LOCUS NP_075049 823 aa linear PRI 04-DEC-2023
DEFINITION B-cell lymphoma/leukemia 11B isoform 2 [Homo sapiens].
ACCESSION NP_075049
VERSION NP_075049.1
DBSOURCE REFSEQ: accession NM_022898.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 823)
AUTHORS Wang Y, Zhang F, Gao N, Bu P, Cui W and Xi Y.
TITLE Differential expression of BCL11b and CDKN2A in CD30-positive
peripheral T cell lymphoma: Retrospective study
JOURNAL Medicine (Baltimore) 102 (46), e35531 (2023)
PUBMED 37986346
REMARK GeneRIF: Differential expression of BCL11b and CDKN2A in
CD30-positive peripheral T cell lymphoma: Retrospective study.
REFERENCE 2 (residues 1 to 823)
AUTHORS Liao R, Wu Y, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J,
Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X and Li
P.
TITLE BCL11B and the NuRD complex cooperatively guard T-cell fate and
inhibit OPA1-mediated mitochondrial fusion in T cells
JOURNAL EMBO J 42 (21), e113448 (2023)
PUBMED 37737560
REMARK GeneRIF: BCL11B and the NuRD complex cooperatively guard T-cell
fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
REFERENCE 3 (residues 1 to 823)
AUTHORS Yan Y, Wang S and Lin C.
TITLE BCL11B Upregulates the Expression of RelA in T Cells Stimulated
with Staphylococcal Enterotoxin A
JOURNAL Bull Exp Biol Med 174 (2), 259-264 (2022)
PUBMED 36602602
REMARK GeneRIF: BCL11B Upregulates the Expression of RelA in T Cells
Stimulated with Staphylococcal Enterotoxin A.
REFERENCE 4 (residues 1 to 823)
AUTHORS Johansson P, Laguna T, Ossowski J, Pancaldi V, Brauser M, Duhrsen
U, Keuneke L, Queiros A, Richter J, Martin-Subero JI, Siebert R,
Schlegelberger B, Kuppers R, Durig J, Murga Penas EM, Carillo-de
Santa Pau E and Bergmann AK.
TITLE Epigenome-wide analysis of T-cell large granular lymphocytic
leukemia identifies BCL11B as a potential biomarker
JOURNAL Clin Epigenetics 14 (1), 148 (2022)
PUBMED 36376973
REMARK GeneRIF: Epigenome-wide analysis of T-cell large granular
lymphocytic leukemia identifies BCL11B as a potential biomarker.
Erratum:[Clin Epigenetics. 2023 Jan 6;15(1):3. PMID: 36609404]
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 823)
AUTHORS Liang T, Wang X, Liu Y, Ai H, Wang Q, Wang X, Wei X, Song Y and Yin
Q.
TITLE Decreased TCF1 and BCL11B expression predicts poor prognosis for
patients with chronic lymphocytic leukemia
JOURNAL Front Immunol 13, 985280 (2022)
PUBMED 36211334
REMARK GeneRIF: Decreased TCF1 and BCL11B expression predicts poor
prognosis for patients with chronic lymphocytic leukemia.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 823)
AUTHORS Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D,
Leid M and Schaeffer E.
TITLE Recruitment of Tat to heterochromatin protein HP1 via interaction
with CTIP2 inhibits human immunodeficiency virus type 1 replication
in microglial cells
JOURNAL J Virol 77 (9), 5415-5427 (2003)
PUBMED 12692243
REFERENCE 7 (residues 1 to 823)
AUTHORS Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H,
Shinbo T, Mishima Y, Niwa O and Kominami R.
TITLE Homozygous deletions and point mutations of the Rit1/Bcl11b gene in
gamma-ray induced mouse thymic lymphomas
JOURNAL Biochem Biophys Res Commun 301 (2), 598-603 (2003)
PUBMED 12565905
REFERENCE 8 (residues 1 to 823)
AUTHORS Avram D, Fields A, Senawong T, Topark-Ngarm A and Leid M.
TITLE COUP-TF (chicken ovalbumin upstream promoter transcription
factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA
binding protein
JOURNAL Biochem J 368 (Pt 2), 555-563 (2002)
PUBMED 12196208
REFERENCE 9 (residues 1 to 823)
AUTHORS Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL,
Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG,
Siebert R, Tucker PW and Dyer MJ.
TITLE The BCL11 gene family: involvement of BCL11A in lymphoid
malignancies
JOURNAL Blood 98 (12), 3413-3420 (2001)
PUBMED 11719382
REFERENCE 10 (residues 1 to 823)
AUTHORS Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE and Leid
M.
