LOCUS NP_063947 437 aa linear PRI 14-DEC-2022
DEFINITION transmembrane protease serine 4 isoform 1 [Homo sapiens].
ACCESSION NP_063947
VERSION NP_063947.2
DBSOURCE REFSEQ: accession NM_019894.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 437)
AUTHORS Xu X, Sun T and Jing J.
TITLE TMPRSS4 is a novel biomarker and correlated with immune
infiltration in thyroid carcinoma
JOURNAL BMC Endocr Disord 22 (1), 280 (2022)
PUBMED 36380313
REMARK GeneRIF: TMPRSS4 is a novel biomarker and correlated with immune
infiltration in thyroid carcinoma.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 437)
AUTHORS Temena MA and Acar A.
TITLE Increased TRIM31 gene expression is positively correlated with
SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal
cancers
JOURNAL Sci Rep 12 (1), 11763 (2022)
PUBMED 35970857
REMARK GeneRIF: Increased TRIM31 gene expression is positively correlated
with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in
gastrointestinal cancers.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 437)
AUTHORS Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N,
Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K and Tashiro H.
TITLE Utility of TMPRSS4 as a Prognostic Biomarker and Potential
Therapeutic Target in Patients with Gastric Cancer
JOURNAL J Gastrointest Surg 26 (2), 305-313 (2022)
PUBMED 34379296
REMARK GeneRIF: Utility of TMPRSS4 as a Prognostic Biomarker and Potential
Therapeutic Target in Patients with Gastric Cancer.
REFERENCE 4 (residues 1 to 437)
AUTHORS Zhao XF, Yang YS, Gao DZ and Park YK.
TITLE TMPRSS4 overexpression promotes the metastasis of colorectal cancer
and predicts poor prognosis of stage III-IV colorectal cancer
JOURNAL Int J Biol Markers 36 (3), 23-32 (2021)
PUBMED 34595980
REMARK GeneRIF: TMPRSS4 overexpression promotes the metastasis of
colorectal cancer and predicts poor prognosis of stage III-IV
colorectal cancer.
REFERENCE 5 (residues 1 to 437)
AUTHORS Yang YS, Wen D and Zhao XF.
TITLE Transmembrane Protease TMPRSS4 Promotes the Formation and
Development of Mismatch Repair Deficient Colon Cancer Liver
Metastasis
JOURNAL Bull Exp Biol Med 171 (2), 242-246 (2021)
PUBMED 34173918
REMARK GeneRIF: Transmembrane Protease TMPRSS4 Promotes the Formation and
Development of Mismatch Repair Deficient Colon Cancer Liver
Metastasis.
Erratum:[Bull Exp Biol Med. 2021 Nov;172(1):112. PMID: 34796428]
REFERENCE 6 (residues 1 to 437)
AUTHORS Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch
S, Steffen I, Choi SY, Park Y, Schneider H, Schughart K and
Pohlmann S.
TITLE TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of
influenza virus in Caco-2 cells
JOURNAL J Virol 84 (19), 10016-10025 (2010)
PUBMED 20631123
REMARK GeneRIF: RNAi-mediated knockdown of TMPRSS2 and TMPRSS4 in Caco-2
cells, which released fully infectious virus without trypsin
treatment, markedly reduced the spread of influenza virus,
demonstrating that these proteases were responsible for activation
of HA.
REFERENCE 7 (residues 1 to 437)
AUTHORS Kim S, Kang HY, Nam EH, Choi MS, Zhao XF, Hong CS, Lee JW, Lee JH
and Park YK.
TITLE TMPRSS4 induces invasion and epithelial-mesenchymal transition
through upregulation of integrin alpha5 and its signaling pathways
JOURNAL Carcinogenesis 31 (4), 597-606 (2010)
PUBMED 20118200
REMARK GeneRIF: TMPRSS4 expression was significantly higher in human
colorectal cancer tissues from advanced stages than in that of
early stage.
REFERENCE 8 (residues 1 to 437)
AUTHORS Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS,
Takeda M, Bugge TH, Kim S, Park Y, Marzi A and Pohlmann S.
TITLE Proteolytic activation of the 1918 influenza virus hemagglutinin
JOURNAL J Virol 83 (7), 3200-3211 (2009)
PUBMED 19158246
REMARK GeneRIF: The authors provide evidence that TMPRSS2 and TMPRSS4
activate the 1918 HA by cleavage and therefore may promote viral
spread in lung tissue.
