GenomeNet

Database: RefSeq
Entry: NP_075770
LinkDB: NP_075770
Original site: NP_075770 
LOCUS       NP_075770                664 aa            linear   ROD 01-DEC-2018
DEFINITION  succinate dehydrogenase [ubiquinone] flavoprotein subunit,
            mitochondrial precursor [Mus musculus].
ACCESSION   NP_075770 XP_127445
VERSION     NP_075770.1
DBSOURCE    REFSEQ: accession NM_023281.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 664)
  AUTHORS   Hilse KE, Rupprecht A, Egerbacher M, Bardakji S, Zimmermann L,
            Wulczyn AEMS and Pohl EE.
  TITLE     The Expression of Uncoupling Protein 3 Coincides With the Fatty
            Acid Oxidation Type of Metabolism in Adult Murine Heart
  JOURNAL   Front Physiol 9, 747 (2018)
   PUBMED   29988383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 664)
  AUTHORS   Hilander T, Zhou XL, Konovalova S, Zhang FP, Euro L, Chilov D,
            Poutanen M, Chihade J, Wang ED and Tyynismaa H.
  TITLE     Editing activity for eliminating mischarged tRNAs is essential in
            mammalian mitochondria
  JOURNAL   Nucleic Acids Res. 46 (2), 849-860 (2018)
   PUBMED   29228266
REFERENCE   3  (residues 1 to 664)
  AUTHORS   Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA,
            Sundberg BA, Schofield PN and Pratt CH.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS ONE 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 664)
  AUTHORS   Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy
            I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC,
            Velagapudi V and Rugarli EI.
  TITLE     CLUH regulates mitochondrial metabolism by controlling translation
            and decay of target mRNAs
  JOURNAL   J. Cell Biol. 216 (3), 675-693 (2017)
   PUBMED   28188211
REFERENCE   5  (residues 1 to 664)
  AUTHORS   Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J,
            Stein F, Schultz C, Sauer U and Aulehla A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev. Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (residues 1 to 664)
  AUTHORS   Kullberg M, Nilsson MA, Arnason U, Harley EH and Janke A.
  TITLE     Housekeeping genes for phylogenetic analysis of eutherian
            relationships
  JOURNAL   Mol. Biol. Evol. 23 (8), 1493-1503 (2006)
   PUBMED   16751257
REFERENCE   7  (residues 1 to 664)
  AUTHORS   Schilling B, Murray J, Yoo CB, Row RH, Cusack MP, Capaldi RA and
            Gibson BW.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim. Biophys. Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   8  (residues 1 to 664)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (residues 1 to 664)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J. Biol. Chem. 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (residues 1 to 664)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res. 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034928.1 and AK010561.1.
            On Oct 25, 2004 this sequence version replaced XP_127445.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034928.1, SRR1660815.49108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     Protein         1..664
                     /product="succinate dehydrogenase [ubiquinone]
                     flavoprotein subunit, mitochondrial precursor"
                     /EC_number="1.3.5.1"
                     /note="succinate dehydrogenase [ubiquinone] flavoprotein
                     subunit, mitochondrial; flavoprotein subunit of complex
                     II"
                     /calculated_mol_wt=68104
     transit_peptide 1..42
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Mitochondrion. {ECO:0000250|UniProtKB:Q0QF01};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
                     /calculated_mol_wt=4500
     Region          35..664
                     /region_name="PTZ00139"
                     /note="Succinate dehydrogenase [ubiquinone] flavoprotein
                     subunit; Provisional"
                     /db_xref="CDD:240286"
     mat_peptide     43..664
                     /product="Succinate dehydrogenase [ubiquinone]
                     flavoprotein subunit, mitochondrial"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
                     /calculated_mol_wt=68104
     Region          85..518
                     /region_name="NADB_Rossmann"
                     /note="Rossmann-fold NAD(P)(+)-binding proteins; cl21454"
                     /db_xref="CDD:304358"
     Site            99
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Tele-8alpha-FAD histidine.
                     {ECO:0000250|UniProtKB:Q0QF01}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            167
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            179
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:23576753, ECO:0000244|PubMed:23806337,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            179
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            182
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            215
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by SRC.
                     {ECO:0000250|UniProtKB:P31040}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            250
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            250
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            335
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:23576753,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            335
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            423
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            480
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000269|PubMed:21858060};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            485
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            485
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            498
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:23576753,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            498
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Region          513..664
                     /region_name="Succ_DH_flav_C"
                     /note="Fumarate reductase flavoprotein C-term; pfam02910"
                     /db_xref="CDD:280980"
     Site            517
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            538
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:23576753}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            538
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            547
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:23576753, ECO:0000244|PubMed:23806337,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            547
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000244|PubMed:23806337}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            550
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000269|PubMed:21858060};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            598
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000269|PubMed:21858060};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            608
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753,
                     ECO:0000269|PubMed:21858060}; propagated from
                     UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            615
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine. {ECO:0000244|PubMed:23806337};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            624
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000269|PubMed:21858060};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            633
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000269|PubMed:21858060};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            636
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     Site            647
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:23576753};
                     propagated from UniProtKB/Swiss-Prot (Q8K2B3.1)"
     CDS             1..664
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     C81073; FP; SDH2; SDHF"
                     /coded_by="NM_023281.1:33..2027"
                     /db_xref="CCDS:CCDS26643.1"
                     /db_xref="GeneID:66945"
                     /db_xref="MGI:MGI:1914195"
ORIGIN      
        1 magvgavsrl lrgrrlaltg awpgtlqkqt cgfhfsvgen kkasakvsda istqypvvdh
       61 efdavvvgag gaglraafgl seagfntacl tklfptrsht vaaqgginaa lgnmeednwr
      121 whfydtvkgs dwlgdqdaih ymteqapasv velenygmpf srtedgkiyq rafggqslkf
      181 gkggqahrcc cvadrtghsl lhtlygrslr ydtsyfveyf aldllmenge crgvialcie
      241 dgsihrirak ntviatggyg rtyfsctsah tstgdgtamv traglpcqdl efvqfhptgi
      301 ygagcliteg crgeggilin sqgerfmery apvakdlasr dvvsrsmtle iregrgcgpe
      361 kdhvylqlhh lppeqlatrl pgisetamif agvdvtkepi pvlptvhynm ggiptnykgq
      421 vlkhvngqdq ivpglyacge aacasvhgan rlganslldl vvfgracals iaescrpgdk
      481 vpsikanage esvmnldklr fadgsirtse lrlnmqksmq nhaavfrvgs vlqegcekis
      541 qlygdlkhlk tfdrgmvwnt dlvetlelqn lmlcalqtiy gaearkesrg aharedykvr
      601 vdeydyskpi qgqqkkpfge hwrkhtlsyv diktgkvtle yrpvidktln eadcatvppa
      661 irsy
//
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