TITLE Isolation of a novel family of C(2)H(2) zinc finger proteins
implicated in transcriptional repression mediated by chicken
ovalbumin upstream promoter transcription factor (COUP-TF) orphan
nuclear receptors
JOURNAL J Biol Chem 275 (14), 10315-10322 (2000)
PUBMED 10744719
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL109767.7, AB057669.1 and
AJ404614.1.
Summary: This gene encodes a C2H2-type zinc finger protein and is
closely related to BCL11A, a gene whose translocation may be
associated with B-cell malignancies. Although the specific function
of this gene has not been determined, the encoded protein is known
to be a transcriptional repressor, and is regulated by the NURD
nucleosome remodeling and histone deacetylase complex. Four
alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene. [provided by RefSeq, Aug
2013].
Transcript Variant: This variant (2) lacks an alternate in-frame
exon compared to variant 1. The resulting isoform (2) has the same
N- and C-termini but is shorter compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ404614.1, AB057669.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2153031 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..823
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.2"
Protein 1..823
/product="B-cell lymphoma/leukemia 11B isoform 2"
/note="B-cell lymphoma/leukaemia 11B; zinc finger protein
hRit1 alpha; B-cell lymphoma/leukemia 11B; BCL11B/TRDC
fusion; B-cell CLL/lymphoma 11B/T-cell receptor delta
constant region fusion protein; BCL-11B;
COUP-TF-interacting protein 2; radiation-induced tumor
suppressor gene 1 protein; B-cell CLL/lymphoma 11B (zinc
finger protein); B cell CLL/lymphoma 11B; BCL11B, BAF
complex component; BAF chromatin remodeling complex
subunit BCL11B"
/calculated_mol_wt=88346
Region 357..378
/region_name="zf-C2H2"
/note="Zinc finger, C2H2 type; pfam00096"
/db_xref="CDD:395048"
Region 358..378
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275370"
Site order(363,365,367,369..370,373..374,377,391,393..395,
397..398,402,405)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275370"
Region 370..395
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:433230"
Region 386..406
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275370"
Region 726..747
/region_name="zf-C2H2"
/note="Zinc finger, C2H2 type; pfam00096"
/db_xref="CDD:395048"
Region 727..747
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(732,734,736,738..739,742..743,746,760,762,766..767,
770..771,774,790,792,794,796..797,800..801)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 739..764
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:433230"
Region 755..775
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 785..803
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
CDS 1..823
/gene="BCL11B"
/gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
RIT1; SMARCM2; ZNF856B"
/coded_by="NM_022898.3:980..3451"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS9949.1"
/db_xref="GeneID:64919"
/db_xref="HGNC:HGNC:13222"
/db_xref="MIM:606558"
ORIGIN
1 msrrkqgnpq hlsqrelitp eadhveaail eedegleiee psglglmvgg pdpdlltcgq
61 cqmnfplgdi lvfiehkrkq cggslgacyd kaldkdsppp ssrselrkvs epveigiqvt
121 pdeddhllsp tkgicpkqen iagkdepssy icttckqpfn sawfllqhaq nthgfriyle
181 pgpasssltp rltippplgp eavaqsplmn flgdsnpfnl lrmtgpilrd hpgfgegrlp
241 gtpplfsppp rhhldphrls aeemglvaqh psafdrvmrl npmaidspam dfsrrlrela
301 gnsstpppvs pgrgnpmhrl lnpfqpspks pflstpplpp mppggtpppq ppakskscef
361 cgktfkfqsn livhrrshtg ekpykcqlcd hacsqasklk rhmkthmhka gslagrsddg
421 lsaasspepg tselageglk aadgdfrhhe sdpslghepe eedeeeeeee eelllenesr
481 pessfsmdse lsrnrenggg gvpgvpgagg gaakaladek alvlgkvmen vglgalpqyg
541 elladkqkrg aflkraaggg dagddddagg cgdagaggav ngrgggfapg tepfpglfpr
601 kpaplpspgl nsaakrikve kdlelppaal ipsenvysqw lvgyaasrhf mkdpflgftd
661 arqspfatss ehssengslr fstppgdlld gglsgrsgta sggstphlgg pgpgrpsske
721 grrsdtceyc gkvfkncsnl tvhrrshtge rpykcelcny acaqsskltr hmkthgqigk
781 evyrcdicqm pfsvystlek hmkkwhgehl ltndvkieqa ers
//