REFERENCE 9 (residues 1 to 437)
AUTHORS Jung H, Lee KP, Park SJ, Park JH, Jang YS, Choi SY, Jung JG, Jo K,
Park DY, Yoon JH, Park JH, Lim DS, Hong GR, Choi C, Park YK, Lee
JW, Hong HJ, Kim S and Park YW.
TITLE TMPRSS4 promotes invasion, migration and metastasis of human tumor
cells by facilitating an epithelial-mesenchymal transition
JOURNAL Oncogene 27 (18), 2635-2647 (2008)
PUBMED 17968309
REMARK GeneRIF: TMPRSS4 plays a role in invasion, metastasis, migration
and adhesion in cancer cells. TMPRSS4 may contribute to tumor cell
invasion and metastasis by promoting an epithelial-mesenchymal
transition(EMT) through the strong SIP1/ZEB2 induction.
REFERENCE 10 (residues 1 to 437)
AUTHORS Wallrapp C, Hahnel S, Muller-Pillasch F, Burghardt B, Iwamura T,
Ruthenburger M, Lerch MM, Adler G and Gress TM.
TITLE A novel transmembrane serine protease (TMPRSS3) overexpressed in
pancreatic cancer
JOURNAL Cancer Res 60 (10), 2602-2606 (2000)
PUBMED 10825129
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AP000665.5 and AP002800.4.
This sequence is a reference standard in the RefSeqGene project.
On May 17, 2019 this sequence version replaced NP_063947.1.
Summary: This gene encodes a member of the serine protease family.
Serine proteases are known to be involved in a variety of
biological processes, whose malfunction often leads to human
diseases and disorders. This gene was identified as a gene
overexpressed in pancreatic carcinoma. The encoded protein is
membrane bound with a N-terminal anchor sequence and a glycosylated
extracellular region containing the serine protease domain. The
protein has been found to promote SARS-CoV-2 entry into host cells.
[provided by RefSeq, Aug 2021].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1). The splice acceptor
site used for the first intron of this variant is polymorphic in
the human population (rs2276122), and it is not known if this
variant can be expressed from individuals with the 'A' allele.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC011703.2, AF179224.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968189, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
coronavirus related :: involved in SARS-CoV-2 infection
MANE Ensembl match :: ENST00000437212.8/ ENSP00000416037.3
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..437
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
Protein 1..437
/product="transmembrane protease serine 4 isoform 1"
/note="transmembrane serine protease 3; membrane-type
serine protease 2; type II membrane serine protease;
channel-activating protease 2; transmembrane protease,
serine 4; channel-activating serine protease 2"
/calculated_mol_wt=48116
Site 33..53
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NRS4.2)"
Region 58..92
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(62,71,82..83)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(75,78,82,88..89)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 85..89
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 108..197
/region_name="SRCR_2"
/note="Scavenger receptor cysteine-rich domain; cl02509"
/db_xref="CDD:445805"
Site 130
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9NRS4.2)"
Site 178
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9NRS4.2)"
Region 204..429
/region_name="Tryp_SPc"
/note="Trypsin-like serine protease; smart00020"
/db_xref="CDD:214473"
Site 204..205
/site_type="cleavage"
/note="Cleavage. /evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9NRS4.2)"
Site 205
/site_type="active"
/note="cleavage site [active]"
/db_xref="CDD:238113"
Site order(245,290,387)
/site_type="active"
/db_xref="CDD:238113"
Site order(381,405,407)
/site_type="other"
/note="substrate binding sites [chemical binding]"
/db_xref="CDD:238113"
CDS 1..437
/gene="TMPRSS4"
/gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
/coded_by="NM_019894.4:226..1539"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS31684.1"
/db_xref="GeneID:56649"
/db_xref="HGNC:HGNC:11878"
/db_xref="MIM:606565"
ORIGIN
1 mlqdpdsdqp lnsldvkplr kpripmetfr kvgipiiial lslasiiivv vlikvildky
61 yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp avavrlskdr stlqvldsat
121 gnwfsacfdn ftealaetac rqmgysskpt fraveigpdq dldvveiten sqelrmrnss
181 gpclsgslvs lhclacgksl ktprvvgvee asvdswpwqv siqydkqhvc ggsildphwv
241 ltaahcfrkh tdvfnwkvra gsdklgsfps lavakiiiie fnpmypkdnd ialmklqfpl
301 tfsgtvrpic lpffdeeltp atplwiigwg ftkqnggkms dillqasvqv idstrcnadd
361 ayqgevtekm mcagipeggv dtcqgdsggp lmyqsdqwhv vgivswgygc ggpstpgvyt
421 kvsaylnwiy nvwkael
//
