LOCUS NP_077199 440 aa linear ROD 10-NOV-2023
DEFINITION fibulin-7 precursor [Mus musculus].
ACCESSION NP_077199 XP_991855
VERSION NP_077199.2
DBSOURCE REFSEQ: accession NM_024237.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 440)
AUTHORS Sugiura H, Tsunezumi J, Yanagisawa H, Futaya M, Nitta K and
Tsuchiya K.
TITLE Fibulin7 aggravates calcium oxalate-induced acute kidney injury by
binding to calcium oxalate crystals
JOURNAL J Cell Physiol 238 (1), 165-178 (2023)
PUBMED 36370444
REMARK GeneRIF: Fibulin7 aggravates calcium oxalate-induced acute kidney
injury by binding to calcium oxalate crystals.
REFERENCE 2 (residues 1 to 440)
AUTHORS Raja E, Changarathil G, Oinam L, Tsunezumi J, Ngo YX, Ishii R,
Sasaki T, Imanaka-Yoshida K, Yanagisawa H and Sada A.
TITLE The extracellular matrix fibulin 7 maintains epidermal stem cell
heterogeneity during skin aging
JOURNAL EMBO Rep 23 (12), e55478 (2022)
PUBMED 36278510
REMARK GeneRIF: The extracellular matrix fibulin 7 maintains epidermal
stem cell heterogeneity during skin aging.
REFERENCE 3 (residues 1 to 440)
AUTHORS Chakraborty P, Dash SP, Dalpati N, Kumar P, Jain D and Sarangi PP.
TITLE A C-terminal fragment of adhesion protein fibulin-7 inhibits growth
of murine breast tumor by regulating macrophage reprogramming
JOURNAL FEBS J 288 (3), 803-817 (2021)
PUBMED 32297473
REMARK GeneRIF: A C-terminal fragment of adhesion protein fibulin-7
inhibits growth of murine breast tumor by regulating macrophage
reprogramming.
REFERENCE 4 (residues 1 to 440)
AUTHORS Ikeuchi T, de Vega S, Forcinito P, Doyle AD, Amaral J, Rodriguez
IR, Arikawa-Hirasawa E and Yamada Y.
TITLE Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In
Vivo Antiangiogenic Activity
JOURNAL Sci Rep 8 (1), 17654 (2018)
PUBMED 30518776
REMARK GeneRIF: This study examined the in vivo antiangiogenic activity of
recombinant full-length mouse Fbln7 (Fbln7-FL) and Fbln7-C-Terminal
Fragment proteins using a rat corneal angiogenesis model. Both
Fbln7-FL and Fbln7-C inhibited neovascularization.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 440)
AUTHORS Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro
Y, Kuro-O M and Yanagisawa H.
TITLE Fibulin-7, a heparin binding matricellular protein, promotes renal
tubular calcification in mice
JOURNAL Matrix Biol 74, 5-20 (2018)
PUBMED 29730503
REMARK GeneRIF: Results found that fibulin-7 is highly expressed in the
adult kidney and binds heparin through its N-terminal domain.
Fbln7-deficient mice were protected from renal tubular
calcification and fibrosis after high phosphate diet. The study
suggests that Fbln7 is a local mediator of calcium deposition in
the kidney.
REFERENCE 6 (residues 1 to 440)
AUTHORS Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
SA.
CONSRTM International Mouse Phenotyping Consortium; Jackson Laboratory;
Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
(ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
Center
TITLE High-throughput discovery of novel developmental phenotypes
JOURNAL Nature 537 (7621), 508-514 (2016)
PUBMED 27626380
REMARK Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE 7 (residues 1 to 440)
AUTHORS Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
Flicek P, Skarnes WC, Mallon AM and Parkinson H.
TITLE The International Mouse Phenotyping Consortium Web Portal, a
unified point of access for knockout mice and related phenotyping
data
JOURNAL Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
PUBMED 24194600
REFERENCE 8 (residues 1 to 440)
AUTHORS Segade F.
