"
     CDS             1..599
                     /note="isoform a is encoded by transcript variant 1"
        1 mdpgdaaile sslrilyrlf esvlpplpaa lqsrmnvidh vrdmaaaglh snvrllssll
       61 ltmsnnnpel fsppqkyqll vyhadslfhd keyrnavsky tmalqqkkal sktskvrpst
      121 gnsastpqsq clpseievky kmaecytmlk qdkdaiaild gipsrqrtpk inmmlanlyk
      181 kagqerpsvt sykevlrqcp laldailgll slsvkgaeva smtmnviqtv pnldwlsvwi
      241 kayafvhtgd nsraistics lekksllrdn vdllgsladl yfragdnkns vlkfeqaqml
      301 dpylikgmdv ygyllaregr ledvenlgcr lfnisdqhae pwvvsgchsf yskrysraly
      361 lgakaiqlns nsvqalllkg aalrnmgrvq eaiihfreai rlapcrldcy egliecylas
      421 nsireamvma nnvyktlgan aqtltllatv cledpvtqek aktlldkalt qrpdyikavv
      481 kkaellsreq kyedgiallr nalanqsdcv lhrilgdflv avneyqeamd qysialsldp
      541 ndqkslegmq kmekeesptd atqeedvddm egsgeegdle gsdseaaqwa dqeqwfgmq
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