TITLE Molecular evolution of the fibulins: implications on the
functionality of the elastic fibulins
JOURNAL Gene 464 (1-2), 17-31 (2010)
PUBMED 20595023
REFERENCE 9 (residues 1 to 440)
AUTHORS de Vega S, Iwamoto T, Nakamura T, Hozumi K, McKnight DA, Fisher LW,
Fukumoto S and Yamada Y.
TITLE TM14 is a new member of the fibulin family (fibulin-7) that
interacts with extracellular matrix molecules and is active for
cell binding
JOURNAL J Biol Chem 282 (42), 30878-30888 (2007)
PUBMED 17699513
REMARK GeneRIF: TM14 is a cell adhesion molecule that interacts with
extracellular matrix molecules in teeth and suggest that TM14 plays
important roles in both the differentiation and maintenance of
odontoblasts as well as in dentin formation.
REFERENCE 10 (residues 1 to 440)
AUTHORS Osipovich AB, Singh A and Ruley HE.
TITLE Post-entrapment genome engineering: first exon size does not affect
the expression of fusion transcripts generated by gene entrapment
JOURNAL Genome Res 15 (3), 428-435 (2005)
PUBMED 15741512
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BB867118.1, CK023294.1, BM936626.1, AL808104.14 and BX520805.1.
On Apr 28, 2007 this sequence version replaced NP_077199.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK005465.1, BC095941.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..440
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 62.63 cM"
Protein 1..440
/product="fibulin-7 precursor"
/note="extracellular matrix protein TM14; FIBL-7"
/calculated_mol_wt=45446
sig_peptide 1..24
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q501P1.1)"
/calculated_mol_wt=2500
mat_peptide 25..440
/product="Fibulin-7. /id=PRO_0000313656"
/note="propagated from UniProtKB/Swiss-Prot (Q501P1.1)"
/calculated_mol_wt=45446
Region 81..135
/region_name="CCP"
/note="Complement control protein (CCP) modules (aka short
consensus repeats SCRs or SUSHI repeats) have been
identified in several proteins of the complement system;
cd00033"
/db_xref="CDD:153056"
Site order(91,108)
/site_type="active"
/note="receptor-ligand interactions [active]"
/db_xref="CDD:153056"
Site 124
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q501P1.1)"
Region 136..172
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site order(136,139,153)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region <221..268
/region_name="vWFA"
/note="Von Willebrand factor type A (vWA) domain was
originally found in the blood coagulation protein von
Willebrand factor (vWF). Typically, the vWA domain is made
up of approximately 200 amino acid residues folded into a
classic a/b para-rossmann type of...; cl00057"
/db_xref="CDD:444673"
Site order(225,228,247)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region 251..274
/region_name="cEGF"
/note="Complement Clr-like EGF-like; pfam12662"
/db_xref="CDD:432704"
Region 271..305
/region_name="EGF_CA"
/note="Calcium-binding EGF domain; pfam07645"
/db_xref="CDD:429571"
Site order(271,274,290)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Site 308
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q501P1.1)"
CDS 1..440
/gene="Fbln7"
/gene_synonym="1600015H20Rik; TM14"
/coded_by="NM_024237.4:142..1464"
/db_xref="CCDS:CCDS38235.1"
/db_xref="GeneID:70370"
/db_xref="MGI:MGI:1917620"
ORIGIN
1 mgpgsqralf llllllaspg arafqsclnk qqllttirql qqllkgqetr ftegirnmks
61 rlaalqntvn kmtpdappvs cpaleappdg kkfgskylvd hevyftcnpg fqlvgpssvv
121 clangswtge qprcrdisec ssqpchnggt cveginhyrc icppgktgnr cqhqtqaaap
181 dggeagdpaf sraprcaqve reqhcsceag fhlssttggh svcqdvnece iygqkgrprl
241 cmhacvntpg syrctcpsgy riladgksce dvdecagpqh mcprgttcin tgggfqcvnp
301 ecpegsgnis yvktspfqce rnpcpmdsrp crhlpktisf hylslpsklk tpitlfrmat
361 asipghpgpn slrfgivggn srghfvmqrs drqtgelilt qtlegpqtle vdvdmseyle
421 rsfqanhvsk vtifvsrydf
//
